(70 nodes) Ubiquitin-like protein transferase activity network (Entamoeba histolytica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	470.t00007	RBR-type E3 ubiquitin transferase. (272 aa)
	EHI_029000	Zinc finger domain containing protein. (172 aa)
	EHI_082280	Ubiquitin-conjugating enzyme E2 6, putative. (105 aa)
	EHI_107780	WD domain containing protein. (541 aa)
	EHI_018590	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1342 aa)
	13.t00037	Phospholipase, patatin family protein. (677 aa)
	2.t00108	RING finger protein, putative. (94 aa)
	2.t00090	F-box/WD domain containing protein. (720 aa)
	2.t00084	Uncharacterized protein. (579 aa)
	2.t00075	Zinc finger domain containing protein. (446 aa)
	6.t00077	SP-RING zinc finger domain containing protein. (501 aa)
	10.t00049	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (756 aa)
	150.t00011	Uncharacterized protein. (222 aa)
	4.t00046	Ubiquitin-conjugating enzyme family protein. (344 aa)
	25.t00026	RBR-type E3 ubiquitin transferase. (605 aa)
	96.t00004	Ubiquitin-conjugating enzyme family protein; Belongs to the ubiquitin-conjugating enzyme family. (160 aa)
	12.t00025	Ubiquitin-protein ligase, putative. (652 aa)
	48.t00012	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1229 aa)
	23.t00064	Zinc finger domain containing protein. (442 aa)
	24.t00013	RBR-type E3 ubiquitin transferase. (441 aa)
	364.t00002	SP-RING zinc finger domain containing protein. (539 aa)
	77.t00018	SP-RING zinc finger domain containing protein. (406 aa)
	19.t00023	Zinc finger domain containing protein. (234 aa)
	9.t00066	Zinc finger domain containing protein. (382 aa)
	37.t00038	Retinoblatoma-binding protein 6, putative. (394 aa)
	3.t00035	RBR-type E3 ubiquitin transferase. (322 aa)
	415.t00009	Ubiquitin ligase, putative. (2416 aa)
	42.t00021	Ubiquitin-conjugating enzyme family protein; Belongs to the ubiquitin-conjugating enzyme family. (173 aa)
	42.t00005	Ubiquitin-protein ligase, putative. (750 aa)
	46.t00033	Autophagy-related protein 3. (268 aa)
	131.t00019	RBR-type E3 ubiquitin transferase. (507 aa)
	65.t00026	Autophagy protein apg7, putative. (581 aa)
	151.t00018	Ubiquitin-conjugating enzyme family protein; Belongs to the ubiquitin-conjugating enzyme family. (219 aa)
	153.t00005	Zinc finger domain containing protein. (87 aa)
	19.t00039	Ubiquitin-like protein. (114 aa)
	195.t00010	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1385 aa)
	408.t00002	Ubiquitin-conjugating enzyme family protein; Belongs to the ubiquitin-conjugating enzyme family. (150 aa)
	127.t00014	Zinc finger protein, putative. (478 aa)
	22.t00037	Ubiquitin-conjugating enzyme family protein. (159 aa)
	35.t00018	Uncharacterized protein. (245 aa)
	107.t00018	Ubiquitin-conjugating enzyme family protein; Belongs to the ubiquitin-conjugating enzyme family. (165 aa)
	346.t00007	Ubiquitin-conjugating enzyme family protein. (152 aa)
	35.t00023	Uncharacterized protein. (959 aa)
	551.t00003	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1305 aa)
	100.t00027	Cullin, putative; Belongs to the cullin family. (721 aa)
	166.t00006	HECT domain-containing protein. (2123 aa)
	191.t00004	WD domain containing protein. (516 aa)
	59.t00017	RBR-type E3 ubiquitin transferase. (638 aa)
	108.t00020	Ubiquitin-conjugating enzyme family protein; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
	97.t00005	Uncharacterized protein. (219 aa)
	51.t00013	Ubiquitin-conjugating enzyme family protein; Belongs to the ubiquitin-conjugating enzyme family. (162 aa)
	321.t00009	SPRY domain protein. (1034 aa)
	125.t00010	Zinc finger domain containing protein. (310 aa)
	484.t00005	Ubiquitin-conjugating enzyme family protein; Belongs to the ubiquitin-conjugating enzyme family. (156 aa)
	211.t00003	RBR-type E3 ubiquitin transferase. (358 aa)
	EHI_159910	RBR-type E3 ubiquitin transferase. (233 aa)
	182.t00018	RBR-type E3 ubiquitin transferase. (268 aa)
	74.t00002	Zinc finger domain containing protein. (217 aa)
	142.t00027	Ubiquitin-conjugating enzyme family protein; Belongs to the ubiquitin-conjugating enzyme family. (164 aa)
	259.t00006	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1263 aa)
	222.t00012	Uncharacterized protein. (240 aa)
	90.t00003	Ubiquitin-protein ligase, putative. (661 aa)
	98.t00007	Ubiquitin-conjugating enzyme family protein; Belongs to the ubiquitin-conjugating enzyme family. (185 aa)
	17.t00016	Uncharacterized protein. (202 aa)
	57.t00010	Uncharacterized protein. (703 aa)
	165.t00003	Uncharacterized protein. (1407 aa)
	97.t00022	RBR-type E3 ubiquitin transferase. (267 aa)
	354.t00009	RBR-type E3 ubiquitin transferase. (252 aa)
	369.t00006	RBR-type E3 ubiquitin transferase. (613 aa)
	237.t00010	Uncharacterized protein. (575 aa)

