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| | lplA | Lipoate-protein ligase A; Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Belongs to the LplA family. (335 aa) |
| | icd_2 | Isocitrate/isopropylmalate dehydrogenase family protein. (57 aa) |
| | icd | Prok_nadp_idh: isocitrate dehydrogenase, NADP-dependent. (417 aa) |
| | fabF | Beta-ketoacyl-acyl-carrier-protein synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa) |
| | fabG | 3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa) |
| | fabD | fabD: malonyl CoA-acyl carrier protein transacylase. (310 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (317 aa) |
| | fabA | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (172 aa) |
| | maeA | NAD-dependent malic enzyme. (565 aa) |
| | fabZ_2 | fabA-like domain protein. (141 aa) |
| | fadI | acetyl-CoA C-acyltransferase FadI; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (434 aa) |
| | fadJ | Fatty oxidation complex, alpha subunit FadJ; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (718 aa) |
| | sucD | succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa) |
| | sucC | succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa) |
| | sucB | Dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (401 aa) |
| | sucA | 2oxo_dh_E1: oxoglutarate dehydrogenase (succinyl-transferring), E1 component. (934 aa) |
| | sdhB | Succinate dehydrogenase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa) |
| | sdhA | sdhA_forward: succinate dehydrogenase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa) |
| | sdhD | Succinate dehydrogenase, hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (114 aa) |
| | sdhC | succ_dehyd_cytB: succinate dehydrogenase, cytochrome b556 subunit. (125 aa) |
| | gltA | cit_synth_I: citrate (Si)-synthase; Belongs to the citrate synthase family. (427 aa) |
| | fabB | 3-oxoacyl-[acyl-carrier-protein] synthase 1; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (403 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (320 aa) |
| | pta | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (714 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | accB | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (156 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | frdA | Fumarate reductase, flavoprotein subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (598 aa) |
| | frdB | Fumarate reductase iron-sulfur subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (241 aa) |
| | frdC | Fumarate reductase subunit C; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (130 aa) |
| | frdD | Fumarate reductase subunit D; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (119 aa) |
| | accC_2 | D-ala D-ala ligase family protein. (581 aa) |
| | aceB | malate_syn_A: malate synthase A; Belongs to the malate synthase family. (530 aa) |
| | aceA | Isocit_lyase: isocitrate lyase. (435 aa) |
| | aceK | Isocitrate dehydrogenase kinase/phosphatase. (573 aa) |
| | pduL | Propanediol utilization PduL family protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (214 aa) |
| | DR95_2270 | Bacterial transferase hexapeptide family protein. (197 aa) |
| | caiD | carnitinyl-CoA dehydratase; Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA. (261 aa) |
| | lcfB_2 | AMP-binding enzyme family protein; Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine. (518 aa) |
| | caiB | Carnitine CoA-transferase; Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L- carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA. Belongs to the CoA-transferase III family. CaiB subfamily. (406 aa) |
| | caiA | crotonobetainyl-CoA dehydrogenase; Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA; Belongs to the acyl-CoA dehydrogenase family. (380 aa) |
| | caiT | L-carnitine/gamma-butyrobetaine antiporter; Belongs to the BCCT transporter (TC 2.A.15) family. (504 aa) |
| | etfB_2 | Electron transfer flavodomain protein; Required for anaerobic carnitine reduction. May bring reductant to CaiA. (257 aa) |
| | etfA_2 | Electron transfer flavodomain protein; Required for anaerobic carnitine reduction. May bring reductant to CaiA. (312 aa) |
| | DR95_2278 | FAD binding domain protein; Part of an electron transfer system. Belongs to the ETF-QO/FixC family. (430 aa) |
| | fixX_1 | Putative ferredoxin-like protein fixX; Could be a 3Fe-4S cluster-containing protein. (95 aa) |
| | ygcS | Sugar (and other) transporter family protein. (443 aa) |
| | lcfB_1 | AMP-binding enzyme family protein. (545 aa) |
| | fldA_1 | coA-transferase III family protein; Belongs to the CoA-transferase III family. (411 aa) |
| | hgdC | Activator of (R)-2-hydroxyglutaryl-CoA dehydratase. (275 aa) |
| | hgdA | (R)-2-hydroxyglutaryl-CoA dehydratase subunit alpha. (413 aa) |
| | hgdB | (R)-2-hydroxyglutaryl-CoA dehydratase subunit beta. (377 aa) |
| | DR95_2286 | Citrate transporter family protein. (439 aa) |
| | acdA | Hypothetical protein; acyl-CoA dehydrogenase, N-terminal domain protein. (379 aa) |
| | etfB_1 | Electron transfer flavodomain protein. (258 aa) |
| | etfA_1 | Electron transfer flavodomain protein. (313 aa) |
| | DR95_2290 | FAD binding domain protein; Part of an electron transfer system. Belongs to the ETF-QO/FixC family. (428 aa) |
| | DR95_2291 | Putative 4Fe-4S ferredoxin-type oxidoreductase subunit; Could be a 3Fe-4S cluster-containing protein. (94 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (150 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | acs | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (652 aa) |
| | aceE | Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (888 aa) |
| | aceF | Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (619 aa) |
| | lpdA | lipoamide_DH: dihydrolipoyl dehydrogenase. (475 aa) |
| | acnB | acnB: aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family. (865 aa) |
| | fabG_2 | Short-chain dehydrogenase/reductase SDR. (251 aa) |
| | mdh | Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa) |
| | gabD | Succinate-semialdehyde dehydrogenase [NADP+]; Belongs to the aldehyde dehydrogenase family. (482 aa) |
| | fadB | Fatty oxidation complex, alpha subunit FadB; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (726 aa) |
| | fadA | acetyl-CoA C-acyltransferase FadA; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (387 aa) |
| | fadE | Hypothetical protein; acyl-CoA dehydrogenase, N-terminal domain protein. (815 aa) |
| | birA | Bifunctional protein BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. (320 aa) |
| | maeB | NADP-dependent malic enzyme. (760 aa) |
| | adhE | Aldehyde-alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (888 aa) |
| | fadD | long-chain-fatty-acid--CoA ligase. (562 aa) |
| | accA_1 | Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (65 aa) |
| | fumC | Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa) |
| | acnA | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (890 aa) |
| | fabI | Enoyl-[acyl-carrier-protein] reductase [NADH]. (262 aa) |
