(12 nodes) Formate metabolic process network (Escherichia coli IAI1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hyfF	Hydrogenase 4, membrane subunit; Function experimentally demonstrated in the studied species; membrane component. (526 aa)
	fdnH	Formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (294 aa)
	fdhF	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (715 aa)
	nrfC	Formate-dependent nitrite reductase, 4Fe4S subunit; Function experimentally demonstrated in the studied species; carrier. (223 aa)
	fdoH	Formate dehydrogenase-O, Fe-S subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (300 aa)
	hybB	Function of strongly homologous gene; carrier. (392 aa)
	hycB	Hydrogenase 3, Fe-S subunit; Function experimentally demonstrated in the studied species; carrier. (203 aa)
	hycD	Hydrogenase 3, membrane subunit; Function experimentally demonstrated in the studied species; membrane component. (307 aa)
	hycF	Formate hydrogenlyase complex iron-sulfur protein; Function experimentally demonstrated in the studied species; carrier. (180 aa)
	hyfE	Hydrogenase 4, membrane subunit; Function experimentally demonstrated in the studied species; membrane component. (216 aa)
	hyfC	Hydrogenase 4, membrane subunit; Function experimentally demonstrated in the studied species; membrane component. (322 aa)
	ydhX	Putative 4Fe-4S ferridoxin-type subunit of oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (222 aa)

Your Current Organism:

Escherichia coli IAI1

NCBI taxonomy Id: 585034
Other names: E. coli IAI1, Escherichia coli str. IAI1, Escherichia coli strain IAI1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
fdhF	fdnH	ECIAI1_4313	ECIAI1_1479	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.	0.465
fdhF	fdoH	ECIAI1_4313	ECIAI1_4097	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Formate dehydrogenase-O, Fe-S subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.	0.465
fdhF	hycB	ECIAI1_4313	ECIAI1_2818	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase 3, Fe-S subunit; Function experimentally demonstrated in the studied species; carrier.	0.998
fdhF	hycD	ECIAI1_4313	ECIAI1_2816	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase 3, membrane subunit; Function experimentally demonstrated in the studied species; membrane component.	0.986
fdhF	hycF	ECIAI1_4313	ECIAI1_2814	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Formate hydrogenlyase complex iron-sulfur protein; Function experimentally demonstrated in the studied species; carrier.	0.993
fdhF	hyfC	ECIAI1_4313	ECIAI1_2534	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase 4, membrane subunit; Function experimentally demonstrated in the studied species; membrane component.	0.580
fdhF	hyfF	ECIAI1_4313	ECIAI1_2537	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Hydrogenase 4, membrane subunit; Function experimentally demonstrated in the studied species; membrane component.	0.429
fdhF	nrfC	ECIAI1_4313	ECIAI1_4306	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Formate-dependent nitrite reductase, 4Fe4S subunit; Function experimentally demonstrated in the studied species; carrier.	0.492
fdhF	ydhX	ECIAI1_4313	ECIAI1_1722	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Putative 4Fe-4S ferridoxin-type subunit of oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier.	0.408
fdnH	fdhF	ECIAI1_1479	ECIAI1_4313	Formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	0.465
fdnH	hybB	ECIAI1_1479	ECIAI1_3144	Formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.	Function of strongly homologous gene; carrier.	0.695
fdnH	hycB	ECIAI1_1479	ECIAI1_2818	Formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.	Hydrogenase 3, Fe-S subunit; Function experimentally demonstrated in the studied species; carrier.	0.477
fdoH	fdhF	ECIAI1_4097	ECIAI1_4313	Formate dehydrogenase-O, Fe-S subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	0.465
fdoH	hybB	ECIAI1_4097	ECIAI1_3144	Formate dehydrogenase-O, Fe-S subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.	Function of strongly homologous gene; carrier.	0.657
hybB	fdnH	ECIAI1_3144	ECIAI1_1479	Function of strongly homologous gene; carrier.	Formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.	0.695
hybB	fdoH	ECIAI1_3144	ECIAI1_4097	Function of strongly homologous gene; carrier.	Formate dehydrogenase-O, Fe-S subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.	0.657
hybB	nrfC	ECIAI1_3144	ECIAI1_4306	Function of strongly homologous gene; carrier.	Formate-dependent nitrite reductase, 4Fe4S subunit; Function experimentally demonstrated in the studied species; carrier.	0.701
hybB	ydhX	ECIAI1_3144	ECIAI1_1722	Function of strongly homologous gene; carrier.	Putative 4Fe-4S ferridoxin-type subunit of oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier.	0.698
hycB	fdhF	ECIAI1_2818	ECIAI1_4313	Hydrogenase 3, Fe-S subunit; Function experimentally demonstrated in the studied species; carrier.	Formate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	0.998
hycB	fdnH	ECIAI1_2818	ECIAI1_1479	Hydrogenase 3, Fe-S subunit; Function experimentally demonstrated in the studied species; carrier.	Formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.	0.477