STRINGSTRING
ACX73022.1 ACX73022.1 ACX73590.1 ACX73590.1 ogt ogt ACX73560.1 ACX73560.1 pcm pcm ACX73499.1 ACX73499.1 ACX73439.1 ACX73439.1 cbiD cbiD cbiT cbiT ACX73307.1 ACX73307.1 ACX73301.1 ACX73301.1 ACX73295.1 ACX73295.1 ACX73258.1 ACX73258.1 thyA thyA ACX73236.1 ACX73236.1 ACX73234.1 ACX73234.1 ACX73189.1 ACX73189.1 taw3 taw3 ACX73163.1 ACX73163.1 ACX73161.1 ACX73161.1 ACX73140.1 ACX73140.1 dphB dphB ACX73117.1 ACX73117.1 ACX73110.1 ACX73110.1 ACX73084.1 ACX73084.1 ACX73070.1 ACX73070.1 ACX73056.1 ACX73056.1 nep1 nep1 ACX73035.1 ACX73035.1 ACX72990.1 ACX72990.1 ACX72957.1 ACX72957.1 cdhE cdhE ACX72877.1 ACX72877.1 rlmE rlmE ACX72834.1 ACX72834.1 ACX72817.1 ACX72817.1 ACX72798.1 ACX72798.1 trmY trmY ACX72773.1 ACX72773.1 ACX72766.1 ACX72766.1 ACX72761.1 ACX72761.1 flpA flpA ACX72749.1 ACX72749.1 ACX72704.1 ACX72704.1 ACX72648.1 ACX72648.1 ACX72587.1 ACX72587.1 ACX72582.1 ACX72582.1 ACX72526.1 ACX72526.1 ACX71913.1 ACX71913.1 ACX71915.1 ACX71915.1 ACX71951.1 ACX71951.1 ACX71975.1 ACX71975.1 ACX72007.1 ACX72007.1 ACX72012.1 ACX72012.1 mtrE mtrE mtrD mtrD mtrC mtrC mtrB mtrB mtrA mtrA mtrF mtrF mtrG mtrG mtrH mtrH ACX72037.1 ACX72037.1 ACX72043.1 ACX72043.1 ACX72047.1 ACX72047.1 rsmA rsmA ACX72102.1 ACX72102.1 ACX72113.1 ACX72113.1 ACX72149.1 ACX72149.1 ACX72175.1 ACX72175.1 ACX72207.1 ACX72207.1 ACX72218.1 ACX72218.1 ACX72231.1 ACX72231.1 trm1 trm1 ACX72314.1 ACX72314.1 taw2 taw2 ACX72383.1 ACX72383.1 ACX72400.1 ACX72400.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACX73022.1PFAM: Methyltransferase type 11; UbiE/COQ5 methyltransferase; Methyltransferase type 12; KEGG: mja:MJ1123 hypothetical protein. (255 aa)
ACX73590.1PFAM: protein of unknown function UPF0153; KEGG: mja:MJ0939 hypothetical protein. (270 aa)
ogtmethylated-DNA/protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (161 aa)
ACX73560.1PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mfe:Mefer_1094 radical SAM domain protein. (320 aa)
pcmprotein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (214 aa)
ACX73499.1PFAM: Protein of unknown function DUF166; KEGG: mja:MJ0575 hypothetical protein. (230 aa)
ACX73439.1DNA adenine methylase; KEGG: mja:MJ0598 modification methylase, type II R/M system 2; TIGRFAM: DNA adenine methylase; PFAM: D12 class N6 adenine-specific DNA methyltransferase. (292 aa)
cbiDCobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (363 aa)
cbiTprecorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. (180 aa)
ACX73307.1PFAM: putative RNA methylase; THUMP domain protein; DNA methylase N-4/N-6 domain protein; KEGG: mfe:Mefer_1079 putative RNA methylase. (351 aa)
ACX73301.1TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mfe:Mefer_0849 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (240 aa)
ACX73295.1PFAM: DNA methylase N-4/N-6 domain protein; KEGG: mja:MJ1498 modification methylase, type II R/M system. (293 aa)
ACX73258.1PFAM: Radical SAM domain protein; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mja:MJ1155 hypothetical protein. (593 aa)
thyAThymidylate synthase, methanogen type; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. (221 aa)
ACX73236.1PFAM: protein of unknown function Met10; KEGG: mja:MJ0883 hypothetical protein. (336 aa)
ACX73234.1PFAM: methyltransferase small; putative RNA methylase; KEGG: mja:MJ0882 hypothetical protein. (196 aa)
ACX73189.1TIGRFAM: DNA-cytosine methyltransferase; PFAM: C-5 cytosine-specific DNA methylase; KEGG: mja:MJ1200 modification methylase, type II R/M system; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (364 aa)
taw3Protein of unknown function DUF207; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. (204 aa)
ACX73163.1PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: mja:MJ0638 hypothetical protein. (224 aa)
