102 items (Thermothielavioides terrestris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	THITE_2117187	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (555 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (359 aa)
	THITE_160423	Uncharacterized protein. (102 aa)
	THITE_2050611	Reverse transcriptase domain-containing protein. (83 aa)
	THITE_2051656	Uncharacterized protein. (98 aa)
	THITE_52411	Uncharacterized protein. (79 aa)
	THITE_2117872	Sld5 domain-containing protein. (197 aa)
	THITE_2051073	Reverse transcriptase domain-containing protein. (90 aa)
	THITE_2050467	Uncharacterized protein. (107 aa)
	THITE_52113	Uncharacterized protein. (79 aa)
	THITE_2117766	DNA ligase. (881 aa)
	THITE_2048230	Reverse transcriptase domain-containing protein. (90 aa)
	THITE_2047525	Reverse transcriptase domain-containing protein. (90 aa)
	THITE_2047669	Reverse transcriptase domain-containing protein. (83 aa)
	THITE_2049134	Uncharacterized protein. (90 aa)
	THITE_2045588	Reverse transcriptase domain-containing protein. (90 aa)
	THITE_2170173	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa)
	THITE_2113671	Vezatin domain-containing protein. (641 aa)
	THITE_2115090	Uncharacterized protein. (435 aa)
	THITE_2049337	Reverse transcriptase domain-containing protein. (90 aa)
	THITE_2025197	Uncharacterized protein. (83 aa)
	THITE_2036388	Uncharacterized protein. (84 aa)
	THITE_2046104	Uncharacterized protein. (83 aa)
	THITE_2114674	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (274 aa)
	THITE_2043440	Reverse transcriptase domain-containing protein. (83 aa)
	THITE_2047704	Uncharacterized protein. (90 aa)
	THITE_2048977	Reverse transcriptase domain-containing protein. (87 aa)
	THITE_2048834	Reverse transcriptase domain-containing protein. (83 aa)
	THITE_2048464	Reverse transcriptase domain-containing protein. (90 aa)
	THITE_2045437	Reverse transcriptase domain-containing protein. (87 aa)
	THITE_2046527	Reverse transcriptase domain-containing protein. (97 aa)
	THITE_2044068	Uncharacterized protein. (95 aa)
	THITE_2045454	Uncharacterized protein. (83 aa)
	THITE_2112208	AAA domain-containing protein. (383 aa)
	THITE_2108112	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (501 aa)
	THITE_2106493	TPR_REGION domain-containing protein. (503 aa)
	THITE_2106430	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (610 aa)
	THITE_2040240	Integrase catalytic domain-containing protein. (64 aa)
	THITE_2109616	Zds_C domain-containing protein. (913 aa)
	THITE_2039201	Uncharacterized protein. (83 aa)
	THITE_2041100	Reverse transcriptase Ty1/copia-type domain-containing protein. (142 aa)
	THITE_116310	Uncharacterized protein. (513 aa)
	THITE_2039230	Reverse transcriptase domain-containing protein. (90 aa)
	THITE_2043084	Reverse transcriptase domain-containing protein. (90 aa)
	THITE_2107832	Uncharacterized protein. (515 aa)
	THITE_2107682	DNA polymerase. (1103 aa)
	THITE_2037473	Reverse transcriptase domain-containing protein. (83 aa)
	THITE_2037951	Uncharacterized protein. (100 aa)
	THITE_2037037	Reverse transcriptase domain-containing protein. (90 aa)
	THITE_2023573	Uncharacterized protein. (88 aa)
	THITE_2042885	Reverse transcriptase domain-containing protein. (90 aa)
	THITE_2109176	Uncharacterized protein. (389 aa)
	THITE_2038189	Reverse transcriptase domain-containing protein. (83 aa)
	THITE_2107397	Uncharacterized protein. (106 aa)
	THITE_2038542	Reverse transcriptase domain-containing protein. (83 aa)
	THITE_2037479	Reverse transcriptase domain-containing protein. (83 aa)
	THITE_40208	Uncharacterized protein. (79 aa)
	THITE_2038798	Uncharacterized protein. (96 aa)
	THITE_131345	Uncharacterized protein. (1447 aa)
	THITE_2041779	Reverse transcriptase domain-containing protein. (83 aa)
	THITE_2042370	Uncharacterized protein. (109 aa)
	THITE_2041727	Reverse transcriptase domain-containing protein. (83 aa)
	THITE_2042654	Reverse transcriptase domain-containing protein. (83 aa)
	THITE_2038933	Reverse transcriptase domain-containing protein. (83 aa)
	THITE_2038289	Reverse transcriptase domain-containing protein. (90 aa)
	THITE_2108468	Uncharacterized protein. (518 aa)
	THITE_2038751	Reverse transcriptase domain-containing protein. (90 aa)
	THITE_2013508	Uncharacterized protein. (99 aa)
	THITE_2106865	AAA domain-containing protein. (358 aa)
	THITE_2123710	Amino_oxidase domain-containing protein. (518 aa)
	THITE_2059344	Reverse transcriptase domain-containing protein. (83 aa)
	THITE_2082804	Uncharacterized protein. (211 aa)
	THITE_2123413	Uncharacterized protein. (721 aa)
	THITE_2059222	Cnn_1N domain-containing protein. (587 aa)
	THITE_2124823	AAA domain-containing protein. (389 aa)
	THITE_2060071	Uncharacterized protein. (79 aa)
	THITE_2124524	Replication factor C subunit 1. (1058 aa)
	THITE_2059508	Uncharacterized protein. (83 aa)
	THITE_2124521	AAA domain-containing protein. (352 aa)
	THITE_72944	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (221 aa)
	THITE_2121480	Sld5 domain-containing protein. (216 aa)
	THITE_2057014	Uncharacterized protein. (79 aa)
	THITE_2020757	Reverse transcriptase domain-containing protein. (82 aa)
	THITE_2038514	Uncharacterized protein. (89 aa)
	THITE_2057218	Uncharacterized protein. (83 aa)
	THITE_2055852	Reverse transcriptase domain-containing protein. (90 aa)
	THITE_2057533	Reverse transcriptase domain-containing protein. (90 aa)
	THITE_2057917	Uncharacterized protein. (83 aa)
	THITE_2057984	Reverse transcriptase domain-containing protein. (90 aa)
	THITE_2119752	Uncharacterized protein. (223 aa)
	THITE_2054697	Uncharacterized protein. (83 aa)
	THITE_2054329	Reverse transcriptase domain-containing protein. (90 aa)
	THITE_2120339	AAA domain-containing protein. (1278 aa)
	THITE_2052550	Uncharacterized protein. (90 aa)
	THITE_2120214	DNA polymerase. (1484 aa)
	THITE_2053365	Uncharacterized protein. (83 aa)
	THITE_2052832	Uncharacterized protein. (98 aa)
	THITE_2053979	Reverse transcriptase domain-containing protein. (108 aa)
	THITE_2053993	Reverse transcriptase domain-containing protein. (80 aa)
	THITE_2053533	Uncharacterized protein. (83 aa)
	THITE_43396	DNA ligase. (749 aa)
	THITE_2051589	Uncharacterized protein. (97 aa)

