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| | ACX71883.1 | TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; KEGG: mja:MJ0571 aspartate kinase; Belongs to the aspartokinase family. (471 aa) |
| | hmd | Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (358 aa) |
| | ACX71920.1 | PFAM: phosphoadenosine phosphosulfate reductase; PUA domain containing protein; SMART: PUA domain containing protein; KEGG: mja:MJ0066 hypothetical protein. (480 aa) |
| | sat | KEGG: ton:TON_1707 sulfate adenylyltransferase; TIGRFAM: sulfate adenylyltransferase; PFAM: ATP-sulfurylase. (382 aa) |
| | cysC | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (173 aa) |
| | cofC | 2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (219 aa) |
| | ACX72013.1 | KEGG: mja:MJ0842 methyl coenzyme M reductase I, subunit beta (McrB); TIGRFAM: methyl-coenzyme M reductase, beta subunit; PFAM: Methyl-coenzyme M reductase, beta subunit. (444 aa) |
| | ACX72014.1 | TIGRFAM: methyl-coenzyme M reductase operon protein D; PFAM: Methyl-coenzyme M reductase, protein D; KEGG: mja:MJ0843 methyl coenzyme M reductase I, operon protein D (McrD). (162 aa) |
| | ACX72015.1 | TIGRFAM: methyl-coenzyme M reductase I operon protein C; PFAM: Methyl-coenzyme M reductase protein C; KEGG: mja:MJ0844 methyl coenzyme M reductase I, operon protein C (McrC). (200 aa) |
| | ACX72016.1 | KEGG: mfe:Mefer_0937 methyl-coenzyme M reductase, gamma subunit; TIGRFAM: methyl-coenzyme M reductase, gamma subunit; PFAM: Methyl-coenzyme M reductase, gamma subunit. (260 aa) |
| | ACX72017.1 | Methyl-coenzyme M reductase, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (553 aa) |
| | mtrE | Tetrahydromethanopterin S-methyltransferase, subunit E; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (303 aa) |
| | mtrD | Tetrahydromethanopterin S-methyltransferase, subunit D; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (230 aa) |
| | mtrC | Tetrahydromethanopterin S-methyltransferase, subunit C; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (266 aa) |
| | mtrB | Tetrahydromethanopterin S-methyltransferase; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (109 aa) |
| | mtrA | Tetrahydromethanopterin S-methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (241 aa) |
| | mtrF | Tetrahydromethanopterin S-methyltransferase, F subunit; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (68 aa) |
| | mtrG | Tetrahydromethanopterin S-methyltransferase, subunit G; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (84 aa) |
| | mtrH | Tetrahydromethanopterin S-methyltransferase, MtrH subunit; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA. (319 aa) |
| | mer | 5,10-methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. (331 aa) |
| | rpiA | Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (226 aa) |
| | cofG | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. (364 aa) |
| | ACX72147.1 | KEGG: mja:MJ0863 heterodisulfide reductase, subunit B2 (hdrB2); TIGRFAM: CoB/CoM heterodisulfide reductase, subunit B; PFAM: protein of unknown function DUF224 cysteine-rich region domain protein. (296 aa) |
| | ACX72148.1 | TIGRFAM: CoB/CoM heterodisulfide reductase, subunit C; KEGG: mja:MJ0864 heterodisulfide reductase, subunit C2 (hdrC2). (186 aa) |
| | mtd | Methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (277 aa) |
| | ACX72226.1 | PFAM: Lactate/malate dehydrogenase; KEGG: mfe:Mefer_0722 malate dehydrogenase (NADP(+)); Belongs to the LDH/MDH superfamily. (313 aa) |
| | ACX72233.1 | PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: mfe:Mefer_0658 fructose-bisphosphate aldolase. (305 aa) |
| | ACX72237.1 | PFAM: class II aldolase/adducin family protein; KEGG: mja:MJ1418 fuculose-1-phosphate aldolase (FucA). (181 aa) |
