(20 nodes) Nickel cation binding, and Protein maturation network (Proteus mirabilis)

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	AND12825.1	Carbamoyltransferase HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. (766 aa)
	AND14291.1	Hydrogenase isoenzymes formation protein; involved in the formation of the cyanate group of the large subunit of the hydrogenase; catalyzes the formation of thiocyanate from thiocarbamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
	hypD	Hydrogenase formation protein HypD; Necessary for the synthesis of all three hydrogenase isoenzymes; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HypD family. (378 aa)
	hybG	Hydrogenase 2 accessory protein HypG; Derived by automated computational analysis using gene prediction method: Protein Homology. (88 aa)
	AND14294.1	Hydrogenase accessory protein HypB; Derived by automated computational analysis using gene prediction method: Protein Homology. (394 aa)
	hybE	Hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
	hybD	Hydrogenase 2 maturation endopeptidase; Protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); Derived by automated computational analysis using gene prediction method: Protein Homology. (162 aa)
	hybC	Hydrogenase 2 large subunit; Involved in hydrogen uptake; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (567 aa)
	hybB	HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
	hybA	Hydrogenase 2 protein HybA; Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
	hybO	Hydrogenase 2 small subunit; Involved in hydrogen uptake; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
	ureG	Urease accessory protein UreG; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG. (205 aa)
	ureF	Urease accessory protein UreF; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter. (221 aa)
	ureE	Urease accessory protein UreE; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family. (161 aa)
	ureC	Urease subunit alpha; Ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; Derived by automated computational analysis using gene prediction method: Protein Homology. (567 aa)
	ureB	Urease subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the urease beta subunit family. (108 aa)
	ureA	Urease subunit gamma; UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the urease gamma subunit family. (100 aa)
	UreD	Urease accessory protein ureD; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter. (274 aa)
	hybG-2	Hydrogenase assembly protein HupF; Derived by automated computational analysis using gene prediction method: Protein Homology. (96 aa)
	hypA	Hydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (113 aa)

Your Current Organism:

Proteus mirabilis

NCBI taxonomy Id: 584
Other names: ATCC 29906, CCUG 26767, CIP 103181, DSM 4479, LMG 3257, LMG:3257, NCTC 11938, P. mirabilis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AND12825.1	AND14291.1	AOUC001_08060	AOUC001_15905	Carbamoyltransferase HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	Hydrogenase isoenzymes formation protein; involved in the formation of the cyanate group of the large subunit of the hydrogenase; catalyzes the formation of thiocyanate from thiocarbamate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.976
AND12825.1	AND14294.1	AOUC001_08060	AOUC001_15920	Carbamoyltransferase HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	Hydrogenase accessory protein HypB; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.816
AND12825.1	hybC	AOUC001_08060	AOUC001_15935	Carbamoyltransferase HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	Hydrogenase 2 large subunit; Involved in hydrogen uptake; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	0.842
AND12825.1	hybD	AOUC001_08060	AOUC001_15930	Carbamoyltransferase HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	Hydrogenase 2 maturation endopeptidase; Protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); Derived by automated computational analysis using gene prediction method: Protein Homology.	0.824
AND12825.1	hybG	AOUC001_08060	AOUC001_15915	Carbamoyltransferase HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	Hydrogenase 2 accessory protein HypG; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.843
AND12825.1	hybG-2	AOUC001_08060	AOUC001_16795	Carbamoyltransferase HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	Hydrogenase assembly protein HupF; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.852
AND12825.1	hybO	AOUC001_08060	AOUC001_15950	Carbamoyltransferase HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	Hydrogenase 2 small subunit; Involved in hydrogen uptake; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.783
AND12825.1	hypA	AOUC001_08060	AOUC001_16800	Carbamoyltransferase HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	Hydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.858
AND12825.1	hypD	AOUC001_08060	AOUC001_15910	Carbamoyltransferase HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	Hydrogenase formation protein HypD; Necessary for the synthesis of all three hydrogenase isoenzymes; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HypD family.	0.899
AND14291.1	AND12825.1	AOUC001_15905	AOUC001_08060	Hydrogenase isoenzymes formation protein; involved in the formation of the cyanate group of the large subunit of the hydrogenase; catalyzes the formation of thiocyanate from thiocarbamate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carbamoyltransferase HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	0.976
AND14291.1	AND14294.1	AOUC001_15905	AOUC001_15920	Hydrogenase isoenzymes formation protein; involved in the formation of the cyanate group of the large subunit of the hydrogenase; catalyzes the formation of thiocyanate from thiocarbamate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrogenase accessory protein HypB; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.960
AND14291.1	hybA	AOUC001_15905	AOUC001_15945	Hydrogenase isoenzymes formation protein; involved in the formation of the cyanate group of the large subunit of the hydrogenase; catalyzes the formation of thiocyanate from thiocarbamate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrogenase 2 protein HybA; Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.624
AND14291.1	hybB	AOUC001_15905	AOUC001_15940	Hydrogenase isoenzymes formation protein; involved in the formation of the cyanate group of the large subunit of the hydrogenase; catalyzes the formation of thiocyanate from thiocarbamate; Derived by automated computational analysis using gene prediction method: Protein Homology.	HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.637
AND14291.1	hybC	AOUC001_15905	AOUC001_15935	Hydrogenase isoenzymes formation protein; involved in the formation of the cyanate group of the large subunit of the hydrogenase; catalyzes the formation of thiocyanate from thiocarbamate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrogenase 2 large subunit; Involved in hydrogen uptake; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	0.929
AND14291.1	hybD	AOUC001_15905	AOUC001_15930	Hydrogenase isoenzymes formation protein; involved in the formation of the cyanate group of the large subunit of the hydrogenase; catalyzes the formation of thiocyanate from thiocarbamate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrogenase 2 maturation endopeptidase; Protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); Derived by automated computational analysis using gene prediction method: Protein Homology.	0.910
AND14291.1	hybE	AOUC001_15905	AOUC001_15925	Hydrogenase isoenzymes formation protein; involved in the formation of the cyanate group of the large subunit of the hydrogenase; catalyzes the formation of thiocyanate from thiocarbamate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.738
AND14291.1	hybG	AOUC001_15905	AOUC001_15915	Hydrogenase isoenzymes formation protein; involved in the formation of the cyanate group of the large subunit of the hydrogenase; catalyzes the formation of thiocyanate from thiocarbamate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrogenase 2 accessory protein HypG; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.989
AND14291.1	hybG-2	AOUC001_15905	AOUC001_16795	Hydrogenase isoenzymes formation protein; involved in the formation of the cyanate group of the large subunit of the hydrogenase; catalyzes the formation of thiocyanate from thiocarbamate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrogenase assembly protein HupF; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.958
AND14291.1	hybO	AOUC001_15905	AOUC001_15950	Hydrogenase isoenzymes formation protein; involved in the formation of the cyanate group of the large subunit of the hydrogenase; catalyzes the formation of thiocyanate from thiocarbamate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrogenase 2 small subunit; Involved in hydrogen uptake; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.902
AND14291.1	hypA	AOUC001_15905	AOUC001_16800	Hydrogenase isoenzymes formation protein; involved in the formation of the cyanate group of the large subunit of the hydrogenase; catalyzes the formation of thiocyanate from thiocarbamate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.869