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| | mogA | Molybdochelatase MogA, involved in Moco biosynthesis; Function experimentally demonstrated in the studied species; factor. (195 aa) |
| | ribF | Bifunctional riboflavin kinase and FAD synthetase; Function experimentally demonstrated in the studied species; enzyme. (313 aa) |
| | carA | Carbamoyl phosphate synthetase small subunit, glutamine amidotransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the CarA family. (382 aa) |
| | carB | Carbamoyl-phosphate synthase large subunit; Function experimentally demonstrated in the studied species; enzyme; Belongs to the CarB family. (1073 aa) |
| | caiF | Transcriptional activator; Function experimentally demonstrated in the studied species; regulator. (131 aa) |
| | folA | Dihydrofolate reductase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the dihydrofolate reductase family. (159 aa) |
| | apaG | Protein associated with Co2+ and Mg2+ efflux; Function of strongly homologous gene; transporter. (125 aa) |
| | pdxA | 4-hydroxy-L-threonine phosphate dehydrogenase, NAD-dependent; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (329 aa) |
| | polB | DNA polymerase II; Function experimentally demonstrated in the studied species; enzyme. (783 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (206 aa) |
| | nadC | Quinolinate phosphoribosyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the NadC/ModD family. (297 aa) |
| | hpt | Hypoxanthine phosphoribosyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (178 aa) |
| | folK | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase; Function experimentally demonstrated in the studied species; enzyme. (159 aa) |
| | hemL | Glutamate-1-semialdehyde aminotransferase (aminomutase); Function experimentally demonstrated in the studied species; enzyme. (426 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa) |
| | dnaE | DNA polymerase III alpha subunit; Function experimentally demonstrated in the studied species; enzyme. (1160 aa) |
| | accA | acetyl-CoA carboxylase, carboxytransferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | gmhB | D,D-heptose 1,7-bisphosphate phosphatase; Function experimentally demonstrated in the studied species; enzyme. (190 aa) |
| | dkgB | 2,5-diketo-D-gluconate reductase B; Function experimentally demonstrated in the studied species; enzyme. (267 aa) |
| | dnaQ | DNA polymerase III epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (243 aa) |
| | dinB | DNA polymerase IV; Function experimentally demonstrated in the studied species; enzyme. (351 aa) |
| | gpt | Guanine-hypoxanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (152 aa) |
| | proB | Gamma-glutamate kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (367 aa) |
| | proA | Gamma-glutamylphosphate reductase; Function experimentally demonstrated in the studied species; enzyme. (417 aa) |
| | hemB | Porphobilinogen synthase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the ALAD family. (324 aa) |
| | proC | Pyrroline-5-carboxylate reductase, NAD(P)-binding; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (269 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (356 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (375 aa) |
| | ribD | Fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; Function experimentally demonstrated in the studied species; enzyme. (367 aa) |
| | ribE | Riboflavin synthase beta chain; Function experimentally demonstrated in the studied species; enzyme. (156 aa) |
| | nusB | Transcription antitermination protein; Function experimentally demonstrated in the studied species; factor. (139 aa) |
| | thiL | Thiamin-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (325 aa) |
| | dxs | 1-deoxyxylulose-5-phosphate synthase, thiamine-requiring, FAD-requiring; Function experimentally demonstrated in the studied species; enzyme. (620 aa) |
| | thiI | Sulfurtransferase required for thiamine and 4-thiouridine biosynthesis; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa) |
| | cyoE | Protoheme IX farnesyltransferase; Function experimentally demonstrated in the studied species; enzyme. (296 aa) |
| | bolA | Regulator of penicillin binding proteins and beta lactamase transcription (morphogene); Function experimentally demonstrated in the studied species; regulator; Belongs to the BolA/IbaG family. (105 aa) |
| | queC | Queuosine biosynthesis protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (231 aa) |
| | cof | Thiamin pyrimidine pyrophosphate hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P). Belongs to the HAD-like hydrolase superfamily. Cof family. (272 aa) |