ACX73161.1TIGRFAM: methylase; PFAM: methyltransferase small; Methyltransferase type 12; KEGG: mja:MJ0928 protoporphyrinogen oxidase (HemK). (198 aa)
ACX73140.1PFAM: protein of unknown function DUF1156; KEGG: pab:PAB0588 hypothetical protein. (993 aa)
dphBDiphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. (257 aa)
ACX73117.1TIGRFAM: RNA methyltransferase, TrmH family, group 1; PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: mja:MJ1476 hypothetical protein. (227 aa)
ACX73110.1Precorrin-4 C11-methyltransferase; KEGG: mja:MJ1578 cobalamin biosynthesis precorrin-3 methylase (CbiF); TIGRFAM: precorrin-4 C11-methyltransferase; uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. (258 aa)
ACX73084.1KEGG: sul:SYO3AOP1_1669 hypothetical protein. (1197 aa)
ACX73070.1PFAM: protein of unknown function DUF752; KEGG: mja:MJ0670 hypothetical protein. (360 aa)
ACX73056.1PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mja:MJ0966 hypothetical protein. (459 aa)
nep1Suppressor Mra1 family protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. (204 aa)
ACX73035.1PFAM: DNA methylase N-4/N-6 domain protein; KEGG: mja:MJ1448 modification methylase, type II R/M system. (530 aa)
ACX72990.1KEGG: mfe:Mefer_1015 protein of unknown function Met10. (265 aa)
ACX72957.1PFAM: protein of unknown function Met10; putative RNA methylase; SMART: PUA domain containing protein; KEGG: mfe:Mefer_0268 protein of unknown function Met10. (378 aa)
cdhECO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). (489 aa)
ACX72877.1KEGG: tpt:Tpet_1772 adenine-specific DNA methylase. (703 aa)
rlmERibosomal RNA large subunit methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (248 aa)
ACX72834.1PFAM: O-methyltransferase family 2; KEGG: mfe:Mefer_0400 hypothetical protein. (351 aa)
ACX72817.1TIGRFAM: RNA methylase, NOL1/NOP2/sun family; PFAM: Fmu (Sun) domain protein; KEGG: mfe:Mefer_1246 RNA methylase, NOL1/NOP2/sun family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (265 aa)
ACX72798.1Site-specific DNA-methyltransferase (adenine-specific); PFAM: N-6 DNA methylase; KEGG: mja:MJECL42 type I restriction system protein M. (523 aa)
trmYProtein of unknown function DUF358; Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs; Belongs to the methyltransferase superfamily. TrmY family. (202 aa)
ACX72773.1PFAM: Methionine synthase vitamin-B12 independent; Cobalamin-independent synthase MetE domain protein; KEGG: mja:MJ1473 methionine synthase. (310 aa)
ACX72766.1PFAM: Methyltransferase type 11; UbiE/COQ5 methyltransferase; Methyltransferase type 12; KEGG: mfe:Mefer_0371 methyltransferase type 11. (230 aa)
ACX72761.1PFAM: Methyltransferase type 11; protein of unknown function Met10; putative RNA methylase; KEGG: mja:MJ1233 hypothetical protein. (280 aa)
flpAFibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (229 aa)
ACX72749.1PFAM: protein of unknown function DUF343; KEGG: mfe:Mefer_0545 protein of unknown function DUF343. (51 aa)
ACX72704.1PFAM: THUMP domain protein; KEGG: mja:MJ0421 hypothetical protein. (343 aa)
ACX72648.1PFAM: Radical SAM domain protein; KEGG: mja:MJ0619 hypothetical protein. (506 aa)
ACX72587.1TIGRFAM: methanogen marker protein 4; KEGG: mfe:Mefer_0014 methanogen marker protein 4. (251 aa)
ACX72582.1PFAM: protein of unknown function Met10; putative RNA methylase; SMART: PUA domain containing protein; KEGG: mja:MJ1653 hypothetical protein. (385 aa)
ACX72526.1PFAM: methyltransferase small; KEGG: mfe:Mefer_0857 methyltransferase small. (217 aa)
ACX71913.1TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mfe:Mefer_1034 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. (229 aa)
ACX71915.1PFAM: Radical SAM domain protein; cobalamin B12-binding domain protein; deoxyribonuclease/rho motif-related TRAM; SMART: Elongator protein 3/MiaB/NifB; KEGG: mja:MJ1620 hypothetical protein. (498 aa)
