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| | hisC | Histidinol-phosphate aminotransferase; Function experimentally demonstrated in the studied species; enzyme. (356 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit with HisF; Function experimentally demonstrated in the studied species; enzyme. (196 aa) |
| | hisA | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the HisA/HisF family. (245 aa) |
| | hisF | Imidazole glycerol phosphate synthase, catalytic subunit with HisH; Function experimentally demonstrated in the studied species; enzyme; Belongs to the HisA/HisF family. (258 aa) |
| | hisI | Fused phosphoribosyl-AMP cyclohydrolase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the PRA-PH family. (202 aa) |
| | wcaB | Putative acyl transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (162 aa) |
| | yfbQ | Putative aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (405 aa) |
| | usg | Putative semialdehyde dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (337 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa) |
| | cysZ | Putative inner membrane protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (253 aa) |
| | cysK | Cysteine synthase A, O-acetylserine sulfhydrolase A subunit; Function experimentally demonstrated in the studied species; enzyme; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa) |
| | cysM | Cysteine synthase B (O-acetylserine sulfhydrolase B); Function experimentally demonstrated in the studied species; enzyme. (303 aa) |
| | dapE | N-succinyl-diaminopimelate deacylase; Function experimentally demonstrated in the studied species; enzyme. (375 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | pheA | Fused chorismate mutase P; Function experimentally demonstrated in the studied species; enzyme. (386 aa) |
| | tyrA | Fused chorismate mutase T; Function experimentally demonstrated in the studied species; enzyme. (373 aa) |
| | aroF | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tyrosine-repressible; Function experimentally demonstrated in the studied species; enzyme. (356 aa) |
| | cysI | Sulfite reductase, beta subunit, NAD(P)-binding, heme-binding; Function experimentally demonstrated in the studied species; enzyme. (570 aa) |
| | cysJ | Sulfite reductase, alpha subunit, flavoprotein; Function experimentally demonstrated in the studied species; enzyme. (599 aa) |
| | argA | Fused acetylglutamate kinase homolog (inactive); Function experimentally demonstrated in the studied species; enzyme; Belongs to the acetyltransferase family. ArgA subfamily. (443 aa) |
| | lysA | Diaminopimelate decarboxylase, PLP-binding; Function experimentally demonstrated in the studied species; enzyme. (420 aa) |
| | lysR | DNA-binding transcriptional dual regulator; Function experimentally demonstrated in the studied species; regulator. (311 aa) |
| | ygeX | 2,3-diaminopropionate ammonia-lyase; Function experimentally demonstrated in the studied species; enzyme. (398 aa) |
| | ygfK | Putative oxidoreductase, Fe-S subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (1032 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa) |
| | argG | Argininosuccinate synthetase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (447 aa) |
| | gltB | Glutamate synthase, large subunit; Function experimentally demonstrated in the studied species; enzyme. (1517 aa) |
| | gltD | Glutamate synthase, 4Fe-4S protein, small subunit; Function experimentally demonstrated in the studied species; carrier. (472 aa) |
| | argR | DNA-binding transcriptional dual regulator, L-arginine-binding; Regulates arginine biosynthesis genes. (156 aa) |
| | aroE | Dehydroshikimate reductase, NAD(P)-binding; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa) |
| | argD | Bifunctional acetylornithine aminotransferase and succinyldiaminopimelate aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (406 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (362 aa) |
| | aroK | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase, NAD(P)-binding; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (367 aa) |
| | cysE | Serine acetyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the transferase hexapeptide repeat family. (273 aa) |
| | ilvN | Acetolactate synthase I, small subunit; Function experimentally demonstrated in the studied species; enzyme. (96 aa) |
| | ilvB | Acetolactate synthase I, large subunit; Function experimentally demonstrated in the studied species; enzyme. (562 aa) |
| | asnA | Asparagine synthetase A; Function experimentally demonstrated in the studied species; enzyme. (330 aa) |
| | ilvL | ilvG operon leader peptide; Function experimentally demonstrated in the studied species; leader peptide. (32 aa) |
| | ilvG | Acetolactate synthase isozyme II large subunit; Function of strongly homologous gene; enzyme. (548 aa) |
| | ilvM | Acetolactate synthase II, small subunit; Function experimentally demonstrated in the studied species; enzyme. (87 aa) |
| | ilvE | Branched-chain amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (309 aa) |
| | ilvD | Dihydroxyacid dehydratase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the IlvD/Edd family. (616 aa) |
| | ilvA | Threonine deaminase; Function experimentally demonstrated in the studied species; enzyme. (514 aa) |
| | ilvC | Ketol-acid reductoisomerase, NAD(P)-binding; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (491 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa) |
| | metR | DNA-binding transcriptional activator, homocysteine-binding; Function experimentally demonstrated in the studied species; regulator; Belongs to the LysR transcriptional regulatory family. (317 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (753 aa) |
| | glnA | Glutamine synthetase; Function experimentally demonstrated in the studied species; enzyme. (469 aa) |
| | metJ | DNA-binding transcriptional repressor, S-adenosylmethionine-binding; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. (105 aa) |
| | metL | Fused aspartokinase II; Function experimentally demonstrated in the studied species; enzyme. (810 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the methylenetetrahydrofolate reductase family. (296 aa) |
| | argE | Acetylornithine deacetylase; Function experimentally demonstrated in the studied species; enzyme. (383 aa) |
| | ivbL | ilvB operon leader peptide; Function experimentally demonstrated in the studied genus; leader peptide. (32 aa) |
