(57 nodes) Pleckstrin homology domain network (Entamoeba histolytica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	222.t00007	PH domain containing protein. (654 aa)
	3.t00056	PH domain containing protein. (308 aa)
	8.t00039	Rho guanine nucleotide exchange factor, putative. (730 aa)
	150.t00001	Rho guanine nucleotide exchange factor, putative. (441 aa)
	21.t00018	PH domain containing protein. (575 aa)
	152.t00002	Rho guanine nucleotide exchange factor, putative. (452 aa)
	85.t00032	Uncharacterized protein. (469 aa)
	11.t00002	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily. (441 aa)
	32.t00047	Uncharacterized protein. (406 aa)
	14.t00028	RhoGAP domain containing protein. (474 aa)
	17.t00062	Protein with RhoGEF and ArfGAP domains. (1045 aa)
	84.t00019	Protein with RhoGEF and ArfGAP domains. (989 aa)
	43.t00028	Uncharacterized protein. (1190 aa)
	55.t00022	PH domain-containing protein. (482 aa)
	249.t00015	Uncharacterized protein. (338 aa)
	317.t00002	Uncharacterized protein. (726 aa)
	18.t00061	Pleckstrin homology (PH) domain containing protein. (417 aa)
	47.t00004	Uncharacterized protein. (493 aa)
	578.t00002	Uncharacterized protein. (418 aa)
	64.t00004	Protein with RhoGEF and ArfGAP domains. (1098 aa)
	46.t00001	Protein with RhoGEF and ArfGAP domains. (997 aa)
	30.t00025	Rho guanine nucleotide exchange factor, putative. (455 aa)
	53.t00028	Uncharacterized protein. (964 aa)
	151.t00015	Rho guanine nucleotide exchange factor, putative. (725 aa)
	313.t00002	Uncharacterized protein. (509 aa)
	9.t00044	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily. (433 aa)
	9.t00046	PH domain containing protein. (553 aa)
	94.t00034	Oxysterol binding protein, putative. (698 aa)
	4.t00093	Protein kinase, putative; Belongs to the protein kinase superfamily. (434 aa)
	128.t00007	Rho guanine nucleotide exchange factor, putative. (565 aa)
	166.t00014	Rho guanine nucleotide exchange factor, putative. (876 aa)
	11.t00019	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily. (433 aa)
	63.t00021	Uncharacterized protein. (404 aa)
	139.t00021	Uncharacterized protein. (982 aa)
	137.t00011	Uncharacterized protein. (974 aa)
	54.t00022	Rho guanine nucleotide exchange factor, putative. (696 aa)
	59.t00014	Coronin; Belongs to the WD repeat coronin family. (1602 aa)
	30.t00048	Rho guanine nucleotide exchange factor, putative. (492 aa)
	104.t00016	Rho guanine nucleotide exchange factor, putative. (1130 aa)
	427.t00003	PH-protein kinase domain containing protein. (579 aa)
	134.t00004	Uncharacterized protein. (1134 aa)
	197.t00006	PH-protein kinase domain containing protein. (377 aa)
	304.t00006	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily. (439 aa)
	1.t00065	Protein kinase, putative. (479 aa)
	35.t00048	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily. (466 aa)
	1.t00127	P21-activated kinase; Belongs to the protein kinase superfamily. (467 aa)
	160.t00021	Non-specific serine/threonine protein kinase. (470 aa)
	388.t00006	PH domain-containing protein. (1248 aa)
	138.t00015	Rho guanine nucleotide exchange factor, putative. (631 aa)
	457.t00004	Uncharacterized protein. (230 aa)
	310.t00003	Rho guanine nucleotide exchange factor, putative. (555 aa)
	3.t00144	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (440 aa)
	EHI_127250	Uncharacterized protein. (590 aa)
	EHI_192960	PH domain containing protein. (574 aa)
	EHI_168500	Uncharacterized protein. (418 aa)
	13.t00025	Rho guanine nucleotide exchange factor, putative. (495 aa)
	2.t00128	ARF GTPase activating protein, putative. (742 aa)

Your Current Organism:

Entamoeba histolytica

NCBI taxonomy Id: 5759
Other names: E. histolytica

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
1.t00065	11.t00002	C4LT57	C4LVW8	Protein kinase, putative.	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	0.450
1.t00065	11.t00019	C4LT57	C4M4G9	Protein kinase, putative.	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	0.465
1.t00065	304.t00006	C4LT57	C4M933	Protein kinase, putative.	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	0.455
1.t00065	35.t00048	C4LT57	Q761W9	Protein kinase, putative.	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	0.440
1.t00065	4.t00093	C4LT57	C4M3C2	Protein kinase, putative.	Protein kinase, putative; Belongs to the protein kinase superfamily.	0.452
1.t00065	84.t00019	C4LT57	C4LY76	Protein kinase, putative.	Protein with RhoGEF and ArfGAP domains.	0.573
1.t00065	9.t00044	C4LT57	C4M2W0	Protein kinase, putative.	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	0.469
1.t00127	11.t00002	Q5FZP2	C4LVW8	P21-activated kinase; Belongs to the protein kinase superfamily.	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	0.447
1.t00127	11.t00019	Q5FZP2	C4M4G9	P21-activated kinase; Belongs to the protein kinase superfamily.	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	0.459
1.t00127	304.t00006	Q5FZP2	C4M933	P21-activated kinase; Belongs to the protein kinase superfamily.	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	0.458
1.t00127	35.t00048	Q5FZP2	Q761W9	P21-activated kinase; Belongs to the protein kinase superfamily.	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	0.441
1.t00127	4.t00093	Q5FZP2	C4M3C2	P21-activated kinase; Belongs to the protein kinase superfamily.	Protein kinase, putative; Belongs to the protein kinase superfamily.	0.438
1.t00127	84.t00019	Q5FZP2	C4LY76	P21-activated kinase; Belongs to the protein kinase superfamily.	Protein with RhoGEF and ArfGAP domains.	0.574
1.t00127	9.t00044	Q5FZP2	C4M2W0	P21-activated kinase; Belongs to the protein kinase superfamily.	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	0.463
11.t00002	1.t00065	C4LVW8	C4LT57	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	Protein kinase, putative.	0.450
11.t00002	1.t00127	C4LVW8	Q5FZP2	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	P21-activated kinase; Belongs to the protein kinase superfamily.	0.447
11.t00002	160.t00021	C4LVW8	C4MBQ2	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.442
11.t00002	3.t00144	C4LVW8	B1N2G7	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.577
11.t00019	1.t00065	C4M4G9	C4LT57	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	Protein kinase, putative.	0.465
11.t00019	1.t00127	C4M4G9	Q5FZP2	PH-protein kinase domain containing protein; Belongs to the protein kinase superfamily.	P21-activated kinase; Belongs to the protein kinase superfamily.	0.459