Your Current Organism:

Entamoeba histolytica

NCBI taxonomy Id: 5759
Other names: E. histolytica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
10.t00049	107.t00018	C4LTS7	C4M2Y3	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Ubiquitin-conjugating enzyme family protein; Belongs to the ubiquitin-conjugating enzyme family.	0.503
10.t00049	108.t00020	C4LTS7	C4M5T2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Ubiquitin-conjugating enzyme family protein; Belongs to the ubiquitin-conjugating enzyme family.	0.546
10.t00049	12.t00025	C4LTS7	C4LVT5	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Ubiquitin-protein ligase, putative.	0.401
10.t00049	13.t00037	C4LTS7	C4LSD0	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Phospholipase, patatin family protein.	0.577
10.t00049	142.t00027	C4LTS7	C4M911	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Ubiquitin-conjugating enzyme family protein; Belongs to the ubiquitin-conjugating enzyme family.	0.971
10.t00049	151.t00018	C4LTS7	C4M0U2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Ubiquitin-conjugating enzyme family protein; Belongs to the ubiquitin-conjugating enzyme family.	0.506
10.t00049	165.t00003	C4LTS7	C4M9T6	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Uncharacterized protein.	0.764
10.t00049	166.t00006	C4LTS7	C4M4F0	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	HECT domain-containing protein.	0.575
10.t00049	195.t00010	C4LTS7	C4M1E6	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.482
10.t00049	259.t00006	C4LTS7	C4M988	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.490
10.t00049	346.t00007	C4LTS7	C4M310	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Ubiquitin-conjugating enzyme family protein.	0.621
10.t00049	35.t00018	C4LTS7	C4M2U3	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Uncharacterized protein.	0.723
10.t00049	35.t00023	C4LTS7	C4M3H2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Uncharacterized protein.	0.638
10.t00049	4.t00046	C4LTS7	C4LUH3	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Ubiquitin-conjugating enzyme family protein.	0.498
10.t00049	408.t00002	C4LTS7	C4M1S2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Ubiquitin-conjugating enzyme family protein; Belongs to the ubiquitin-conjugating enzyme family.	0.546
10.t00049	415.t00009	C4LTS7	C4LZ66	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Ubiquitin ligase, putative.	0.575
10.t00049	42.t00005	C4LTS7	C4LZJ4	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Ubiquitin-protein ligase, putative.	0.654
10.t00049	484.t00005	C4LTS7	C4M7J0	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Ubiquitin-conjugating enzyme family protein; Belongs to the ubiquitin-conjugating enzyme family.	0.971
10.t00049	51.t00013	C4LTS7	C4M6M3	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	Ubiquitin-conjugating enzyme family protein; Belongs to the ubiquitin-conjugating enzyme family.	0.498
10.t00049	551.t00003	C4LTS7	C4M418	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.484