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talB talB aceE aceE aceF aceF acnB acnB gcd gcd accA accA prpR prpR prpB prpB prpC prpC prpD prpD prpE prpE gltA gltA sdhC sdhC sdhD sdhD sdhA sdhA sdhB sdhB sucA sucA sucC sucC sucD sucD gpmA gpmA pgl pgl ybhJ ybhJ ybiW ybiW ybiY ybiY fsaA fsaA pflA pflA pflB pflB icd icd adhE adhE acnA acnA gapC gapC sfcA sfcA fumC fumC fumA fumA ydhZ ydhZ pykF pykF pps pps pfkB pfkB gapA gapA zwf zwf pykA pykA gnd gnd fbaB fbaB mqo mqo yfbQ yfbQ ackA ackA pta pta accD accD dedA dedA usg usg pdxB pdxB yfdZ yfdZ eutI eutI maeB maeB talA talA tktB tktB yfiD yfiD eno eno serA serA rpiA rpiA fbaA fbaA pgk pgk epd epd yggD yggD yggF yggF tktA tktA ygiP ygiP ttdA ttdA ttdB ttdB ygjE ygjE tdcE tdcE tdcD tdcD mdh mdh yhdH yhdH accB accB accC accC rpe rpe pck pck avtA avtA gpmI gpmI pfkA pfkA tpiA tpiA glpX glpX ppc ppc pgi pgi acs acs CAR01066.1 CAR01066.1 fumB fumB frdD frdD frdC frdC frdB frdB frdA frdA fbp fbp ytjC ytjC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
talBTransaldolase B; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 1 subfamily. (317 aa)
aceEPyruvate dehydrogenase, decarboxylase component E1, thiamin-binding; Function experimentally demonstrated in the studied species; enzyme. (887 aa)
aceFPyruvate dehydrogenase, dihydrolipoyltransacetylase component E2; Function experimentally demonstrated in the studied species; enzyme. (630 aa)
acnBBifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase; Function experimentally demonstrated in the studied species; enzyme. (865 aa)
gcdGlucose dehydrogenase; Function experimentally demonstrated in the studied species; enzyme. (796 aa)
accAacetyl-CoA carboxylase, carboxytransferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa)
prpRDNA-binding transcriptional activator; Function experimentally demonstrated in the studied species; regulator. (528 aa)
prpB2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (296 aa)
prpC2-methylcitrate synthase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the citrate synthase family. (389 aa)
prpD2-methylcitrate dehydratase; Function experimentally demonstrated in the studied species; enzyme. (483 aa)
prpEpropionyl-CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; putative enzyme. (628 aa)
gltACitrate synthase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the citrate synthase family. (427 aa)
sdhCSuccinate dehydrogenase, membrane subunit, binds cytochrome b556; Function experimentally demonstrated in the studied species; membrane component. (129 aa)
sdhDSuccinate dehydrogenase, membrane subunit, binds cytochrome b556; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
sdhASuccinate dehydrogenase, flavoprotein subunit; Function experimentally demonstrated in the studied species; carrier; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)
sdhBSuccinate dehydrogenase, FeS subunit; Function experimentally demonstrated in the studied species; carrier. (238 aa)
sucA2-oxoglutarate decarboxylase, thiamin-requiring; Function experimentally demonstrated in the studied species; enzyme. (933 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDsuccinyl-CoA synthetase, NAD(P)-binding, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa)
gpmAFunction experimentally demonstrated in the studied species; enzyme. (250 aa)
pgl6-phosphogluconolactonase; Catalyzes the hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. (331 aa)
ybhJPutative enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (753 aa)
ybiWPutative glycyl radical cofactor protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (810 aa)
ybiYPutative AdoMet-dependent glycyl radical activating enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (308 aa)
fsaAFructose-6-phosphate aldolase 1; Function experimentally demonstrated in the studied species; enzyme. (220 aa)
pflAPyruvate formate lyase activating enzyme 1; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (246 aa)
pflBPyruvate formate lyase I; Function experimentally demonstrated in the studied species; enzyme. (760 aa)
icdIsocitrate dehydrogenase, specific for NADP+; Function experimentally demonstrated in the studied species; extrachromosomal origin. (416 aa)
adhEFused acetaldehyde-CoA dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (891 aa)
acnAAconitate hydratase 1; Function experimentally demonstrated in the studied species; enzyme. (891 aa)
gapCGlyceraldehyde-3-phosphate dehydrogenase C; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (333 aa)
sfcAMalate dehydrogenase, (decarboxylating, NAD-requiring) (malic enzyme); Function experimentally demonstrated in the studied species; enzyme. (565 aa)
fumCFumarate hydratase (fumarase C),aerobic Class II; Function experimentally demonstrated in the studied species; enzyme. (467 aa)
fumAFumarate hydratase (fumarase A), aerobic Class I; Function experimentally demonstrated in the studied species; enzyme. (548 aa)
ydhZConserved hypothetical protein; Homologs of previously reported genes of unknown function. (69 aa)
pykFPyruvate kinase I; Function experimentally demonstrated in the studied species; enzyme; Belongs to the pyruvate kinase family. (470 aa)
ppsPhosphoenolpyruvate synthase; Function experimentally demonstrated in the studied species; enzyme. (792 aa)
pfkB6-phosphofructokinase II; Function experimentally demonstrated in the studied species; enzyme; Belongs to the carbohydrate kinase PfkB family. (309 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase A; Function experimentally demonstrated in the studied species; enzyme. (331 aa)
zwfGlucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa)
pykAPyruvate kinase II; Function experimentally demonstrated in the studied species; enzyme; Belongs to the pyruvate kinase family. (480 aa)
