STRINGSTRING
ispG ispG ispH ispH aceE aceE aceF aceF lpd lpd panD panD panC panC panB panB dxr dxr fabZ fabZ accA accA gloB gloB fadE fadE ykgF ykgF ykgG ykgG yahK yahK prpR prpR prpB prpB prpD prpD prpE prpE mhpA mhpA mhpB mhpB mhpC mhpC mhpD mhpD mhpF mhpF mhpE mhpE yaiS yaiS acpH acpH panE panE ybaW ybaW gcl gcl hyi hyi glxR glxR lipA lipA gpmA gpmA ybhH ybhH bioA bioA bioB bioB bioF bioF bioC bioC bioD bioD poxB poxB ycbL ycbL fabA fabA plsX plsX hyfF hyfF hyfE hyfE hyfC hyfC yfeU yfeU glk glk yfcY yfcY yfcX yfcX fabB fabB accD accD dld dld fbaB fbaB gnd gnd pykA pykA edd edd fadD fadD gapA gapA pps pps ydiD ydiD ydiO ydiO aroD aroD ydiJ ydiJ pykF pykF ydhX ydhX cfa cfa gloA gloA anmK anmK hdhA hdhA ynfK ynfK ydfG ydfG yneI yneI uxaB uxaB lsrF lsrF scoA scoA CAQ98345.1 CAQ98345.1 sfcA sfcA fdnH fdnH aldA aldA paaY paaY paaX paaX paaK paaK paaE paaE paaI paaI paaH paaH paaG paaG paaF paaF paaJ paaJ paaD paaD paaC paaC paaB paaB paaA paaA maoC maoC puuE puuE fabI fabI yciA yciA ispE ispE fadR fadR ycgM ycgM icd icd fabF fabF acpP acpP fabH fabH fabG fabG fabD fabD ytjC ytjC yjjN yjjN hpaG hpaG hpaE hpaE hpaI hpaI hpaB hpaB uxuA uxuA gntP gntP yjgB yjgB yjeK yjeK fdhF fdhF nrfC nrfC acs acs ubiC ubiC pgi pgi aceK aceK aceA aceA aceB aceB fabR fabR tpiA tpiA pfkA pfkA fdoH fdoH yiiD yiiD fadB fadB fadA fadA dgoK dgoK dgoA dgoA dgoD dgoD yidR yidR dfp dfp gpmI gpmI lldD lldD tiaE tiaE yhhK yhhK gntU gntU bioH bioH gph gph yheT yheT slyX slyX aroE aroE accC accC accB accB yhbO yhbO garR garR tdcA tdcA tdcB tdcB tdcD tdcD tdcF tdcF yhaM yhaM uxaC uxaC uxaA uxaA fadH fadH hybB hybB CAQ99941.1 CAQ99941.1 glcD glcD glcE glcE glcF glcF glcB glcB pgk pgk fbaA fbaA ygfH ygfH ygfG ygfG yliK yliK kduD kduD aas aas eno eno ygcU ygcU ispD ispD ispF ispF ygbM ygbM hycB hycB hycD hycD hycF hycF gabT gabT gabD gabD acpS acpS hcaB hcaB hcaC hcaC hcaF hcaF hcaE hcaE
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Known Interactions
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experimentally determined
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gene neighborhood
gene fusions
gene co-occurrence
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co-expression
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ispG1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Function experimentally demonstrated in the studied species; enzyme. (372 aa)
ispH1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. (316 aa)
aceEPyruvate dehydrogenase, decarboxylase component E1, thiamin-binding; Function experimentally demonstrated in the studied species; enzyme. (887 aa)
aceFPyruvate dehydrogenase, dihydrolipoyltransacetylase component E2; Function experimentally demonstrated in the studied species; enzyme. (630 aa)
lpdLipoamide dehydrogenase, E3 component is part of three enzyme complexes; Function experimentally demonstrated in the studied species; enzyme. (474 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine; Belongs to the PanD family. (126 aa)
panCPantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (283 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (264 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Function experimentally demonstrated in the studied species; enzyme. (398 aa)
fabZ(3R)-hydroxymyristol acyl carrier protein dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (151 aa)
accAacetyl-CoA carboxylase, carboxytransferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa)
gloBPutative hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. (251 aa)
fadEAcyl coenzyme A dehydrogenase; Function experimentally demonstrated in the studied species; enzyme. (814 aa)
ykgFPutative oxidoreductase subunit with NAD(P)-binding domain and ferridoxin-like domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (475 aa)
ykgGConserved hypothetical protein; Homologs of previously reported genes of unknown function. (231 aa)
yahKPutative oxidoreductase, Zn-dependent and NAD(P)-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (349 aa)
prpRDNA-binding transcriptional activator; Function experimentally demonstrated in the studied species; regulator. (528 aa)
prpB2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (296 aa)
prpD2-methylcitrate dehydratase; Function experimentally demonstrated in the studied species; enzyme. (483 aa)
prpEpropionyl-CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; putative enzyme. (628 aa)
mhpA3-(3-hydroxyphenyl)propionate hydroxylase; Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3-hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI). (554 aa)
mhpB2,3-dihydroxyphenylpropionate 1,2-dioxygenase; Function experimentally demonstrated in the studied species; enzyme. (314 aa)
mhpC2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase; Function experimentally demonstrated in the studied species; enzyme. (293 aa)
mhpD2-keto-4-pentenoate hydratase; Function experimentally demonstrated in the studied species; enzyme. (269 aa)
mhpFacetaldehyde-CoA dehydrogenase II, NAD-binding; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (316 aa)
