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| | yadR | Putative chaperone involved in Fe-S cluster assembly and activation; Required for insertion of 4Fe-4S clusters for at least IspG. (114 aa) |
| | pfs | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulatio [...] (232 aa) |
| | accA | acetyl-CoA carboxylase, carboxytransferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | yaeR | Putative S-C lyase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (129 aa) |
| | tauD | Taurine dioxygenase, 2-oxoglutarate-dependent; Function experimentally demonstrated in the studied species; enzyme. (283 aa) |
| | thiL | Thiamin-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (325 aa) |
| | yajO | Aldoketo-oxidoreductase, NADP-binding; Function experimentally demonstrated in the studied species; enzyme. (324 aa) |
| | dxs | 1-deoxyxylulose-5-phosphate synthase, thiamine-requiring, FAD-requiring; Function experimentally demonstrated in the studied species; enzyme. (620 aa) |
| | thiI | Sulfurtransferase required for thiamine and 4-thiouridine biosynthesis; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa) |
| | bolA | Regulator of penicillin binding proteins and beta lactamase transcription (morphogene); Function experimentally demonstrated in the studied species; regulator; Belongs to the BolA/IbaG family. (105 aa) |
| | cof | Thiamin pyrimidine pyrophosphate hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P). Belongs to the HAD-like hydrolase superfamily. Cof family. (272 aa) |
| | tesB | acyl-CoA thioesterase II; Function experimentally demonstrated in the studied species; enzyme. (286 aa) |
| | folD | 5,10-methylene-tetrahydrofolate dehydrogenase; Function experimentally demonstrated in the studied species; enzyme. (288 aa) |
| | citF | Citrate lyase, citrate-ACP transferase (alpha) subunit; Function experimentally demonstrated in the studied species; enzyme. (510 aa) |
| | citE | Citrate lyase, citryl-ACP lyase (beta) subunit; Function experimentally demonstrated in the studied species; enzyme; Belongs to the HpcH/HpaI aldolase family. (302 aa) |
| | citD | Citrate lyase, acyl carrier (gamma) subunit; Function experimentally demonstrated in the studied species; enzyme. (98 aa) |
| | lipA | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa) |
| | sucB | Dihydrolipoyltranssuccinase; Function experimentally demonstrated in the studied species; enzyme. (405 aa) |
| | bioA | 7,8-diaminopelargonic acid synthase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme. (429 aa) |
| | bioB | Biotin synthase; Function experimentally demonstrated in the studied species; enzyme. (346 aa) |
| | bioF | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (384 aa) |
| | bioC | Putative methltransferase, enzyme of biotin synthesis; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (251 aa) |
| | bioD | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (225 aa) |
| | yliJ | Putative glutathione S-transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (208 aa) |
| | dmsA | Dimethyl sulfoxide reductase, anaerobic, subunit A; Function experimentally demonstrated in the studied species; enzyme. (814 aa) |
| | dmsB | Dimethyl sulfoxide reductase, anaerobic, subunit B; Function experimentally demonstrated in the studied species; enzyme. (205 aa) |
| | grxB | Glutaredoxin 2 (Grx2); Function experimentally demonstrated in the studied species; carrier. (215 aa) |
| | ycfN | Thiamin kinase; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). Belongs to the LpoB family. (274 aa) |
| | chaC | Regulatory protein for cation transport; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (238 aa) |
| | thiG | Thiamin biosynthesis ThiGH complex subunit; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa) |
| | thiS | Sulphur carrier protein; Function experimentally demonstrated in the studied species; carrier. (66 aa) |
| | thiF | Thiamin (thiazole moiety) biosynthesis protein; Function experimentally demonstrated in the studied species; enzyme. (251 aa) |
| | thiE | Thiamin phosphate synthase (thiamin phosphate pyrophosphorylase); Function experimentally demonstrated in the studied species; enzyme. (211 aa) |
| | thiC | Thiamin (pyrimidine moiety) biosynthesis protein; Function experimentally demonstrated in the studied species; enzyme. (631 aa) |
| | metA | Homoserine transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (309 aa) |
| | metH | homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; Function experimentally demonstrated in the studied species; enzyme. (1227 aa) |
| | acs | acetyl-CoA synthetase; Function experimentally demonstrated in the studied species; enzyme. (652 aa) |
| | yjcS | Putative alkyl sulfatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (661 aa) |
| | phnB | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; 9650256, 2155230. (147 aa) |