| | ACX72238.1 | KEGG: mfe:Mefer_0815 2-phosphosulfolactate phosphatase; TIGRFAM: 2-phosphosulfolactate phosphatase; PFAM: 2-phosphosulfolactate phosphatase. (224 aa) |
| | ACX72243.1 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (244 aa) |
| | gap | KEGG: mfe:Mefer_0809 glyceraldehyde-3-phosphate dehydrogenase, type II; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type II; PFAM: glyceraldehyde 3-phosphate dehydrogenase. (343 aa) |
| | ACX72255.1 | TIGRFAM: 6-phospho 3-hexuloisomerase; PFAM: sugar isomerase (SIS); KEGG: mja:MJ1247 hypothetical protein. (176 aa) |
| | sucD | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (287 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (297 aa) |
| | ACX72301.1 | KEGG: mja:MJ0743 heterodisulfide reductase, subunit B1 (hdrB1); TIGRFAM: CoB/CoM heterodisulfide reductase, subunit B; PFAM: protein of unknown function DUF224 cysteine-rich region domain protein. (294 aa) |
| | ACX72302.1 | TIGRFAM: CoB/CoM heterodisulfide reductase, subunit C; KEGG: mja:MJ0744 heterodisulfide reductase, subunit C (HdrC). (194 aa) |
| | ACX72351.1 | TIGRFAM: siroheme synthase; KEGG: mja:MJ0140 hypothetical protein. (202 aa) |
| | ftr | Formylmethanofuran/tetrahydromethanopterin N-formyltransferase; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family. (301 aa) |
| | ACX72377.1 | KEGG: mja:MJ1294 fumarate hydratase; TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate alpha region. (282 aa) |
| | ubiX | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (185 aa) |
| | cbiX | Cobalamin (vitamin B12) biosynthesis CbiX protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (141 aa) |
| | ACX72400.1 | PFAM: Dimethylmenaquinone methyltransferase; KEGG: mja:MJ0644 S-adenosylmethionine:2-demethylmenaquinone methyltransferase (MenG). (196 aa) |
| | ACX72401.1 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mfe:Mefer_0258 porphobilinogen synthase; Belongs to the ALAD family. (324 aa) |
| | pgk | PFAM: phosphoglycerate kinase; KEGG: mja:MJ0641 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (414 aa) |
| | ACX72409.1 | PFAM: Thiolase; KEGG: mja:MJ1549 acetyl-CoA acetyltransferase. (392 aa) |
| | ACX72487.1 | KEGG: mja:MJ0728 carbon monoxide dehydrogenase, catalytic subunit (CooS); TIGRFAM: carbon-monoxide dehydrogenase, catalytic subunit; PFAM: Prismane. (628 aa) |
| | ACX72488.1 | KEGG: mja:MJ0727 coenzyme F420-reducing hydrogenase, alpha subunit. (298 aa) |
| | ACX72489.1 | PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mja:MJ0726 coenzyme F420-reducing hydrogenase, gamma subunit. (216 aa) |
| | ACX72490.1 | PFAM: coenzyme F420 hydrogenase/dehydrogenase beta subunit domain protein; KEGG: mja:MJ0725 coenzyme F420-reducing hydrogenase subunit beta. (271 aa) |
| | argD | KEGG: mja:MJ0721 acetylornithine aminotransferase; TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; aminotransferase class I and II; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (397 aa) |
| | hacB | 3-isopropylmalate dehydratase, small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD [...] (163 aa) |
| | ACX72552.1 | PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: mja:MJ0276 2-oxoglutarate ferredoxin oxidoreductase subunit alpha. (366 aa) |
| | ACX72558.1 | TIGRFAM: coenzyme F420-reducing hydrogenase delta subunit; hydrogenase maturation protease; PFAM: peptidase M52 hydrogen uptake protein; KEGG: mfe:Mefer_0104 coenzyme F420-reducing hydrogenase delta subunit. (158 aa) |
| | ACX72566.1 | PFAM: formylmethanofuran dehydrogenase subunit E region; KEGG: mfe:Mefer_0555 formylmethanofuran dehydrogenase subunit E region. (214 aa) |
| | ACX72568.1 | PFAM: coenzyme F420 hydrogenase/dehydrogenase beta subunit domain protein; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mja:MJ0005 formate dehydrogenase, beta subunit. (379 aa) |
