STRINGSTRING
ilvD ilvD Tlie_0137 Tlie_0137 Tlie_0138 Tlie_0138 leuD leuD leuC leuC leuA leuA ilvC ilvC Tlie_0143 Tlie_0143 Tlie_0144 Tlie_0144 Tlie_0184 Tlie_0184 Tlie_0406 Tlie_0406 Tlie_0407 Tlie_0407 Tlie_0773 Tlie_0773 Tlie_0882 Tlie_0882 Tlie_0883 Tlie_0883 Tlie_0884 Tlie_0884 Tlie_0885 Tlie_0885 Tlie_0955 Tlie_0955 Tlie_0956 Tlie_0956 Tlie_0957 Tlie_0957 Tlie_0958 Tlie_0958 Tlie_1114 Tlie_1114 Tlie_1115 Tlie_1115 Tlie_1116 Tlie_1116 Tlie_1117 Tlie_1117 Tlie_1406 Tlie_1406 Tlie_1479 Tlie_1479 Tlie_1562 Tlie_1562 leuD-2 leuD-2 leuC-2 leuC-2 leuD-3 leuD-3 Tlie_1566 Tlie_1566 ilvE ilvE Tlie_1706 Tlie_1706 Tlie_1718 Tlie_1718 Tlie_1755 Tlie_1755 Tlie_1756 Tlie_1756 Tlie_1792 Tlie_1792 leuD-4 leuD-4 leuC-3 leuC-3 Tlie_1835 Tlie_1835 Tlie_1836 Tlie_1836 Tlie_1837 Tlie_1837 Tlie_1871 Tlie_1871
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ilvDPFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR004404: IPR010916: IPR020558: IPR000581; KEGG: tjr:TherJR_0359 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (553 aa)
Tlie_0137Acetolactate synthase, large subunit; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012846: IPR012001: IPR012000: IPR011766; KEGG: pmo:Pmob_1592 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; [...] (560 aa)
Tlie_0138PFAM: Isocitrate/isopropylmalate dehydrogenase; COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR019818: IPR001804; KEGG: aco:Amico_0098 3-isopropylmalate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: 3-isopropylmalate dehydrogenase. (378 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (171 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (432 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (513 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (336 aa)
Tlie_0143PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit; COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR004789: IPR002912: IPR019455; KEGG: msv:Mesil_2144 acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit. (164 aa)
Tlie_0144PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR000581; KEGG: nth:Nther_1850 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (560 aa)
Tlie_0184Pyruvate carboxyltransferase; PFAM: HMGL-like; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR002034: IPR000891; KEGG: aco:Amico_1308 pyruvate carboxyltransferase; PFAM: pyruvate carboxyltransferase; SPTR: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (408 aa)
Tlie_0406Biotin/lipoyl attachment domain-containing protein; PFAM: Biotin-requiring enzyme; COGs: COG0511 Biotin carboxyl carrier protein; InterPro IPR000089: IPR001882; KEGG: aco:Amico_0269 biotin/lipoyl attachment domain-containing protein; PFAM: biotin/lipoyl attachment domain-containing protein; SPTR: Biotin/lipoyl attachment domain-containing protein. (135 aa)
Tlie_0407PFAM: subunit; TIGRFAM: sodium ion-translocating decarboxylase, beta subunit; COGs: COG1883 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase beta subunit; InterPro IPR005661; KEGG: aco:Amico_0883 sodium ion-translocating decarboxylase, beta subunit; PFAM: Na+transporting methylmalonyl-CoA/oxaloacetate decarboxylase beta subunit; PRIAM: Glutaconyl-CoA decarboxylase; SPTR: Sodium ion-translocating decarboxylase, beta subunit; TIGRFAM: sodium ion-translocating decarboxylase, beta subunit. (374 aa)
Tlie_0773PFAM: HMGL-like; Conserved carboxylase domain; COGs: COG5016 Pyruvate/oxaloacetate carboxyltransferase; InterPro IPR000891: IPR003379; KEGG: aco:Amico_0751 conserved carboxylase region; PFAM: Conserved carboxylase region; pyruvate carboxyltransferase; SPTR: Conserved carboxylase region. (498 aa)
Tlie_0882InterPro IPR017900: IPR017896; KEGG: aco:Amico_1019 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: 4Fe-4S ferredoxin iron-sulfur binding domain protein. (73 aa)
Tlie_0883PFAM: domain; Transketolase, C-terminal domain; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR002880; KEGG: aco:Amico_1018 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; SPTR: Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (349 aa)
