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sucA sucA acnA acnA fumC fumC dmsB-4 dmsB-4 dmsC_1 dmsC_1 DR95_785 DR95_785 dmsB-3 dmsB-3 dmsA_2 dmsA_2 cydA_1 cydA_1 cydB-2 cydB-2 pasT pasT nqrB nqrB nqrE nqrE ubiE ubiE DR95_3428 DR95_3428 fdrA fdrA mdh mdh fdoI fdoI fdxH fdxH fdoG_2 fdoG_2 fdoG_1 fdoG_1 ppc ppc lutA lutA acnB acnB DR95_2854 DR95_2854 ttrA ttrA ttrB ttrB dmsA dmsA dmsB-2 dmsB-2 dmsC_3 dmsC_3 DR95_2515 DR95_2515 dmsA_3 dmsA_3 dmsB dmsB dmsC_2 dmsC_2 DR95_2324 DR95_2324 nuoI_2 nuoI_2 hyfG hyfG hyfB_1 hyfB_1 hyfE hyfE mrpA_2 mrpA_2 hyfC hyfC hyfB hyfB aspA aspA aceK aceK aceB aceB nuoN nuoN frdC frdC nuoM nuoM frdB frdB frdA frdA nuoL nuoL glpC glpC nuoK nuoK nuoI nuoI nuoH nuoH nuoG nuoG nuoE nuoE nuoC nuoC hybO hybO hybA hybA hybB hybB hybC hybC DR95_1851 DR95_1851 ydhX_2 ydhX_2 ydhY ydhY cyoC cyoC cyoB cyoB DR95_1746 DR95_1746 dmsB_5 dmsB_5 ynfE ynfE gltA gltA sdhC sdhC sdhD sdhD sdhA sdhA sdhB sdhB sucC sucC sucD sucD cydA cydA cydB cydB ybgT ybgT psrA psrA ydhX_1 ydhX_1 DR95_141 DR95_141 dld dld icd icd icd_2 icd_2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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sucA2oxo_dh_E1: oxoglutarate dehydrogenase (succinyl-transferring), E1 component. (934 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (890 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa)
dmsB-4DMSO_dmsB: dimethylsulfoxide reductase, chain B. (205 aa)
dmsC_1DMSO reductase anchor subunit family protein. (284 aa)
DR95_785DMSO reductase anchor subunit family protein. (290 aa)
dmsB-3DMSO_dmsB: dimethylsulfoxide reductase, chain B. (209 aa)
dmsA_2dmsA_ynfE: anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (796 aa)
cydA_1Bacterial Cytochrome Ubiquinol Oxidase family protein. (444 aa)
cydB-2cydB: cytochrome d ubiquinol oxidase, subunit II. (335 aa)
pasTPutative toxin YfjG. (144 aa)
nqrBUbiquinone oxidoreductase, Na(+)-translocating, B subunit; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. (412 aa)
nqrEUbiquinone oxidoreductase, Na(+)-translocating, E subunit; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol; Belongs to the NqrDE/RnfAE family. (198 aa)
ubiEUbiquinone/menaquinone biosynthesis methyltransferase ubiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (251 aa)
DR95_3428Hypothetical protein. (421 aa)
fdrAProtein fdrA. (555 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa)
fdoIformate-DH-gamm: formate dehydrogenase, gamma subunit. (218 aa)
fdxHFormate dehydrogenase, beta subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (312 aa)
fdoG_2formate-DH-alph: formate dehydrogenase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (803 aa)
fdoG_1Molybdopterin oxidoreductase Fe4S4 domain protein. (195 aa)
ppcPhosphoenolpyruvate carboxylase family protein; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (878 aa)
lutACysteine-rich domain protein. (239 aa)
acnBacnB: aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family. (865 aa)
DR95_2854Prokaryotic cytochrome b561 family protein. (184 aa)
ttrAMolybdopterin oxidoreductase Fe4S4 domain protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1026 aa)
ttrB4Fe-4S dicluster domain protein. (247 aa)
dmsAAnaerobic dimethyl sulfoxide reductase chain A; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (806 aa)
dmsB-2DMSO_dmsB: dimethylsulfoxide reductase, chain B. (213 aa)
dmsC_3DMSO reductase anchor subunit family protein. (299 aa)
DR95_2515Cysteine-rich domain protein. (245 aa)
dmsA_3dmsA_ynfE: anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (810 aa)
dmsBDMSO_dmsB: dimethylsulfoxide reductase, chain B. (205 aa)
dmsC_2DMSO reductase anchor subunit family protein. (258 aa)
DR95_2324Hypothetical protein. (513 aa)
nuoI_24Fe-4S binding domain protein. (184 aa)
hyfGHydrogenase-4 component G. (577 aa)
