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dmsB dmsB fdoI fdoI fdxH fdxH AND14870.1 AND14870.1 AND14869.1 AND14869.1 ppc ppc mdh mdh ubiE ubiE frdC frdC frdB frdB AND14453.1 AND14453.1 glpC glpC hybO hybO hybA hybA hybB hybB hybC hybC AND14269.1 AND14269.1 AND14268.1 AND14268.1 ydhY ydhY cyoC cyoC AND14235.1 AND14235.1 nqrB nqrB nqrE nqrE gltA gltA sdhC sdhC sdhD sdhD sdhA sdhA sdhB sdhB sucA sucA sucC sucC sucD sucD cydA cydA cydB-2 cydB-2 ybgT ybgT dld dld AND13374.1 AND13374.1 AND13131.1 AND13131.1 dmsB-4 dmsB-4 AND13129.1 AND13129.1 dmsC_2 dmsC_2 dmsB-3 dmsB-3 fumC fumC AND12996.1 AND12996.1 AND12893.1 AND12893.1 appB_2 appB_2 AND12658.1 AND12658.1 AND12656.1 AND12656.1 AND12634.1 AND12634.1 dmsB-2 dmsB-2 dmsC_1 dmsC_1 nuoN nuoN nuoM nuoM nuoL nuoL nuoK nuoK nuoI nuoI nuoH nuoH nuoG nuoG nuoE nuoE nuoC nuoC AND12453.1 AND12453.1 dmsB_3 dmsB_3 phsC phsC ratA ratA mqo mqo AND12281.1 AND12281.1 AND12181.1 AND12181.1 yceJ yceJ AND12033.1 AND12033.1 fdrA fdrA cydB cydB AND11865.1 AND11865.1 AND11804.1 AND11804.1 hyfH hyfH hycE hycE hyfF hyfF hyfE hyfE AND11789.1 AND11789.1 hycD hycD hyfB hyfB aspA aspA aceK aceK aceB aceB AND11440.1 AND11440.1 AND11438.1 AND11438.1
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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dmsB4Fe-4S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
fdoIFormate dehydrogenase; Cytochrome b556(FDO) component; heme containing; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
fdxHFormate dehydrogenase subunit beta; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (312 aa)
AND14870.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (803 aa)
AND14869.1Sulfate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (878 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa)
ubiEBifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (251 aa)
frdCFumarate reductase subunit C; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (131 aa)
frdBPart of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
AND14453.1Fumarate reductase (quinol) flavoprotein subunit; Part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; Derived by automated computational analysis using gene prediction method: Protein Homology. (598 aa)
glpCSn-glycerol-3-phosphate dehydrogenase subunit C; Anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (397 aa)
hybOHydrogenase 2 small subunit; Involved in hydrogen uptake; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
hybAHydrogenase 2 protein HybA; Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
hybBHybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
hybCHydrogenase 2 large subunit; Involved in hydrogen uptake; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (567 aa)
AND14269.1Thiosulfate reductase cytochrome B subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
AND14268.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa)
ydhYHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
cyoCCytochrome o ubiquinol oxidase subunit III; Derived by automated computational analysis using gene prediction method: Protein Homology. (203 aa)
AND14235.1Cytochrome o ubiquinol oxidase subunit I; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the heme-copper respiratory oxidase family. (660 aa)
nqrBNADH:ubiquinone reductase (Na(+)-transporting) subunit B; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. (412 aa)
nqrENADH:ubiquinone reductase (Na(+)-transporting) subunit E; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol; Belongs to the NqrDE/RnfAE family. (198 aa)
gltACitrate (Si)-synthase; Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cit [...] (427 aa)
sdhCSuccinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (125 aa)
sdhDSuccinate dehydrogenase; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (114 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)
sdhBPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
sucA2-oxoglutarate dehydrogenase E1 component; Derived by automated computational analysis using gene prediction method: Protein Homology. (934 aa)
sucCsuccinate--CoA ligase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDsuccinate--CoA ligase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
cydACytochrome d terminal oxidase subunit 1; Part of the aerobic respiratory chain; catalyzes the ubiquinol to ubiquinone; Derived by automated computational analysis using gene prediction method: Protein Homology. (522 aa)
cydB-2Cytochrome d ubiquinol oxidase subunit 2; Derived by automated computational analysis using gene prediction method: Protein Homology. (385 aa)
ybgTCyd operon protein YbgT; Derived by automated computational analysis using gene prediction method: Protein Homology. (37 aa)
dldD-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (589 aa)
AND13374.1Isocitrate dehydrogenase (NADP(+)); Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (417 aa)
AND13131.1Dimethyl sulfoxide reductase subunit A; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (798 aa)
dmsB-44Fe-4S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
AND13129.1Dimethyl sulfoxide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (290 aa)
dmsC_2Dimethylsulfoxide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
