(66 nodes) Tetratricopeptide-like helical domain superfamily network (Entamoeba histolytica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	15.t00018	Uncharacterized protein. (522 aa)
	15.t00040	Peptidylprolyl isomerase. (394 aa)
	25.t00027	TPR repeat protein. (564 aa)
	61.t00036	Uncharacterized protein. (982 aa)
	72.t00020	Uncharacterized protein. (863 aa)
	148.t00008	Serine/threonine-protein phosphatase. (434 aa)
	162.t00013	Uncharacterized protein. (1079 aa)
	247.t00017	Heat shock protein STI1, putative. (435 aa)
	EHI_098370	Cleavage stimulation factor, putative. (550 aa)
	EHI_051870	Peptidylprolyl isomerase. (379 aa)
	EHI_000300	N-ethylmaleimide-sensitive factor attachment protein, alpha, putative. (225 aa)
	EHI_033670	rRNA biogenesis protein RRP5, putative. (799 aa)
	59.t00022	Uncharacterized protein. (685 aa)
	217.t00016	TPR repeat protein. (922 aa)
	122.t00023	Co-chaperone protein, putative. (303 aa)
	56.t00024	Uncharacterized protein. (521 aa)
	56.t00036	Uncharacterized protein. (209 aa)
	45.t00008	Uncharacterized protein. (634 aa)
	8.t00007	Chaperone protein dnaK, putative; Belongs to the heat shock protein 70 family. (660 aa)
	211.t00008	TPR repeat protein. (931 aa)
	248.t00007	Uncharacterized protein. (284 aa)
	182.t00017	Separin, putative. (1450 aa)
	90.t00028	Protein phosphatase, putative. (473 aa)
	276.t00006	Uncharacterized protein. (335 aa)
	293.t00007	Uncharacterized protein. (441 aa)
	345.t00003	Uncharacterized protein. (241 aa)
	358.t00001	Uncharacterized protein. (606 aa)
	420.t00001	rRNA biogenesis protein RRP5, putative. (811 aa)
	357.t00003	Uncharacterized protein. (426 aa)
	51.t00018	Uncharacterized protein. (834 aa)
	fus6	COP9 signalosome complex subunit 1, putative. (392 aa)
	3.t00108	Peptidylprolyl isomerase. (306 aa)
	3.t00134	Uncharacterized protein. (219 aa)
	127.t00002	Uncharacterized protein. (306 aa)
	1.t00148	Uncharacterized protein. (440 aa)
	2.t00020	Uncharacterized protein. (440 aa)
	13.t00018	Tetratricopeptide repeat domain containing protein. (179 aa)
	EHI_117370	Uncharacterized protein. (407 aa)
	EHI_175820	Uncharacterized protein. (209 aa)
	EHI_018490	Uncharacterized protein. (866 aa)
	EHI_160440	rRNA biogenesis protein RRP5, putative. (517 aa)
	EHI_128170	Uncharacterized protein. (528 aa)
	208.t00013	Crooked neck protein, putative. (473 aa)
	40.t00050	rRNA biogenesis protein RRP5, putative. (1710 aa)
	198.t00005	Hsc70-interacting protein, putative. (359 aa)
	33.t00011	Soluble NSF attachment protein gamma isoform, putative. (360 aa)
	71.t00003	FK506-binding protein, putative. (252 aa)
	177.t00028	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2342 aa)
	29.t00016	TPR repeat protein. (890 aa)
	228.t00012	Uncharacterized protein. (581 aa)
	19.t00038	Cleavage stimulation factor, putative. (550 aa)
	98.t00010	TPR repeat protein. (917 aa)
	178.t00016	Alpha-soluble NSF attachment protein, putative. (292 aa)
	7.t00028	Actin binding protein, putative. (775 aa)
	18.t00052	Uncharacterized protein. (497 aa)
	18.t00053	Uncharacterized protein. (328 aa)
	62.t00009	Uncharacterized protein. (559 aa)
	261.t00007	Uncharacterized protein. (517 aa)
	3.t00022	Pre-mRNA splicing factor, putative. (870 aa)
	17.t00044	Protein kinase, putative. (1038 aa)
	37.t00014	Uncharacterized protein. (227 aa)
	9.t00070	Uncharacterized protein. (699 aa)
	55.t00012	Uncharacterized protein. (234 aa)
	400.t00006	Uncharacterized protein. (601 aa)
	14.t00016	Uncharacterized protein. (496 aa)
	461.t00007	Uncharacterized protein. (310 aa)

Your Current Organism:

Entamoeba histolytica

NCBI taxonomy Id: 5759
Other names: E. histolytica

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
122.t00023	148.t00008	C4M713	C4M424	Co-chaperone protein, putative.	Serine/threonine-protein phosphatase.	0.409
122.t00023	18.t00052	C4M713	C4LYY5	Co-chaperone protein, putative.	Uncharacterized protein.	0.779
122.t00023	182.t00017	C4M713	C4M8H8	Co-chaperone protein, putative.	Separin, putative.	0.503
122.t00023	293.t00007	C4M713	C4M8X9	Co-chaperone protein, putative.	Uncharacterized protein.	0.433
122.t00023	357.t00003	C4M713	C4MAW6	Co-chaperone protein, putative.	Uncharacterized protein.	0.433
122.t00023	37.t00014	C4M713	C4LXR3	Co-chaperone protein, putative.	Uncharacterized protein.	0.409
122.t00023	62.t00009	C4M713	C4LYN3	Co-chaperone protein, putative.	Uncharacterized protein.	0.408
122.t00023	8.t00007	C4M713	C4M7P0	Co-chaperone protein, putative.	Chaperone protein dnaK, putative; Belongs to the heat shock protein 70 family.	0.438
122.t00023	90.t00028	C4M713	C4M8I7	Co-chaperone protein, putative.	Protein phosphatase, putative.	0.416
122.t00023	fus6	C4M713	Q8WQ58	Co-chaperone protein, putative.	COP9 signalosome complex subunit 1, putative.	0.742
13.t00018	62.t00009	C4LSE8	C4LYN3	Tetratricopeptide repeat domain containing protein.	Uncharacterized protein.	0.412
14.t00016	40.t00050	C4LX68	C4M2T6	Uncharacterized protein.	rRNA biogenesis protein RRP5, putative.	0.879
14.t00016	420.t00001	C4LX68	C4MAW0	Uncharacterized protein.	rRNA biogenesis protein RRP5, putative.	0.879
14.t00016	59.t00022	C4LX68	C4M5M9	Uncharacterized protein.	Uncharacterized protein.	0.531
14.t00016	EHI_033670	C4LX68	B1N3M7	Uncharacterized protein.	rRNA biogenesis protein RRP5, putative.	0.879
14.t00016	EHI_117370	C4LX68	B1N5X7	Uncharacterized protein.	Uncharacterized protein.	0.879
14.t00016	EHI_160440	C4LX68	B1N4H4	Uncharacterized protein.	rRNA biogenesis protein RRP5, putative.	0.879
148.t00008	122.t00023	C4M424	C4M713	Serine/threonine-protein phosphatase.	Co-chaperone protein, putative.	0.409
148.t00008	3.t00108	C4M424	C4LTA4	Serine/threonine-protein phosphatase.	Peptidylprolyl isomerase.	0.402
148.t00008	71.t00003	C4M424	C4M276	Serine/threonine-protein phosphatase.	FK506-binding protein, putative.	0.410