STRINGSTRING
fhiA fhiA mbhA mbhA yahA yahA yaiC yaiC ylaB ylaB fimZ fimZ yliE yliE yliF yliF flgN flgN flgM flgM flgA flgA flgB flgB flgC flgC flgD flgD flgF flgF flgG flgG flgH flgH flgI flgI flgJ flgJ flgK flgK flgL flgL ycgG ycgG ycgR ycgR narL narL narX narX gmr gmr ydaM ydaM trg trg dos dos yddV yddV yneF yneF ydeH ydeH rstA rstA rstB rstB ydiV ydiV yeaI yeaI yeaJ yeaJ yeaP yeaP adrB adrB flhA flhA flhB flhB cheZ cheZ cheY cheY cheB cheB cheR cheR tap tap tar tar cheW cheW cheA cheA motB motB motA motA flhC flhC flhD flhD uvrY uvrY sdiA sdiA fliZ fliZ fliA fliA fliC fliC fliD fliD fliS fliS fliE fliE fliF fliF fliG fliG fliH fliH fliI fliI fliJ fliJ fliK fliK fliL fliL fliM fliM fliN fliN fliO fliO fliP fliP fliQ fliQ fliR fliR yedQ yedQ yegE yegE mlrA mlrA rtn rtn narP narP evgA evgA evgS evgS yfeA yfeA narQ narQ yfgF yfgF csrA csrA barA barA aer aer arcB arcB csrD csrD envZ envZ ompR ompR yhjB yhjB yhjH yhjH yhjK yhjK yjcC yjcC tsr tsr arcA arcA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fhiAFlagellar system protein; Gene remnant; structure. (579 aa)
mbhAFlagellar system protein; Function of strongly homologous gene; structure. (296 aa)
yahACyclic di-GMP phosphodiesterase; Function experimentally demonstrated in the studied species; enzyme. (362 aa)
yaiCPutative diguanylate cyclase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (371 aa)
ylaBConserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (516 aa)
fimZDNA-binding transcriptional regulator, isolated component of a two-component regulator system; Function experimentally demonstrated in the studied species; regulator. (210 aa)
yliEConserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (782 aa)
yliFPutative diguanylate cyclase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (442 aa)
flgNExport chaperone for FlgK and FlgL; Function experimentally demonstrated in the studied species; factor. (138 aa)
flgMAnti-sigma factor for FliA (sigma 28); Function experimentally demonstrated in the studied species; factor. (97 aa)
flgAAssembly protein for flagellar basal-body periplasmic P ring; Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P- ring assembly; Belongs to the FlgA family. (219 aa)
flgBFlagellar component of cell-proximal portion of basal-body rod; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body. (138 aa)
flgCFlagellar component of cell-proximal portion of basal-body rod; Function experimentally demonstrated in the studied species; structure; Belongs to the flagella basal body rod proteins family. (134 aa)
flgDFlagellar hook assembly protein; Required for flagellar hook formation. May act as a scaffolding protein. (231 aa)
flgFFragment of flagellar hook protein (partial); Gene remnant; structure. (251 aa)
flgGFlagellar component of cell-distal portion of basal-body rod; Function experimentally demonstrated in the studied species; structure; Belongs to the flagella basal body rod proteins family. (260 aa)
flgHFlagellar protein of basal-body outer-membrane L ring; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (232 aa)
flgIFlagellar basal body P-ring protein; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (365 aa)
flgJMuramidase; Function experimentally demonstrated in the studied species; enzyme. (313 aa)
flgKFlagellar hook-filament junction protein 1; Function experimentally demonstrated in the studied species; structure. (547 aa)
flgLFlagellar hook-filament junction protein; Function experimentally demonstrated in the studied species; structure. (317 aa)
ycgGConserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (507 aa)
ycgRProtein involved in flagellar function; Function of strongly homologous gene; cell process. (244 aa)
narLDNA-binding response regulator in two-component regulatory system with NarX (or NarQ); Function experimentally demonstrated in the studied species; regulator. (216 aa)
narXSensory histidine kinase in two-component regulatory system with NarL; Function experimentally demonstrated in the studied species; regulator. (598 aa)
gmrModulator of Rnase II stability; Function experimentally demonstrated in the studied species; putative factor. (661 aa)
ydaMPutative diguanylate cyclase, GG[D/E]EF domain signalling protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (410 aa)
trgMethyl-accepting chemotaxis protein III, ribose and galactose sensor receptor; Function experimentally demonstrated in the studied species; regulator. (546 aa)