| | ACX72569.1 | PFAM: molybdopterin oxidoreductase; molybdopterin oxidoreductase Fe4S4 region; KEGG: mja:MJ0006 formate dehydrogenase, alpha subunit. (378 aa) |
| | ACX72571.1 | KEGG: mja:MJ1194m formylmethanofuran dehydrogenase (tungsten), subunit B, selenocysteine-containing; TIGRFAM: formylmethanofuran dehydrogenase subunit B; PFAM: molybdopterin oxidoreductase. (441 aa) |
| | ACX72572.1 | 4Fe-4S ferredoxin iron-sulfur binding domain protein; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (654 aa) |
| | ACX72574.1 | PFAM: nickel-dependent hydrogenase large subunit; KEGG: mae:Maeo_0097 nickel-dependent hydrogenase large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (479 aa) |
| | ACX72575.1 | PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit; KEGG: mae:Maeo_0098 NADH ubiquinone oxidoreductase 20 kDa subunit. (299 aa) |
| | ACX72576.1 | PFAM: methyl-viologen-reducing hydrogenase delta subunit; KEGG: mae:Maeo_0099 methyl-viologen-reducing hydrogenase delta subunit. (150 aa) |
| | ACX72580.1 | Phosphonopyruvate decarboxylase-related protein; KEGG: mja:MJ0010 BcpC phosphonopyruvate decarboxylase; TIGRFAM: phosphonopyruvate decarboxylase-related protein; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; metalloenzyme domain protein. (426 aa) |
| | ACX72594.1 | TIGRFAM: methanogenesis marker 13 metalloprotein; KEGG: mja:MJ1423 vanadium nitrogenase-associated protein N. (357 aa) |
| | cofH | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. (359 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (295 aa) |
| | ACX72610.1 | KEGG: mja:MJ1596 3-isopropylmalate dehydrogenase 2 (leuB2); TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (346 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (430 aa) |
| | ACX72622.1 | PFAM: Aldehyde Dehydrogenase; KEGG: mja:MJ1411 glyceraldehyde-3-phosphate dehydrogenase, NADP-dependent (GapN). (463 aa) |
| | apgM | Phosphonopyruvate decarboxylase-related protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (412 aa) |
| | pgi | PFAM: phosphoglucose isomerase (PGI); KEGG: mja:MJ1605 glucose-6-phosphate isomerase; Belongs to the GPI family. (406 aa) |
| | pfkC | ADP-specific phosphofructokinase; Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor. (466 aa) |
| | ACX72646.1 | KEGG: mfe:Mefer_0211 hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate beta region. (196 aa) |
| | ACX72655.1 | KEGG: mja:MJ1171 formylmethanofuran dehydrogenase, subunit C (tungsten) (FwdC); TIGRFAM: formylmethanofuran dehydrogenase subunit C; PFAM: glutamate synthase alpha subunit domain protein. (273 aa) |
| | ACX72657.1 | TIGRFAM: formylmethanofuran dehydrogenase subunit A; PFAM: Amidohydrolase 3; KEGG: mja:MJ1169 formylmethanofuran dehydrogenase, subunit A (tungsten) (FwdA). (567 aa) |
| | ACX72658.1 | PFAM: molydopterin dinucleotide-binding region; KEGG: mja:MJ1168 formylmethanofuran dehydrogenase, subunit D (tungsten) (FwdD). (133 aa) |
| | ACX72659.1 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mfe:Mefer_0157 4Fe-4S ferredoxin iron-sulfur binding domain protein. (82 aa) |
| | ACX72660.1 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mja:MJ1166 formylmethanofuran dehydrogenase, subunit F (tungsten) (FwdF). (356 aa) |
| | ACX72661.1 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mja:MJ1165 formylmethanofuran dehydrogenase, subunit E (tungsten) (FwdE). (151 aa) |
| | cofD | LPPG domain protein containing protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (308 aa) |
| | ACX72693.1 | PFAM: Mur ligase middle domain protein; KEGG: mfe:Mefer_0369 Mur ligase middle domain protein. (406 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (162 aa) |
| | hemL | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: mja:MJ0603 glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (422 aa) |