| | yjfC | Putative synthetase/amidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (387 aa) |
| | cysQ | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase; Function experimentally demonstrated in the studied species; enzyme. (246 aa) |
| | csdA | Cysteine sulfinate desulfinase; Function experimentally demonstrated in the studied species; enzyme. (401 aa) |
| | ygdK | Putative Fe-S metabolism protein (sufE-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (147 aa) |
| | ygfH | propionyl-CoA:succinate-CoA transferase; Function experimentally demonstrated in the studied species; enzyme. (492 aa) |
| | metK | Methionine adenosyltransferase 1; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (384 aa) |
| | gshB | Glutathione synthetase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the prokaryotic GSH synthase family. (316 aa) |
| | gss | Fused glutathionylspermidine amidase; Function experimentally demonstrated in the studied species; enzyme. (619 aa) |
| | yghU | S-transferase; Function of strongly homologous gene; enzyme. (288 aa) |
| | metC | Cystathionine beta-lyase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme. (395 aa) |
| | ygiC | Putative enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (386 aa) |
| | yqjG | S-transferase; Function of strongly homologous gene; enzyme. (328 aa) |
| | yhaM | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0597 family. (436 aa) |
| | yrbA | Putative DNA-binding transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator; Belongs to the BolA/IbaG family. (84 aa) |
| | yciA | Putative hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (132 aa) |
| | cysB | DNA-binding transcriptional dual regulator, O-acetyl-L-serine-binding; Function experimentally demonstrated in the studied species; regulator. (324 aa) |
| | fabI | Enoyl-[acyl-carrier-protein] reductase, NADH-dependent; Function experimentally demonstrated in the studied species; enzyme. (262 aa) |
| | yncG | Putative enzyme with similarity with GST; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (205 aa) |
| | ynfK | Putative synthase (similar to dethiobiotin synthetase); Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (231 aa) |
| | gst | Glutathionine S-transferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the GST superfamily. (201 aa) |
| | ydhD | Monothiol glutaredoxin; Function experimentally demonstrated in the studied species; enzyme; Belongs to the glutaredoxin family. Monothiol subfamily. (115 aa) |
| | sufE | Sulfur acceptor protein; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process; Belongs to the SufE family. (138 aa) |
| | sufS | Selenocysteine lyase, PLP-dependent; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. (406 aa) |
| | sufD | Component of SufBCD complex; Function experimentally demonstrated in the studied species; factor. (423 aa) |
| | sufC | Component of SufBCD complex, ATP-binding component of ABC superfamily; Function experimentally demonstrated in the studied species; transporter. (248 aa) |
| | sufB | Component of SufBCD complex; Function of strongly homologous gene; putative transporter. (495 aa) |
| | sufA | Fe-S cluster assembly protein; Function experimentally demonstrated in the studied species; factor; Belongs to the HesB/IscA family. (122 aa) |
| | ynjE | Putative exported thiosulfate sulfur transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (435 aa) |
| | wcaB | Putative acyl transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (162 aa) |
| | thiD | Bifunctional hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase; Function experimentally demonstrated in the studied species; enzyme. (266 aa) |
| | thiM | Hydoxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ). Belongs to the Thz kinase family. (262 aa) |
| | mrp | Antiporter inner membrane protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (369 aa) |
| | ackA | Acetate kinase A and propionate kinase 2; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | pta | Phosphate acetyltransferase; Function experimentally demonstrated in the studied species; enzyme. (714 aa) |
| | yfcF | Putative enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (214 aa) |
| | yfcG | Putative S-transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the GST superfamily. (215 aa) |
| | accD | acetyl-CoA carboxylase, beta (carboxyltranferase) subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. Belongs to the AccD/PCCB family. (304 aa) |
| | cysZ | Putative inner membrane protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (253 aa) |
| | cysK | Cysteine synthase A, O-acetylserine sulfhydrolase A subunit; Function experimentally demonstrated in the studied species; enzyme; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa) |
