(42 nodes) Preribosome network (Entamoeba histolytica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	34.t00039	Protein MAK16 homolog; Belongs to the MAK16 family. (264 aa)
	EHI_038320	UPF0113 domain-containing protein. (59 aa)
	EHI_038310	60S ribosome subunit biogenesis protein NIP7, putative. (86 aa)
	EHI_051880	WD domain containing protein. (405 aa)
	EHI_174260	Uncharacterized protein. (226 aa)
	EHI_195100	Brix domain-containing protein. (297 aa)
	EHI_094780	Pescadillo homolog, putative. (163 aa)
	178.t00005	U3 small nucleolar ribonucleoprotein subunit, putative. (186 aa)
	611.t00001	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (183 aa)
	EHI_173750	Uncharacterized protein. (117 aa)
	EHI_048860	U3 small nucleolar ribonucleo protein protein MPP10, putative. (215 aa)
	2.t00040	WD domain containing protein. (881 aa)
	183.t00019	RIO1 family protein. (474 aa)
	8.t00062	WD domain containing protein. (831 aa)
	5.t00044	Pumilio family RNA-binding protein. (494 aa)
	15.t00039	WD domain containing protein. (423 aa)
	15.t00009	Uncharacterized protein. (612 aa)
	85.t00004	WD domain containing protein. (392 aa)
	309.t00003	Nucleolar protein 10, putative. (422 aa)
	48.t00006	RNA-binding protein, putative. (255 aa)
	18.t00015	U3 small nucleolar ribonucleoprotein subunit, putative. (345 aa)
	87.t00003	Uncharacterized protein. (268 aa)
	155.t00010	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (226 aa)
	14.t00016	Uncharacterized protein. (496 aa)
	88.t00030	Uncharacterized protein; Belongs to the NOB1 family. (518 aa)
	70.t00019	U3 small nucleolar ribonucleoprotein protein IMP4, putative. (273 aa)
	376.t00009	Bystin, putative. (431 aa)
	114.t00007	Uncharacterized protein. (675 aa)
	368.t00004	Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family. (545 aa)
	7.t00057	Uncharacterized protein. (668 aa)
	74.t00033	Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family. (605 aa)
	63.t00023	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (183 aa)
	90.t00020	WD domain containing protein. (884 aa)
	59.t00011	U3 small nucleolar RNA-associated protein 11, putative. (207 aa)
	108.t00021	Nuclear complex protein 4, putative. (333 aa)
	29.t00039	Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits. (829 aa)
	202.t00010	Uncharacterized protein. (191 aa)
	460.t00001	Uncharacterized protein. (565 aa)
	186.t00021	RIO1 family protein. (345 aa)
	302.t00001	Uncharacterized protein. (298 aa)
	9.t00076	Nucleolar complex protein 2 homolog, putative. (508 aa)
	447.t00009	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (225 aa)

Your Current Organism:

Entamoeba histolytica

NCBI taxonomy Id: 5759
Other names: E. histolytica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
108.t00021	114.t00007	C4M5T1	C4M0L5	Nuclear complex protein 4, putative.	Uncharacterized protein.	0.920
108.t00021	14.t00016	C4M5T1	C4LX68	Nuclear complex protein 4, putative.	Uncharacterized protein.	0.999
108.t00021	15.t00009	C4M5T1	C4LUX0	Nuclear complex protein 4, putative.	Uncharacterized protein.	0.999
108.t00021	15.t00039	C4M5T1	C4LUV0	Nuclear complex protein 4, putative.	WD domain containing protein.	0.994
108.t00021	155.t00010	C4M5T1	C4LX57	Nuclear complex protein 4, putative.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.728
108.t00021	178.t00005	C4M5T1	B1N507	Nuclear complex protein 4, putative.	U3 small nucleolar ribonucleoprotein subunit, putative.	0.997
108.t00021	18.t00015	C4M5T1	C4LW64	Nuclear complex protein 4, putative.	U3 small nucleolar ribonucleoprotein subunit, putative.	0.987
108.t00021	183.t00019	C4M5T1	C4LTW9	Nuclear complex protein 4, putative.	RIO1 family protein.	0.768
108.t00021	186.t00021	C4M5T1	C4M7J5	Nuclear complex protein 4, putative.	RIO1 family protein.	0.908
108.t00021	2.t00040	C4M5T1	C4LSH9	Nuclear complex protein 4, putative.	WD domain containing protein.	0.999
108.t00021	202.t00010	C4M5T1	C4M6Z5	Nuclear complex protein 4, putative.	Uncharacterized protein.	0.999
108.t00021	29.t00039	C4M5T1	C4M6R5	Nuclear complex protein 4, putative.	Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.	0.739
108.t00021	302.t00001	C4M5T1	C4M977	Nuclear complex protein 4, putative.	Uncharacterized protein.	0.913
108.t00021	309.t00003	C4M5T1	C4LW22	Nuclear complex protein 4, putative.	Nucleolar protein 10, putative.	0.999
108.t00021	34.t00039	C4M5T1	C4LWR5	Nuclear complex protein 4, putative.	Protein MAK16 homolog; Belongs to the MAK16 family.	0.718
108.t00021	368.t00004	C4M5T1	C4M0Q1	Nuclear complex protein 4, putative.	Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family.	0.856
108.t00021	376.t00009	C4M5T1	C4M090	Nuclear complex protein 4, putative.	Bystin, putative.	0.995
108.t00021	447.t00009	C4M5T1	C4MAY8	Nuclear complex protein 4, putative.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.728
108.t00021	460.t00001	C4M5T1	C4M7E0	Nuclear complex protein 4, putative.	Uncharacterized protein.	0.540
108.t00021	48.t00006	C4M5T1	C4LW47	Nuclear complex protein 4, putative.	RNA-binding protein, putative.	0.999