(128 nodes) Negative regulation of macromolecule metabolic process network (Entamoeba histolytica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCP	Hydroxylamine reductase, putative. (539 aa)
	211.t00008	TPR repeat protein. (931 aa)
	203.t00018	Serine-threonine protein kinase YAK1. (608 aa)
	48.t00008	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (414 aa)
	Caf1	CAF1 family ribonuclease, putative. (311 aa)
	163.t00015	CCR4/NOT transcription complex subunit 3, putative. (482 aa)
	121.t00020	Calmodulin, putative. (146 aa)
	407.t00006	Uncharacterized protein. (484 aa)
	83.t00014	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (260 aa)
	5.t00088	Uncharacterized protein. (843 aa)
	275.t00014	60S ribosomal protein L16-B, putative. (202 aa)
	63.t00003	Serine/threonine-protein kinase, putative. (682 aa)
	297.t00006	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (779 aa)
	223.t00009	MAGE domain-containing protein. (296 aa)
	223.t00003	Scavenger mRNA decapping enzyme, putative. (287 aa)
	293.t00010	5'-3' exonuclease domain containing protein. (628 aa)
	180.t00014	3' exoribonuclease family protein. (223 aa)
	142.t00014	Pumilio family RNA-binding protein. (394 aa)
	201.t00018	Exosome component 10, putative. (517 aa)
	203.t00019	Uncharacterized protein. (233 aa)
	203.t00014	Uncharacterized protein. (175 aa)
	203.t00024	Serine/threonine-protein kinase, putative. (676 aa)
	103.t00029	Uncharacterized protein. (861 aa)
	178.t00012	Uncharacterized protein. (536 aa)
	98.t00010	TPR repeat protein. (917 aa)
	98.t00016	Zinc finger protein, putative. (212 aa)
	4.t00006	Myb-like DNA-binding domain containing protein. (150 aa)
	205.t00005	Uncharacterized protein. (241 aa)
	37.t00027	RNA recognition motif domain containing protein. (685 aa)
	217.t00004	Uncharacterized protein. (175 aa)
	80.t00012	Pumilio family RNA-binding protein. (484 aa)
	23.t00062	Calmodulin, putative. (150 aa)
	22.t00005	5'-3' exonuclease domain containing protein. (666 aa)
	361.t00011	Dephospho-CoA kinase, putative. (206 aa)
	5.t00013	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (937 aa)
	267.t00008	N-acetylmuraminidase, putative. (215 aa)
	447.t00009	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (225 aa)
	357.t00003	Uncharacterized protein. (426 aa)
	174.t00008	Protein kinase domain-containing protein. (666 aa)
	377.t00002	Protein kinase, putative. (576 aa)
	3.t00001	Pelota protein, putative. (403 aa)
	319.t00002	Uncharacterized protein. (372 aa)
	392.t00003	LSM domain containing protein. (91 aa)
	17.t00041	Regulator of nonsense transcripts, putative. (937 aa)
	104.t00026	Uncharacterized protein. (719 aa)
	55.t00006	Uncharacterized protein. (109 aa)
	78.t00002	Uncharacterized protein. (338 aa)
	62.t00030	Negative cofactor 2-beta. (156 aa)
	18.t00069	Uncharacterized protein. (536 aa)
	18.t00045	Protein kinase, putative. (675 aa)
	47.t00024	Dr1-associated corepressor, putative. (119 aa)
	106.t00010	Pumilio family RNA-binding protein. (438 aa)
	91.t00009	Exosome complex exonuclease, putative. (265 aa)
	91.t00027	Uncharacterized protein. (598 aa)
	7.t00046	CAF1 family ribonuclease, putative. (303 aa)
	75.t00036	3' exoribonuclease family protein. (265 aa)
	69.t00026	Scavenger mRNA decapping enzyme, putative. (281 aa)
