(19 nodes) Terpenoid backbone biosynthesis network (Naegleria gruberi)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	D2UY59_NAEGR	Alkyl transferase; Belongs to the UPP synthase family. (241 aa)
	D2UYB3_NAEGR	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (495 aa)
	D2UZ21_NAEGR	Predicted protein. (223 aa)
	D2UZI7_NAEGR	Predicted protein; Belongs to the thiolase-like superfamily. Thiolase family. (409 aa)
	D2UZQ1_NAEGR	Predicted protein; Belongs to the FPP/GGPP synthase family. (310 aa)
	D2V1L6_NAEGR	Predicted protein. (547 aa)
	D2V4P3_NAEGR	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (467 aa)
	D2V4P8_NAEGR	Protein-S-isoprenylcysteine O-methyltransferase. (150 aa)
	D2V786_NAEGR	Predicted protein; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
	D2V9S8_NAEGR	Mevalonate kinase. (434 aa)
	D2VBE2_NAEGR	Isopentenyl diphosphate isomerase. (256 aa)
	D2VH24_NAEGR	Predicted protein. (486 aa)
	D2VHW3_NAEGR	Predicted protein. (215 aa)
	D2VX26_NAEGR	Predicted protein. (547 aa)
	D2VY47_NAEGR	Predicted protein. (226 aa)
	D2VYB1_NAEGR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (547 aa)
	D2VZQ6_NAEGR	Predicted protein. (311 aa)
	D2W352_NAEGR	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (391 aa)
	D2W640_NAEGR	Predicted protein. (246 aa)

Your Current Organism:

Naegleria gruberi

NCBI taxonomy Id: 5762
Other names: N. gruberi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
D2UY59_NAEGR	D2UYB3_NAEGR	D2UY59	D2UYB3	Alkyl transferase; Belongs to the UPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.655
D2UY59_NAEGR	D2UZQ1_NAEGR	D2UY59	D2UZQ1	Alkyl transferase; Belongs to the UPP synthase family.	Predicted protein; Belongs to the FPP/GGPP synthase family.	0.989
D2UY59_NAEGR	D2V4P3_NAEGR	D2UY59	D2V4P3	Alkyl transferase; Belongs to the UPP synthase family.	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	0.953
D2UY59_NAEGR	D2V9S8_NAEGR	D2UY59	D2V9S8	Alkyl transferase; Belongs to the UPP synthase family.	Mevalonate kinase.	0.536
D2UY59_NAEGR	D2VBE2_NAEGR	D2UY59	D2VBE2	Alkyl transferase; Belongs to the UPP synthase family.	Isopentenyl diphosphate isomerase.	0.875
D2UY59_NAEGR	D2VHW3_NAEGR	D2UY59	D2VHW3	Alkyl transferase; Belongs to the UPP synthase family.	Predicted protein.	0.954
D2UY59_NAEGR	D2VX26_NAEGR	D2UY59	D2VX26	Alkyl transferase; Belongs to the UPP synthase family.	Predicted protein.	0.433
D2UY59_NAEGR	D2VY47_NAEGR	D2UY59	D2VY47	Alkyl transferase; Belongs to the UPP synthase family.	Predicted protein.	0.981
D2UY59_NAEGR	D2VYB1_NAEGR	D2UY59	D2VYB1	Alkyl transferase; Belongs to the UPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.575
D2UY59_NAEGR	D2VZQ6_NAEGR	D2UY59	D2VZQ6	Alkyl transferase; Belongs to the UPP synthase family.	Predicted protein.	0.531
D2UY59_NAEGR	D2W352_NAEGR	D2UY59	D2W352	Alkyl transferase; Belongs to the UPP synthase family.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.748
D2UY59_NAEGR	D2W640_NAEGR	D2UY59	D2W640	Alkyl transferase; Belongs to the UPP synthase family.	Predicted protein.	0.536
D2UYB3_NAEGR	D2UY59_NAEGR	D2UYB3	D2UY59	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Alkyl transferase; Belongs to the UPP synthase family.	0.655
D2UYB3_NAEGR	D2UZI7_NAEGR	D2UYB3	D2UZI7	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Predicted protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.998
D2UYB3_NAEGR	D2UZQ1_NAEGR	D2UYB3	D2UZQ1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Predicted protein; Belongs to the FPP/GGPP synthase family.	0.882
D2UYB3_NAEGR	D2V786_NAEGR	D2UYB3	D2V786	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Predicted protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.998
D2UYB3_NAEGR	D2V9S8_NAEGR	D2UYB3	D2V9S8	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Mevalonate kinase.	0.792
D2UYB3_NAEGR	D2VBE2_NAEGR	D2UYB3	D2VBE2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Isopentenyl diphosphate isomerase.	0.948
D2UYB3_NAEGR	D2VH24_NAEGR	D2UYB3	D2VH24	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Predicted protein.	0.755
D2UYB3_NAEGR	D2VX26_NAEGR	D2UYB3	D2VX26	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Predicted protein.	0.463