STRINGSTRING
118.t00012 118.t00012 EHI_197000 EHI_197000 5.t00069 5.t00069 3.t00144 3.t00144 18.t00052 18.t00052 18.t00056 18.t00056 18.t00069 18.t00069 249.t00015 249.t00015 62.t00021 62.t00021 261.t00007 261.t00007 349.t00003 349.t00003 55.t00039 55.t00039 43.t00034 43.t00034 20.t00027 20.t00027 17.t00065 17.t00065 406.t00009 406.t00009 37.t00021 37.t00021 9.t00048 9.t00048 64.t00008 64.t00008 27.t00021 27.t00021 19.t00008 19.t00008 400.t00007 400.t00007 77.t00023 77.t00023 14.t00047 14.t00047 890.t00001 890.t00001 194.t00008 194.t00008 117.t00036 117.t00036 12.t00058 12.t00058 12.t00065 12.t00065 160.t00009 160.t00009 118.t00011 118.t00011 118.t00013 118.t00013 92.t00018 92.t00018 50.t00035 50.t00035 15.t00058 15.t00058 81.t00017 81.t00017 73.t00027 73.t00027 135.t00014 135.t00014 145.t00010 145.t00010 836.t00001 836.t00001 89.t00019 89.t00019 89.t00013 89.t00013 119.t00008 119.t00008 5.t00037 5.t00037 8.t00037 8.t00037 EhRab5 EhRab5 203.t00017 203.t00017 67.t00005 67.t00005 EhRabN2 EhRabN2 1.t00127 1.t00127 rac1 rac1 122.t00024 122.t00024 147.t00022 147.t00022 9.t00052 9.t00052 827.t00001 827.t00001 160.t00021 160.t00021 587.t00004 587.t00004 156.t00003 156.t00003 395.t00002 395.t00002 13.t00006 13.t00006 8.t00058 8.t00058 377.t00003 377.t00003 191.t00007 191.t00007 110.t00006 110.t00006 378.t00001 378.t00001 156.t00012 156.t00012 165.t00011 165.t00011 269.t00003 269.t00003 52.t00026 52.t00026 162.t00011 162.t00011 219.t00017 219.t00017 147.t00016 147.t00016 146.t00004 146.t00004 108.t00028 108.t00028 296.t00006 296.t00006 4.t00072 4.t00072 288.t00005 288.t00005 370.t00002 370.t00002 54.t00039 54.t00039 298.t00014 298.t00014 141.t00009 141.t00009 97.t00016 97.t00016 16.t00017 16.t00017 78.t00022 78.t00022 11.t00034 11.t00034 8.t00018 8.t00018 87.t00013 87.t00013 206.t00008 206.t00008 128.t00012 128.t00012 35.t00039 35.t00039 41.t00002 41.t00002 41.t00017 41.t00017 4.t00075 4.t00075 67.t00015 67.t00015 3.t00092 3.t00092 83.t00026 83.t00026 102.t00006 102.t00006 133.t00026 133.t00026 144.t00022 144.t00022 1.t00065 1.t00065 1.t00135 1.t00135 24.t00022 24.t00022 429.t00005 429.t00005 6.t00091 6.t00091 2.t00128 2.t00128 2.t00087 2.t00087 2.t00065 2.t00065 197.t00011 197.t00011 244.t00014 244.t00014 31.t00042 31.t00042 227.t00008 227.t00008 277.t00003 277.t00003 213.t00008 213.t00008 211.t00012 211.t00012 452.t00002 452.t00002 167.t00022 167.t00022 13.t00030 13.t00030 13.t00001 13.t00001 24.t00052 24.t00052 EHI_190990 EHI_190990 150.t00004 150.t00004 EHI_042680 EHI_042680 EHI_016010 EHI_016010 EHI_031740 EHI_031740 18.t00037 18.t00037 EHI_018960 EHI_018960 EHI_075040 EHI_075040 EHI_002150 EHI_002150 EHI_114810 EHI_114810 EHI_083140 EHI_083140 EHI_052870 EHI_052870 EHI_053200 EHI_053200 EHI_006200 EHI_006200 EHI_164460 EHI_164460 EHI_134490 EHI_134490 EHI_134340 EHI_134340 EHI_194070 EHI_194070 EHI_104560 EHI_104560 EHI_094060 EHI_094060 EHI_094030 EHI_094030 EHI_142190 EHI_142190 71.t00025 71.t00025 116.t00013 116.t00013 22.t00027 22.t00027 1.t00038 1.t00038 467.t00006 467.t00006 467.t00004 467.t00004 69.t00028 69.t00028 69.t00033 69.t00033 68.t00040 68.t00040 68.t00037 68.t00037 68.t00034 68.t00034 68.t00017 68.t00017 153.t00005 153.t00005 110.t00017 110.t00017 52.t00012 52.t00012 114.t00013 114.t00013 124.t00019 124.t00019 53.t00004 53.t00004 103.t00012 103.t00012 30.t00030 30.t00030 30.t00029 30.t00029 46.t00049 46.t00049 46.t00027 46.t00027 86.t00013 86.t00013 106.t00026 106.t00026 3.t00014 3.t00014 38.t00042 38.t00042 18.t00028 18.t00028