doscAMP phosphodiesterase, heme-regulated; Function experimentally demonstrated in the studied species; enzyme. (799 aa)
yddVPutative diguanylate cyclase YddV; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (460 aa)
yneFPutative membrane-associated diguanylate cyclase (GGDEF domain); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (472 aa)
ydeHConserved hypothetical protein; Homologs of previously reported genes of unknown function. (296 aa)
rstADNA-binding response regulator in two-component regulatory system with RstB; Function experimentally demonstrated in the studied species; regulator. (242 aa)
rstBSensory histidine kinase in two-component regulatory system with RstA; Function experimentally demonstrated in the studied species; regulator. (433 aa)
ydiVFragment of conserved hypothetical protein (part 1); Gene remnant. (237 aa)
yeaIPutative diguanylate cyclase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (491 aa)
yeaJPutative diguanylate cyclase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (496 aa)
yeaPPutative diguanylate cyclase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (341 aa)
adrBPutative cyclic di-GMP phosphodiesterase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (532 aa)
flhAPutative flagellar export pore protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (692 aa)
flhBFlagellar export pore protein; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family. (382 aa)
cheZChemotaxis regulator, protein phosphatase for CheY; Function experimentally demonstrated in the studied species; regulator. (214 aa)
cheYChemotaxis regulator transmitting signal to flagellar motor component; Function experimentally demonstrated in the studied species; regulator. (129 aa)
cheBFused chemotaxis regulator; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (349 aa)
cheRChemotaxis regulator, protein-glutamate methyltransferase; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. (286 aa)
tapMethyl-accepting protein IV; Function experimentally demonstrated in the studied species; regulator. (533 aa)
tarMethyl-accepting chemotaxis protein II; Function experimentally demonstrated in the studied species; regulator. (553 aa)
cheWPurine-binding chemotaxis protein; Function experimentally demonstrated in the studied species; regulator. (167 aa)
cheAChemotaxis protein CheA; Function experimentally demonstrated in the studied species; regulator. (654 aa)
motBProtein that enables flagellar motor rotation; Function experimentally demonstrated in the studied species; cell process. (308 aa)
motAProton conductor component of flagella motor; Function experimentally demonstrated in the studied species; cell process. (295 aa)
flhCDNA-binding transcriptional dual regulator with FlhD; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family. (192 aa)
flhDDNA-binding transcriptional dual regulator with FlhC; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family. (119 aa)
uvrYDNA-binding response regulator in two-component regulatory system with BarA; Function experimentally demonstrated in the studied species; regulator. (218 aa)
sdiADNA-binding transcriptional activator; Function experimentally demonstrated in the studied species; regulator. (240 aa)
fliZPutative regulator of FliA activity; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (183 aa)
fliARNA polymerase, sigma 28 (sigma F) factor; Function experimentally demonstrated in the studied species; factor. (239 aa)
fliCFlagellar filament structural protein (flagellin); Function experimentally demonstrated in the studied species; structure. (610 aa)
fliDFlagellar filament capping protein; Function experimentally demonstrated in the studied species; structure. (468 aa)
fliSFlagellar protein potentiates polymerization; Function experimentally demonstrated in the studied species; factor. (136 aa)
fliEFlagellar basal-body component; Function experimentally demonstrated in the studied species; structure. (104 aa)
fliFFlagellar basal-body MS-ring and collar protein; Function experimentally demonstrated in the studied species; structure. (552 aa)
fliGFlagellar motor switching and energizing component; FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. (331 aa)
fliHFlagellar biosynthesis protein; Function experimentally demonstrated in the studied species; structure. (228 aa)
fliIFlagellum-specific ATP synthase; Function experimentally demonstrated in the studied species; enzyme. (457 aa)
