(31 nodes) MTOR signalling, and Regulation of protein kinase B signaling network (Entamoeba histolytica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	3.t00144	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (440 aa)
	EHI_050580	Uncharacterized protein. (139 aa)
	EHI_197000	Phosphatidylinositol-3,4, 5-trisphosphate3-phosphatase, putative. (247 aa)
	EHI_124520	Ras-1, putative. (200 aa)
	EHI_006200	3-phosphoinositide-dependent protein kinase 1, putative. (199 aa)
	EHI_020470	Protein kinase domain containing protein. (261 aa)
	EHI_091840	Cysteine surface protein, putative. (347 aa)
	3.t00056	PH domain containing protein. (308 aa)
	25.t00037	GTP-binding protein, putative. (305 aa)
	15.t00002	GTP-binding protein, putative. (308 aa)
	207.t00014	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2526 aa)
	32.t00020	Protein kinase, putative; Belongs to the protein kinase superfamily. (411 aa)
	400.t00007	WD domain containing protein. (1065 aa)
	203.t00010	Ras family GTPase. (183 aa)
	177.t00028	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2342 aa)
	144.t00022	HEAT repeat domain containing protein. (1074 aa)
	9.t00044	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily. (433 aa)
	99.t00019	14-3-3 protein 1; Belongs to the 14-3-3 family. (239 aa)
	4.t00093	Protein kinase, putative; Belongs to the protein kinase superfamily. (434 aa)
	41.t00002	Protein kinase, putative. (395 aa)
	11.t00019	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily. (433 aa)
	135.t00014	Cytosolic regulator pianissimo, putative. (1206 aa)
	89.t00013	Ras family GTPase. (181 aa)
	59.t00031	Protein kinase domain containing protein; Belongs to the protein kinase superfamily. (359 aa)
	304.t00006	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily. (439 aa)
	370.t00002	Protein kinase domain containing protein. (386 aa)
	281.t00002	Protein kinase, putative; Belongs to the protein kinase superfamily. (266 aa)
	757.t00002	Ras guanine nucleotide exchange factor, putative. (763 aa)
	651.t00003	Protein kinase domain containing protein; Belongs to the protein kinase superfamily. (479 aa)
	rac1	Serine/threonine protein kinase; Belongs to the protein kinase superfamily. (409 aa)
	203.t00017	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (347 aa)

Your Current Organism:

Entamoeba histolytica

NCBI taxonomy Id: 5759
Other names: E. histolytica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
11.t00019	135.t00014	C4M4G9	C4M692	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	Cytosolic regulator pianissimo, putative.	0.707
11.t00019	144.t00022	C4M4G9	C4M2F5	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	HEAT repeat domain containing protein.	0.518
11.t00019	15.t00002	C4M4G9	C4LUU1	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	GTP-binding protein, putative.	0.616
11.t00019	177.t00028	C4M4G9	C4M249	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.559
11.t00019	203.t00010	C4M4G9	C4M081	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	Ras family GTPase.	0.413
11.t00019	203.t00017	C4M4G9	Q8WQH7	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.573
11.t00019	207.t00014	C4M4G9	C4LW70	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.562
11.t00019	25.t00037	C4M4G9	C4LUN2	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	GTP-binding protein, putative.	0.536
11.t00019	3.t00144	C4M4G9	B1N2G7	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.574
11.t00019	32.t00020	C4M4G9	C4LWL7	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	Protein kinase, putative; Belongs to the protein kinase superfamily.	0.627
11.t00019	370.t00002	C4M4G9	C4M9B3	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain containing protein.	0.518
11.t00019	400.t00007	C4M4G9	C4LXC3	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	WD domain containing protein.	0.521
11.t00019	41.t00002	C4M4G9	C4M3E9	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	Protein kinase, putative.	0.715
11.t00019	59.t00031	C4M4G9	C4M8P5	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain containing protein; Belongs to the protein kinase superfamily.	0.617
11.t00019	89.t00013	C4M4G9	C4M6J2	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	Ras family GTPase.	0.415
11.t00019	99.t00019	C4M4G9	C4M323	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	14-3-3 protein 1; Belongs to the 14-3-3 family.	0.479
11.t00019	EHI_006200	C4M4G9	B1N3H6	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	3-phosphoinositide-dependent protein kinase 1, putative.	0.680
11.t00019	EHI_020470	C4M4G9	B1N4X2	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain containing protein.	0.433
11.t00019	EHI_124520	C4M4G9	B1N354	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	Ras-1, putative.	0.407
11.t00019	EHI_197000	C4M4G9	B1N2P8	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	Phosphatidylinositol-3,4, 5-trisphosphate3-phosphatase, putative.	0.415