(35 nodes) Disease network (Entamoeba histolytica)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	436.t00002	Topoisomerase, putative. (365 aa)
	25.t00013	Glucosidase, putative; Belongs to the glycosyl hydrolase 31 family. (871 aa)
	92.t00014	Importin beta-3 subunit family protein, putative. (964 aa)
	85.t00026	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (118 aa)
	85.t00023	Protein tyrosine phosphatase, putative. (157 aa)
	23.t00001	Thioredoxin reductase. (314 aa)
	77.t00016	Importin beta family protein 3. (1097 aa)
	400.t00001	Importin beta-3 family protein, putative. (1088 aa)
	406.t00005	Topoisomerase, putative. (400 aa)
	17.t00036	Protein kinase, putative. (371 aa)
	3.t00041	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (423 aa)
	3.t00023	Glycosyltransferase, putative. (445 aa)
	274.t00008	Vacular protein sorting 33A, putative; Belongs to the STXBP/unc-18/SEC1 family. (995 aa)
	68.t00040	Coronin; Belongs to the WD repeat coronin family. (457 aa)
	7.t00073	Importin beta-3 family protein, putative. (1071 aa)
	59.t00014	Coronin; Belongs to the WD repeat coronin family. (1602 aa)
	122.t00033	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (406 aa)
	248.t00006	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (423 aa)
	304.t00002	HEAT repeat domain containing protein. (1055 aa)
	54.t00039	Coronin; Belongs to the WD repeat coronin family. (433 aa)
	312.t00006	Uncharacterized protein. (563 aa)
	62.t00006	Oligosaccharyl transferase, putative. (710 aa)
	210.t00008	Protein kinase, putative. (386 aa)
	65.t00010	HEAT repeat domain containing protein. (1062 aa)
	EHI_045470	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (398 aa)
	EHI_023620	Uncharacterized protein. (530 aa)
	EHI_024110	Disulphide oxidoreductase, putative. (122 aa)
	EHI_042580	Dolychil-diphosphooligosaccharide--protein glycosyltransferase subunit, putative. (160 aa)
	13.t00019	Protein tyrosine phosphatase, putative. (157 aa)
	2.t00025	Protein RFT1 homolog; May be involved in N-linked oligosaccharide assembly. Belongs to the RFT1 family. (495 aa)
	2.t00107	HEAT repeat domain containing protein. (1074 aa)
	1.t00145	Uncharacterized protein. (414 aa)
	16.t00004	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A, putative. (721 aa)
	370.t00004	Uncharacterized protein. (338 aa)
	641.t00003	Sec1 family domain containing protein; Belongs to the STXBP/unc-18/SEC1 family. (689 aa)

Your Current Organism:

Entamoeba histolytica

NCBI taxonomy Id: 5759
Other names: E. histolytica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
122.t00033	16.t00004	C4M718	C4LTI8	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A, putative.	0.813
122.t00033	248.t00006	C4M718	C4M7V5	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	0.540
122.t00033	25.t00013	C4M718	C4LUQ2	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	Glucosidase, putative; Belongs to the glycosyl hydrolase 31 family.	0.445
122.t00033	3.t00041	C4M718	C4LYH0	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	0.540
122.t00033	62.t00006	C4M718	C4LYN6	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	Oligosaccharyl transferase, putative.	0.814
122.t00033	85.t00026	C4M718	C4LVM0	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...]	0.957
122.t00033	EHI_042580	C4M718	B1N615	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	Dolychil-diphosphooligosaccharide--protein glycosyltransferase subunit, putative.	0.813
122.t00033	EHI_045470	C4M718	B1N2H8	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	0.540
13.t00019	23.t00001	C4LSE7	C4LW95	Protein tyrosine phosphatase, putative.	Thioredoxin reductase.	0.401
13.t00019	EHI_024110	C4LSE7	B1N4N8	Protein tyrosine phosphatase, putative.	Disulphide oxidoreductase, putative.	0.401
16.t00004	122.t00033	C4LTI8	C4M718	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A, putative.	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	0.813
16.t00004	248.t00006	C4LTI8	C4M7V5	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A, putative.	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	0.984
16.t00004	25.t00013	C4LTI8	C4LUQ2	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A, putative.	Glucosidase, putative; Belongs to the glycosyl hydrolase 31 family.	0.431
16.t00004	3.t00023	C4LTI8	C4LYI6	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A, putative.	Glycosyltransferase, putative.	0.659
16.t00004	3.t00041	C4LTI8	C4LYH0	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A, putative.	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	0.848
16.t00004	62.t00006	C4LTI8	C4LYN6	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A, putative.	Oligosaccharyl transferase, putative.	0.903
16.t00004	85.t00026	C4LTI8	C4LVM0	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A, putative.	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...]	0.991
16.t00004	EHI_045470	C4LTI8	B1N2H8	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A, putative.	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	0.845
2.t00025	3.t00023	C4LSG7	C4LYI6	Protein RFT1 homolog; May be involved in N-linked oligosaccharide assembly. Belongs to the RFT1 family.	Glycosyltransferase, putative.	0.734
23.t00001	13.t00019	C4LW95	C4LSE7	Thioredoxin reductase.	Protein tyrosine phosphatase, putative.	0.401