| | priC | Primosomal replication protein N'; Function experimentally demonstrated in the studied species; factor. (175 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa) |
| | dnaX | DNA polymerase III/DNA elongation factor III, tau and gamma subunits; Function experimentally demonstrated in the studied species; enzyme. (643 aa) |
| | adk | Adenylate kinase; Function experimentally demonstrated in the studied species; enzyme. (214 aa) |
| | hemH | Ferrochelatase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the ferrochelatase family. (320 aa) |
| | gsk | Inosine/guanosine kinase; Function experimentally demonstrated in the studied species; enzyme. (434 aa) |
| | purK | N5-carboxyaminoimidazole ribonucleotide synthase; Function experimentally demonstrated in the studied species; enzyme. (355 aa) |
| | purE | N5-carboxyaminoimidazole ribonucleotide mutase; Function experimentally demonstrated in the studied species; enzyme. (169 aa) |
| | folD | 5,10-methylene-tetrahydrofolate dehydrogenase; Function experimentally demonstrated in the studied species; enzyme. (288 aa) |
| | entD | Phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Function experimentally demonstrated in the studied species; enzyme; Belongs to the P-Pant transferase superfamily. (209 aa) |
| | ybdZ | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (72 aa) |
| | entF | Enterobactin synthase multienzyme complex component, ATP-dependent; Function experimentally demonstrated in the studied species; enzyme. (1293 aa) |
| | entC | Isochorismate synthase 1; Function experimentally demonstrated in the studied species; enzyme. (391 aa) |
| | entE | 2,3-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex; Function experimentally demonstrated in the studied species; enzyme. (536 aa) |
| | entB | Isochorismatase; Function experimentally demonstrated in the studied species; enzyme. (285 aa) |
| | ybdB | Putative esterase; Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules. Belongs to the thioesterase PaaI family. (137 aa) |
| | uspG | Universal stress protein UP12; Function experimentally demonstrated in the studied species; factor. (142 aa) |
| | lipA | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa) |
| | phpB | Putative phosphatase with phosphoglycerate mutase domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the phosphoglycerate mutase family. (203 aa) |
| | nadD | Nicotinic acid mononucleotide adenylyltransferase, NAD(P)-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the NadD family. (213 aa) |
| | holA | DNA polymerase III, delta subunit; Function experimentally demonstrated in the studied species; enzyme. (343 aa) |
| | ybeX | Putative protein involved in divalent ion export; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (292 aa) |
| | nadA | Quinolinate synthase, subunit A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (347 aa) |
| | bioA | 7,8-diaminopelargonic acid synthase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme. (429 aa) |
| | bioB | Biotin synthase; Function experimentally demonstrated in the studied species; enzyme. (346 aa) |
| | bioF | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (384 aa) |
| | bioC | Putative methltransferase, enzyme of biotin synthesis; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (251 aa) |
| | bioD | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (225 aa) |
| | moaA | Molybdopterin biosynthesis protein A; Function experimentally demonstrated in the studied species; enzyme. (329 aa) |
| | moaB | Molybdopterin biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (170 aa) |
| | moaC | Molybdopterin biosynthesis, protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (161 aa) |
| | moaD | Molybdopterin synthase, small subunit; Function experimentally demonstrated in the studied species; enzyme. (81 aa) |
| | moaE | Molybdopterin synthase, large subunit; Function experimentally demonstrated in the studied species; enzyme. (150 aa) |
| | ybiA | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (160 aa) |
| | ybiB | Putative transferase/phosphorylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (320 aa) |
| | ybiV | Type II HAD phosphatase; Function experimentally demonstrated in the studied species; enzyme. (271 aa) |
| | moeB | Molybdopterin synthase sulfurylase; Function experimentally demonstrated in the studied species; enzyme. (249 aa) |
| | moeA | Molybdopterin biosynthesis protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (411 aa) |
| | ybjI | Putative phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (271 aa) |
| | ybjK | Putative DNA-binding transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (178 aa) |