| | cysM | Cysteine synthase B (O-acetylserine sulfhydrolase B); Function experimentally demonstrated in the studied species; enzyme. (303 aa) |
| | sseA | 3-mercaptopyruvate sulfurtransferase; Function experimentally demonstrated in the studied species; enzyme. (281 aa) |
| | yfhJ | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; putative factor. (66 aa) |
| | hscA | DnaK-like molecular chaperone specific for IscU; Function experimentally demonstrated in the studied species; factor. (616 aa) |
| | hscB | DnaJ-like molecular chaperone specific for IscU; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (171 aa) |
| | iscA | FeS cluster assembly protein; Function experimentally demonstrated in the studied species; factor; Belongs to the HesB/IscA family. (107 aa) |
| | iscU | Scaffold protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (128 aa) |
| | iscS | Cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate. (404 aa) |
| | gshA | Gamma-glutamate-cysteine ligase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the glutamate--cysteine ligase type 1 family. (518 aa) |
| | cysC | Adenosine 5'-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate. (201 aa) |
| | cysN | Sulfate adenylyltransferase, subunit 1; Function experimentally demonstrated in the studied species; enzyme. (475 aa) |
| | cysD | Sulfate adenylyltransferase, subunit 2; Function experimentally demonstrated in the studied species; enzyme. (302 aa) |
| | cysH | 3'-phosphoadenosine 5'-phosphosulfate reductase; Function experimentally demonstrated in the studied species; enzyme. (244 aa) |
| | cysI | Sulfite reductase, beta subunit, NAD(P)-binding, heme-binding; Function experimentally demonstrated in the studied species; enzyme. (570 aa) |
| | cysJ | Sulfite reductase, alpha subunit, flavoprotein; Function experimentally demonstrated in the studied species; enzyme. (599 aa) |
| | sspA | Stringent starvation protein A; Function experimentally demonstrated in the studied species; regulator; Belongs to the GST superfamily. (212 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase subunit; Function experimentally demonstrated in the studied species; enzyme. (449 aa) |
| | bioH | Carboxylesterase of pimeloyl-CoA synthesis; Function experimentally demonstrated in the studied species; enzyme. (256 aa) |
| | gntY | Putative gluconate transport associated protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (191 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase, NAD(P)-binding; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (367 aa) |
| | ggt | Gamma-glutamyltranspeptidase; Function experimentally demonstrated in the studied species; enzyme. (580 aa) |
| | gor | Glutathione oxidoreductase; Function experimentally demonstrated in the studied species; carrier. (450 aa) |
| | yibF | Putative glutathione S-transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (202 aa) |
| | cysE | Serine acetyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the transferase hexapeptide repeat family. (273 aa) |
| | cyaY | Frataxin, iron-binding and oxidizing protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. (106 aa) |
| | yigL | Putative hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (266 aa) |
| | metR | DNA-binding transcriptional activator, homocysteine-binding; Function experimentally demonstrated in the studied species; regulator; Belongs to the LysR transcriptional regulatory family. (317 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (753 aa) |
| | yihS | Putative glucosamine isomerase; Catalyzes the isomerization of sulfoquinovose (SQ) to 6- deoxy-6-sulfo-D-fructose (SF). (413 aa) |
| | yihT | Putative aldolase; Cleaves 6-deoxy-6-sulfo-D-fructose 1-phosphate (SFP) to form dihydroxyacetone phosphate (DHAP) and 3-sulfolactaldehyde (SLA). Belongs to the aldolase LacD family. (292 aa) |
| | yihU | Putative oxidoreductase with NAD(P)-binding Rossmann-fold domain; Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1- sulfonate (DHPS); Belongs to the HIBADH-related family. 3-sulfolactaldehyde reductase subfamily. (298 aa) |
| | yihV | Putative sugar kinase; Phosphorylates 6-deoxy-6-sulfo-D-fructose (SF) to 6-deoxy-6- sulfo-D-fructose 1-phosphate (SFP); Belongs to the carbohydrate kinase PfkB family. (298 aa) |
| | fpr | ferredoxin-NADP reductase; Function experimentally demonstrated in the studied species; enzyme. (248 aa) |
| | metJ | DNA-binding transcriptional repressor, S-adenosylmethionine-binding; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. (105 aa) |
| | metB | Cystathionine gamma-synthase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme. (386 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the methylenetetrahydrofolate reductase family. (296 aa) |
| | thiH | Thiamin biosynthesis ThiGH complex subunit; Function experimentally demonstrated in the studied species; enzyme. (377 aa) |
