STRINGSTRING
SDY72027.1 SDY72027.1 SDY72572.1 SDY72572.1 SDY72922.1 SDY72922.1 SDY88015.1 SDY88015.1 SDY73006.1 SDY73006.1 SDY73283.1 SDY73283.1 gmd gmd SDY74532.1 SDY74532.1 SDY74566.1 SDY74566.1 dapB dapB SDY75349.1 SDY75349.1 SDY76203.1 SDY76203.1 gpsA gpsA ahcY ahcY SDY77049.1 SDY77049.1 SDY77065.1 SDY77065.1 aroE aroE SDY77665.1 SDY77665.1 proC-2 proC-2 SDY66237.1 SDY66237.1 SDY66496.1 SDY66496.1 SDY66653.1 SDY66653.1 SDY80613.1 SDY80613.1 SDY81483.1 SDY81483.1 SDY81653.1 SDY81653.1 SDY87503.1 SDY87503.1 SDY87479.1 SDY87479.1 SDY08124.1 SDY08124.1 SDY26328.1 SDY26328.1 SDY26721.1 SDY26721.1 SDY26977.1 SDY26977.1 SDY27972.1 SDY27972.1 SDY28322.1 SDY28322.1 SDY28722.1 SDY28722.1 SDY08622.1 SDY08622.1 folD folD SDY08736.1 SDY08736.1 SDY09303.1 SDY09303.1 SDY09999.1 SDY09999.1 SDY10103.1 SDY10103.1 SDY06406.1 SDY06406.1 SDY10639.1 SDY10639.1 SDY11699.1 SDY11699.1 folD-2 folD-2 SDY12215.1 SDY12215.1 lcdH lcdH SDY12852.1 SDY12852.1 SDY13127.1 SDY13127.1 SDY13219.1 SDY13219.1 SDY14705.1 SDY14705.1 SDY07009.1 SDY07009.1 SDY16677.1 SDY16677.1 SDY07137.1 SDY07137.1 SDY07273.1 SDY07273.1 sucD sucD mdh mdh SDY18611.1 SDY18611.1 SDY18720.1 SDY18720.1 ilvC ilvC SDY20711.1 SDY20711.1 SDY20764.1 SDY20764.1 SDY20835.1 SDY20835.1 SDY21599.1 SDY21599.1 SDY21822.1 SDY21822.1 SDY21937.1 SDY21937.1 SDY21986.1 SDY21986.1 SDY22004.1 SDY22004.1 SDY22037.1 SDY22037.1 SDY22305.1 SDY22305.1 SDY22472.1 SDY22472.1 murD murD SDY24882.1 SDY24882.1 SDY42074.1 SDY42074.1 SDY40150.1 SDY40150.1 proC proC SDY42764.1 SDY42764.1 SDY42943.1 SDY42943.1 SDY43022.1 SDY43022.1 SDY45584.1 SDY45584.1 SDY46807.1 SDY46807.1 SDY51413.1 SDY51413.1 SDY51995.1 SDY51995.1 SDY52433.1 SDY52433.1 SDY52902.1 SDY52902.1 SDY53131.1 SDY53131.1 SDY53311.1 SDY53311.1 zwf zwf dxr dxr SDY54683.1 SDY54683.1 SDY41391.1 SDY41391.1 SDY56577.1 SDY56577.1 SDY56835.1 SDY56835.1 SDY56924.1 SDY56924.1 argC argC SDY68812.1 SDY68812.1 SDY68848.1 SDY68848.1 asd asd SDY70192.1 SDY70192.1 SDY70407.1 SDY70407.1 SDY70522.1 SDY70522.1 SDY71128.1 SDY71128.1 SDY71841.1 SDY71841.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
SDY72027.1L-alanine dehydrogenase; Belongs to the AlaDH/PNT family. (371 aa)
SDY72572.1NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family. (239 aa)
SDY72922.12-deoxy-D-gluconate 3-dehydrogenase. (254 aa)
SDY88015.1S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (371 aa)
SDY73006.1Short-chain dehydrogenase. (243 aa)
SDY73283.1NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family. (222 aa)
gmdGDPmannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (337 aa)
SDY74532.1acetyl-CoA synthetase. (674 aa)
SDY74566.1UDP-glucose dehydrogenase. (442 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (269 aa)
SDY75349.1Short-chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (256 aa)
SDY76203.1NADP-dependent 3-hydroxy acid dehydrogenase YdfG; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (250 aa)
gpsAGlycerol-3-phosphate dehydrogenase (NAD(P)+); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (318 aa)
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (462 aa)
SDY77049.1dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (345 aa)
SDY77065.1dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (277 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (277 aa)
SDY77665.1NADH dehydrogenase. (326 aa)
proC-2Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (272 aa)
SDY66237.1Hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (317 aa)
SDY66496.1Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+). (759 aa)
SDY66653.13-hydroxyacyl-CoA dehydrogenase. (291 aa)
SDY80613.1UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (327 aa)
SDY81483.1Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+). (751 aa)
SDY81653.1Nucleoside-diphosphate-sugar epimerase. (285 aa)
SDY87503.1Threonine dehydrogenase. (326 aa)
SDY87479.1Gluconate 5-dehydrogenase. (253 aa)
SDY08124.1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (531 aa)
SDY26328.13-oxoacyl-[acyl-carrier protein] reductase. (259 aa)
SDY26721.13-hydroxybutyrate dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (267 aa)
SDY26977.1Enoyl-CoA hydratase/carnithine racemase. (700 aa)
SDY27972.1NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (251 aa)
SDY28322.1Alcohol dehydrogenase. (347 aa)
SDY28722.1acrylyl-CoA reductase (NADPH). (330 aa)
SDY08622.1Pyrroline-5-carboxylate reductase. (238 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa)
SDY08736.16-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (465 aa)