| | grxA | Glutaredoxin 1, redox coenzyme for ribonucleotide reductase (RNR1a); Function experimentally demonstrated in the studied species; carrier. (85 aa) |
| | ybjS | Putative NAD(P)H-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (337 aa) |
| | serS | seryl-tRNA synthetase, also charges selenocysteinyl-tRNA with serine; Function experimentally demonstrated in the studied species; enzyme. (430 aa) |
| | ycaN | Putative DNA-binding transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator; Belongs to the LysR transcriptional regulatory family. (302 aa) |
| | serC | 3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa) |
| | cmk | Cytidylate kinase; Function experimentally demonstrated in the studied species; enzyme. (227 aa) |
| | kdsB | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (248 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (400 aa) |
| | pyrD | Dihydro-orotate oxidase, FMN-linked; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa) |
| | pyrC | Dihydro-orotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa) |
| | pabC | 4-amino-4-deoxychorismate lyase component of para-aminobenzoate synthase multienzyme complex; Function experimentally demonstrated in the studied species; enzyme. (269 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (213 aa) |
| | holB | DNA polymerase III, delta prime subunit; Function experimentally demonstrated in the studied species; enzyme. (334 aa) |
| | ycfN | Thiamin kinase; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). Belongs to the LpoB family. (274 aa) |
| | purB | Adenylosuccinate lyase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa) |
| | prsA | Phosphoribosylpyrophosphate synthase; Function experimentally demonstrated in the studied species; enzyme. (315 aa) |
| | hemA | Glutamyl tRNA reductase; Function experimentally demonstrated in the studied species; enzyme. (418 aa) |
| | purU | tRNA-Tyr; Gene remnant. (280 aa) |
| | tdk | Thymidine kinase/deoxyuridine kinase; Function experimentally demonstrated in the studied species; enzyme. (205 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa) |
| | trpC | Fused indole-3-glycerolphosphate synthetase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the TrpF family. (452 aa) |
| | trpD | Fused glutamine amidotransferase (component II) of anthranilate synthase; Function experimentally demonstrated in the studied species; enzyme. (531 aa) |
| | trpE | Component I of anthranilate synthase; Function experimentally demonstrated in the studied species; enzyme. (520 aa) |
| | btuR | cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (196 aa) |
| | ribA | GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. (196 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (245 aa) |
| | fabI | Enoyl-[acyl-carrier-protein] reductase, NADH-dependent; Function experimentally demonstrated in the studied species; enzyme. (262 aa) |
| | puuR | DNA-binding transcriptional repressor; Function experimentally demonstrated in the studied species; regulator. (185 aa) |
| | feaB | Phenylacetaldehyde dehydrogenase; Function experimentally demonstrated in the studied species; enzyme. (499 aa) |
| | paaX | DNA-binding transcriptional repressor of phenylacetic acid degradation, aryl-CoA responsive; Function experimentally demonstrated in the studied species; regulator. (316 aa) |
| | ydbC | Putative aldo/keto reductase, NAD(P)-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (286 aa) |
| | hipB | DNA-binding transcriptional regulator; Function experimentally demonstrated in the studied species; regulator. (88 aa) |
| | lsrR | DNA-binding transcriptional regulator; Function experimentally demonstrated in the studied species; regulator. (317 aa) |
| | ydeJ | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the CinA family. (172 aa) |
| | relB | Bifunctional antitoxin of the RelE-RelB toxin-antitoxin system and transcriptional repressor; Function experimentally demonstrated in the studied species; extrachromosomal origin. (79 aa) |
| | dicA | Putative transcriptional regulator for DicB; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (135 aa) |
| | ynfK | Putative synthase (similar to dethiobiotin synthetase); Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (231 aa) |
| | dgsA | DNA-binding transcriptional repressor; Function experimentally demonstrated in the studied species; regulator. (406 aa) |
| | manA | Mannose-6-phosphate isomerase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the mannose-6-phosphate isomerase type 1 family. (391 aa) |
| | uidR | DNA-binding transcriptional repressor; Function experimentally demonstrated in the studied species; regulator. (196 aa) |
