| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score | 
| DR95_2938 | folD | DR95_2938 | DR95_3474 | MTHFS_bact: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.  | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.  | 0.753 | 
| DR95_2938 | glyA | DR95_2938 | DR95_83 | MTHFS_bact: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.  | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.  | 0.456 | 
| fhs | folD | DR95_1442 | DR95_3474 | Formate--tetrahydrofolate ligase family protein; Belongs to the formate--tetrahydrofolate ligase family.  | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.  | 0.974 | 
| fhs | glyA | DR95_1442 | DR95_83 | Formate--tetrahydrofolate ligase family protein; Belongs to the formate--tetrahydrofolate ligase family.  | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.  | 0.679 | 
| fhs | metF | DR95_1442 | DR95_2634 | Formate--tetrahydrofolate ligase family protein; Belongs to the formate--tetrahydrofolate ligase family.  | Fadh2: 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.  | 0.432 | 
| folD | DR95_2938 | DR95_3474 | DR95_2938 | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.  | MTHFS_bact: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.  | 0.753 | 
| folD | fhs | DR95_3474 | DR95_1442 | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.  | Formate--tetrahydrofolate ligase family protein; Belongs to the formate--tetrahydrofolate ligase family.  | 0.974 | 
| folD | glyA | DR95_3474 | DR95_83 | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.  | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.  | 0.985 | 
| folD | metF | DR95_3474 | DR95_2634 | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.  | Fadh2: 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.  | 0.938 | 
| glyA | DR95_2938 | DR95_83 | DR95_2938 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.  | MTHFS_bact: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.  | 0.456 | 
| glyA | fhs | DR95_83 | DR95_1442 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.  | Formate--tetrahydrofolate ligase family protein; Belongs to the formate--tetrahydrofolate ligase family.  | 0.679 | 
| glyA | folD | DR95_83 | DR95_3474 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.  | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.  | 0.985 | 
| glyA | metF | DR95_83 | DR95_2634 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.  | Fadh2: 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.  | 0.952 | 
| metF | fhs | DR95_2634 | DR95_1442 | Fadh2: 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.  | Formate--tetrahydrofolate ligase family protein; Belongs to the formate--tetrahydrofolate ligase family.  | 0.432 | 
| metF | folD | DR95_2634 | DR95_3474 | Fadh2: 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.  | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.  | 0.938 | 
| metF | glyA | DR95_2634 | DR95_83 | Fadh2: 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.  | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.  | 0.952 |