(17 nodes) Mixed, incl. Formate dehydrogenase complex, and Proton-conducting membrane transporter network (Proteus mirabilis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AND11425.1	Formate dehydrogenase subunit alpha; Selenocysteine-containing polypeptide; hydrogen linked formate dehydrogenase which catalyzes the oxidation of formate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (722 aa)
	AND11786.1	Electron transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
	hyfB	Hydrogenase 4 subunit B; Derived by automated computational analysis using gene prediction method: Protein Homology. (671 aa)
	hycD	Hydrogenase 3 membrane subunit; Formate hydrogenlyase subunit 4; HycBCDEFG is part of the formate hydrogenlyase system which is involved in the cleaving of formate to dihydrogen and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. (316 aa)
	AND11789.1	Hydrogenase 4 subunit D; Derived by automated computational analysis using gene prediction method: Protein Homology. (482 aa)
	hyfE	Hydrogenase 4 membrane subunit; Interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
	hyfF	Hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (522 aa)
	hycE	Hydrogenase 3 large subunit; Formate hydrogenlyase subunit 5; HycBCDEFG is part of the formate hydrogenlyase system which is involved in the cleaving of formate to dihydrogen and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. (577 aa)
	hyfH	Electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
	nuoB	Hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
	hycH	Formate hydrogenlyase maturation protein HycH; Derived by automated computational analysis using gene prediction method: Protein Homology. (136 aa)
	hycI	Hydrogenase 3 maturation endopeptidase HyCI; Involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; Derived by automated computational analysis using gene prediction method: Protein Homology. (166 aa)
	AND11864.1	CbbBc protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (761 aa)
	hydN	Effector protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (185 aa)
	AND14463.1	Formate dehydrogenase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (558 aa)
	AND14464.1	Spermidine/putrescine ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa)
	fdhD	Sufurtransferase FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (276 aa)

Your Current Organism:

Proteus mirabilis

NCBI taxonomy Id: 584
Other names: ATCC 29906, CCUG 26767, CIP 103181, DSM 4479, LMG 3257, LMG:3257, NCTC 11938, P. mirabilis

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AND11425.1	AND11786.1	AOUC001_00590	AOUC001_02455	Formate dehydrogenase subunit alpha; Selenocysteine-containing polypeptide; hydrogen linked formate dehydrogenase which catalyzes the oxidation of formate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Electron transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.812
AND11425.1	fdhD	AOUC001_00590	AOUC001_19085	Formate dehydrogenase subunit alpha; Selenocysteine-containing polypeptide; hydrogen linked formate dehydrogenase which catalyzes the oxidation of formate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Sufurtransferase FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family.	0.754
AND11425.1	hycD	AOUC001_00590	AOUC001_02465	Formate dehydrogenase subunit alpha; Selenocysteine-containing polypeptide; hydrogen linked formate dehydrogenase which catalyzes the oxidation of formate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase 3 membrane subunit; Formate hydrogenlyase subunit 4; HycBCDEFG is part of the formate hydrogenlyase system which is involved in the cleaving of formate to dihydrogen and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.667
AND11425.1	hycE	AOUC001_00590	AOUC001_02485	Formate dehydrogenase subunit alpha; Selenocysteine-containing polypeptide; hydrogen linked formate dehydrogenase which catalyzes the oxidation of formate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase 3 large subunit; Formate hydrogenlyase subunit 5; HycBCDEFG is part of the formate hydrogenlyase system which is involved in the cleaving of formate to dihydrogen and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.976
AND11425.1	hycI	AOUC001_00590	AOUC001_02505	Formate dehydrogenase subunit alpha; Selenocysteine-containing polypeptide; hydrogen linked formate dehydrogenase which catalyzes the oxidation of formate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase 3 maturation endopeptidase HyCI; Involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.404
AND11425.1	hydN	AOUC001_00590	AOUC001_16805	Formate dehydrogenase subunit alpha; Selenocysteine-containing polypeptide; hydrogen linked formate dehydrogenase which catalyzes the oxidation of formate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Effector protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.810
AND11425.1	hyfB	AOUC001_00590	AOUC001_02460	Formate dehydrogenase subunit alpha; Selenocysteine-containing polypeptide; hydrogen linked formate dehydrogenase which catalyzes the oxidation of formate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase 4 subunit B; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.601
AND11425.1	hyfF	AOUC001_00590	AOUC001_02480	Formate dehydrogenase subunit alpha; Selenocysteine-containing polypeptide; hydrogen linked formate dehydrogenase which catalyzes the oxidation of formate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.511
AND11425.1	hyfH	AOUC001_00590	AOUC001_02490	Formate dehydrogenase subunit alpha; Selenocysteine-containing polypeptide; hydrogen linked formate dehydrogenase which catalyzes the oxidation of formate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.633
AND11425.1	nuoB	AOUC001_00590	AOUC001_02495	Formate dehydrogenase subunit alpha; Selenocysteine-containing polypeptide; hydrogen linked formate dehydrogenase which catalyzes the oxidation of formate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.755
AND11786.1	AND11425.1	AOUC001_02455	AOUC001_00590	Electron transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Formate dehydrogenase subunit alpha; Selenocysteine-containing polypeptide; hydrogen linked formate dehydrogenase which catalyzes the oxidation of formate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	0.812
AND11786.1	AND11789.1	AOUC001_02455	AOUC001_02470	Electron transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrogenase 4 subunit D; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.829
AND11786.1	AND14463.1	AOUC001_02455	AOUC001_16820	Electron transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Formate dehydrogenase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	0.811
AND11786.1	AND14464.1	AOUC001_02455	AOUC001_16825	Electron transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Spermidine/putrescine ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.476
AND11786.1	hycD	AOUC001_02455	AOUC001_02465	Electron transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrogenase 3 membrane subunit; Formate hydrogenlyase subunit 4; HycBCDEFG is part of the formate hydrogenlyase system which is involved in the cleaving of formate to dihydrogen and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.925
AND11786.1	hycE	AOUC001_02455	AOUC001_02485	Electron transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrogenase 3 large subunit; Formate hydrogenlyase subunit 5; HycBCDEFG is part of the formate hydrogenlyase system which is involved in the cleaving of formate to dihydrogen and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.996
AND11786.1	hycH	AOUC001_02455	AOUC001_02500	Electron transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Formate hydrogenlyase maturation protein HycH; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
AND11786.1	hycI	AOUC001_02455	AOUC001_02505	Electron transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrogenase 3 maturation endopeptidase HyCI; Involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.932
AND11786.1	hyfB	AOUC001_02455	AOUC001_02460	Electron transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrogenase 4 subunit B; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.909
AND11786.1	hyfE	AOUC001_02455	AOUC001_02475	Electron transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrogenase 4 membrane subunit; Interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.885