72 items (Thermothielavioides terrestris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	THITE_2108076	Uncharacterized protein. (376 aa)
	THITE_2108375	Uncharacterized protein. (154 aa)
	THITE_2106700	Uncharacterized protein. (437 aa)
	THITE_2109894	Uncharacterized protein. (752 aa)
	THITE_2120244	SRP9-21 domain-containing protein. (221 aa)
	THITE_2123693	Uncharacterized protein. (334 aa)
	THITE_2123254	Uncharacterized protein. (867 aa)
	THITE_2109327	Uncharacterized protein. (313 aa)
	THITE_2147703	Bac_luciferase domain-containing protein. (365 aa)
	THITE_2058099	Uncharacterized protein. (139 aa)
	THITE_2058437	Uncharacterized protein. (362 aa)
	GET1	Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. (218 aa)
	THITE_2091763	Uncharacterized protein. (348 aa)
	PFA4	Palmitoyltransferase PFA4; Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function; Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily. (484 aa)
	MDM12	Mitochondrial distribution and morphology protein 12; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pat [...] (486 aa)
	THITE_160290	Uncharacterized protein. (284 aa)
	THITE_2108888	Uncharacterized protein. (631 aa)
	THITE_2121054	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (118 aa)
	THITE_2120107	J domain-containing protein. (740 aa)
	THITE_43797	Uncharacterized protein. (360 aa)
	THITE_2109740	Uncharacterized protein; Belongs to the heat shock protein 70 family. (663 aa)
	THITE_2108074	Uncharacterized protein. (212 aa)
	THITE_2112226	Uncharacterized protein. (234 aa)
	THITE_2112286	ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family. (260 aa)
	THITE_2116055	TPR_REGION domain-containing protein. (363 aa)
	THITE_2050626	DUF2263 domain-containing protein. (393 aa)
	THITE_2037471	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (676 aa)
	THITE_2084928	Uncharacterized protein. (53 aa)
	THITE_2107635	Uncharacterized protein. (353 aa)
	THITE_2110648	Bac_surface_Ag domain-containing protein. (512 aa)
	THITE_2107413	Signal recognition particle subunit SRP72; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP72 family. (681 aa)
	THITE_2110588	Uncharacterized protein. (422 aa)
	THITE_2120877	Uncharacterized protein; Belongs to the AAA ATPase family. (462 aa)
	THITE_2112643	AAA domain-containing protein. (703 aa)
	THITE_2112737	Uncharacterized protein. (116 aa)
	THITE_2112916	Uncharacterized protein. (407 aa)
	THITE_2114824	Uncharacterized protein. (431 aa)
	THITE_2111458	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (412 aa)
	THITE_2115047	AAA domain-containing protein; Belongs to the AAA ATPase family. (420 aa)
	THITE_2120808	zf-Tim10_DDP domain-containing protein. (92 aa)
	THITE_2122618	Uncharacterized protein. (395 aa)
	THITE_2120749	Letm1 RBD domain-containing protein. (560 aa)
	THITE_2106112	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (521 aa)
	THITE_2107851	Plug_translocon domain-containing protein. (476 aa)
	THITE_2107678	Uncharacterized protein. (333 aa)
	GET3	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] (340 aa)
	THITE_2120709	Uncharacterized protein. (520 aa)
	THITE_121986	zf-Tim10_DDP domain-containing protein; Belongs to the small Tim family. (88 aa)
	MMM1	Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 su [...] (497 aa)
	THITE_2117422	Uncharacterized protein. (333 aa)
	THITE_2090702	Uncharacterized protein. (212 aa)
	THITE_2119224	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (183 aa)
	THITE_2118778	Uncharacterized protein. (582 aa)
	THITE_2142830	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (630 aa)
	THITE_2115184	Signal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP68 family. (630 aa)
	THITE_2153916	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (150 aa)
	THITE_2108960	Uncharacterized protein. (326 aa)
	THITE_2086774	Rab proteins geranylgeranyltransferase; Belongs to the Rab GDI family. (481 aa)
	THITE_2120356	Uncharacterized protein; Belongs to the AAA ATPase family. (671 aa)
	MDM10	Mitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the recepto [...] (450 aa)
	THITE_2108073	TPR_REGION domain-containing protein. (206 aa)
	THITE_133645	Uncharacterized protein. (316 aa)
	THITE_2106323	Uncharacterized protein. (131 aa)
	THITE_2043159	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (422 aa)
	THITE_2047513	Uncharacterized protein. (472 aa)
	THITE_2114013	Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX. (328 aa)
	THITE_2116699	Uncharacterized protein. (142 aa)
	THITE_2117151	Uncharacterized protein. (216 aa)
	THITE_2109584	UBIQUITIN_CONJUGAT_2 domain-containing protein. (155 aa)
	THITE_133987	Uncharacterized protein. (552 aa)
	THITE_2108525	Uncharacterized protein. (70 aa)
	THITE_2108409	Uncharacterized protein. (732 aa)

Your Current Organism:

Thermothielavioides terrestris

NCBI taxonomy Id: 578455
Other names: T. terrestris NRRL 8126, Thermothielavioides terrestris NRRL 8126

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GET1	GET3	G2RFQ5	G2QRN2	Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	0.995
GET1	MDM12	G2RFQ5	G2REN5	Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.	Mitochondrial distribution and morphology protein 12; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pat [...]	0.516
GET1	THITE_133987	G2RFQ5	G2QW79	Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.	Uncharacterized protein.	0.521
GET1	THITE_160290	G2RFQ5	G2R7Z9	Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.	Uncharacterized protein.	0.493
GET1	THITE_2107678	G2RFQ5	G2QUP8	Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.	Uncharacterized protein.	0.619
GET1	THITE_2107851	G2RFQ5	G2QVM3	Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.	Plug_translocon domain-containing protein.	0.554
GET1	THITE_2108960	G2RFQ5	G2QT18	Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.	Uncharacterized protein.	0.485
GET1	THITE_2112286	G2RFQ5	G2QY74	Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.	ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family.	0.528
GET1	THITE_2116055	G2RFQ5	G2QZT1	Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.	TPR_REGION domain-containing protein.	0.618
GET1	THITE_2121054	G2RFQ5	G2REC9	Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.	0.660
GET1	THITE_43797	G2RFQ5	G2R902	Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.	Uncharacterized protein.	0.935
GET3	GET1	G2QRN2	G2RFQ5	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.	0.995
GET3	THITE_160290	G2QRN2	G2R7Z9	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	Uncharacterized protein.	0.447
GET3	THITE_2058437	G2QRN2	G2RFQ6	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	Uncharacterized protein.	0.902
GET3	THITE_2106112	G2QRN2	G2QW30	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily.	0.559
GET3	THITE_2107678	G2QRN2	G2QUP8	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	Uncharacterized protein.	0.994
GET3	THITE_2107851	G2QRN2	G2QVM3	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	Plug_translocon domain-containing protein.	0.613
GET3	THITE_2108960	G2QRN2	G2QT18	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	Uncharacterized protein.	0.457
GET3	THITE_2112286	G2QRN2	G2QY74	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family.	0.495
GET3	THITE_2115047	G2QRN2	G2R2Z8	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.527