Your Current Organism:

Thermothielavioides terrestris

NCBI taxonomy Id: 578455
Other names: T. terrestris NRRL 8126, Thermothielavioides terrestris NRRL 8126

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	THITE_131345	G2R7Q1	G2QS70	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.918
FEN1	THITE_2106430	G2R7Q1	G2QXN0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.780
FEN1	THITE_2106865	G2R7Q1	G2QRW7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	AAA domain-containing protein.	0.909
FEN1	THITE_2107682	G2R7Q1	G2QUQ0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase.	0.989
FEN1	THITE_2107832	G2R7Q1	G2QVL6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.826
FEN1	THITE_2108112	G2R7Q1	G2QXT1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family.	0.841
FEN1	THITE_2108468	G2R7Q1	G2QRK5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.960
FEN1	THITE_2112208	G2R7Q1	G2QY36	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	AAA domain-containing protein.	0.926
FEN1	THITE_2113671	G2R7Q1	G2R3S7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Vezatin domain-containing protein.	0.977
FEN1	THITE_2114674	G2R7Q1	G2R139	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	0.543
FEN1	THITE_2115090	G2R7Q1	G2R318	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.677
FEN1	THITE_2117187	G2R7Q1	G2R7Q7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.887
FEN1	THITE_2117766	G2R7Q1	G2R5L3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA ligase.	0.918
FEN1	THITE_2120214	G2R7Q1	G2R9U3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase.	0.851
FEN1	THITE_2120339	G2R7Q1	G2RA70	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	AAA domain-containing protein.	0.911
FEN1	THITE_2124521	G2R7Q1	G2RFX6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	AAA domain-containing protein.	0.933
FEN1	THITE_2124524	G2R7Q1	G2RFX8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Replication factor C subunit 1.	0.883
FEN1	THITE_2124823	G2R7Q1	G2RGU2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	AAA domain-containing protein.	0.888
FEN1	THITE_2170173	G2R7Q1	G2R3S8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.977
FEN1	THITE_43396	G2R7Q1	G2R901	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA ligase.	0.926