Tlie_0884Thiamine pyrophosphate TPP-binding domain-containing protein; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: aco:Amico_1017 thiamine pyrophosphate protein domain protein TPP-binding protein; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; SPTR: Thiamine pyrophosphate protein domain protein TPP-binding protein. (252 aa)
Tlie_0885Pyruvate/ketoisovalerate oxidoreductase, catalytic domain protein; PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; COGs: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase gamma subunit; InterPro IPR019752; KEGG: aco:Amico_1016 pyruvate/ketoisovalerate oxidoreductase; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; SPTR: Pyruvate/ketoisovalerate oxidoreductase. (189 aa)
Tlie_0955PFAM: 4Fe-4S binding domain; InterPro IPR017900: IPR017896; KEGG: tai:Taci_0967 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: 4Fe-4S ferredoxin iron-sulfur binding domain protein. (68 aa)
Tlie_0956PFAM: domain; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR002880; KEGG: aco:Amico_0795 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; SPTR: Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (377 aa)
Tlie_0957Thiamine pyrophosphate TPP-binding domain-containing protein; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: aco:Amico_0796 thiamine pyrophosphate protein domain protein TPP-binding protein; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; SPTR: Thiamine pyrophosphate protein domain protein TPP-binding protein. (275 aa)
Tlie_0958Pyruvate/ketoisovalerate oxidoreductase, catalytic domain protein; PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; COGs: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase gamma subunit; InterPro IPR019752; KEGG: tai:Taci_0964 pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; SPTR: Pyruvate ferredoxin/flavodoxin oxidoreductase. (181 aa)
Tlie_1114PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; COGs: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase gamma subunit; InterPro IPR005479: IPR011894: IPR019752; KEGG: aco:Amico_1313 pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; SPTR: Pyruvate/ketoisovalerate oxidoreductase, gamma subunit; TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit. (190 aa)
Tlie_1115PFAM: 4Fe-4S binding domain; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; COGs: COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase delta subunit; InterPro IPR017900: IPR011898: IPR017896; KEGG: aco:Amico_1314 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; SPTR: Pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit. (95 aa)
Tlie_1116PFAM: domain; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR002880; KEGG: aco:Amico_1315 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; SPTR: Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (388 aa)
Tlie_1117Thiamine pyrophosphate TPP-binding domain-containing protein; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: aco:Amico_1316 thiamine pyrophosphate protein domain protein TPP-binding protein; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; SPTR: Thiamine pyrophosphate protein domain protein TPP-binding protein. (313 aa)
Tlie_1406CoA-binding domain protein; PFAM: CoA binding domain; COGs: COG1042 Acyl-CoA synthetase (NDP forming); InterPro IPR003781: IPR013650: IPR011761; KEGG: tai:Taci_1407 CoA-binding domain protein; PFAM: CoA-binding domain protein; ATP-grasp domain protein; SPTR: Acetyl-CoA synthetase / acetyltransferase family protein. (701 aa)
Tlie_1479PFAM: subunit; TIGRFAM: sodium ion-translocating decarboxylase, beta subunit; COGs: COG1883 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase beta subunit; InterPro IPR005661; KEGG: tai:Taci_0241 sodium ion-translocating decarboxylase, beta subunit; PFAM: Na+transporting methylmalonyl-CoA/oxaloacetate decarboxylase beta subunit; PRIAM: Oxaloacetate decarboxylase; SPTR: Sodium ion-translocating decarboxylase, beta subunit; TIGRFAM: sodium ion-translocating decarboxylase, beta subunit. (373 aa)