mhpE4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase, class I; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (337 aa)
yaiSConserved hypothetical protein; Homologs of previously reported genes of unknown function. (223 aa)
acpHAcyl carrier protein phosphodiesterase; Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; Belongs to the AcpH family. (193 aa)
panE2-dehydropantoate reductase, NADPH-specific; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (303 aa)
ybaWConserved hypothetical protein; Homologs of previously reported genes of unknown function. (132 aa)
gclGlyoxylate carboligase; Function experimentally demonstrated in the studied species; enzyme. (593 aa)
hyiHydroxypyruvate isomerase; Function experimentally demonstrated in the studied species; enzyme. (258 aa)
glxRTartronate semialdehyde reductase, NADH-dependent; Function experimentally demonstrated in the studied species; enzyme. (292 aa)
lipALipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa)
gpmAFunction experimentally demonstrated in the studied species; enzyme. (250 aa)
ybhHConserved hypothetical protein; Homologs of previously reported genes of unknown function. (350 aa)
bioA7,8-diaminopelargonic acid synthase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme. (429 aa)
bioBBiotin synthase; Function experimentally demonstrated in the studied species; enzyme. (346 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (384 aa)
bioCPutative methltransferase, enzyme of biotin synthesis; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (251 aa)
bioDDethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (225 aa)
poxBPyruvate dehydrogenase (pyruvate oxidase), thiamin-dependent, FAD-binding; Function experimentally demonstrated in the studied species; enzyme; Belongs to the TPP enzyme family. (572 aa)
ycbLPutative metal-binding hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (215 aa)
fabABeta-hydroxydecanoyl thioester dehydrase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (172 aa)
plsXFatty acid/phospholipid synthesis protein; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (356 aa)
hyfFHydrogenase 4, membrane subunit; Function experimentally demonstrated in the studied species; membrane component. (526 aa)
hyfEHydrogenase 4, membrane subunit; Function experimentally demonstrated in the studied species; membrane component. (216 aa)
hyfCHydrogenase 4, membrane subunit; Function experimentally demonstrated in the studied species; membrane component. (322 aa)
yfeUPutative PTS component; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate; Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily. (298 aa)
glkGlucokinase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the bacterial glucokinase family. (321 aa)
yfcYbeta-ketoacyl-CoA thiolase, anaerobic, subunit; Function experimentally demonstrated in the studied species; enzyme. (436 aa)
yfcXFused enoyl-CoA hydratase and epimerase and isomerase; Function experimentally demonstrated in the studied species; enzyme. (714 aa)
fabB3-oxoacyl-[acyl-carrier-protein] synthase I; Function experimentally demonstrated in the studied species; enzyme; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (406 aa)
accDacetyl-CoA carboxylase, beta (carboxyltranferase) subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. Belongs to the AccD/PCCB family. (304 aa)
dldD-lactate dehydrogenase, FAD-binding, NADH independent; Function experimentally demonstrated in the studied species; enzyme. (571 aa)
fbaBFructose-bisphosphate aldolase class I; Function experimentally demonstrated in the studied species; enzyme. (350 aa)
gndGluconate-6-phosphate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa)
pykAPyruvate kinase II; Function experimentally demonstrated in the studied species; enzyme; Belongs to the pyruvate kinase family. (480 aa)
edd6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (603 aa)
fadDacyl-CoA synthetase (long-chain-fatty-acid--CoA ligase); Function experimentally demonstrated in the studied species; enzyme. (561 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase A; Function experimentally demonstrated in the studied species; enzyme. (331 aa)
ppsPhosphoenolpyruvate synthase; Function experimentally demonstrated in the studied species; enzyme. (792 aa)
ydiDShort chain acyl-CoA synthetase, anaerobic; Function experimentally demonstrated in the studied species; enzyme. (566 aa)
ydiOPutative acyl-CoA dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (383 aa)
aroD3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (252 aa)
ydiJPutative conserved FAD-linked oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (1018 aa)
pykFPyruvate kinase I; Function experimentally demonstrated in the studied species; enzyme; Belongs to the pyruvate kinase family. (470 aa)
ydhXPutative 4Fe-4S ferridoxin-type subunit of oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (222 aa)
cfaCyclopropane fatty acyl phospholipid synthase (unsaturated-phospholipid methyltransferase); Function experimentally demonstrated in the studied species; enzyme. (382 aa)