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
118.t00012Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (136 aa)
EHI_197000Phosphatidylinositol-3,4, 5-trisphosphate3-phosphatase, putative. (247 aa)
5.t00069Protein kinase, putative; Belongs to the protein kinase superfamily. (467 aa)
3.t00144Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (440 aa)
18.t00052Uncharacterized protein. (497 aa)
18.t00056DNA helicase; Belongs to the MCM family. (881 aa)
18.t00069Uncharacterized protein. (536 aa)
249.t00015Uncharacterized protein. (338 aa)
62.t00021Uncharacterized protein. (135 aa)
261.t00007Uncharacterized protein. (517 aa)
349.t00003Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (366 aa)
55.t00039Villidin, putative. (812 aa)
43.t00034Villin, putative. (657 aa)
20.t00027Eukaryotic translation initiation factor 5A. (155 aa)
17.t00065Ras GTPase activating protein, putative. (787 aa)
406.t00009Rho family GTPase. (189 aa)
37.t00021RhoGAP domain containing protein. (360 aa)
9.t00048Phosphatidylinositol 3-kinase 1, putative; Belongs to the PI3/PI4-kinase family. (814 aa)
64.t00008ADP-ribosylation factor 1, putative; Belongs to the small GTPase superfamily. Arf family. (174 aa)
27.t00021Uncharacterized protein. (299 aa)
19.t00008Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, putative. (996 aa)
400.t00007WD domain containing protein. (1065 aa)
77.t00023RhoGAP domain containing protein. (370 aa)
14.t00047Rho family GTPase. (199 aa)
890.t00001Actin-related protein 3, putative; Belongs to the actin family. (416 aa)
194.t00008Uncharacterized protein. (640 aa)
117.t00036Rho family GTPase. (212 aa)
12.t00058Actin-binding protein, cofilin/tropomyosin family. (146 aa)
12.t00065Actin-binding protein, cofilin/tropomyosin family. (343 aa)
160.t00009Eukaryotic translation initiation factor 5A. (157 aa)
118.t00011Actin binding protein, putative. (383 aa)
118.t00013Cortexillin II, putative. (584 aa)
92.t00018Uncharacterized protein. (781 aa)
50.t00035Uncharacterized protein. (133 aa)
15.t00058Rho family GTPase. (202 aa)
81.t00017LIM zinc finger domain containing protein; Belongs to the paxillin family. (470 aa)
73.t00027Diaphanous protein, putative. (1183 aa)
135.t00014Cytosolic regulator pianissimo, putative. (1206 aa)
145.t00010FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (376 aa)
836.t00001Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (177 aa)
89.t00019PX domain protein. (237 aa)
89.t00013Ras family GTPase. (181 aa)
119.t00008Cell division protein kinase 2, putative; Belongs to the protein kinase superfamily. (291 aa)
5.t00037Myosin heavy chain; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2151 aa)
8.t00037Protein kinase domain containing protein. (310 aa)
EhRab5Rab family GTPase. (195 aa)
203.t00017Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (347 aa)
67.t00005Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (352 aa)
EhRabN2Small GTPase EhRabN2. (198 aa)
1.t00127P21-activated kinase; Belongs to the protein kinase superfamily. (467 aa)
rac1Serine/threonine protein kinase; Belongs to the protein kinase superfamily. (409 aa)
122.t00024ADP-ribosylation factor 1, putative; Belongs to the small GTPase superfamily. Arf family. (176 aa)
147.t00022ADP ribosylation factor family GTPase, putative; Belongs to the small GTPase superfamily. Arf family. (174 aa)
9.t00052ADP-ribosylation factor, putative. (176 aa)
827.t00001WH2 motif domain contaning protein. (181 aa)