| | add | Adenosine deaminase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (333 aa) |
| | pdxY | Pyridoxal kinase 2/pyridoxine kinase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the pyridoxine kinase family. (287 aa) |
| | pdxH | Pyridoxine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (218 aa) |
| | purR | DNA-binding transcriptional repressor, hypoxanthine-binding; Function experimentally demonstrated in the studied species; regulator. (341 aa) |
| | ribC | Riboflavin synthase, alpha subunit; Function experimentally demonstrated in the studied species; enzyme. (213 aa) |
| | nadE | NAD synthetase, NH3/glutamine-dependent; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (275 aa) |
| | pncA | Nicotinamidase/pyrazinamidase; Function experimentally demonstrated in the studied species; enzyme. (213 aa) |
| | pabB | Aminodeoxychorismate synthase, subunit I; Function experimentally demonstrated in the studied species; enzyme. (453 aa) |
| | holE | DNA polymerase III, theta subunit; Function experimentally demonstrated in the studied species; enzyme. (76 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. Belongs to the PurK/PurT family. (392 aa) |
| | nudB | dATP pyrophosphohydrolase; Function experimentally demonstrated in the studied species; enzyme. (150 aa) |
| | fliA | RNA polymerase, sigma 28 (sigma F) factor; Function experimentally demonstrated in the studied species; factor. (239 aa) |
| | fliI | Flagellum-specific ATP synthase; Function experimentally demonstrated in the studied species; enzyme. (457 aa) |
| | amn | AMP nucleosidase; Function experimentally demonstrated in the studied species; enzyme. (484 aa) |
| | cobT | Nicotinate-nucleotide dimethylbenzimidazole-P phophoribosyl transferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). Belongs to the CobT family. (359 aa) |
| | cobS | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (247 aa) |
| | cobU | Bifunctional cobinamide kinase and cobinamide phosphate guanylyltransferase; Function experimentally demonstrated in the studied species; enzyme. (181 aa) |
| | cpsG | Phosphomannomutase (PMM); Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O9 antigen; Belongs to the phosphohexose mutase family. (468 aa) |
| | cpsB | Mannose-1-phosphate guanylyltransferase (GDP); Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O9 antigen. (471 aa) |
| | ugd | UDP-glucose 6-dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (388 aa) |
| | cpsG-2 | Phosphomannomutase; Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O7 antigen. (456 aa) |
| | cpsB-2 | Mannose-1-phosphate guanyltransferase; Function experimentally demonstrated in the studied species; enzyme. (478 aa) |
| | fcl | GDP-L-fucose synthase; Function experimentally demonstrated in the studied species; enzyme. (321 aa) |
| | gmd | GDP-D-mannose dehydratase, NAD(P)-binding; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (373 aa) |
| | dcd | 2'-deoxycytidine 5'-triphosphate deaminase; Function experimentally demonstrated in the studied species; enzyme. (193 aa) |
| | udk | Uridine/cytidine kinase; Function experimentally demonstrated in the studied species; enzyme. (213 aa) |
| | thiD | Bifunctional hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase; Function experimentally demonstrated in the studied species; enzyme. (266 aa) |
| | thiM | Hydoxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ). Belongs to the Thz kinase family. (262 aa) |
| | folE | GTP cyclohydrolase I; Function experimentally demonstrated in the studied species; enzyme. (222 aa) |
| | napA | Nitrate reductase, periplasmic, large subunit; Function experimentally demonstrated in the studied species; enzyme. (828 aa) |
| | nrdB | Ribonucleoside diphosphate reductase 1, beta subunit, ferritin-like; Function experimentally demonstrated in the studied species; carrier. (376 aa) |
| | yfaY | Fragment of putative 2,4-dihydroxyhept-2-ene-1, 7-dioic acid-like aldolase (partial); Gene remnant; putative enzyme; Belongs to the CinA family. (400 aa) |
| | elaA | Putative acyltransferase with acyl-CoA N-acyltransferase domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (153 aa) |
| | yfbR | Deoxyribonucleoside 5'-monophosphatase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (199 aa) |
| | ackA | Acetate kinase A and propionate kinase 2; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | pta | Phosphate acetyltransferase; Function experimentally demonstrated in the studied species; enzyme. (714 aa) |
| | purF | Amidophosphoribosyltransferase; Function experimentally demonstrated in the studied species; enzyme. (505 aa) |
