(10 nodes) Regulation of PTEN gene transcription, and Ribosomal protein S6 kinase activity network (Entamoeba histolytica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EHI_124520	Ras-1, putative. (200 aa)
	25.t00037	GTP-binding protein, putative. (305 aa)
	15.t00002	GTP-binding protein, putative. (308 aa)
	207.t00014	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2526 aa)
	400.t00007	WD domain containing protein. (1065 aa)
	177.t00028	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2342 aa)
	144.t00022	HEAT repeat domain containing protein. (1074 aa)
	135.t00014	Cytosolic regulator pianissimo, putative. (1206 aa)
	rac1	Serine/threonine protein kinase; Belongs to the protein kinase superfamily. (409 aa)
	203.t00017	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (347 aa)

Your Current Organism:

Entamoeba histolytica

NCBI taxonomy Id: 5759
Other names: E. histolytica

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
135.t00014	144.t00022	C4M692	C4M2F5	Cytosolic regulator pianissimo, putative.	HEAT repeat domain containing protein.	0.874
135.t00014	15.t00002	C4M692	C4LUU1	Cytosolic regulator pianissimo, putative.	GTP-binding protein, putative.	0.675
135.t00014	177.t00028	C4M692	C4M249	Cytosolic regulator pianissimo, putative.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.996
135.t00014	203.t00017	C4M692	Q8WQH7	Cytosolic regulator pianissimo, putative.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.924
135.t00014	207.t00014	C4M692	C4LW70	Cytosolic regulator pianissimo, putative.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.996
135.t00014	25.t00037	C4M692	C4LUN2	Cytosolic regulator pianissimo, putative.	GTP-binding protein, putative.	0.656
135.t00014	400.t00007	C4M692	C4LXC3	Cytosolic regulator pianissimo, putative.	WD domain containing protein.	0.874
135.t00014	rac1	C4M692	Q26334	Cytosolic regulator pianissimo, putative.	Serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.963
144.t00022	135.t00014	C4M2F5	C4M692	HEAT repeat domain containing protein.	Cytosolic regulator pianissimo, putative.	0.874
144.t00022	15.t00002	C4M2F5	C4LUU1	HEAT repeat domain containing protein.	GTP-binding protein, putative.	0.987
144.t00022	177.t00028	C4M2F5	C4M249	HEAT repeat domain containing protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.993
144.t00022	203.t00017	C4M2F5	Q8WQH7	HEAT repeat domain containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.797
144.t00022	207.t00014	C4M2F5	C4LW70	HEAT repeat domain containing protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.972
144.t00022	25.t00037	C4M2F5	C4LUN2	HEAT repeat domain containing protein.	GTP-binding protein, putative.	0.974
144.t00022	400.t00007	C4M2F5	C4LXC3	HEAT repeat domain containing protein.	WD domain containing protein.	0.602
144.t00022	EHI_124520	C4M2F5	B1N354	HEAT repeat domain containing protein.	Ras-1, putative.	0.532
144.t00022	rac1	C4M2F5	Q26334	HEAT repeat domain containing protein.	Serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.795
15.t00002	135.t00014	C4LUU1	C4M692	GTP-binding protein, putative.	Cytosolic regulator pianissimo, putative.	0.675
15.t00002	144.t00022	C4LUU1	C4M2F5	GTP-binding protein, putative.	HEAT repeat domain containing protein.	0.987
15.t00002	177.t00028	C4LUU1	C4M249	GTP-binding protein, putative.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.980