(22 nodes) Formate metabolic process, and NADH dehydrogenase (ubiquinone) activity network (Escherichia coli IAI1)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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Your Input:
	hyfA	Hydrogenase 4, 4Fe-4S subunit; Function experimentally demonstrated in the studied species; carrier. (205 aa)
	hyfB	Hydrogenase 4, membrane subunit; Function experimentally demonstrated in the studied species; membrane component. (672 aa)
	hyfC	Hydrogenase 4, membrane subunit; Function experimentally demonstrated in the studied species; membrane component. (322 aa)
	hyfD	Hydrogenase 4, membrane subunit; Function experimentally demonstrated in the studied species; membrane component. (450 aa)
	hyfE	Hydrogenase 4, membrane subunit; Function experimentally demonstrated in the studied species; membrane component. (216 aa)
	hyfF	Hydrogenase 4, membrane subunit; Function experimentally demonstrated in the studied species; membrane component. (526 aa)
	hyfG	Hydrogenase 4, subunit; Function experimentally demonstrated in the studied species; carrier. (555 aa)
	hyfH	Hydrogenase 4, Fe-S subunit; Function experimentally demonstrated in the studied species; carrier. (179 aa)
	hyfI	Hydrogenase 4, Fe-S subunit; Function experimentally demonstrated in the studied species; carrier. (252 aa)
	hyfJ	Putative processing element hydrogenase 4; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (137 aa)
	hyfR	DNA-binding transcriptional activator, formate sensing; Function experimentally demonstrated in the studied species; regulator. (670 aa)
	hydN	Formate dehydrogenase-H, [4Fe-4S] ferredoxin subunit; Function experimentally demonstrated in the studied species; carrier. (175 aa)
	hycI	Protease involved in processing C-terminal end of HycE; Function experimentally demonstrated in the studied species; enzyme. (156 aa)
	hycH	Protein required for maturation of hydrogenase 3; Function experimentally demonstrated in the studied species; factor. (136 aa)
	hycG	Hydrogenase 3 and formate hydrogenase complex, HycG subunit; Function experimentally demonstrated in the studied species; enzyme. (255 aa)
	hycF	Formate hydrogenlyase complex iron-sulfur protein; Function experimentally demonstrated in the studied species; carrier. (180 aa)
	hycE	Hydrogenase 3, large subunit; Function experimentally demonstrated in the studied species; enzyme. (569 aa)
	hycD	Hydrogenase 3, membrane subunit; Function experimentally demonstrated in the studied species; membrane component. (307 aa)
	hycC	Hydrogenase 3, membrane subunit; Function experimentally demonstrated in the studied species; membrane component. (608 aa)
	hycB	Hydrogenase 3, Fe-S subunit; Function experimentally demonstrated in the studied species; carrier. (203 aa)
	hycA	Regulator of the transcriptional regulator FhlA; Function experimentally demonstrated in the studied species; regulator. (153 aa)
	fdhF	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (715 aa)

Your Current Organism:

Escherichia coli IAI1

NCBI taxonomy Id: 585034
Other names: E. coli IAI1, Escherichia coli str. IAI1, Escherichia coli strain IAI1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
fdhF	hycA	ECIAI1_4313	ECIAI1_2819	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Regulator of the transcriptional regulator FhlA; Function experimentally demonstrated in the studied species; regulator.	0.771
fdhF	hycB	ECIAI1_4313	ECIAI1_2818	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase 3, Fe-S subunit; Function experimentally demonstrated in the studied species; carrier.	0.998
fdhF	hycC	ECIAI1_4313	ECIAI1_2817	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase 3, membrane subunit; Function experimentally demonstrated in the studied species; membrane component.	0.980
fdhF	hycD	ECIAI1_4313	ECIAI1_2816	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase 3, membrane subunit; Function experimentally demonstrated in the studied species; membrane component.	0.986
fdhF	hycE	ECIAI1_4313	ECIAI1_2815	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase 3, large subunit; Function experimentally demonstrated in the studied species; enzyme.	0.999
fdhF	hycF	ECIAI1_4313	ECIAI1_2814	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Formate hydrogenlyase complex iron-sulfur protein; Function experimentally demonstrated in the studied species; carrier.	0.993
fdhF	hycG	ECIAI1_4313	ECIAI1_2813	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase 3 and formate hydrogenase complex, HycG subunit; Function experimentally demonstrated in the studied species; enzyme.	0.995
fdhF	hycH	ECIAI1_4313	ECIAI1_2812	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Protein required for maturation of hydrogenase 3; Function experimentally demonstrated in the studied species; factor.	0.552
fdhF	hycI	ECIAI1_4313	ECIAI1_2811	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Protease involved in processing C-terminal end of HycE; Function experimentally demonstrated in the studied species; enzyme.	0.407
fdhF	hydN	ECIAI1_4313	ECIAI1_2805	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Formate dehydrogenase-H, [4Fe-4S] ferredoxin subunit; Function experimentally demonstrated in the studied species; carrier.	0.893
fdhF	hyfA	ECIAI1_4313	ECIAI1_2532	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase 4, 4Fe-4S subunit; Function experimentally demonstrated in the studied species; carrier.	0.739
fdhF	hyfB	ECIAI1_4313	ECIAI1_2533	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase 4, membrane subunit; Function experimentally demonstrated in the studied species; membrane component.	0.487
fdhF	hyfC	ECIAI1_4313	ECIAI1_2534	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase 4, membrane subunit; Function experimentally demonstrated in the studied species; membrane component.	0.580
fdhF	hyfF	ECIAI1_4313	ECIAI1_2537	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase 4, membrane subunit; Function experimentally demonstrated in the studied species; membrane component.	0.429
fdhF	hyfG	ECIAI1_4313	ECIAI1_2538	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase 4, subunit; Function experimentally demonstrated in the studied species; carrier.	0.895
fdhF	hyfH	ECIAI1_4313	ECIAI1_2539	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase 4, Fe-S subunit; Function experimentally demonstrated in the studied species; carrier.	0.693
fdhF	hyfI	ECIAI1_4313	ECIAI1_2540	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase 4, Fe-S subunit; Function experimentally demonstrated in the studied species; carrier.	0.633
hycA	fdhF	ECIAI1_2819	ECIAI1_4313	Regulator of the transcriptional regulator FhlA; Function experimentally demonstrated in the studied species; regulator.	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	0.771
hycA	hycB	ECIAI1_2819	ECIAI1_2818	Regulator of the transcriptional regulator FhlA; Function experimentally demonstrated in the studied species; regulator.	Hydrogenase 3, Fe-S subunit; Function experimentally demonstrated in the studied species; carrier.	0.961
hycA	hycC	ECIAI1_2819	ECIAI1_2817	Regulator of the transcriptional regulator FhlA; Function experimentally demonstrated in the studied species; regulator.	Hydrogenase 3, membrane subunit; Function experimentally demonstrated in the studied species; membrane component.	0.803