dmsB-3Oxidoreductase, Fe-S subunit; terminal electron transfer protein for the reduction of DMSO; Derived by automated computational analysis using gene prediction method: Protein Homology. (205 aa)
fumCClass II fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa)
AND12996.1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (890 aa)
AND12893.1Cytochrome D ubiquinol oxidase subunit I; Derived by automated computational analysis using gene prediction method: Protein Homology. (444 aa)
appB_2Ubiquinol oxidase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
AND12658.1Tetrathionate reductase subunit A; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1026 aa)
AND12656.1Tetrathionate reductase subunit B; Derived by automated computational analysis using gene prediction method: Protein Homology. (246 aa)
AND12634.1Dimethyl sulfoxide reductase subunit A; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (810 aa)
dmsB-24Fe-4S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (205 aa)
dmsC_1Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
nuoNNADH:ubiquinone oxidoreductase subunit N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (489 aa)
nuoMNADH-quinone oxidoreductase subunit M; Derived by automated computational analysis using gene prediction method: Protein Homology. (509 aa)
nuoLNADH-quinone oxidoreductase subunit L; Catalyzes the transfer of electrons from NADH to ubiquinone; Derived by automated computational analysis using gene prediction method: Protein Homology. (611 aa)
nuoKNADH-quinone oxidoreductase subunit K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (100 aa)
nuoINADH-quinone oxidoreductase subunit I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (180 aa)
nuoHNADH-quinone oxidoreductase subunit H; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. (325 aa)
nuoGNADH-quinone oxidoreductase subunit G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (910 aa)
nuoENADH-quinone oxidoreductase subunit E; Catalyzes the transfer of electrons from NADH to quinone; Derived by automated computational analysis using gene prediction method: Protein Homology. (181 aa)
nuoCNADH-quinone oxidoreductase subunit C/D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family. (598 aa)
AND12453.1Thiosulfate reductase PhsA; Catalyzes the production of hydrogen sulfide from thiosulfate; Derived by automated computational analysis using gene prediction method: Protein Homology. (759 aa)
dmsB_3Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
phsCThiosulfate reductase cytochrome B subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
ratAUbiquinone-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
mqoMalate:quinone oxidoreductase; Malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (498 aa)
AND12281.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (239 aa)
AND12181.1Aconitate hydratase B; Catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aconitase/IPM isomerase family. (865 aa)
yceJDerived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
AND12033.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (421 aa)
fdrAacyl-CoA synthetase FdrA; Multicopy suppressor of dominant negative ftsH mutations; putative acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (555 aa)
cydBUbiquinol oxidase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
AND11865.1Cytochrome D ubiquinol oxidase subunit I; Derived by automated computational analysis using gene prediction method: Protein Homology. (450 aa)
AND11804.1YjjI family glycine radical enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
hyfHElectron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
hycEHydrogenase 3 large subunit; Formate hydrogenlyase subunit 5; HycBCDEFG is part of the formate hydrogenlyase system which is involved in the cleaving of formate to dihydrogen and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. (577 aa)
hyfFHydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (522 aa)
hyfEHydrogenase 4 membrane subunit; Interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
AND11789.1Hydrogenase 4 subunit D; Derived by automated computational analysis using gene prediction method: Protein Homology. (482 aa)
hycDHydrogenase 3 membrane subunit; Formate hydrogenlyase subunit 4; HycBCDEFG is part of the formate hydrogenlyase system which is involved in the cleaving of formate to dihydrogen and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. (316 aa)
hyfBHydrogenase 4 subunit B; Derived by automated computational analysis using gene prediction method: Protein Homology. (671 aa)
aspAAspartate ammonia-lyase; Catalyzes the formation of fumarate from aspartate; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
aceKBifunctional isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (572 aa)
aceBMalate synthase A; Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; Derived by automated computational analysis using gene prediction method: Protein Homology. (530 aa)
AND11440.1Dimethyl sulfoxide reductase subunit A; Derived by automated computational analysis using gene prediction method: Protein Homology. (805 aa)
AND11438.1Reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (299 aa)
Your Current Organism:
Proteus mirabilis
NCBI taxonomy Id: 584
Other names: ATCC 29906, CCUG 26767, CIP 103181, DSM 4479, LMG 3257, LMG:3257, NCTC 11938, P. mirabilis
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