node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
amiC | ftsI | AOUC001_03235 | AOUC001_04400 | N-acetylmuramoyl-L-alanine amidase; Hydrolyzes the bond between N-acetylmuramic acid and amino acid residues in peptidoglycan; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cell division protein FtsI; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | 0.668 |
amiC | ftsN | AOUC001_03235 | AOUC001_18575 | N-acetylmuramoyl-L-alanine amidase; Hydrolyzes the bond between N-acetylmuramic acid and amino acid residues in peptidoglycan; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | 0.401 |
amiC | ftsQ | AOUC001_03235 | AOUC001_04445 | N-acetylmuramoyl-L-alanine amidase; Hydrolyzes the bond between N-acetylmuramic acid and amino acid residues in peptidoglycan; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.688 |
amiC | ftsX | AOUC001_03235 | AOUC001_16670 | N-acetylmuramoyl-L-alanine amidase; Hydrolyzes the bond between N-acetylmuramic acid and amino acid residues in peptidoglycan; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cell division protein FtsX; Part of the ABC transporter FtsEX involved in cellular division; Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. | 0.743 |
amiC | lpoB | AOUC001_03235 | AOUC001_11035 | N-acetylmuramoyl-L-alanine amidase; Hydrolyzes the bond between N-acetylmuramic acid and amino acid residues in peptidoglycan; Derived by automated computational analysis using gene prediction method: Protein Homology. | Penicillin-binding protein activator LpoB; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). Belongs to the LpoB family. | 0.446 |
amiC | mepM | AOUC001_03235 | AOUC001_09890 | N-acetylmuramoyl-L-alanine amidase; Hydrolyzes the bond between N-acetylmuramic acid and amino acid residues in peptidoglycan; Derived by automated computational analysis using gene prediction method: Protein Homology. | Murein DD-endopeptidase MepM; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.504 |
amiC | mltA | AOUC001_03235 | AOUC001_03255 | N-acetylmuramoyl-L-alanine amidase; Hydrolyzes the bond between N-acetylmuramic acid and amino acid residues in peptidoglycan; Derived by automated computational analysis using gene prediction method: Protein Homology. | Murein transglycosylase A; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. | 0.651 |
amiC | mrcB | AOUC001_03235 | AOUC001_15155 | N-acetylmuramoyl-L-alanine amidase; Hydrolyzes the bond between N-acetylmuramic acid and amino acid residues in peptidoglycan; Derived by automated computational analysis using gene prediction method: Protein Homology. | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | 0.571 |
amiC | mrdA | AOUC001_03235 | AOUC001_13680 | N-acetylmuramoyl-L-alanine amidase; Hydrolyzes the bond between N-acetylmuramic acid and amino acid residues in peptidoglycan; Derived by automated computational analysis using gene prediction method: Protein Homology. | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.511 |
amiC | nlpD | AOUC001_03235 | AOUC001_03625 | N-acetylmuramoyl-L-alanine amidase; Hydrolyzes the bond between N-acetylmuramic acid and amino acid residues in peptidoglycan; Derived by automated computational analysis using gene prediction method: Protein Homology. | Outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.902 |
amiC | spr | AOUC001_03235 | AOUC001_11230 | N-acetylmuramoyl-L-alanine amidase; Hydrolyzes the bond between N-acetylmuramic acid and amino acid residues in peptidoglycan; Derived by automated computational analysis using gene prediction method: Protein Homology. | Lipoprotein Spr; Mutational suppressor of prc thermosensitivity; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.688 |
ftsA | ftsE | AOUC001_04450 | AOUC001_16675 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Cell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division. | 0.612 |
ftsA | ftsI | AOUC001_04450 | AOUC001_04400 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Cell division protein FtsI; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | 0.954 |
ftsA | ftsN | AOUC001_04450 | AOUC001_18575 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | 0.912 |
ftsA | ftsQ | AOUC001_04450 | AOUC001_04445 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.991 |
ftsA | ftsW | AOUC001_04450 | AOUC001_04425 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | 0.963 |
ftsA | ftsX | AOUC001_04450 | AOUC001_16670 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Cell division protein FtsX; Part of the ABC transporter FtsEX involved in cellular division; Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. | 0.755 |
ftsA | ftsZ | AOUC001_04450 | AOUC001_04455 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.999 |
ftsA | mepM | AOUC001_04450 | AOUC001_09890 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Murein DD-endopeptidase MepM; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.447 |
ftsA | mrcB | AOUC001_04450 | AOUC001_15155 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | 0.657 |