| | ACX72734.1 | TIGRFAM: acetyl-CoA carboxylase, biotin carboxylase; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; biotin carboxylase domain protein; RimK domain protein ATP-grasp; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: mja:MJ1229 pyruvate carboxylase subunit A. (501 aa) |
| | ACX72736.1 | TIGRFAM: oxaloacetate decarboxylase alpha subunit; PFAM: Conserved carboxylase region; pyruvate carboxyltransferase; biotin/lipoyl attachment domain-containing protein; KEGG: mja:MJ1231 pyruvate carboxylase subunit B. (567 aa) |
| | nifH | Nitrogenase iron protein; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein; Belongs to the NifH/BchL/ChlL family. (277 aa) |
| | ACX72753.1 | PFAM: coenzyme F420 hydrogenase/dehydrogenase beta subunit domain protein; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mja:MJ1349 coenzyme F420-reducing hydrogenase, beta subunit. (359 aa) |
| | ACX72770.1 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (405 aa) |
| | ACX72777.1 | KEGG: mja:MJ0658 hypothetical protein. (322 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (295 aa) |
| | fbp | Protein of unknown function DUF100; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (386 aa) |
| | ACX72803.1 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (766 aa) |
| | cdhC | CO dehydrogenase/acetyl-CoA synthase complex, beta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family. (740 aa) |
| | asd-2 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (348 aa) |
| | rbcL | Ribulose bisphosphate carboxylase, type III; Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily. (425 aa) |
| | cdhD | CO dehydrogenase/acetyl-CoA synthase, delta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex. Belongs to the CdhD family. (405 aa) |
| | cdhE | CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). (489 aa) |
| | nifH-2 | Nitrogenase iron protein; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein; Belongs to the NifH/BchL/ChlL family. (284 aa) |
| | ACX72942.1 | KEGG: mae:Maeo_1431 nitrogenase component I, alpha chain; TIGRFAM: nitrogenase component I, alpha chain; nitrogenase alpha chain; PFAM: oxidoreductase/nitrogenase component 1. (478 aa) |
| | ACX72943.1 | Nitrogenase; PFAM: oxidoreductase/nitrogenase component 1; KEGG: mae:Maeo_1430 nitrogenase. (464 aa) |
| | ACX72964.1 | KEGG: mja:MJ0108 pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (444 aa) |
| | ACX72981.1 | KEGG: mja:MJ1242 methyl coenzyme M reductase system, component A2 (AtwA); TIGRFAM: methyl coenzyme M reductase system, component A2; PFAM: ABC transporter related; SMART: AAA ATPase. (534 aa) |
| | ACX73015.1 | TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; KEGG: mja:MJ0269 pyruvate ferredoxin oxidoreductase subunit gamma. (179 aa) |
| | ACX73016.1 | TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mja:MJ0268 pyruvate ferredoxin oxidoreductase, subunit delta (PorD). (86 aa) |
| | ACX73017.1 | PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: mja:MJ0267 pyruvate ferredoxin oxidoreductase, subunit alpha (PorA). (386 aa) |
| | ACX73018.1 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: mfe:Mefer_0883 thiamine pyrophosphate protein domain protein TPP-binding. (295 aa) |
| | ACX73019.1 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mja:MJ0265 carbon monoxide dehydrogenase, iron sulfur subunit CooF-1 (cooF2). (164 aa) |
| | ACX73020.1 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mja:MJ0264 carbon monoxide dehydrogenase, iron sulfur subunit CooF-1 (cooF1). (137 aa) |
| | ACX73021.1 | Contains selenocysteine; TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: molybdopterin oxidoreductase; molybdopterin oxidoreductase Fe4S4 region; molydopterin dinucleotide-binding region; KEGG: mja:MJ1353m formate dehydrogenase. (677 aa) |
