79 items (Entamoeba histolytica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	349.t00004	Rab family GTPase. (180 aa)
	62.t00004	Vacuolar sorting protein-associating protein 4A (VPS4), putative; Belongs to the AAA ATPase family. (419 aa)
	42.t00004	Ras family GTPase. (203 aa)
	103.t00012	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (276 aa)
	65.t00026	Autophagy protein apg7, putative. (581 aa)
	53.t00022	14-3-3 protein 3; Belongs to the 14-3-3 family. (240 aa)
	114.t00014	Ribose-phosphate pyrophosphokinase, putative. (337 aa)
	52.t00007	Lysozyme, putative. (722 aa)
	68.t00040	Coronin; Belongs to the WD repeat coronin family. (457 aa)
	22.t00031	Aspartate ammonia-lyase, putative. (472 aa)
	83.t00026	Phosphatidylinositol 3-kinase, putative; Belongs to the PI3/PI4-kinase family. (1047 aa)
	306.t00002	Inositol polyphosphate 5-phosphatase, putative. (970 aa)
	67.t00015	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1043 aa)
	107.t00022	Purine nucleoside phosphorylase, putative. (320 aa)
	99.t00019	14-3-3 protein 1; Belongs to the 14-3-3 family. (239 aa)
	206.t00008	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (270 aa)
	154.t00006	Dynamin-like protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (663 aa)
	191.t00007	Actin-binding protein, cofilin/tropomyosin family. (148 aa)
	414.t00007	Glutamine synthetase, putative; Belongs to the glutamine synthetase family. (709 aa)
	269.t00003	Phosphatidylinositol 3-kinase, putative; Belongs to the PI3/PI4-kinase family. (1124 aa)
	247.t00012	40S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (132 aa)
	219.t00007	Ras family GTPase. (197 aa)
	878.t00001	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. (254 aa)
	141.t00009	Coronin; Belongs to the WD repeat coronin family. (896 aa)
	97.t00017	Protein kinase domain containing protein. (600 aa)
	135.t00013	Lysozyme, putative. (212 aa)
	51.t00002	Rho GDP exchange inhibitor, putative. (175 aa)
	393.t00004	Zinc transporter, putative. (439 aa)
	258.t00007	Autophagy-related protein. (134 aa)
	5.t00007	Thioredoxin, putative. (504 aa)
	5.t00034	Zinc/cadmium transporter, putative. (437 aa)
	425.t00004	Hydrolase TatD family protein. (270 aa)
	3.t00064	Thioredoxin, putative. (485 aa)
	2.t00128	ARF GTPase activating protein, putative. (742 aa)
	81.t00009	Autophagy protein 5; Involved in autophagic vesicle formation. (288 aa)
	35.t00006	60S ribosomal protein L21, putative. (166 aa)
	66.t00016	Protein kinase domain containing protein. (518 aa)
	160.t00011	40S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (132 aa)
	221.t00016	Uncharacterized protein. (214 aa)
	23.t00038	Glutamine synthetase, putative; Belongs to the glutamine synthetase family. (718 aa)
	6.t00052	Lysozyme, putative. (212 aa)
	32.t00040	60S ribosomal protein L21, putative. (166 aa)
	890.t00001	Actin-related protein 3, putative; Belongs to the actin family. (416 aa)
	87.t00026	Lysozyme, putative. (211 aa)
	13.t00027	Inositol polyphosphate 5-phosphatase, putative. (764 aa)
	13.t00030	Rho family GTPase. (199 aa)
	13.t00002	40S ribosomal protein S12, putative. (136 aa)
	EHI_131670	Dynamin-1-like protein, putative. (214 aa)
	56.t00032	Elongation factor 1 beta, putative. (122 aa)
	EHI_162340	Serine/threonine kinase 3, putative. (607 aa)
	EHI_125180	Glutamine synthetase, putative. (266 aa)
	EHI_082270	Aspartate ammonia-lyase, putative. (177 aa)
	EHI_127850	Phosphatidylinositol 3-kinase 3, putative; Belongs to the PI3/PI4-kinase family. (273 aa)
	EHI_134490	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (170 aa)
	EHI_118220	Vacuolar ATP synthase subunit B, putative. (168 aa)
	256.t00004	Inositol polyphosphate 5-phosphatase, putative. (676 aa)
	282.t00012	Dynamin-1-like protein, putative; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (682 aa)
	77.t00022	14-3-3 protein 2; Belongs to the 14-3-3 family. (238 aa)
	337.t00002	Autophagy-related protein. (129 aa)
	9.t00048	Phosphatidylinositol 3-kinase 1, putative; Belongs to the PI3/PI4-kinase family. (814 aa)
	17.t00052	Ribose-phosphate pyrophosphokinase, putative. (332 aa)
	192.t00007	Cdc48-like protein, putative. (772 aa)
	25.t00049	Histidine triad nucleotide-binding protein; Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. May also function as scaffolding protein that mediates prote [...] (113 aa)
	67.t00005	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (352 aa)
	EhRabC7	Small GTPase EhRabC7. (195 aa)
	18.t00032	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (496 aa)
	Ehras1	Ras family GTPase. (205 aa)
	cpn60	Chaperonin 1 60 kDa; Belongs to the chaperonin (HSP60) family. (536 aa)
	584.t00001	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family. (524 aa)
	41.t00034	Purine nucleoside phosphorylase, putative. (320 aa)
	21.t00035	Phosphoinositide kinase, putative. (711 aa)
	213.t00015	Inositol polyphosphate-5-phosphatase, putative. (920 aa)
	143.t00003	Protein kinase domain containing protein. (561 aa)
	30.t00010	Purine nucleoside phosphorylase, putative. (318 aa)
	183.t00010	Inositol polyphosphate 5-phosphatase, putative. (675 aa)
	54.t00039	Coronin; Belongs to the WD repeat coronin family. (433 aa)
	281.t00003	Inositol polyphosphate 5-phosphatase, putative. (797 aa)
	404.t00002	Lysozyme, putative. (208 aa)
	EhRabH	Rab family GTPase. (208 aa)

