(42 nodes) Response to metal ion network (Entamoeba histolytica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	442.t00004	Peroxiredoxin. (233 aa)
	140.t00002	Diacylglycerol kinase. (539 aa)
	322.t00001	WD domain containing protein. (333 aa)
	298.t00001	Peroxiredoxin, putative. (233 aa)
	234.t00004	Replication factor A protein 1, putative. (588 aa)
	254.t00012	Centromere/microtubule binding protein cbf5, putative. (484 aa)
	472.t00010	WD domain containing protein. (474 aa)
	45.t00004	70 kDa heat shock protein, putative; Belongs to the heat shock protein 70 family. (661 aa)
	136.t00007	Peroxiredoxin. (234 aa)
	53.t00037	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family. (632 aa)
	90.t00019	Heat shock protein 70 family; Belongs to the heat shock protein 70 family. (660 aa)
	203.t00014	Uncharacterized protein. (175 aa)
	1.t00001	Actin-like protein, putative. (401 aa)
	208.t00004	Inositol-1-monophosphatase. (295 aa)
	101.t00003	Histidine acid phosphatase family protein; Belongs to the histidine acid phosphatase family. (426 aa)
	410.t00003	Cyclin, putative; Belongs to the cyclin family. (307 aa)
	125.t00008	Cyclin, putative; Belongs to the cyclin family. (400 aa)
	828.t00001	Peroxiredoxin, putative. (233 aa)
	153.t00007	Histone H3, putative. (135 aa)
	EHI_123390	Peroxiredoxin. (237 aa)
	EHI_106660	Uncharacterized protein. (129 aa)
	EHI_084260	Peroxiredoxin, putative. (250 aa)
	EHI_121620	Peroxiredoxin, putative. (133 aa)
	EHI_018740	Peroxiredoxin family protein. (132 aa)
	EHI_139570	Peroxiredoxin, putative. (192 aa)
	13.t00032	Diacylglycerol kinase. (567 aa)
	13.t00026	Diacylglycerol kinase, putative. (481 aa)
	78.t00033	Diacylglycerol kinase. (557 aa)
	25.t00034	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (118 aa)
	96.t00006	Histone H3, putative. (205 aa)
	39.t00045	Histone H2B; Belongs to the histone H2B family. (133 aa)
	23.t00058	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family. (697 aa)
	139.t00014	Histone H3, putative. (146 aa)
	890.t00001	Actin-related protein 3, putative; Belongs to the actin family. (416 aa)
	84.t00017	Histone H3, putative. (147 aa)
	3.t00039	Histone H3, putative. (119 aa)
	18.t00073	Diacylglycerol kinase. (523 aa)
	18.t00050	Ribosome biogenesis protein WDR12 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat WDR12/YTM1 family. (406 aa)
	217.t00004	Uncharacterized protein. (175 aa)
	94.t00032	Peroxiredoxin, putative. (237 aa)
	294.t00003	Peroxiredoxin. (229 aa)
	155.t00009	Uncharacterized protein. (175 aa)

Your Current Organism:

Entamoeba histolytica

NCBI taxonomy Id: 5759
Other names: E. histolytica

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
1.t00001	125.t00008	C4M5I6	C4M7E8	Actin-like protein, putative.	Cyclin, putative; Belongs to the cyclin family.	0.680
1.t00001	139.t00014	C4M5I6	C4LWH7	Actin-like protein, putative.	Histone H3, putative.	0.461
1.t00001	153.t00007	C4M5I6	C4M0Z4	Actin-like protein, putative.	Histone H3, putative.	0.468
1.t00001	155.t00009	C4M5I6	B1N2V1	Actin-like protein, putative.	Uncharacterized protein.	0.410
1.t00001	203.t00014	C4M5I6	C4M078	Actin-like protein, putative.	Uncharacterized protein.	0.410
1.t00001	217.t00004	C4M5I6	C4MBR6	Actin-like protein, putative.	Uncharacterized protein.	0.416
1.t00001	25.t00034	C4M5I6	C4LUN4	Actin-like protein, putative.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.607
1.t00001	3.t00039	C4M5I6	C4LYH2	Actin-like protein, putative.	Histone H3, putative.	0.461
1.t00001	39.t00045	C4M5I6	C4LV75	Actin-like protein, putative.	Histone H2B; Belongs to the histone H2B family.	0.493
1.t00001	410.t00003	C4M5I6	C4M1F5	Actin-like protein, putative.	Cyclin, putative; Belongs to the cyclin family.	0.685
1.t00001	84.t00017	C4M5I6	C4LY78	Actin-like protein, putative.	Histone H3, putative.	0.464
1.t00001	890.t00001	C4M5I6	C4LWT9	Actin-like protein, putative.	Actin-related protein 3, putative; Belongs to the actin family.	0.999
1.t00001	96.t00006	C4M5I6	C4LUR4	Actin-like protein, putative.	Histone H3, putative.	0.463
1.t00001	EHI_106660	C4M5I6	B1N5A9	Actin-like protein, putative.	Uncharacterized protein.	0.410
101.t00003	208.t00004	C4M349	C4M3A8	Histidine acid phosphatase family protein; Belongs to the histidine acid phosphatase family.	Inositol-1-monophosphatase.	0.846
125.t00008	1.t00001	C4M7E8	C4M5I6	Cyclin, putative; Belongs to the cyclin family.	Actin-like protein, putative.	0.680
125.t00008	25.t00034	C4M7E8	C4LUN4	Cyclin, putative; Belongs to the cyclin family.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.518
125.t00008	890.t00001	C4M7E8	C4LWT9	Cyclin, putative; Belongs to the cyclin family.	Actin-related protein 3, putative; Belongs to the actin family.	0.680
13.t00032	78.t00033	C4LSD5	C4LTH2	Diacylglycerol kinase.	Diacylglycerol kinase.	0.905
139.t00014	1.t00001	C4LWH7	C4M5I6	Histone H3, putative.	Actin-like protein, putative.	0.461