STRINGSTRING
coaA coaA glpK glpK pfkA pfkA cpxA cpxA hipA hipA rbsK-4 rbsK-4 aroK aroK AND15000.1 AND15000.1 prkB prkB rdoA rdoA rcsD rcsD AND12642.1 AND12642.1 AND12655.1 AND12655.1 AND12670.1 AND12670.1 yegS yegS baeS baeS rbsK rbsK ydiA ydiA pykF pykF anmK anmK pdxY pdxY AND13013.1 AND13013.1 xylB xylB dhaK2 dhaK2 AND13093.1 AND13093.1 rbsK_6 rbsK_6 AND13107.1 AND13107.1 pyk pyk sirB1 sirB1 ispE ispE AOUC001_10610 AOUC001_10610 phoQ phoQ thiK thiK AND13445.1 AND13445.1 lpxK lpxK udk_2 udk_2 AND13710.1 AND13710.1 AND13853.1 AND13853.1 aroL aroL glnL glnL envZ envZ AND11462.1 AND11462.1 rcsC rcsC AND11448.1 AND11448.1 chbB chbB ulaA ulaA AND12487.1 AND12487.1 AND12394.1 AND12394.1 ppnK ppnK galK galK AND12258.1 AND12258.1 coaE coaE agaV agaV AND12084.1 AND12084.1 AND12078.1 AND12078.1 fruK fruK gsk gsk AND12045.1 AND12045.1 AND12009.1 AND12009.1 cysC cysC ptsG ptsG hldE hldE AND11845.1 AND11845.1 AND11840.1 AND11840.1 dhaL dhaL AND11838.1 AND11838.1 AND11836.1 AND11836.1 AND11833.1 AND11833.1 nadR nadR gntK gntK dgkA dgkA aceK aceK slyX slyX treB treB AND14157.1 AND14157.1 rbsK-2 rbsK-2 phoR phoR ribF ribF thrB thrB arcB arcB ptsN ptsN AND14433.1 AND14433.1 AND14471.1 AND14471.1 ubiB ubiB AND14518.1 AND14518.1 rbsK-3 rbsK-3 AND14564.1 AND14564.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
coaAType I pantothenate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (510 aa)
pfkAATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (325 aa)
cpxAPart of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; Derived by automated computational analysis using gene prediction method: Protein Homology. (463 aa)
hipASerine/threonine protein kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (437 aa)
rbsK-4Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (308 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa)
AND15000.1APH(3') family aminoglycoside O-phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aminoglycoside phosphotransferase family. (271 aa)
prkBPhosphoribulokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
rdoAStress response kinase A; A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response. (331 aa)
rcsDDNA mismatch repair protein MutT; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. (897 aa)
AND12642.1Two-component sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (467 aa)
AND12655.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (587 aa)
AND12670.1Chemotaxis protein CheA; Derived by automated computational analysis using gene prediction method: Protein Homology. (739 aa)
yegSLipid kinase YegS; Probably phosphorylates lipids; the in vivo substrate is unknown; Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily. (297 aa)
baeSTwo-component system sensor histidine kinase BaeA; Derived by automated computational analysis using gene prediction method: Protein Homology. (458 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (406 aa)
ydiAPhosphoenolpyruvate synthase regulatory protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (288 aa)
pykFPyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (470 aa)
anmKanhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (370 aa)
pdxYPyridoxal kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (289 aa)
AND13013.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (155 aa)
xylBXylulokinase; Catalyzes the formation of D-xylulose-5-phosphate fro D-xylulose; Derived by automated computational analysis using gene prediction method: Protein Homology. (484 aa)
dhaK2Dihydroxyacetone kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (203 aa)
AND13093.1With DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
rbsK_6Ribokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (414 aa)
AND13107.1Sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (900 aa)
pykPyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
sirB1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (269 aa)
ispE4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol; Belongs to the GHMP kinase family. IspE subfamily. (291 aa)
AOUC001_10610Transcriptional regulator; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (180 aa)
phoQSensor protein PhoQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (487 aa)
thiKKinase; Catalyzes the phosphorylation of thiamine to thiamine phosphate. (303 aa)
AND13445.1Response regulator receiver protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (166 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (333 aa)
udk_2Uridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
AND13710.1Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (311 aa)
AND13853.1PTS N-acetyl glucosamine transporter subunit IIABC; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (681 aa)
aroLShikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (170 aa)
glnLSensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
envZMembrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; Derived by automated computational analysis using gene prediction method: Protein Homology. (446 aa)
AND11462.1Sugar kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (528 aa)