| | folC | Bifunctional folylpolyglutamate synthase and dihydrofolate synthase; Function experimentally demonstrated in the studied species; enzyme. (422 aa) |
| | accD | acetyl-CoA carboxylase, beta (carboxyltranferase) subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. Belongs to the AccD/PCCB family. (304 aa) |
| | pdxB | Erythronate-4-phosphate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (378 aa) |
| | ypeB | Conserved hypothetical protein; Doubtful CDS. (105 aa) |
| | pdxK | Pyridoxal-pyridoxamine kinase/hydroxymethylpyrimidine kinase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the pyridoxine kinase family. (283 aa) |
| | hemF | Coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (299 aa) |
| | eutT | Putative cobalamin adenosyltransferase in ethanolamine utilization; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (267 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthetase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the SAICAR synthetase family. (237 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa) |
| | purM | Phosphoribosylaminoimidazole synthetase; Function experimentally demonstrated in the studied species; enzyme. (345 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase 1; Function experimentally demonstrated in the studied species; enzyme. (212 aa) |
| | guaA | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. (525 aa) |
| | guaB | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa) |
| | purL | Phosphoribosylformyl-glycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1295 aa) |
| | CAQ99502.1 | Putative DNA polymerase from bacteriophage origin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (687 aa) |
| | pdxJ | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (243 aa) |
| | rpoE | RNA polymerase, sigma 24 (sigma E) factor; Function experimentally demonstrated in the studied species; factor; Belongs to the sigma-70 factor family. ECF subfamily. (191 aa) |
| | nadB | Quinolinate synthase, L-aspartate oxidase (B protein) subunit; Function experimentally demonstrated in the studied species; enzyme. (540 aa) |
| | yfjB | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (292 aa) |
| | nrdF | Ribonucleoside-diphosphate reductase 2, beta subunit, ferritin-like; Function experimentally demonstrated in the studied species; carrier. (319 aa) |
| | ygaD | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the CinA family. (165 aa) |
| | ygbA | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (117 aa) |
| | ygcM | 6-pyruvoyl tetrahydrobiopterin synthase (PTPS); Function experimentally demonstrated in the studied species; enzyme. (121 aa) |
| | ygcF | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (223 aa) |
| | pyrG | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | relA | (p)ppGpp synthetase I/GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (744 aa) |
| | queF | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (282 aa) |
| | thyA | Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | xdhA | Xanthine dehydrogenase, molybdenum binding subunit; Function experimentally demonstrated in the studied species; enzyme. (752 aa) |
| | xdhB | Xanthine dehydrogenase, FAD-binding subunit; Function experimentally demonstrated in the studied species; enzyme. (292 aa) |
| | xdhC | Xanthine dehydrogenase, Fe-S binding subunit; Function experimentally demonstrated in the studied species; carrier. (159 aa) |
| | ygfJ | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (192 aa) |
| | xdhD | Fused putative xanthine/hypoxanthine oxidase: molybdopterin-binding subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (956 aa) |
| | epd | D-erythrose 4-phosphate dehydrogenase; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. (339 aa) |
| | selA_2 | Putative transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (369 aa) |
| | yqgE | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. (187 aa) |
| | yggW | Putative oxidoreductase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (378 aa) |
| | glcG | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (134 aa) |
| | ECIAI1_3125 | Fragment of Putative AMP-dependent synthetase (part 1); Gene remnant; putative enzyme. (374 aa) |
| | yghR | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (252 aa) |
| | yghS | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (237 aa) |
| | yghT | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (230 aa) |
| | dkgA | 2,5-diketo-D-gluconate reductase A; Function experimentally demonstrated in the studied species; enzyme. (275 aa) |
| | ribB | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Function experimentally demonstrated in the studied species; enzyme. (217 aa) |