160.t00021Non-specific serine/threonine protein kinase. (470 aa)
587.t00004Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (474 aa)
156.t00003Profilin; Belongs to the profilin family. (130 aa)
395.t00002Rho family GTPase. (200 aa)
13.t00006Uncharacterized protein. (510 aa)
8.t00058Uncharacterized protein. (1127 aa)
377.t00003GTP-binding protein; Belongs to the small GTPase superfamily. SAR1 family. (190 aa)
191.t00007Actin-binding protein, cofilin/tropomyosin family. (148 aa)
110.t00006Rho family GTPase. (202 aa)
378.t00001WD domain containing protein. (334 aa)
156.t00012Uncharacterized protein; Belongs to the small heat shock protein (HSP20) family. (512 aa)
165.t00011Rho family GTPase. (198 aa)
269.t00003Phosphatidylinositol 3-kinase, putative; Belongs to the PI3/PI4-kinase family. (1124 aa)
52.t00026Rho family GTPase. (215 aa)
162.t00011Uncharacterized protein. (387 aa)
219.t00017Cell division control protein 42, putative. (196 aa)
147.t00016Protein kinase domain containing protein; Belongs to the protein kinase superfamily. (382 aa)
146.t00004Rho family GTPase. (201 aa)
108.t00028Rho family GTPase. (194 aa)
296.t00006Rho family GTPase. (199 aa)
4.t00072Rho family GTPase. (191 aa)
288.t00005Protein kinase domain containing protein; Belongs to the protein kinase superfamily. (335 aa)
370.t00002Protein kinase domain containing protein. (386 aa)
54.t00039Coronin; Belongs to the WD repeat coronin family. (433 aa)
298.t00014Prefoldin subunit 2, putative. (116 aa)
141.t00009Coronin; Belongs to the WD repeat coronin family. (896 aa)
97.t00016Rho family GTPase. (196 aa)
16.t00017Rho family GTPase. (200 aa)
78.t00022Uncharacterized protein. (1117 aa)
11.t00034Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, putative. (381 aa)
8.t00018Rho family GTPase. (193 aa)
87.t00013Rho family GTPase. (216 aa)
206.t00008F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (270 aa)
128.t00012Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (129 aa)
35.t00039Uncharacterized protein. (187 aa)
41.t00002Protein kinase, putative. (395 aa)
41.t00017Uncharacterized protein. (323 aa)
4.t00075Small GTPase RhoA, putative. (191 aa)
67.t00015Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1043 aa)
3.t00092Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (366 aa)
83.t00026Phosphatidylinositol 3-kinase, putative; Belongs to the PI3/PI4-kinase family. (1047 aa)
102.t00006Uncharacterized protein. (271 aa)
133.t00026Uncharacterized protein. (471 aa)
144.t00022HEAT repeat domain containing protein. (1074 aa)
1.t00065Protein kinase, putative. (479 aa)
1.t00135Protein kinase, putative; Belongs to the protein kinase superfamily. (370 aa)
24.t00022EH-domain containing protein, putative; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (508 aa)
429.t00005Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (191 aa)
6.t00091Protein kinase domain containing protein. (537 aa)
2.t00128ARF GTPase activating protein, putative. (742 aa)
2.t00087Eukaryotic translation initiation factor 5A. (155 aa)
2.t00065Eukaryotic translation initiation factor 5A. (165 aa)
197.t00011Rho family GTPase. (195 aa)
244.t00014Formin homology 2 domain containing protein. (859 aa)
31.t00042Rho family GTPase. (189 aa)
227.t00008GTP-binding protein, Ras family. (314 aa)
277.t00003Uncharacterized protein. (402 aa)
213.t00008Rho family GTPase. (197 aa)
211.t00012Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (293 aa)
452.t00002Meiotic check point regulator, putative. (803 aa)
