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DR95_2290 DR95_2290 DR95_1038 DR95_1038 dld dld corC_2 corC_2 dusC dusC sdhA sdhA ubiF ubiF corC corC mnmC mnmC dusB dusB hmp hmp ahpF ahpF lhgO lhgO betA betA nirB nirB murB murB nqrF nqrF corC_4 corC_4 ilvB-2 ilvB-2 cysJ_2 cysJ_2 ilvB ilvB corC_1 corC_1 gidA gidA poxB poxB sthA sthA ubiI ubiI ubiH ubiH lpdA lpdA hcr hcr DR95_2017 DR95_2017 glpA glpA frdA frdA dusA dusA caiA caiA etfA_2 etfA_2 DR95_2278 DR95_2278 acdA acdA etfA_1 etfA_1 gor gor
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
DR95_2290FAD binding domain protein; Part of an electron transfer system. Belongs to the ETF-QO/FixC family. (428 aa)
DR95_1038Hypothetical protein; FAD linked oxidase, C-terminal domain protein. (1018 aa)
dldD-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (589 aa)
corC_2Transporter associated domain protein. (526 aa)
dusCtRNA-dihydrouridine synthase C; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. (310 aa)
sdhAsdhA_forward: succinate dehydrogenase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)
ubiF2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase. (394 aa)
corCMagnesium and cobalt efflux protein CorC. (293 aa)
mnmCtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein mnmC; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the C-terminal section; belongs to the DAO family. (683 aa)
dusBtRNA-dihydrouridine synthase B; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. (323 aa)
hmpFlavohemoprotein; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily. (398 aa)
ahpFahpF: alkyl hydroperoxide reductase subunit F. (521 aa)
lhgOFAD dependent oxidoreductase family protein. (396 aa)
betACholine dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. (559 aa)
nirBnitri_red_nirB: nitrite reductase [NAD(P)H], large subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (848 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (344 aa)
nqrFUbiquinone oxidoreductase, Na(+)-translocating, F subunit; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway. (408 aa)
corC_4Hypothetical protein. (424 aa)
ilvB-2Acolac_lg: acetolactate synthase, large subunit, biosynthetic type. (565 aa)
cysJ_2Sulfite reductase [NADPH] flavoprotein, alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the N-terminal section; belongs to the flavodoxin family. (603 aa)
ilvBAcolac_lg: acetolactate synthase, large subunit, biosynthetic type. (549 aa)
corC_1Hypothetical protein. (460 aa)
gidAtRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. (632 aa)
poxBPyruvate dehydrogenase ubiquinone; Belongs to the TPP enzyme family. (574 aa)
sthAFAD binding domain protein; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (465 aa)
ubiIubi-OHases: ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family protein. (411 aa)
ubiHubiH: 2-polyprenyl-6-methoxyphenol 4-hydroxylase. (390 aa)
lpdAlipoamide_DH: dihydrolipoyl dehydrogenase. (475 aa)
hcrNADH oxidoreductase hcr. (334 aa)
DR95_2017Hypothetical protein. (250 aa)
glpAglycerol3P_GlpA: glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (551 aa)
frdAFumarate reductase, flavoprotein subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (598 aa)
dusAtRNA dihydrouridine synthase A family protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. (344 aa)
caiAcrotonobetainyl-CoA dehydrogenase; Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA; Belongs to the acyl-CoA dehydrogenase family. (380 aa)
etfA_2Electron transfer flavodomain protein; Required for anaerobic carnitine reduction. May bring reductant to CaiA. (312 aa)
DR95_2278FAD binding domain protein; Part of an electron transfer system. Belongs to the ETF-QO/FixC family. (430 aa)
acdAHypothetical protein; acyl-CoA dehydrogenase, N-terminal domain protein. (379 aa)
etfA_1Electron transfer flavodomain protein. (313 aa)
gorGluta_reduc_1: glutathione-disulfide reductase. (451 aa)
Your Current Organism:
Proteus vulgaris
NCBI taxonomy Id: 585
Other names: ATCC 29905, CCUG 35382, CCUG 39507, CDC PR1, CIP 104989, DSM 13387, LMG 16708, LMG:16708, NCTC 13145, P. vulgaris, strain PR 1
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