| | rfaE | Fused heptose 7-phosphate kinase; Function experimentally demonstrated in the studied species; enzyme. (477 aa) |
| | folB | Bifunctioal dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (122 aa) |
| | dnaG | DNA primase; Function experimentally demonstrated in the studied species; enzyme. (581 aa) |
| | rpoD | RNA polymerase, sigma 70 (sigma D) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (613 aa) |
| | nusA | Transcription termination/antitermination L factor; Participates in both transcription termination and antitermination. (495 aa) |
| | folP | 7,8-dihydropteroate synthase; Function experimentally demonstrated in the studied species; enzyme. (282 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa) |
| | rpoN | RNA polymerase, sigma 54 (sigma N) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (477 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase subunit; Function experimentally demonstrated in the studied species; enzyme. (449 aa) |
| | zntR | DNA-binding transcriptional activator in response to Zn(II); Function experimentally demonstrated in the studied species; regulator. (141 aa) |
| | rpoA | RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (329 aa) |
| | cysG | Fused siroheme synthase 1, 3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (457 aa) |
| | bioH | Carboxylesterase of pimeloyl-CoA synthesis; Function experimentally demonstrated in the studied species; enzyme. (256 aa) |
| | rpoH | RNA polymerase, sigma 32 (sigma H) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (284 aa) |
| | yhhQ | Conserved hypothetical protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (221 aa) |
| | sgbH | 3-keto-L-gulonate 6-phosphate decarboxylase; Function experimentally demonstrated in the studied species; enzyme. (220 aa) |
| | selA | Selenocysteine synthase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis; Belongs to the SelA family. (463 aa) |
| | yibT | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (69 aa) |
| | grxC | Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. (83 aa) |
| | waaD | ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding; Function experimentally demonstrated in the studied species; enzyme. (310 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa) |
| | dfp | Fused 4'-phosphopantothenoylcysteine decarboxylase; Function experimentally demonstrated in the studied species; enzyme. (406 aa) |
| | dut | Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (151 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa) |
| | gmk | Guanylate kinase; Function experimentally demonstrated in the studied species; enzyme. (207 aa) |
| | rpoZ | RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (91 aa) |
| | spoT | Bifunctional (p)ppGpp synthetase II and guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Function experimentally demonstrated in the studied species; enzyme. (702 aa) |
| | dnaN | DNA polymerase III, beta subunit; Function experimentally demonstrated in the studied species; enzyme. (366 aa) |
| | glmU | Fused N-acetyl glucosamine-1-phosphate uridyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (456 aa) |
| | atpC | F1 sector of membrane-bound ATP synthase, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (139 aa) |
| | atpD | F1 sector of membrane-bound ATP synthase, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (460 aa) |
| | atpG | F1 sector of membrane-bound ATP synthase, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (287 aa) |
| | atpA | F1 sector of membrane-bound ATP synthase, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (513 aa) |
| | atpH | F1 sector of membrane-bound ATP synthase, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (177 aa) |
| | atpF | F0 sector of membrane-bound ATP synthase, subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa) |
| | atpE | F0 sector of membrane-bound ATP synthase, subunit c; Function experimentally demonstrated in the studied species; enzyme. (79 aa) |
| | atpB | F0 sector of membrane-bound ATP synthase, subunit a; Function experimentally demonstrated in the studied species; enzyme. (271 aa) |
| | gpp | Guanosine pentaphosphatase/exopolyphosphatase; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. (494 aa) |
| | rho | Transcription termination factor; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (419 aa) |
| | hemY | RyiA; Gene remnant; enzyme. (398 aa) |
| | hemD | Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (246 aa) |
| | hemC | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (313 aa) |
| | cyaA | Adenylate cyclase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the adenylyl cyclase class-1 family. (848 aa) |