| | leuL | Leu operon leader peptide; Function experimentally demonstrated in the studied genus; leader peptide. (28 aa) |
| | serB | 3-phosphoserine phosphatase; Function experimentally demonstrated in the studied species; enzyme. (322 aa) |
| | yjgM | Putative acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (167 aa) |
| | argI | Fragment of conserved hypothetical protein (part 3); Gene remnant. (334 aa) |
| | yjgF | Ketoacid-binding protein; Function experimentally demonstrated in the studied species; putative enzyme. (128 aa) |
| | alr | Alanine racemase 1, PLP-binding, biosynthetic; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (359 aa) |
| | lysC | Aspartokinase III; Function experimentally demonstrated in the studied species; enzyme; Belongs to the aspartokinase family. (449 aa) |
| | metH | homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; Function experimentally demonstrated in the studied species; enzyme. (1227 aa) |
| | metA | Homoserine transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (309 aa) |
| | argH | Argininosuccinate lyase; Function experimentally demonstrated in the studied species; enzyme. (457 aa) |
| | argB | Acetylglutamate kinase; Function experimentally demonstrated in the studied species; enzyme. (257 aa) |
| | argC | N-acetyl-gamma-glutamylphosphate reductase, NAD(P)-binding; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (334 aa) |
| | thrA | Fused aspartokinase I; Function experimentally demonstrated in the studied species; enzyme; Belongs to the aspartokinase family. (820 aa) |
| | thrB | Homoserine kinase; Function experimentally demonstrated in the studied species; enzyme. (310 aa) |
| | thrC | Threonine synthase; Function experimentally demonstrated in the studied species; enzyme. (428 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa) |
| | carA | Carbamoyl phosphate synthetase small subunit, glutamine amidotransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the CarA family. (382 aa) |
| | carB | Carbamoyl-phosphate synthase large subunit; Function experimentally demonstrated in the studied species; enzyme; Belongs to the CarB family. (1073 aa) |
| | folA | Dihydrofolate reductase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the dihydrofolate reductase family. (159 aa) |
| | leuD | 3-isopropylmalate isomerase subunit; Function experimentally demonstrated in the studied species; enzyme. (201 aa) |
| | leuC | 3-isopropylmalate isomerase subunit, dehydratase component; Function experimentally demonstrated in the studied species; enzyme. (466 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Function experimentally demonstrated in the studied species; enzyme. (363 aa) |
| | leuA | 2-isopropylmalate synthase; Function experimentally demonstrated in the studied species; enzyme. (523 aa) |
| | ilvI | Acetolactate synthase III, large subunit; Function experimentally demonstrated in the studied species; enzyme. (574 aa) |
| | ilvH | Acetolactate synthase III, thiamin-dependent, small subunit; Function experimentally demonstrated in the studied species; enzyme. (163 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine; Belongs to the PanD family. (126 aa) |
| | pfs | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulatio [...] (232 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the transferase hexapeptide repeat family. (274 aa) |
| | proB | Gamma-glutamate kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (367 aa) |
| | proA | Gamma-glutamylphosphate reductase; Function experimentally demonstrated in the studied species; enzyme. (417 aa) |
| | proC | Pyrroline-5-carboxylate reductase, NAD(P)-binding; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (269 aa) |
| | aroL | Shikimate kinase II; Function experimentally demonstrated in the studied species; enzyme. (174 aa) |
| | aroM | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; 3001025. (225 aa) |
| | folD | 5,10-methylene-tetrahydrofolate dehydrogenase; Function experimentally demonstrated in the studied species; enzyme. (288 aa) |
| | asnB | Asparagine synthetase B; Function experimentally demonstrated in the studied species; enzyme. (554 aa) |
| | aroG | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine repressible; Function experimentally demonstrated in the studied species; enzyme. (350 aa) |
| | ybiB | Putative transferase/phosphorylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (320 aa) |
| | serS | seryl-tRNA synthetase, also charges selenocysteinyl-tRNA with serine; Function experimentally demonstrated in the studied species; enzyme. (430 aa) |
| | serC | 3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa) |
| | aroA | 5-enolpyruvylshikimate-3-phosphate synthetase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (427 aa) |
| | putA | Fused DNA-binding transcriptional regulator; Function experimentally demonstrated in the studied species; enzyme. (1320 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa) |
| | trpC | Fused indole-3-glycerolphosphate synthetase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the TrpF family. (452 aa) |
| | trpD | Fused glutamine amidotransferase (component II) of anthranilate synthase; Function experimentally demonstrated in the studied species; enzyme. (531 aa) |
| | trpE | Component I of anthranilate synthase; Function experimentally demonstrated in the studied species; enzyme. (520 aa) |
| | cysB | DNA-binding transcriptional dual regulator, O-acetyl-L-serine-binding; Function experimentally demonstrated in the studied species; regulator. (324 aa) |
| | puuA | gamma-Glu-putrescine synthase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the glutamine synthetase family. (472 aa) |
| | ydiB | Quinate/shikimate 5-dehydrogenase, NAD(P)-binding; The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD. (288 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (252 aa) |
| | aroH | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repressible; Function experimentally demonstrated in the studied species; enzyme. (348 aa) |
| | astC | Succinylornithine transaminase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme. (406 aa) |
| | selD | Selenophosphate synthase; Function experimentally demonstrated in the studied species; enzyme. (347 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (299 aa) |
| | hisD | Bifunctional histidinal dehydrogenase and histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa) |
| | hisB | Fused histidinol-phosphatase; Function experimentally demonstrated in the studied species; enzyme. (355 aa) |
