(57 nodes) Cellular response to topologically incorrect protein network (Entamoeba histolytica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EHI_034960	Heat shock protein70, hsp70A2, putative. (295 aa)
	EHI_132530	Heat shock protein70, hsp70A2, putative. (141 aa)
	EHI_132540	Heat shock protein70, hsp70A2, putative. (162 aa)
	EHI_108130	Heat shock protein70, hsp70A2, putative. (113 aa)
	EHI_130160	Heat shock protein 70, putative. (389 aa)
	EHI_071800	Heat shock protein70, mitochondrial, putative. (374 aa)
	EHI_175600	Heat shock protein 70, mitochondrial, putative. (199 aa)
	EHI_026590	Heat shock protein 70, putative. (269 aa)
	65.t00008	OTU-like cysteine protease, putative. (262 aa)
	52.t00010	UDP-glucose:glycoprotein glucosyltransferase, putative. (1281 aa)
	69.t00034	Heat shock protein70, hsp70A2, putative; Belongs to the heat shock protein 70 family. (665 aa)
	41.t00020	Uncharacterized protein. (374 aa)
	35.t00051	WD repeat protein. (341 aa)
	218.t00008	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family. (656 aa)
	90.t00019	Heat shock protein 70 family; Belongs to the heat shock protein 70 family. (660 aa)
	141.t00011	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family. (619 aa)
	111.t00021	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family. (523 aa)
	57.t00021	WD repeat protein. (332 aa)
	53.t00037	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family. (632 aa)
	136.t00006	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family. (575 aa)
	45.t00004	70 kDa heat shock protein, putative; Belongs to the heat shock protein 70 family. (661 aa)
	342.t00008	Ubiquitin fusion degradation protein, putative. (447 aa)
	163.t00016	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (198 aa)
	279.t00018	Heat shock protein 70, putative. (312 aa)
	74.t00002	Zinc finger domain containing protein. (217 aa)
	455.t00003	WD repeat protein. (332 aa)
	455.t00007	Uncharacterized protein. (328 aa)
	7.t00068	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family. (637 aa)
	253.t00012	Protein kinase, putative. (779 aa)
	450.t00003	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family. (558 aa)
	418.t00001	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family. (557 aa)
	584.t00001	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family. (524 aa)
	279.t00016	Trucated hsp70 family protein. (116 aa)
	558.t00002	Heat shock protein 70, mitochondrial, putative; Belongs to the heat shock protein 70 family. (598 aa)
	192.t00007	Cdc48-like protein, putative. (772 aa)
	47.t00035	WD repeat protein. (335 aa)
	38.t00041	Heat shock protein70, hsp70A2, putative; Belongs to the heat shock protein 70 family. (599 aa)
	76.t00017	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family. (543 aa)
	61.t00012	Protein kinase, putative. (765 aa)
	EHI_125920	Ubiquitin fusion degradation protein 1 homolog, putative. (254 aa)
	EHI_133950	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family. (523 aa)
	EHI_070450	Heat shock protein70, mitochondrial, putative. (226 aa)
	EHI_007150	Mitochondrial-type heat shock protein 70; Belongs to the heat shock protein 70 family. (598 aa)
	EHI_188610	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family. (637 aa)
	EHI_091570	Heat shock protein 70, putative. (387 aa)
	EHI_101120	Heat shock protein 70, mitochondrial, putative; Belongs to the heat shock protein 70 family. (512 aa)
	EHI_100810	Heat shock protein 70, mitochondrial, putative. (174 aa)
	EHI_166050	Mitochondrial-typeheat shock protein70, putative. (449 aa)
	EHI_061640	Heat shock protein70, hsp70A2, putative. (462 aa)
	EHI_127700	Heat shock protein 70, mitochondrial, putative; Belongs to the heat shock protein 70 family. (598 aa)
	EHI_077770	UDP-glucose:glyco protein glucosyltransferase 1, putative. (98 aa)
	EHI_112590	Heat shock protein 70 family. (325 aa)
	EHI_082800	Uncharacterized protein. (447 aa)
	3.t00133	Uncharacterized protein. (318 aa)
	23.t00058	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family. (697 aa)
	71.t00020	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family. (559 aa)
	17.t00045	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (254 aa)

Your Current Organism:

Entamoeba histolytica

NCBI taxonomy Id: 5759
Other names: E. histolytica

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
111.t00021	141.t00011	C4M668	C4M5U2	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	0.604
111.t00021	163.t00016	C4M668	C4M7Y6	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.533
111.t00021	17.t00045	C4M668	C4LXY8	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.533
111.t00021	192.t00007	C4M668	C4LY22	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	Cdc48-like protein, putative.	0.562
111.t00021	218.t00008	C4M668	C4M3S5	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	0.576
111.t00021	253.t00012	C4M668	C4MAN9	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	Protein kinase, putative.	0.585
111.t00021	279.t00016	C4M668	C4MBG4	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	Trucated hsp70 family protein.	0.576
111.t00021	279.t00018	C4M668	C4M8D4	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	Heat shock protein 70, putative.	0.582
111.t00021	38.t00041	C4M668	C4LZ45	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	Heat shock protein70, hsp70A2, putative; Belongs to the heat shock protein 70 family.	0.587
111.t00021	418.t00001	C4M668	C4MBA9	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	0.610
111.t00021	558.t00002	C4M668	C4MBK4	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	Heat shock protein 70, mitochondrial, putative; Belongs to the heat shock protein 70 family.	0.508
111.t00021	584.t00001	C4M668	C4MBE1	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	0.571
111.t00021	61.t00012	C4M668	C4LU28	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	Protein kinase, putative.	0.585
111.t00021	69.t00034	C4M668	C4M1G4	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	Heat shock protein70, hsp70A2, putative; Belongs to the heat shock protein 70 family.	0.586
111.t00021	7.t00068	C4M668	C4M9V9	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	0.585
111.t00021	EHI_007150	C4M668	B1N431	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	Mitochondrial-type heat shock protein 70; Belongs to the heat shock protein 70 family.	0.506
111.t00021	EHI_026590	C4M668	B1N5W1	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	Heat shock protein 70, putative.	0.574
111.t00021	EHI_034960	C4M668	B1N5J5	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	Heat shock protein70, hsp70A2, putative.	0.693
111.t00021	EHI_061640	C4M668	B1N4N6	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	Heat shock protein70, hsp70A2, putative.	0.582
111.t00021	EHI_070450	C4M668	B1N3V8	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family.	Heat shock protein70, mitochondrial, putative.	0.536