rcsCTwo-component system sensor histidine kinase/response regulator; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (919 aa)
AND11448.1PTS N N'-diacetylchitobiose transporter subunit IIC; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (452 aa)
chbBPTS sugar transporter subunit IIB; Catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; Derived by automated computational analysis using gene prediction method: Protein Homology. (108 aa)
ulaAPTS ascorbate transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
AND12487.1PTS ascorbate transporter subunit IIB; Derived by automated computational analysis using gene prediction method: Protein Homology. (95 aa)
AND12394.1Two-component sensor histidine kinase; Part of the GlrKR two-component signal transduction system involved in the regulation of glmY; Derived by automated computational analysis using gene prediction method: Protein Homology. (482 aa)
ppnKNAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (299 aa)
galKGalactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (390 aa)
AND12258.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (115 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (204 aa)
agaVPTS N-acetylgalactosamine transporter subunit IIB; Catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
AND12084.1Ketodeoxygluconokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
AND12078.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
fruK1-phosphofructokinase; Converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. (313 aa)
gskCatalyzes the formation of inosine/guanosine monophosphate from inosine or guanosine and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
AND12045.1Fructokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
AND12009.1PTS beta-glucoside transporter subunit EIIBCA; Derived by automated computational analysis using gene prediction method: Protein Homology. (629 aa)
cysCAdenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. (204 aa)
ptsGPTS glucose transporter subunit IIBC; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (481 aa)
hldEBifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (474 aa)
AND11845.1Sugar kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
AND11840.1With DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)
dhaLDihydroxyacetone kinase; With DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa)
AND11838.1Dihydroxyacetone kinase subunit DhaM; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PEP-utilizing enzyme family. (482 aa)
AND11836.1Two-component sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (791 aa)
AND11833.1Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (483 aa)
nadRNicotinamide-nucleotide adenylyltransferase; Catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; catalyzes the formation of nicotinamide mononucleotide from nicotinamide riboside; also has a regulatory function; Derived by automated computational analysis using gene prediction method: Protein Homology. (414 aa)
gntKGluconate kinase; Thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
dgkADiacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (123 aa)
aceKBifunctional isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (572 aa)
slyXSlyX protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SlyX family. (72 aa)
treBPTS trehalose transporter subunit IIBC; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
AND14157.1MASE1 sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (515 aa)
rbsK-2Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (308 aa)
phoRMembrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; Derived by automated computational analysis using gene prediction method: Protein Homology. (430 aa)
ribFBifunctional riboflavin kinase/FMN adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (313 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)
arcBAerobic respiration two-component sensor histidine kinase ArcB; Sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; Derived by automated computational analysis using gene prediction method: Protein Homology. (778 aa)
ptsNTranscriptional regulator; Involved in nitrogen metabolism; protein IIA is phosphorylated by enzyme I(Ntr); Derived by automated computational analysis using gene prediction method: Protein Homology. (155 aa)
AND14433.1Glycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycerate kinase type-1 family. (382 aa)
AND14471.1Nitrate/nitrite two-component system sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (609 aa)
ubiBUbiquinone biosynthesis regulatory protein kinase UbiB; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. (545 aa)
AND14518.1PTS sugar transporter subunit IIA; Derived by automated computational analysis using gene prediction method: Protein Homology. (454 aa)
rbsK-3Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (306 aa)
AND14564.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (567 aa)
Your Current Organism:
Proteus mirabilis
NCBI taxonomy Id: 584
Other names: ATCC 29906, CCUG 26767, CIP 103181, DSM 4479, LMG 3257, LMG:3257, NCTC 11938, P. mirabilis
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.