	29.t00016	TPR repeat protein. (890 aa)
	29.t00024	Regulator of nonsense transcripts, putative. (909 aa)
	142.t00012	Protein kinase domain containing protein. (612 aa)
	1.t00039	Uncharacterized protein. (375 aa)
	177.t00002	Uncharacterized protein. (601 aa)
	116.t00019	Serine/threonine-protein kinase, putative. (682 aa)
	144.t00006	3' exoribonuclease family protein. (238 aa)
	199.t00010	60S ribosomal protein L13, putative. (205 aa)
	128.t00006	Protein kinase domain containing protein. (602 aa)
	256.t00007	Exosome complex exonuclease RRP4, putative. (263 aa)
	109.t00007	Uncharacterized protein. (580 aa)
	109.t00016	Uncharacterized protein. (1598 aa)
	108.t00010	Uncharacterized protein. (430 aa)
	100.t00009	Nuclear cap-binding protein subunit 2. (184 aa)
	154.t00014	Uncharacterized protein. (212 aa)
	67.t00013	Histone acetyltransferase type B catalytic subunit. (405 aa)
	19.t00008	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, putative. (996 aa)
	77.t00018	SP-RING zinc finger domain containing protein. (406 aa)
	77.t00025	MutT/nudix family protein. (286 aa)
	155.t00010	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (226 aa)
	88.t00006	Protein kinase, putative. (753 aa)
	364.t00002	SP-RING zinc finger domain containing protein. (539 aa)
	6.t00035	DEAD/DEAH box helicase, putative; Belongs to the DEAD box helicase family. (535 aa)
	117.t00038	3' exoribonuclease family protein. (227 aa)
	11.t00070	PIWI, putative; Belongs to the argonaute family. (937 aa)
	12.t00016	Transcription initiation factor SPT5, putative. (774 aa)
	12.t00057	PIWI domain protein; Belongs to the argonaute family. (913 aa)
	12.t00063	Uncharacterized protein. (559 aa)
	92.t00018	Uncharacterized protein. (781 aa)
	15.t00053	Uncharacterized protein. (1999 aa)
	134.t00015	Calmodulin, putative. (144 aa)
	96.t00002	Regulator of nonsense transcripts, putative. (915 aa)
	81.t00024	Protein kinase, putative. (703 aa)
	LSM4	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (81 aa)
	58.t00033	Regulator of nonsense transcripts, putative. (965 aa)
	16.t00050	Protein kinase, putative. (688 aa)
	3.t00067	Uncharacterized protein. (255 aa)
	3.t00005	Calmodulin, putative. (146 aa)
	1.t00058	Regulator of nonsense transcripts, putative. (966 aa)
	1.t00122	Pumilio family RNA-binding protein. (439 aa)
	6.t00077	SP-RING zinc finger domain containing protein. (501 aa)
	2.t00084	Uncharacterized protein. (579 aa)
	2.t00031	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily. (383 aa)
	24.t00065	Myb-like DNA-binding domain containing protein. (154 aa)
	13.t00063	Protein kinase domain containing protein. (584 aa)
	EHI_106660	Uncharacterized protein. (129 aa)
	EHI_120470	Uncharacterized protein. (333 aa)
	EHI_200090	Ribosomal protein L13A, putative. (148 aa)
	EHI_128220	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (869 aa)
	EHI_133550	Myb-like DNA-binding domain containing protein. (128 aa)
	EHI_124520	Ras-1, putative. (200 aa)
	155.t00009	Uncharacterized protein. (175 aa)
	EHI_186710	Serine/threonine-protein kinase C823.03, putative. (156 aa)
	EHI_197000	Phosphatidylinositol-3,4, 5-trisphosphate3-phosphatase, putative. (247 aa)
	63.t00025	Uncharacterized protein. (1005 aa)
	191.t00011	Myb-like DNA-binding domain containing protein. (160 aa)
