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iscA iscA hscB hscB sufC sufC sufD sufD sufE sufE ydhD ydhD bolA bolA yadR yadR hscA hscA fpr fpr cyaY cyaY gntY gntY yrbA yrbA yfhJ yfhJ csdA csdA iscS iscS mrp mrp iscU iscU sufA sufA sufB sufB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
iscAFeS cluster assembly protein; Function experimentally demonstrated in the studied species; factor; Belongs to the HesB/IscA family. (107 aa)
hscBDnaJ-like molecular chaperone specific for IscU; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (171 aa)
sufCComponent of SufBCD complex, ATP-binding component of ABC superfamily; Function experimentally demonstrated in the studied species; transporter. (248 aa)
sufDComponent of SufBCD complex; Function experimentally demonstrated in the studied species; factor. (423 aa)
sufESulfur acceptor protein; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process; Belongs to the SufE family. (138 aa)
ydhDMonothiol glutaredoxin; Function experimentally demonstrated in the studied species; enzyme; Belongs to the glutaredoxin family. Monothiol subfamily. (115 aa)
bolARegulator of penicillin binding proteins and beta lactamase transcription (morphogene); Function experimentally demonstrated in the studied species; regulator; Belongs to the BolA/IbaG family. (105 aa)
yadRPutative chaperone involved in Fe-S cluster assembly and activation; Required for insertion of 4Fe-4S clusters for at least IspG. (114 aa)
hscADnaK-like molecular chaperone specific for IscU; Function experimentally demonstrated in the studied species; factor. (616 aa)
fprferredoxin-NADP reductase; Function experimentally demonstrated in the studied species; enzyme. (248 aa)
cyaYFrataxin, iron-binding and oxidizing protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. (106 aa)
gntYPutative gluconate transport associated protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (191 aa)
yrbAPutative DNA-binding transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator; Belongs to the BolA/IbaG family. (84 aa)
yfhJConserved hypothetical protein; Homologs of previously reported genes of unknown function; putative factor. (66 aa)
csdACysteine sulfinate desulfinase; Function experimentally demonstrated in the studied species; enzyme. (401 aa)
iscSCysteine desulfurase (tRNA sulfurtransferase), PLP-dependent; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate. (404 aa)
mrpAntiporter inner membrane protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (369 aa)
iscUScaffold protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (128 aa)
sufAFe-S cluster assembly protein; Function experimentally demonstrated in the studied species; factor; Belongs to the HesB/IscA family. (122 aa)
sufBComponent of SufBCD complex; Function of strongly homologous gene; putative transporter. (495 aa)
Your Current Organism:
Escherichia coli IAI1
NCBI taxonomy Id: 585034
Other names: E. coli IAI1, Escherichia coli str. IAI1, Escherichia coli strain IAI1
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