| | yigB | Putative hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (238 aa) |
| | yigL | Putative hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (266 aa) |
| | udp | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (253 aa) |
| | hemG | Protoporphyrin oxidase, flavoprotein; Function experimentally demonstrated in the studied species; carrier. (181 aa) |
| | mobB | Molybdopterin-guanine dinucleotide biosynthesis protein B; Function experimentally demonstrated in the studied species; putative factor. (170 aa) |
| | mobA | Molybdopterin-guanine dinucleotide synthase; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (194 aa) |
| | polA | Fused DNA polymerase I 5'->3' exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (928 aa) |
| | hemN | Coproporphyrinogen III oxidase, SAM and NAD(P)H dependent, oxygen-independent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (457 aa) |
| | yiiD | Putative acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (329 aa) |
| | fdhD | Formate dehydrogenase formation protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (277 aa) |
| | priA | Primosome factor n' (replication factor Y); Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (732 aa) |
| | coaA | Pantothenate kinase; Function experimentally demonstrated in the studied species; enzyme. (316 aa) |
| | nusG | Transcription termination factor; Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination; Belongs [...] (181 aa) |
| | rpoB | RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1342 aa) |
| | rpoC | RNA polymerase, beta prime subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1407 aa) |
| | thiH | Thiamin biosynthesis ThiGH complex subunit; Function experimentally demonstrated in the studied species; enzyme. (377 aa) |
| | thiG | Thiamin biosynthesis ThiGH complex subunit; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa) |
| | thiS | Sulphur carrier protein; Function experimentally demonstrated in the studied species; carrier. (66 aa) |
| | thiF | Thiamin (thiazole moiety) biosynthesis protein; Function experimentally demonstrated in the studied species; enzyme. (251 aa) |
| | thiE | Thiamin phosphate synthase (thiamin phosphate pyrophosphorylase); Function experimentally demonstrated in the studied species; enzyme. (211 aa) |
| | thiC | Thiamin (pyrimidine moiety) biosynthesis protein; Function experimentally demonstrated in the studied species; enzyme. (631 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the uroporphyrinogen decarboxylase family. (354 aa) |
| | purD | Phosphoribosylglycinamide synthetase phosphoribosylamine-glycine ligase; Function experimentally demonstrated in the studied species; enzyme. (429 aa) |
| | purH | Fused IMP cyclohydrolase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the PurH family. (529 aa) |
| | dnaB | Replicative DNA helicase; Function experimentally demonstrated in the studied species; enzyme. (471 aa) |
| | acs | acetyl-CoA synthetase; Function experimentally demonstrated in the studied species; enzyme. (652 aa) |
| | phnB | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; 9650256, 2155230. (147 aa) |
| | yjeS | Putative Fe-S electron transport protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (379 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa) |
| | ulaD | 3-keto-L-gulonate 6-phosphate decarboxylase; Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization. Belongs to the HPS/KGPDC family. KGPDC subfamily. (216 aa) |
| | priB | Primosomal protein N; Function experimentally demonstrated in the studied species; factor. (104 aa) |
| | nrdG | Anaerobic ribonucleotide reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (154 aa) |
| | pyrI | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (153 aa) |
| | pyrB | Aspartate carbamoyltransferase, catalytic subunit; Function experimentally demonstrated in the studied species; enzyme. (311 aa) |
| | holC | DNA polymerase III, chi subunit; Function experimentally demonstrated in the studied species; enzyme. (147 aa) |
| | dnaC | DNA biosynthesis protein; Function experimentally demonstrated in the studied species; cell process. (245 aa) |
| | dnaT | DNA biosynthesis protein (primosomal protein I); Function experimentally demonstrated in the studied species; factor. (179 aa) |
| | holD | DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. (137 aa) |
| | nadR | Bifunctional DNA-binding transcriptional repressor and NMN adenylyltransferase; Function experimentally demonstrated in the studied species; regulator. (410 aa) |
| | pyrL | pyrBI operon leader peptide; Function experimentally demonstrated in the studied genus; leader peptide. (44 aa) |