	98.t00004	Zinc finger domain containing protein. (229 aa)
	134.t00020	Regulator of nonsense transcripts, putative. (931 aa)
	232.t00005	Serine protease inhibitor, putative; Belongs to the serpin family. (371 aa)
	49.t00006	Helicase, putative. (956 aa)
	230.t00023	mRNA decapping protein, putative. (232 aa)
	54.t00054	Regulator of nonsense transcripts, putative. (979 aa)
	30.t00050	Pumilio family RNA-binding protein. (528 aa)
	414.t00003	DEAD/DEAH box helicase, putative. (1062 aa)
	338.t00004	Protein kinase, putative. (739 aa)
	251.t00014	Sir2 family transcriptional regulator, putative. (359 aa)
	391.t00002	Uncharacterized protein. (1372 aa)
	171.t00022	RNA-dependent RNA polymerase. (1026 aa)
	231.t00005	Myb-like DNA-binding domain containing protein. (160 aa)
	372.t00006	Regulator of nonsense transcripts, putative. (896 aa)
	277.t00007	Protein kinase, putative. (675 aa)

Your Current Organism:

Entamoeba histolytica

NCBI taxonomy Id: 5759
Other names: E. histolytica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
1.t00039	109.t00016	C4M1V1	C4M3Y6	Uncharacterized protein.	Uncharacterized protein.	0.969
1.t00039	15.t00053	C4M1V1	C4LUT6	Uncharacterized protein.	Uncharacterized protein.	0.969
1.t00039	163.t00015	C4M1V1	C4M7Y3	Uncharacterized protein.	CCR4/NOT transcription complex subunit 3, putative.	0.982
1.t00039	391.t00002	C4M1V1	C4M6S8	Uncharacterized protein.	Uncharacterized protein.	0.969
1.t00039	7.t00046	C4M1V1	C4LZS1	Uncharacterized protein.	CAF1 family ribonuclease, putative.	0.930
1.t00039	78.t00002	C4M1V1	C4LYF8	Uncharacterized protein.	Uncharacterized protein.	0.995
1.t00039	Caf1	C4M1V1	Q56AY2	Uncharacterized protein.	CAF1 family ribonuclease, putative.	0.930
1.t00058	100.t00009	C4LT63	C4M4C7	Regulator of nonsense transcripts, putative.	Nuclear cap-binding protein subunit 2.	0.681
1.t00058	108.t00010	C4LT63	C4M4B3	Regulator of nonsense transcripts, putative.	Uncharacterized protein.	0.475
1.t00058	230.t00023	C4LT63	C4M5G6	Regulator of nonsense transcripts, putative.	mRNA decapping protein, putative.	0.425
1.t00058	6.t00035	C4LT63	C4LWF2	Regulator of nonsense transcripts, putative.	DEAD/DEAH box helicase, putative; Belongs to the DEAD box helicase family.	0.438
1.t00058	77.t00025	C4LT63	C4LXA8	Regulator of nonsense transcripts, putative.	MutT/nudix family protein.	0.425
1.t00058	HCP	C4LT63	Q8WR14	Regulator of nonsense transcripts, putative.	Hydroxylamine reductase, putative.	0.799
1.t00122	7.t00046	C4LT03	C4LZS1	Pumilio family RNA-binding protein.	CAF1 family ribonuclease, putative.	0.437
1.t00122	Caf1	C4LT03	Q56AY2	Pumilio family RNA-binding protein.	CAF1 family ribonuclease, putative.	0.433
100.t00009	1.t00058	C4M4C7	C4LT63	Nuclear cap-binding protein subunit 2.	Regulator of nonsense transcripts, putative.	0.681
100.t00009	108.t00010	C4M4C7	C4M4B3	Nuclear cap-binding protein subunit 2.	Uncharacterized protein.	0.441
100.t00009	12.t00016	C4M4C7	C4LVU5	Nuclear cap-binding protein subunit 2.	Transcription initiation factor SPT5, putative.	0.819
100.t00009	134.t00020	C4M4C7	C4M4V4	Nuclear cap-binding protein subunit 2.	Regulator of nonsense transcripts, putative.	0.681
100.t00009	155.t00010	C4M4C7	C4LX57	Nuclear cap-binding protein subunit 2.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.599