SDY09303.1Lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa)
SDY09999.1NADPH2:quinone reductase. (324 aa)
SDY10103.1NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (252 aa)
SDY06406.1S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (377 aa)
SDY10639.13-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase. (732 aa)
SDY11699.1Prephenate dehydrogenase. (304 aa)
folD-25,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (296 aa)
SDY12215.1Short-chain dehydrogenase. (249 aa)
lcdHCarnitine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3- dehydrocarnitine. (491 aa)
SDY12852.1NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family. (251 aa)
SDY13127.13-hydroxyisobutyrate dehydrogenase. (314 aa)
SDY13219.1Glutamate dehydrogenase (NAD(P)+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (531 aa)
SDY14705.1NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family. (260 aa)
SDY07009.1Glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
SDY16677.1Ornithine cyclodeaminase. (329 aa)
SDY07137.1Molybdenum cofactor sulfurylase. (266 aa)
SDY07273.17-alpha-hydroxysteroid dehydrogenase. (267 aa)
sucDsuccinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
SDY18611.1crotonyl-CoA carboxylase/reductase. (428 aa)
SDY18720.1NADP-dependent 3-hydroxy acid dehydrogenase YdfG; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (239 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (340 aa)
SDY20711.1Zn-dependent alcohol dehydrogenase. (360 aa)
SDY20764.1NADPH2:quinone reductase. (329 aa)
SDY20835.1Enoyl-[acyl-carrier-protein] reductase [NADH]. (262 aa)
SDY21599.1Short chain enoyl-CoA hydratase. (649 aa)
SDY21822.1Acyl transferase domain-containing protein. (2024 aa)
SDY21937.1Predicted dehydrogenase. (697 aa)
SDY21986.1Nucleoside-diphosphate-sugar epimerase. (304 aa)
SDY22004.1Predicted dehydrogenase. (375 aa)
SDY22037.1NADP-dependent 3-hydroxy acid dehydrogenase YdfG; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (256 aa)
SDY22305.1Kef-type potassium/proton antiporter, CPA2 family; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. (619 aa)
SDY22472.1Hypothetical protein. (157 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (465 aa)
SDY24882.1NAD(P) transhydrogenase subunit alpha; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. (523 aa)
SDY42074.13-oxoacyl-[acyl-carrier-protein] reductase. (240 aa)
SDY40150.1Alcohol dehydrogenase. (344 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (264 aa)
SDY42764.1NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (215 aa)
SDY42943.1Homoserine dehydrogenase. (428 aa)
SDY43022.1Glyoxylate/hydroxypyruvate reductase A. (310 aa)
SDY45584.1NADPH2:quinone reductase. (324 aa)
SDY46807.1L-threonine 3-dehydrogenase. (344 aa)
SDY51413.1NADP-dependent 3-hydroxy acid dehydrogenase YdfG. (214 aa)
SDY51995.1uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (462 aa)
SDY52433.13-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (245 aa)
SDY52902.13-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (290 aa)
SDY53131.1Glyceraldehyde-3-phosphate dehydrogenase (NAD+); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
SDY53311.1Ornithine cyclodeaminase. (347 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (484 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (388 aa)
SDY54683.1Enoyl-[acyl-carrier-protein] reductase [NADH]. (273 aa)
SDY41391.1Short-chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (276 aa)
SDY56577.13-hydroxybutyrate dehydrogenase. (257 aa)
SDY56835.13-hydroxyisobutyrate dehydrogenase. (290 aa)
SDY56924.1Trk system potassium uptake protein TrkA. (458 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (342 aa)
SDY68812.1Saccharopine dehydrogenase (NAD+, L-lysine forming). (347 aa)
SDY68848.1Saccharopine dehydrogenase (NADP+, L-glutamate forming). (380 aa)
asdAspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (340 aa)
SDY70192.13-oxoacyl-[acyl-carrier protein] reductase. (248 aa)
SDY70407.1NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family. (273 aa)
SDY70522.1Hypothetical protein. (346 aa)
SDY71128.1Ornithine cyclodeaminase. (304 aa)
SDY71841.1Putative NAD(P)H quinone oxidoreductase, PIG3 family. (323 aa)
Your Current Organism:
Lentibacter algarum
NCBI taxonomy Id: 576131
Other names: CGMCC 1.10234, L. algarum, LMG 24861, LMG:24861, Lentibacter algarum Li et al. 2012, alpha proteobacterium ZXM098, alpha proteobacterium ZXM100, strain ZXM100
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