(16 nodes) Endoplasmic reticulum organization network (Entamoeba histolytica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	266.t00003	Protein SEY1 homolog 2; Probable GTP-binding protein that may be involved in cell development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. RHD3 subfamily. (825 aa)
	149.t00022	Vesicular integral membrane protein VIP36, putative. (410 aa)
	511.t00006	Uncharacterized protein. (135 aa)
	118.t00015	WD domain containing protein. (998 aa)
	EHI_012430	Uncharacterized protein. (127 aa)
	EHI_098970	GB1/RHD3-type G domain-containing protein. (243 aa)
	13.t00018	Tetratricopeptide repeat domain containing protein. (179 aa)
	1.t00151	ER membrane protein complex subunit 3. (273 aa)
	33.t00044	Protein SEY1 homolog 1; Probable GTP-binding protein that may be involved in cell development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. RHD3 subfamily. (959 aa)
	61.t00012	Protein kinase, putative. (765 aa)
	6.t00020	Uncharacterized protein. (622 aa)
	323.t00007	ATPase ASNA1 homolog; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for ins [...] (327 aa)
	237.t00006	Vesicular integral membrane protein VIP36, putative. (414 aa)
	38.t00038	Vesicular integral membrane protein VIP36, putative. (380 aa)
	41.t00020	Uncharacterized protein. (374 aa)
	253.t00012	Protein kinase, putative. (779 aa)

Your Current Organism:

Entamoeba histolytica

NCBI taxonomy Id: 5759
Other names: E. histolytica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
1.t00151	13.t00018	C4LSX6	C4LSE8	ER membrane protein complex subunit 3.	Tetratricopeptide repeat domain containing protein.	0.999
1.t00151	323.t00007	C4LSX6	C4LY44	ER membrane protein complex subunit 3.	ATPase ASNA1 homolog; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for ins [...]	0.734
1.t00151	511.t00006	C4LSX6	C4MBJ2	ER membrane protein complex subunit 3.	Uncharacterized protein.	0.991
1.t00151	6.t00020	C4LSX6	C4LWD8	ER membrane protein complex subunit 3.	Uncharacterized protein.	0.999
1.t00151	EHI_012430	C4LSX6	B1N2I5	ER membrane protein complex subunit 3.	Uncharacterized protein.	0.991
118.t00015	149.t00022	Q1EQ51	C4MAP1	WD domain containing protein.	Vesicular integral membrane protein VIP36, putative.	0.594
118.t00015	237.t00006	Q1EQ51	C4LZ13	WD domain containing protein.	Vesicular integral membrane protein VIP36, putative.	0.588
118.t00015	38.t00038	Q1EQ51	C4LZ48	WD domain containing protein.	Vesicular integral membrane protein VIP36, putative.	0.588
13.t00018	1.t00151	C4LSE8	C4LSX6	Tetratricopeptide repeat domain containing protein.	ER membrane protein complex subunit 3.	0.999
13.t00018	511.t00006	C4LSE8	C4MBJ2	Tetratricopeptide repeat domain containing protein.	Uncharacterized protein.	0.988
13.t00018	6.t00020	C4LSE8	C4LWD8	Tetratricopeptide repeat domain containing protein.	Uncharacterized protein.	0.999
13.t00018	EHI_012430	C4LSE8	B1N2I5	Tetratricopeptide repeat domain containing protein.	Uncharacterized protein.	0.988
149.t00022	118.t00015	C4MAP1	Q1EQ51	Vesicular integral membrane protein VIP36, putative.	WD domain containing protein.	0.594
237.t00006	118.t00015	C4LZ13	Q1EQ51	Vesicular integral membrane protein VIP36, putative.	WD domain containing protein.	0.588
253.t00012	61.t00012	C4MAN9	C4LU28	Protein kinase, putative.	Protein kinase, putative.	0.908
323.t00007	1.t00151	C4LY44	C4LSX6	ATPase ASNA1 homolog; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for ins [...]	ER membrane protein complex subunit 3.	0.734
38.t00038	118.t00015	C4LZ48	Q1EQ51	Vesicular integral membrane protein VIP36, putative.	WD domain containing protein.	0.588
511.t00006	1.t00151	C4MBJ2	C4LSX6	Uncharacterized protein.	ER membrane protein complex subunit 3.	0.991
511.t00006	13.t00018	C4MBJ2	C4LSE8	Uncharacterized protein.	Tetratricopeptide repeat domain containing protein.	0.988
511.t00006	6.t00020	C4MBJ2	C4LWD8	Uncharacterized protein.	Uncharacterized protein.	0.986