(54 nodes) Nucleotidyltransferase activity network (Entamoeba histolytica)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	237.t00007	Threonylcarbamoyl-AMP synthase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (357 aa)
	106.t00014	UTP--glucose-1-phosphate uridylyltransferase. (474 aa)
	7.t00016	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (143 aa)
	30.t00023	UDP-N-acetylglucosamine pyrophosphorylase, putative. (401 aa)
	178.t00011	Uncharacterized protein. (549 aa)
	53.t00034	DNA polymerase. (1077 aa)
	53.t00026	Uncharacterized protein. (231 aa)
	4.t00129	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (372 aa)
	242.t00019	Uncharacterized protein. (316 aa)
	133.t00020	Phosphatidate cytidylyltransferase, putative. (295 aa)
	133.t00030	tRNA nucleotidyltransferase, putative; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (461 aa)
	41.t00010	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1122 aa)
	310.t00009	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1570 aa)
	528.t00001	Uncharacterized protein. (861 aa)
	121.t00002	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1106 aa)
	138.t00017	UDP-N-acetylglucosamine pyrophosphorylase, putative. (401 aa)
	370.t00004	Uncharacterized protein. (338 aa)
	59.t00030	Deoxycytidyl transferase, putative. (708 aa)
	RPB1	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1636 aa)
	16.t00038	Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. May acquire specificity through interaction with a cleavage and polyadenylation factor. (522 aa)
	436.t00002	Topoisomerase, putative. (365 aa)
	279.t00017	Uncharacterized protein. (151 aa)
	254.t00012	Centromere/microtubule binding protein cbf5, putative. (484 aa)
	170.t00003	Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. (313 aa)
	186.t00019	Uncharacterized protein. (344 aa)
	171.t00022	RNA-dependent RNA polymerase. (1026 aa)
	51.t00031	DNA-directed RNA polymerases I, II, and III 23 kDa, putative. (122 aa)
	73.t00023	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1379 aa)
	59.t00015	DNA-directed RNA polymerase subunit N, putative. (73 aa)
	162.t00003	DNA-directed RNA polymerase II subunit, putative. (283 aa)
	269.t00004	Phospholipid cytidylyltransferase, putative. (338 aa)
	60.t00017	Phospholipid cytidylyltransferase, putative. (341 aa)
	128.t00009	mRNA capping enzyme, putative. (595 aa)
	EHI_124360	Uncharacterized protein. (212 aa)
	EHI_006680	Phosphopantetheineadenylyltransferase, putative. (233 aa)
	EHI_129630	DNA primase small subunit, putative. (189 aa)
	130.t00019	Nicotinamide-nucleotide adenylyltransferase. (212 aa)
	2.t00064	DNA polymerase. (1132 aa)
	64.t00037	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (122 aa)
	10.t00022	DNA-directed RNA polymerase III subunit, putative. (236 aa)
	8.t00042	DNA polymerase. (1385 aa)
	81.t00015	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1170 aa)
	26.t00024	Poly(A) polymerase, putative. (344 aa)
	79.t00002	Sulfate adenylyltransferase, putative. (423 aa)
	300.t00001	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (380 aa)
	85.t00027	Uncharacterized protein. (456 aa)
	200.t00008	RNA polymerase subunit Rpb5, putative. (204 aa)
	27.t00023	Translation initiation factor eIF-2B epsilon subunit, putative. (634 aa)
	67.t00006	DNA-directed DNA polymerase, putative. (657 aa)
	406.t00005	Topoisomerase, putative. (400 aa)
	169.t00023	RNA polymerases II subunit, putative. (112 aa)
	17.t00048	mRNA_cap_enzyme domain-containing protein. (568 aa)
	44.t00011	tRNA nucleotidyltransferase, putative; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (484 aa)
	18.t00049	Molybdenum cofactor synthesis protein3, putative. (250 aa)

Your Current Organism:

Entamoeba histolytica

NCBI taxonomy Id: 5759
Other names: E. histolytica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
10.t00022	121.t00002	C4LTV3	C4MAB3	DNA-directed RNA polymerase III subunit, putative.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.965
10.t00022	162.t00003	C4LTV3	C4M554	DNA-directed RNA polymerase III subunit, putative.	DNA-directed RNA polymerase II subunit, putative.	0.999
10.t00022	169.t00023	C4LTV3	C4LXS9	DNA-directed RNA polymerase III subunit, putative.	RNA polymerases II subunit, putative.	0.696
10.t00022	178.t00011	C4LTV3	C4M0C8	DNA-directed RNA polymerase III subunit, putative.	Uncharacterized protein.	0.999
10.t00022	18.t00049	C4LTV3	C4LYY8	DNA-directed RNA polymerase III subunit, putative.	Molybdenum cofactor synthesis protein3, putative.	0.490
10.t00022	200.t00008	C4LTV3	C4LW54	DNA-directed RNA polymerase III subunit, putative.	RNA polymerase subunit Rpb5, putative.	0.999
10.t00022	279.t00017	C4LTV3	C4MBG5	DNA-directed RNA polymerase III subunit, putative.	Uncharacterized protein.	0.999
10.t00022	310.t00009	C4LTV3	C4M3E6	DNA-directed RNA polymerase III subunit, putative.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.989
10.t00022	41.t00010	C4LTV3	C4M3E3	DNA-directed RNA polymerase III subunit, putative.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
10.t00022	51.t00031	C4LTV3	C4M6S1	DNA-directed RNA polymerase III subunit, putative.	DNA-directed RNA polymerases I, II, and III 23 kDa, putative.	0.999
10.t00022	59.t00015	C4LTV3	C4M5M4	DNA-directed RNA polymerase III subunit, putative.	DNA-directed RNA polymerase subunit N, putative.	0.999
10.t00022	64.t00037	C4LTV3	C4LT84	DNA-directed RNA polymerase III subunit, putative.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.	0.953
10.t00022	7.t00016	C4LTV3	C4LZP1	DNA-directed RNA polymerase III subunit, putative.	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.	0.999
10.t00022	73.t00023	C4LTV3	C4M626	DNA-directed RNA polymerase III subunit, putative.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
10.t00022	81.t00015	C4LTV3	C4LUK7	DNA-directed RNA polymerase III subunit, putative.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.985
10.t00022	EHI_124360	C4LTV3	B1N352	DNA-directed RNA polymerase III subunit, putative.	Uncharacterized protein.	0.751
10.t00022	RPB1	C4LTV3	Q6IUR3	DNA-directed RNA polymerase III subunit, putative.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.691
106.t00014	138.t00017	C4LZ95	C4MA87	UTP--glucose-1-phosphate uridylyltransferase.	UDP-N-acetylglucosamine pyrophosphorylase, putative.	0.743
106.t00014	242.t00019	C4LZ95	C4M2F4	UTP--glucose-1-phosphate uridylyltransferase.	Uncharacterized protein.	0.402
106.t00014	27.t00023	C4LZ95	C4LXH0	UTP--glucose-1-phosphate uridylyltransferase.	Translation initiation factor eIF-2B epsilon subunit, putative.	0.404