| | ACX73024.1 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: mja:MJ1602 homoserine dehydrogenase. (341 aa) |
| | fae-hps | Formaldehyde-activating enzyme (Fae); Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family. (381 aa) |
| | ACX73039.1 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: mfe:Mefer_0100 thiamine pyrophosphate protein domain protein TPP-binding. (189 aa) |
| | cdhC-2 | CO dehydrogenase/acetyl-CoA synthase complex, beta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family. (466 aa) |
| | ACX73043.1 | 4Fe-4S ferredoxin iron-sulfur binding domain protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (154 aa) |
| | ACX73044.1 | TIGRFAM: CO dehydrogenase/acetyl-CoA synthase complex, epsilon subunit; PFAM: CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit; KEGG: mja:MJ0154 acetyl-CoA decarbonylase/synthase complex subunit epsilon. (146 aa) |
| | cdhA | CO dehydrogenase/acetyl-CoA synthase complex, epsilon subunit; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. (774 aa) |
| | ACX73050.1 | KEGG: mja:MJ0081 methyl coenzyme M reductase II, subunit beta (MrtB); TIGRFAM: methyl-coenzyme M reductase, beta subunit; PFAM: Methyl-coenzyme M reductase, beta subunit. (442 aa) |
| | ACX73051.1 | KEGG: mja:MJ0082 methyl coenzyme M reductase II, subunit gamma (MtrG); TIGRFAM: methyl-coenzyme M reductase, gamma subunit; PFAM: Methyl-coenzyme M reductase, gamma subunit. (266 aa) |
| | ACX73052.1 | Methyl-coenzyme M reductase, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (552 aa) |
| | ACX73053.1 | TIGRFAM: methyl-coenzyme M reductase operon protein D; PFAM: Methyl-coenzyme M reductase, protein D; KEGG: mfe:Mefer_0817 methyl-coenzyme M reductase operon protein D. (160 aa) |
| | ACX73093.1 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: mja:MJ0537 2-oxoglutarate ferredoxin oxidoreductase subunit beta. (271 aa) |
| | ACX73094.1 | TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; KEGG: mfe:Mefer_0782 pyruvate/ketoisovalerate oxidoreductase, gamma subunit. (180 aa) |
| | ACX73102.1 | TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; ferredoxin; KEGG: mja:MJ0092 succinate dehydrogenase/fumarate reductase iron-sulfur subunit. (490 aa) |
| | ACX73135.1 | Contains selenocysteine; TIGRFAM: coenzyme F420 hydrogenase, subunit alpha; PFAM: nickel-dependent hydrogenase large subunit; KEGG: mja:MJ0029 coenzyme F420-reducing hydrogenase, alpha subunit, selenocysteine-containing; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (410 aa) |
| | ACX73136.1 | TIGRFAM: coenzyme F420-reducing hydrogenase delta subunit; hydrogenase maturation protease; PFAM: peptidase M52 hydrogen uptake protein; KEGG: mja:MJ0030 coenzyme F420-reducing hydrogenase, delta subunit (FrcD). (176 aa) |
| | ACX73137.1 | TIGRFAM: coenzyme F420 hydrogenase, subunit gamma; PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mja:MJ0031 coenzyme F420-reducing hydrogenase, gamma subunit. (227 aa) |
| | ACX73138.1 | TIGRFAM: coenzyme F420 hydrogenase, subunit beta; PFAM: coenzyme F420 hydrogenase/dehydrogenase beta subunit domain protein; KEGG: mja:MJ0032 coenzyme F420-reducing hydrogenase subunit beta. (282 aa) |
| | ACX73139.1 | PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; KEGG: mja:MJ0033 succinate dehydrogenase flavoprotein subunit. (531 aa) |
| | ACX73154.1 | PFAM: RimK domain protein ATP-grasp; protein of unknown function DUF201; KEGG: mja:MJ1001 ribosomal protein S6 modification protein 2 (RimK). (291 aa) |
| | leuC-2 | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (419 aa) |
| | ACX73165.1 | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: mfe:Mefer_0246 FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (392 aa) |