167.t00022Protein kinase domain containing protein; Belongs to the protein kinase superfamily. (292 aa)
13.t00030Rho family GTPase. (199 aa)
13.t00001Cell division protein kinase, putative; Belongs to the protein kinase superfamily. (310 aa)
24.t00052Actin-binding protein, cofilin/tropomyosin family; Belongs to the actin-binding proteins ADF family. GMF subfamily. (139 aa)
EHI_190990Diaphanous protein, putative. (448 aa)
150.t00004Rac-like GTP-binding protein RAC2, putative. (239 aa)
EHI_042680Ras family protein. (161 aa)
EHI_01601066 kDa stress protein, putative. (223 aa)
EHI_031740RAS-related protein racG, putative. (197 aa)
18.t00037WD repeat protein. (595 aa)
EHI_018960Small GTPase RhoQ, putative. (102 aa)
EHI_075040GTP-binding protein; Belongs to the small GTPase superfamily. SAR1 family. (190 aa)
EHI_002150Ras-GAP domain-containing protein. (1016 aa)
EHI_114810Uncharacterized protein. (159 aa)
EHI_083140Uncharacterized protein. (398 aa)
EHI_052870ENTH domain protein, putative; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (507 aa)
EHI_053200Glutamic acid-rich protein, putative; Belongs to the small heat shock protein (HSP20) family. (550 aa)
EHI_0062003-phosphoinositide-dependent protein kinase 1, putative. (199 aa)
EHI_164460Leucine-rich repeat containing protein. (725 aa)
EHI_134490F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (170 aa)
EHI_134340Glutamic acid-rich protein, putative; Belongs to the small heat shock protein (HSP20) family. (536 aa)
EHI_19407026S protease regulatory subunit S10B, putative. (247 aa)
EHI_104560Cortexillin, putative. (560 aa)
EHI_094060Actin binding protein, putative. (339 aa)
EHI_094030Actin binding protein, putative. (248 aa)
EHI_142190WD repeat protein 2, putative. (590 aa)
71.t00025Rho family GTPase. (194 aa)
116.t00013Uncharacterized protein. (1231 aa)
22.t00027Villidin, putative. (1657 aa)
1.t00038Cell cycle-associated GTPase, putative. (189 aa)
467.t00006Uncharacterized protein. (133 aa)
467.t00004Actinin-like protein, putative. (458 aa)
69.t00028Diaphanous protein, homolog 1, putative. (1212 aa)
69.t00033Rho family GTPase. (217 aa)
68.t00040Coronin; Belongs to the WD repeat coronin family. (457 aa)
68.t00037Cell division control protein, putative; Belongs to the protein kinase superfamily. (303 aa)
68.t00034Receptor mediated endocytosis protein, putative; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (507 aa)
68.t00017Protein kinase, putative. (582 aa)
153.t00005Zinc finger domain containing protein. (87 aa)
110.t00017Rho family GTPase. (215 aa)
52.t00012Uncharacterized protein. (319 aa)
114.t00013Uncharacterized protein. (483 aa)
124.t00019Leucine-rich repeat containing protein. (508 aa)
53.t00004WH2 domain-containing protein. (468 aa)
103.t00012F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (276 aa)
30.t00030Villidin, putative. (1469 aa)
30.t00029Villidin, putative. (1059 aa)
46.t0004926S protease regulatory subunit, putative; Belongs to the AAA ATPase family. (391 aa)
46.t00027Rho family GTPase. (211 aa)
86.t00013Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (188 aa)
106.t00026Guanine nucleotide-binding protein subunit beta, putative. (351 aa)
3.t00014Filamin 2, putative. (857 aa)
38.t00042Actin binding protein, putative. (590 aa)
18.t00028Diaphanous protein, homolog 1, putative. (1176 aa)
Your Current Organism:
Entamoeba histolytica
NCBI taxonomy Id: 5759
Other names: E. histolytica
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