STRINGSTRING
ACT49335.1 ACT49335.1 ACT49378.1 ACT49378.1 cobT cobT ACT49388.1 ACT49388.1 hisG hisG hisH hisH hisF hisF lgt lgt ftsI ftsI ftsW ftsW murG murG ACT49793.1 ACT49793.1 ACT49797.1 ACT49797.1 ACT49859.1 ACT49859.1 ACT50073.1 ACT50073.1 ACT50084.1 ACT50084.1 ACT50134.1 ACT50134.1 ACT50282.1 ACT50282.1 ACT50323.1 ACT50323.1 mltF mltF ACT50483.1 ACT50483.1 glgB glgB ACT50523.1 ACT50523.1 ACT50524.1 ACT50524.1 ACT50528.1 ACT50528.1 ACT50542.1 ACT50542.1 mltG mltG lpxB lpxB ACT50663.1 ACT50663.1 glgA glgA ACT50697.1 ACT50697.1 purF purF ppnP ppnP ACT50952.1 ACT50952.1 ACT50968.1 ACT50968.1 ACT51003.1 ACT51003.1 ACT51061.1 ACT51061.1 ACT51065.1 ACT51065.1 ACT51068.1 ACT51068.1 ACT51106.1 ACT51106.1 ACT51133.1 ACT51133.1 ACT51135.1 ACT51135.1 ACT51144.1 ACT51144.1 ACT51145.1 ACT51145.1 ACT51146.1 ACT51146.1 ACT51150.1 ACT51150.1 ACT51152.1 ACT51152.1 ACT51153.1 ACT51153.1 ACT51154.1 ACT51154.1 tgt tgt queA queA ACT51520.1 ACT51520.1 apt apt mtgA mtgA ACT51744.1 ACT51744.1 trpD trpD pyrE pyrE mrdB mrdB rlpA rlpA glgE glgE ACT51871.1 ACT51871.1 ACT51937.1 ACT51937.1 ACT52000.1 ACT52000.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACT49335.1KEGG: mfa:Mfla_0083 hypothetical protein. (383 aa)
ACT49378.1KEGG: dal:Dalk_1659 hypothetical protein. (480 aa)
cobTNicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (347 aa)
ACT49388.1PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein; KEGG: bra:BRADO7123 TPR domain-containing protein. (640 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (216 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (214 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa)
lgtProlipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (260 aa)
ftsIPeptidoglycan glycosyltransferase; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (576 aa)
ftsWCell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (387 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (368 aa)
ACT49793.1PFAM: Lytic transglycosylase catalytic; Sel1 domain protein repeat-containing protein; SMART: Sel1 domain protein repeat-containing protein; KEGG: rfr:Rfer_3765 lytic transglycosylase, catalytic. (320 aa)
ACT49797.1PFAM: glycosyl transferase group 1; KEGG: tgr:Tgr7_2734 glycosyl transferase, group 1. (403 aa)
ACT49859.1KEGG: reu:Reut_A2736 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (287 aa)
ACT50073.1PFAM: glycosyl transferase group 1; KEGG: mno:Mnod_1956 glycosyl transferase group 1. (414 aa)
ACT50084.1PFAM: Tetratricopeptide TPR_2 repeat protein; TPR repeat-containing protein; Tetratricopeptide TPR_3; SMART: Tetratricopeptide domain protein; KEGG: bxe:Bxe_B0911 TPR domain-containing protein. (927 aa)
ACT50134.1PFAM: Tetratricopeptide TPR_2 repeat protein; TPR repeat-containing protein; Tetratricopeptide TPR_4; SMART: Tetratricopeptide domain protein; KEGG: gsu:GSU1547 TPR domain-containing protein. (463 aa)
ACT50282.1PFAM: Lytic transglycosylase catalytic; KEGG: mfa:Mfla_2410 lytic transglycosylase, catalytic. (240 aa)
ACT50323.1TIGRFAM: penicillin-binding protein 1C; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase; Penicillin-binding domain protein; KEGG: bph:Bphy_0941 penicillin-binding protein 1C. (789 aa)
mltFExtracellular solute-binding protein family 3; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. (475 aa)
ACT50483.1KEGG: mfa:Mfla_1754 hypothetical protein. (374 aa)
glgB1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (726 aa)
ACT50523.1PFAM: glycosyl transferase family 2; glycoside hydrolase family 17; KEGG: mfa:Mfla_1372 glycosyl transferase family protein. (867 aa)
ACT50524.1KEGG: mfa:Mfla_1373 putative beta (1-6) glucan synthase. (548 aa)
ACT50528.1KEGG: mfa:Mfla_1378 hypothetical protein. (539 aa)
ACT50542.1PFAM: Tetratricopeptide TPR_2 repeat protein; Tetratricopeptide TPR_4; TPR repeat-containing protein; Tetratricopeptide TPR_3; SMART: Tetratricopeptide domain protein; KEGG: mfa:Mfla_1389 TPR repeat-containing protein. (697 aa)
mltGAminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (334 aa)
lpxBlipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (378 aa)
ACT50663.1Methylthioadenosine phosphorylase; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. (248 aa)