| | ACX73172.1 | TIGRFAM: acetyl coenzyme A synthetase (ADP forming), alpha domain protein; PFAM: CoA-binding domain protein; KEGG: mfe:Mefer_1374 acetyl coenzyme A synthetase (ADP forming), alpha domain protein. (700 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (562 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (438 aa) |
| | mch | Methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (323 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (296 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (274 aa) |
| | ACX73280.1 | KEGG: mja:MJ1018 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein; 6-phosphogluconate dehydrogenase NAD-binding. (524 aa) |
| | aroA | Predicted phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (272 aa) |
| | ACX73301.1 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mfe:Mefer_0849 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (240 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (398 aa) |
| | ACX73314.1 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mja:MJ0146 2-ketoglutarate ferredoxin oxidoreductase, subunit delta (KorD). (71 aa) |
| | ACX73322.1 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: mja:MJ1662 methyl coenzyme M reductase system, component A2-like. (550 aa) |
| | ACX73338.1 | 4Fe-4S ferredoxin iron-sulfur binding domain protein; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (658 aa) |
| | ACX73339.1 | Contains selenocysteine; PFAM: methyl-viologen-reducing hydrogenase delta subunit; KEGG: mja:MJ1190a coenzyme F420-reducing hydrogenase, delta subunit. (133 aa) |
| | ACX73340.1 | PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit; KEGG: mja:MJ1191 methylviologen-reducing hydrogenase, gamma chain (VhuG). (288 aa) |
| | ACX73341.1 | PFAM: nickel-dependent hydrogenase large subunit; KEGG: mja:MJ1192m methylviologen-reducing hydrogenase, alpha subunit. (418 aa) |
| | ACX73344.1 | KEGG: mja:MJ1194m formylmethanofuran dehydrogenase (tungsten), subunit B, selenocysteine-containing; Contains selenocysteine; TIGRFAM: formylmethanofuran dehydrogenase subunit B; PFAM: molybdopterin oxidoreductase. (435 aa) |
| | ACX73370.1 | PFAM: Aldehyde ferredoxin oxidoreductase; SMART: Aldehyde ferredoxin oxidoreductase; KEGG: mja:MJ1185 putative aldehyde ferredoxin oxidoreductase (aor). (621 aa) |
| | ACX73374.1 | KEGG: mja:MJ0255a sulfopyruvate decarboxylase subunit ComD. (170 aa) |
| | ACX73375.1 | PFAM: (2R)-phospho-3-sulfolactate synthase ComA; KEGG: mja:MJ0255 hypothetical protein. (259 aa) |
| | ACX73411.1 | PFAM: Transketolase central region; Transketolase domain protein; KEGG: mja:MJ0679 transketolase''. (316 aa) |
| | ACX73412.1 | KEGG: mja:MJ0680 pentose-5-phosphate-3-epimerase; TIGRFAM: ribulose-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase. (237 aa) |
| | ACX73413.1 | PFAM: Transketolase domain protein; KEGG: mja:MJ0681 transketolase'. (275 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (288 aa) |
| | ACX73429.1 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; KEGG: mja:MJ0503 trans-homoaconitate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (406 aa) |
| | sucC | succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (364 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | ACX73531.1 | KEGG: mja:MJ1594 phosphoserine phosphatase (SerB); TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IA, variant 1; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase subfamily IB hypothetical 1. (214 aa) |
| | cofE | F420-dependent oxidoreductase; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives. (254 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (219 aa) |
| | ACX73576.1 | KEGG: mja:MJ1346 glutamine synthetase (GlnA); TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp. (479 aa) |
| | ACX73578.1 | TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: mja:MJ0457 diaminopimelate aminotransferase. (413 aa) |
