STRINGSTRING
EHI_141410 EHI_141410 EHI_129730 EHI_129730 EHI_192770 EHI_192770 EHI_129630 EHI_129630 2.t00064 2.t00064 8.t00042 8.t00042 4.t00027 4.t00027 300.t00001 300.t00001 85.t00006 85.t00006 32.t00015 32.t00015 129.t00030 129.t00030 214.t00007 214.t00007 44.t00003 44.t00003 62.t00007 62.t00007 18.t00056 18.t00056 53.t00034 53.t00034 180.t00010 180.t00010 4.t00129 4.t00129 224.t00013 224.t00013 MCM7 MCM7 40.t00023 40.t00023 73.t00009 73.t00009 60.t00010 60.t00010 1.t00017 1.t00017 113.t00017 113.t00017 318.t00007 318.t00007 135.t00016 135.t00016 173.t00021 173.t00021 FEN1 FEN1 51.t00007 51.t00007 213.t00004 213.t00004 277.t00004 277.t00004 158.t00009 158.t00009 59.t00030 59.t00030 180.t00016 180.t00016 345.t00011 345.t00011 161.t00010 161.t00010 562.t00001 562.t00001 393.t00005 393.t00005
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EHI_141410Uncharacterized protein. (395 aa)
EHI_129730Protein kinase rad3, putative; Belongs to the PI3/PI4-kinase family. (255 aa)
EHI_192770Uncharacterized protein. (391 aa)
EHI_129630DNA primase small subunit, putative. (189 aa)
2.t00064DNA polymerase. (1132 aa)
8.t00042DNA polymerase. (1385 aa)
4.t00027Cell division control protein 45 CDC45, putative. (543 aa)
300.t00001DNA primase; Belongs to the eukaryotic-type primase small subunit family. (380 aa)
85.t00006DNA replication licensing factor MCM3; Belongs to the MCM family. (601 aa)
32.t00015Uncharacterized protein. (199 aa)
129.t00030DNA primase large subunit, putative. (457 aa)
214.t00007Uncharacterized protein. (489 aa)
44.t00003Replication factor C subunit 4, putative. (329 aa)
62.t00007DNA helicase; Belongs to the MCM family. (682 aa)
18.t00056DNA helicase; Belongs to the MCM family. (881 aa)
53.t00034DNA polymerase. (1077 aa)
180.t00010Uncharacterized protein. (440 aa)
4.t00129DNA primase; Belongs to the eukaryotic-type primase small subunit family. (372 aa)
224.t00013Uncharacterized protein. (371 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (690 aa)
40.t00023DNA replication licensing factor, putative; Belongs to the MCM family. (810 aa)
73.t00009Activator 1 subunit, putative. (331 aa)
60.t00010DNA replication licensing factor, putative; Belongs to the MCM family. (733 aa)
1.t00017DNA ligase. (685 aa)
113.t00017DNA replication complex GINS protein PSF1, putative. (189 aa)
318.t00007Activator 1 subunit, putative. (345 aa)
135.t00016Uncharacterized protein. (244 aa)
173.t00021Replication factor C familiy protein. (325 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (376 aa)
51.t00007DNA primase large subunit, putative. (523 aa)
213.t00004DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. (319 aa)
277.t00004Activator 1 140 kDa subunit, putative. (718 aa)
158.t00009Uncharacterized protein. (103 aa)
59.t00030Deoxycytidyl transferase, putative. (708 aa)
180.t00016Activator 1 40 kDa subunit, putative. (315 aa)
345.t00011DNA replication licensing factor, putative; Belongs to the MCM family. (608 aa)
161.t00010Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
562.t00001DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (204 aa)
393.t00005DNA helicase; Belongs to the MCM family. (639 aa)
Your Current Organism:
Entamoeba histolytica
NCBI taxonomy Id: 5759
Other names: E. histolytica
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