glgAGlycogen/starch synthase, ADP-glucose type; Synthesizes alpha-1,4-glucan chains using ADP-glucose. (493 aa)
ACT50697.1PFAM: Lytic transglycosylase catalytic; Peptidoglycan-binding LysM; SMART: Peptidoglycan-binding LysM; KEGG: mfa:Mfla_1482 lytic transglycosylase, catalytic. (587 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (512 aa)
ppnPProtein of unknown function DUF1255; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (103 aa)
ACT50952.1PFAM: protein of unknown function DUF152; KEGG: mfa:Mfla_1611 hypothetical protein; Belongs to the multicopper oxidase YfiH/RL5 family. (246 aa)
ACT50968.1PFAM: phosphoribosyltransferase; KEGG: mfa:Mfla_1280 phosphoribosyltransferase. (204 aa)
ACT51003.1Glycogen/starch/alpha-glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (825 aa)
ACT51061.1PFAM: Lytic transglycosylase catalytic; KEGG: mfa:Mfla_2410 lytic transglycosylase, catalytic. (214 aa)
ACT51065.1TIGRFAM: glycosyl transferase, WecB/TagA/CpsF family; PFAM: glycosyl transferase WecB/TagA/CpsF; KEGG: xfa:XF2360 GumM protein; Belongs to the glycosyltransferase 26 family. (238 aa)
ACT51068.1PFAM: glycosyl transferase group 1; KEGG: ppg:PputGB1_2716 glycosyl transferase group 1. (399 aa)
ACT51106.1PFAM: glycosyl transferase group 1; KEGG: mfa:Mfla_0790 1,2-diacylglycerol 3-glucosyltransferase. (384 aa)
ACT51133.1TIGRFAM: lipopolysaccharide heptosyltransferase II; PFAM: glycosyl transferase family 9; KEGG: mfa:Mfla_0768 lipopolysaccharide heptosyltransferase II. (338 aa)
ACT51135.1PFAM: glycosyl transferase group 1; KEGG: mfa:Mfla_0763 glycosyl transferase, group 1. (365 aa)
ACT51144.1Lipopolysaccharide kinase; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. KdkA/rfaP family. (276 aa)
ACT51145.1PFAM: glycosyl transferase group 1; KEGG: mfa:Mfla_0754 glycosyl transferase, group 1. (380 aa)
ACT51146.1TIGRFAM: lipopolysaccharide heptosyltransferase I; PFAM: glycosyl transferase family 9; KEGG: mfa:Mfla_0753 lipopolysaccharide heptosyltransferase I. (327 aa)
ACT51150.1PFAM: glycosyl transferase family 9; KEGG: noc:Noc_0578 glycosyl transferase family protein. (345 aa)
ACT51152.1PFAM: glycosyl transferase family 9; KEGG: pla:Plav_1688 glycosyl transferase family protein. (304 aa)
ACT51153.1PFAM: glycosyl transferase group 1; KEGG: maq:Maqu_0797 glycosyl transferase, group 1. (337 aa)
ACT51154.1PFAM: glycosyl transferase group 1; KEGG: tgr:Tgr7_0467 glycosyl transferase group 1. (378 aa)
tgtQueuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (376 aa)
queAS-adenosylmethionine/tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (351 aa)
ACT51520.1PFAM: Lytic transglycosylase catalytic; KEGG: mfa:Mfla_0421 lytic transglycosylase, catalytic. (200 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (175 aa)
mtgAMonofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family. (230 aa)
ACT51744.1TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase; KEGG: mfa:Mfla_2462 penicillin-binding protein 1A. (787 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (341 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (219 aa)
mrdBRod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (364 aa)
rlpARare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (323 aa)
glgEAlpha amylase catalytic region; Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB. (717 aa)
ACT51871.1Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (434 aa)
ACT51937.1PFAM: glycosyl transferase family 39; KEGG: pap:PSPA7_5537 hypothetical protein. (484 aa)
ACT52000.1KEGG: mfa:Mfla_2610 sucrose-phosphate synthase, glycosyltransferase region; TIGRFAM: sucrose-phosphate synthase; HAD-superfamily hydrolase, subfamily IIB; PFAM: sucrose-6F-phosphate phosphohydrolase; glycosyl transferase group 1; Haloacid dehalogenase domain protein hydrolase type 3. (735 aa)
Your Current Organism:
Methylovorus glucosetrophus
NCBI taxonomy Id: 582744
Other names: M. glucosetrophus SIP3-4, Methylovorus glucosetrophus SIP3-4, Methylovorus glucosetrophus str. SIP3-4, Methylovorus glucosetrophus strain SIP3-4, Methylovorus sp. SIP3-4
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