hyfB_1NADH-Ubiquinone/plastoquinone (complex I), various chains family protein. (522 aa)
hyfEHydrogenase-4 component E. (216 aa)
mrpA_2NADH-Ubiquinone/plastoquinone (complex I), various chains family protein. (480 aa)
hyfCHydrogenase-4 component C. (316 aa)
hyfBHydrogenase-4 component B. (671 aa)
aspAaspA: aspartate ammonia-lyase. (474 aa)
aceKIsocitrate dehydrogenase kinase/phosphatase. (573 aa)
aceBmalate_syn_A: malate synthase A; Belongs to the malate synthase family. (530 aa)
nuoNNADH-quinone oxidoreductase subunit N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (489 aa)
frdCFumarate reductase subunit C; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (130 aa)
nuoMNADH-quinone oxidoreductase subunit M. (509 aa)
frdBFumarate reductase iron-sulfur subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (241 aa)
frdAFumarate reductase, flavoprotein subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (598 aa)
nuoLNADH-quinone oxidoreductase subunit L. (611 aa)
glpCglycerol3P_GlpC: glycerol-3-phosphate dehydrogenase, anaerobic, C subunit. (397 aa)
nuoKNADH-quinone oxidoreductase subunit K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (100 aa)
nuoINADH-quinone oxidoreductase, chain I family protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (180 aa)
nuoHNADH-quinone oxidoreductase subunit H; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. (325 aa)
nuoGNADH dehydrogenase (quinone), G subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (907 aa)
nuoENADH-quinone oxidoreductase subunit E. (181 aa)
nuoCNADH-quinone oxidoreductase subunit C/D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family. (598 aa)
hybOHydrogenase-2 small chain. (374 aa)
hybA4Fe-4S dicluster domain protein. (337 aa)
hybBPutative membrane protein. (393 aa)
hybCHydrogenase-2 large chain; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (567 aa)
DR95_1851Prokaryotic cytochrome b561 family protein. (265 aa)
ydhX_24Fe-4S dicluster domain protein. (223 aa)
ydhYHypothetical protein. (209 aa)
cyoCcyoC: cytochrome o ubiquinol oxidase, subunit III. (203 aa)
cyoBcyoB: cytochrome o ubiquinol oxidase, subunit I; Belongs to the heme-copper respiratory oxidase family. (660 aa)
DR95_1746DMSO reductase anchor subunit family protein. (272 aa)
dmsB_54Fe-4S dicluster domain protein. (161 aa)
ynfEMolybdopterin oxidoreductase family protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (778 aa)
gltAcit_synth_I: citrate (Si)-synthase; Belongs to the citrate synthase family. (427 aa)
sdhCsucc_dehyd_cytB: succinate dehydrogenase, cytochrome b556 subunit. (125 aa)
sdhDSuccinate dehydrogenase, hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (114 aa)
sdhAsdhA_forward: succinate dehydrogenase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)
sdhBSuccinate dehydrogenase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa)
sucCsuccinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDsuccinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa)
cydACytochrome d ubiquinol oxidase subunit 1. (522 aa)
cydBcydB: cytochrome d ubiquinol oxidase, subunit II. (385 aa)
ybgTcyd_oper_ybgT: cyd operon protein YbgT. (37 aa)
psrAPolysulfide reductase chain A; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (759 aa)
ydhX_14Fe-4S dicluster domain protein. (191 aa)
DR95_141Prokaryotic cytochrome b561 family protein. (259 aa)
dldD-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (589 aa)
icdProk_nadp_idh: isocitrate dehydrogenase, NADP-dependent. (417 aa)
icd_2Isocitrate/isopropylmalate dehydrogenase family protein. (57 aa)
Your Current Organism:
Proteus vulgaris
NCBI taxonomy Id: 585
Other names: ATCC 29905, CCUG 35382, CCUG 39507, CDC PR1, CIP 104989, DSM 13387, LMG 16708, LMG:16708, NCTC 13145, P. vulgaris, strain PR 1
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