Your Current Organism:

Entamoeba histolytica

NCBI taxonomy Id: 5759
Other names: E. histolytica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
103.t00012	13.t00030	C4M096	C4LSD7	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Rho family GTPase.	0.425
103.t00012	191.t00007	C4M096	C4M4P4	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Actin-binding protein, cofilin/tropomyosin family.	0.570
103.t00012	206.t00008	C4M096	C4M3N6	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.999
103.t00012	890.t00001	C4M096	C4LWT9	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Actin-related protein 3, putative; Belongs to the actin family.	0.814
103.t00012	EHI_134490	C4M096	B1N371	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.543
107.t00022	30.t00010	C4M2Y7	C4M7M1	Purine nucleoside phosphorylase, putative.	Purine nucleoside phosphorylase, putative.	0.905
107.t00022	41.t00034	C4M2Y7	C4MAV9	Purine nucleoside phosphorylase, putative.	Purine nucleoside phosphorylase, putative.	0.903
114.t00014	17.t00052	C4M0M2	C4LXZ5	Ribose-phosphate pyrophosphokinase, putative.	Ribose-phosphate pyrophosphokinase, putative.	0.902
114.t00014	22.t00031	C4M0M2	C4M220	Ribose-phosphate pyrophosphokinase, putative.	Aspartate ammonia-lyase, putative.	0.527
114.t00014	56.t00032	C4M0M2	B1N4F4	Ribose-phosphate pyrophosphokinase, putative.	Elongation factor 1 beta, putative.	0.401
114.t00014	878.t00001	C4M0M2	C4M5A0	Ribose-phosphate pyrophosphokinase, putative.	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.	0.652
114.t00014	EHI_082270	C4M0M2	B1N3V9	Ribose-phosphate pyrophosphokinase, putative.	Aspartate ammonia-lyase, putative.	0.527
13.t00002	160.t00011	C4LSC4	C4LVN9	40S ribosomal protein S12, putative.	40S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family.	0.901
13.t00002	247.t00012	C4LSC4	C4M574	40S ribosomal protein S12, putative.	40S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family.	0.901
13.t00002	32.t00040	C4LSC4	C4LWK0	40S ribosomal protein S12, putative.	60S ribosomal protein L21, putative.	0.937
13.t00002	35.t00006	C4LSC4	C4LV69	40S ribosomal protein S12, putative.	60S ribosomal protein L21, putative.	0.942
13.t00002	56.t00032	C4LSC4	B1N4F4	40S ribosomal protein S12, putative.	Elongation factor 1 beta, putative.	0.820
13.t00002	878.t00001	C4LSC4	C4M5A0	40S ribosomal protein S12, putative.	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.	0.993
13.t00027	256.t00004	C4LSE0	C4LX62	Inositol polyphosphate 5-phosphatase, putative.	Inositol polyphosphate 5-phosphatase, putative.	0.912
13.t00027	269.t00003	C4LSE0	C4M4S6	Inositol polyphosphate 5-phosphatase, putative.	Phosphatidylinositol 3-kinase, putative; Belongs to the PI3/PI4-kinase family.	0.922