ACX71951.1precorrin-3B C17-methyltransferase; KEGG: mja:MJ0813 cobalamin biosynthesis precorrin-3 methylase (CbiH); TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. (249 aa)
ACX71975.1PFAM: Methyltransferase type 12; Methyltransferase type 11; KEGG: mja:MJ0906 hypothetical protein. (365 aa)
ACX72007.1PFAM: Protein of unknown function DUF166; KEGG: mja:MJ0838 hypothetical protein. (216 aa)
ACX72012.1TIGRFAM: methanogenesis marker protein 10; PFAM: protein of unknown function DUF512; Radical SAM domain protein; KEGG: mja:MJ0841 hypothetical protein. (415 aa)
mtrETetrahydromethanopterin S-methyltransferase, subunit E; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (303 aa)
mtrDTetrahydromethanopterin S-methyltransferase, subunit D; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (230 aa)
mtrCTetrahydromethanopterin S-methyltransferase, subunit C; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (266 aa)
mtrBTetrahydromethanopterin S-methyltransferase; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (109 aa)
mtrATetrahydromethanopterin S-methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (241 aa)
mtrFTetrahydromethanopterin S-methyltransferase, F subunit; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (68 aa)
mtrGTetrahydromethanopterin S-methyltransferase, subunit G; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (84 aa)
mtrHTetrahydromethanopterin S-methyltransferase, MtrH subunit; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA. (319 aa)
ACX72037.1PFAM: tRNA methyltransferase complex GCD14 subunit; KEGG: mja:MJ0134 L-isoaspartyl protein carboxyl methyltransferase isolog (PimT). (275 aa)
ACX72043.1Protein of unknown function DUF127; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. (177 aa)
ACX72047.1PFAM: putative RNA methylase; THUMP domain protein; KEGG: mja:MJ0438 hypothetical protein. (381 aa)
rsmADimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily. (274 aa)
ACX72102.1PFAM: protein of unknown function DUF890; methyltransferase small; KEGG: mja:MJ0046 hypothetical protein. (261 aa)
ACX72113.1TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mfe:Mefer_0587 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit. (207 aa)
ACX72149.1PFAM: Radical SAM domain protein; cobalamin B12-binding domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mja:MJ0865 hypothetical protein. (439 aa)
ACX72175.1KEGG: mja:MJ0045 hypothetical protein. (217 aa)
ACX72207.1KEGG: mfe:Mefer_0896 DNA methylase N-4/N-6 domain protein. (37 aa)
ACX72218.1PFAM: Pre-mRNA processing ribonucleoprotein, binding domain protein; NOSIC domain protein; KEGG: mja:MJ0694 hypothetical protein. (420 aa)
ACX72231.1TIGRFAM: DNA-cytosine methyltransferase; PFAM: C-5 cytosine-specific DNA methylase; KEGG: mja:MJ0563 modification methylase, type II R/M system; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (310 aa)
trm1N2,N2-dimethylguanosine tRNA methyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (371 aa)
ACX72314.1PFAM: Protein of unknown function DUF166; KEGG: mfe:Mefer_1040 protein of unknown function DUF166. (245 aa)
taw2Protein of unknown function Met10; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). (250 aa)
ACX72383.1KEGG: mfe:Mefer_1107 MCP methyltransferase, CheR-type; PFAM: MCP methyltransferase CheR-type; SMART: MCP methyltransferase CheR-type. (281 aa)
ACX72400.1PFAM: Dimethylmenaquinone methyltransferase; KEGG: mja:MJ0644 S-adenosylmethionine:2-demethylmenaquinone methyltransferase (MenG). (196 aa)
Your Current Organism:
Methanocaldococcus vulcanius
NCBI taxonomy Id: 579137
Other names: M. vulcanius M7, Methanocaldococcus vulcanius M7, Methanocaldococcus vulcanius str. M7, Methanocaldococcus vulcanius strain M7
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