gndGluconate-6-phosphate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa)
fbaBFructose-bisphosphate aldolase class I; Function experimentally demonstrated in the studied species; enzyme. (350 aa)
mqoMalate dehydrogenase, FAD/NAD(P)-binding domain; Function experimentally demonstrated in the studied species; enzyme. (548 aa)
yfbQPutative aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (405 aa)
ackAAcetate kinase A and propionate kinase 2; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa)
ptaPhosphate acetyltransferase; Function experimentally demonstrated in the studied species; enzyme. (714 aa)
accDacetyl-CoA carboxylase, beta (carboxyltranferase) subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. Belongs to the AccD/PCCB family. (304 aa)
dedAConserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (219 aa)
usgPutative semialdehyde dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (337 aa)
pdxBErythronate-4-phosphate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (378 aa)
yfdZPutative aminotransferase, PLP-dependent; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (412 aa)
eutIPutative phosphotransacetylase subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (338 aa)
maeBPutative fused malic enzyme oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (759 aa)
talATransaldolase A; Function experimentally demonstrated in the studied species; enzyme. (316 aa)
tktBTransketolase 2, thiamin-binding; Function experimentally demonstrated in the studied species; enzyme; Belongs to the transketolase family. (667 aa)
yfiDPyruvate formate lyase subunit; Acts as a radical domain for damaged PFL and possibly other radical proteins. (127 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (432 aa)
serAD-3-phosphoglycerate dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa)
rpiARibose 5-phosphate isomerase, constitutive; Function experimentally demonstrated in the studied species; enzyme. (219 aa)
fbaAFructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa)
pgkPhosphoglycerate kinase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the phosphoglycerate kinase family. (387 aa)
epdD-erythrose 4-phosphate dehydrogenase; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. (339 aa)
yggDPutative DNA-binding transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (169 aa)
yggFPutative hexoseP phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (321 aa)
tktATransketolase 1, thiamin-binding; Function experimentally demonstrated in the studied species; enzyme. (663 aa)
ygiPPutative DNA-binding transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator; Belongs to the LysR transcriptional regulatory family. (310 aa)
ttdAL-tartrate dehydratase, alpha subunit; Function experimentally demonstrated in the studied species; enzyme. (303 aa)
ttdBL-tartrate dehydratase, beta subunit; Function experimentally demonstrated in the studied species; enzyme. (201 aa)
ygjEPutative tartrate:succinate antiporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (487 aa)
tdcEPyruvate formate-lyase 4/2-ketobutyrate formate-lyase; Function experimentally demonstrated in the studied species; enzyme. (764 aa)
tdcDPropionate kinase/acetate kinase C, anaerobic; Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. (406 aa)
mdhMalate dehydrogenase, NAD(P)-binding; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa)
yhdHPutative oxidoreductase, Zn-dependent and NAD(P)-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (324 aa)
accBAcetyl CoA carboxylase, BCCP subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (156 aa)
accCacetyl-CoA carboxylase, biotin carboxylase subunit; Function experimentally demonstrated in the studied species; enzyme. (449 aa)
rpeD-ribulose-5-phosphate 3-epimerase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa)
pckPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (540 aa)
avtAValine-pyruvate aminotransferase; Function experimentally demonstrated in the studied species; enzyme. (417 aa)
gpmIPhosphoglycero mutase III, cofactor-independent; Function experimentally demonstrated in the studied species; enzyme. (514 aa)
pfkA6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa)
glpXFructose 1,6-bisphosphatase II; Function experimentally demonstrated in the studied species; enzyme. (336 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (883 aa)
pgiGlucosephosphate isomerase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the GPI family. (549 aa)
acsacetyl-CoA synthetase; Function experimentally demonstrated in the studied species; enzyme. (652 aa)
CAR01066.1Putative ribose-5-phosphate isomerase B (rpiB-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (105 aa)
fumBAnaerobic class I fumarate hydratase (fumarase B); Function experimentally demonstrated in the studied species; enzyme. (548 aa)
frdDFumarate reductase (anaerobic), membrane anchor subunit; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (119 aa)
frdCFumarate reductase (anaerobic), membrane anchor subunit; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (131 aa)
frdBFumarate reductase (anaerobic), Fe-S subunit; Function experimentally demonstrated in the studied species; carrier. (244 aa)
frdAFumarate reductase (anaerobic) catalytic and NAD/flavoprotein subunit; Function experimentally demonstrated in the studied species; enzyme. (602 aa)
fbpFunction experimentally demonstrated in the studied species; enzyme. (332 aa)
ytjCPhosphoglyceromutase 2, co-factor independent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (215 aa)
Your Current Organism:
Escherichia coli IAI1
NCBI taxonomy Id: 585034
Other names: E. coli IAI1, Escherichia coli str. IAI1, Escherichia coli strain IAI1
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