fliJFlagellar protein; Function experimentally demonstrated in the studied species; structure. (147 aa)
fliKFlagellar hook-length control protein; Function experimentally demonstrated in the studied species; structure. (375 aa)
fliLFlagellar biosynthesis protein; Function experimentally demonstrated in the studied species; structure. (154 aa)
fliMFlagellar motor switching and energizing component; Function experimentally demonstrated in the studied species; cell process. (334 aa)
fliNFlagellar motor switching and energizing component; FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. Belongs to the FliN/MopA/SpaO family. (137 aa)
fliOFlagellar biosynthesis protein; Function experimentally demonstrated in the studied species; structure. (121 aa)
fliPFlagellar biosynthesis protein; Function experimentally demonstrated in the studied species; structure. (245 aa)
fliQFlagellar biosynthesis protein; Role in flagellar biosynthesis. Belongs to the FliQ/MopD/SpaQ family. (89 aa)
fliRFlagellar export pore protein; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family. (261 aa)
yedQPutative diguanylate cyclase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (564 aa)
yegEPutative diguanylate cyclase, GGDEF domain signalling protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (1105 aa)
mlrADNA-binding transcriptional regulator; Function experimentally demonstrated in the studied species; regulator. (243 aa)
rtnConserved hypothetical protein; Homologs of previously reported genes of unknown function. (518 aa)
narPDNA-binding response regulator in two-component regulatory system with NarQ or NarX; Function experimentally demonstrated in the studied species; regulator. (215 aa)
evgADNA-binding response regulator in two-component regulatory system with EvgS; Function experimentally demonstrated in the studied species; regulator. (204 aa)
evgSHybrid sensory histidine kinase in two-component regulatory system with EvgA; Function experimentally demonstrated in the studied species; regulator. (1197 aa)
yfeAPutative diguanylate cyclase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (729 aa)
narQSensory histidine kinase in two-component regulatory system with NarP (NarL); Function experimentally demonstrated in the studied species; regulator. (566 aa)
yfgFConserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (747 aa)
csrAPleiotropic regulatory protein for carbon source metabolism; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small [...] (61 aa)
barAHybrid sensory histidine kinase, in two-component regulatory system with UvrY; Function experimentally demonstrated in the studied species; regulator. (918 aa)
aerFused signal transducer for aerotaxis sensory component; Function experimentally demonstrated in the studied species; regulator. (506 aa)
arcBHybrid sensory histidine kinase in two-component regulatory system with ArcA; Function experimentally demonstrated in the studied species; regulator. (778 aa)
csrDInner membrane associated factor modulating specific RNAseE dependent RNA degradation pathways; Function experimentally demonstrated in the studied species; factor. (646 aa)
envZSensory histidine kinase in two-component regulatory system with OmpR; Function experimentally demonstrated in the studied species; regulator. (450 aa)
ompRDNA-binding response regulator in two-component regulatory system with EnvZ; Function experimentally demonstrated in the studied species; regulator. (239 aa)
yhjBPutative DNA-binding response regulator in two-component regulatory system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (200 aa)
yhjHEAL domain containing protein involved in flagellar function; Function experimentally demonstrated in the studied species; regulator. (255 aa)
yhjKPutative diguanylate cyclase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (649 aa)
yjcCPutative signal transduction protein (EAL domain containing protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (528 aa)
tsrMethyl-accepting chemotaxis protein I, serine sensor receptor; Function experimentally demonstrated in the studied species; regulator. (554 aa)
arcADNA-binding response regulator in two-component regulatory system with ArcB or CpxA; Function experimentally demonstrated in the studied species; regulator. (238 aa)
Your Current Organism:
Escherichia coli IAI1
NCBI taxonomy Id: 585034
Other names: E. coli IAI1, Escherichia coli str. IAI1, Escherichia coli strain IAI1
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