Tlie_1562PFAM: Aconitase family (aconitate hydratase); TIGRFAM: 3-isopropylmalate dehydratase, large subunit; homoaconitate hydratase family protein; COGs: COG0065 3-isopropylmalate dehydratase large subunit; InterPro IPR011826: IPR006251: IPR001030; KEGG: tai:Taci_1364 homoaconitate hydratase family protein; PFAM: aconitate hydratase domain-containing protein; SPTR: Homoaconitate hydratase family protein; TIGRFAM: homoaconitate hydratase family protein; 3-isopropylmalate dehydratase. (426 aa)
leuD-23-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (172 aa)
leuC-2Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (418 aa)
leuD-33-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (164 aa)
Tlie_1566PFAM: Isocitrate/isopropylmalate dehydrogenase; COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804: IPR019818; KEGG: tai:Taci_1368 3-isopropylmalate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: 3-isopropylmalate dehydrogenase. (410 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (290 aa)
Tlie_1706PFAM: Aminotransferase class IV; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544; KEGG: aco:Amico_1844 aminotransferase class IV; PFAM: aminotransferase class IV; SPTR: Putative branched-chain amino acid aminotransferase. (274 aa)
Tlie_1718PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001: IPR012000: IPR011766: IPR000399; KEGG: mse:Msed_1037 acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate central domain-containing protein; thiamine pyrophosphate TPP-binding domain-containing protein; SPTR: Thiamine pyrophosphate enzyme. (585 aa)
Tlie_1755PFAM: Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011896: IPR011766; KEGG: aco:Amico_1449 pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; PRIAM: 2-oxoglutarate synthase; SPTR: Pyruvate ferredoxin/flavodoxin oxidoreduc [...] (286 aa)
Tlie_1756PFAM: domain; Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR019752: IPR002880; KEGG: aco:Amico_1450 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; SPTR: Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (572 aa)
Tlie_1792Thiamine pyrophosphate TPP-binding domain-containing protein; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001: IPR012000: IPR011766; KEGG: nth:Nther_1932 thiamine pyrophosphate protein TPP binding domain protein; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Thiamine pyrophosphate-dependent enzyme. (540 aa)
leuD-43-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (169 aa)
leuC-3Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (420 aa)
Tlie_1835Pyruvate carboxyltransferase; PFAM: HMGL-like; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891; KEGG: aco:Amico_1324 pyruvate carboxyltransferase; PFAM: pyruvate carboxyltransferase; SPTR: Pyruvate carboxyltransferase. (306 aa)
Tlie_1836PFAM: CoA-transferase family III; COGs: COG1804 acyl-CoA transferase/carnitine dehydratase; InterPro IPR003673; KEGG: aco:Amico_1323 formyl-CoA transferase; PFAM: L-carnitine dehydratase/bile acid-inducible protein F; PRIAM: Formyl-CoA transferase; SPTR: Formyl-CoA transferase; Belongs to the CoA-transferase III family. (398 aa)
Tlie_1837PFAM: Isocitrate lyase family; TIGRFAM: carboxyvinyl-carboxyphosphonate phosphorylmutase; COGs: COG2513 PEP phosphonomutase; InterPro IPR000918: IPR018523; KEGG: aco:Amico_1318 carboxyvinyl-carboxyphosphonatephosphorylmutase; PFAM: isocitrate lyase and phosphorylmutase; SPTR: Methylisocitrate lyase. (292 aa)
Tlie_1871PFAM: Phosphoenolpyruvate carboxykinase; COGs: COG1866 Phosphoenolpyruvate carboxykinase (ATP); InterPro IPR001272; KEGG: cpo:COPRO5265_0282 phosphoenolpyruvate carboxykinase; PFAM: phosphoenolpyruvate carboxykinase (ATP); SPTR: Phosphoenolpyruvate carboxykinase; Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (502 aa)
Your Current Organism:
Thermovirga lienii
NCBI taxonomy Id: 580340
Other names: T. lienii DSM 17291, Thermovirga lienii DSM 17291, Thermovirga lienii str. DSM 17291, Thermovirga lienii strain DSM 17291
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.