gloAGlyoxalase I, Ni-dependent; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (135 aa)
anmKanhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (369 aa)
hdhA7-alpha-hydroxysteroid dehydrogenase, NAD-dependent; Function experimentally demonstrated in the studied species; enzyme. (255 aa)
ynfKPutative synthase (similar to dethiobiotin synthetase); Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (231 aa)
ydfGL-allo-threonine dehydrogenase, NAD(P)-binding; Function experimentally demonstrated in the studied species; enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa)
yneIPutative aldehyde dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (462 aa)
uxaBAltronate oxidoreductase, NAD-dependent; Function experimentally demonstrated in the studied species; enzyme. (483 aa)
lsrFPutative aldolase; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5- phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA; Belongs to the DeoC/FbaB aldolase family. (291 aa)
scoAsuccinyl-CoA:3-ketoacid-coenzyme A transferase subunit A; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (235 aa)
CAQ98345.1Putative 3-hydroxyacyl-CoA dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (307 aa)
sfcAMalate dehydrogenase, (decarboxylating, NAD-requiring) (malic enzyme); Function experimentally demonstrated in the studied species; enzyme. (565 aa)
fdnHFormate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (294 aa)
aldAAldehyde dehydrogenase A, NAD-linked; Function experimentally demonstrated in the studied species; enzyme. (479 aa)
paaYPutative hexapeptide repeat acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (196 aa)
paaXDNA-binding transcriptional repressor of phenylacetic acid degradation, aryl-CoA responsive; Function experimentally demonstrated in the studied species; regulator. (316 aa)
paaKphenylacetyl-CoA ligase; Function experimentally demonstrated in the studied species; enzyme. (437 aa)
paaEBeta-ketoadipyl CoA thiolase; Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA. (401 aa)
paaIPhenylacetate pathway hotdog-fold thioesterase; Function experimentally demonstrated in the studied species; enzyme. (140 aa)
paaH3-hydroxybutyryl-CoA dehydrogenase; Function experimentally demonstrated in the studied species; enzyme. (475 aa)
paaGacyl-CoA hydratase; Function experimentally demonstrated in the studied species; enzyme. (262 aa)
paaFenoyl-CoA hydratase-isomerase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the enoyl-CoA hydratase/isomerase family. (255 aa)
paaJSubunit of the phenylacetly-CoA oxygenase/reductase; Function experimentally demonstrated in the studied species; enzyme. (356 aa)
paaDPutative multicomponent oxygenase/reductase subunit for phenylacetic acid degradation; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (165 aa)
paaCPutative multicomponent oxygenase/reductase subunit for phenylacetic acid degradation; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (248 aa)
paaBPutative multicomponent oxygenase/reductase subunit for phenylacetic acid degradation; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (95 aa)
paaAPutative multicomponent oxygenase/reductase subunit for phenylacetic acid degradation; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (309 aa)
maoCFused aldehyde dehydrogenase; Function experimentally demonstrated in the studied species; enzyme. (681 aa)
puuEGABA aminotransferase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (421 aa)
fabIEnoyl-[acyl-carrier-protein] reductase, NADH-dependent; Function experimentally demonstrated in the studied species; enzyme. (262 aa)
yciAPutative hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (132 aa)
ispE4-diphosphocytidyl-2-C-methylerythritol kinase; Function experimentally demonstrated in the studied species; enzyme. (283 aa)
fadRDNA-binding transcriptional dual regulator of fatty acid metabolism; Multifunctional regulator of fatty acid metabolism. (239 aa)
ycgMPutative isomerase/hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (219 aa)
icdIsocitrate dehydrogenase, specific for NADP+; Function experimentally demonstrated in the studied species; extrachromosomal origin. (416 aa)
fabF3-oxoacyl-[acyl-carrier-protein] synthase II; Function experimentally demonstrated in the studied species; enzyme; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (413 aa)
acpPAcyl carrier protein (ACP); Function experimentally demonstrated in the studied species; carrier. (78 aa)
fabH3-oxoacyl-[acyl-carrier-protein] synthase III; Function experimentally demonstrated in the studied species; enzyme. (317 aa)
fabG3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa)
fabDmalonyl-CoA-[acyl-carrier-protein] transacylase; Function experimentally demonstrated in the studied species; enzyme. (309 aa)
ytjCPhosphoglyceromutase 2, co-factor independent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (215 aa)
yjjNPutative oxidoreductase, Zn-dependent and NAD(P)-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (340 aa)
hpaG4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Decarboxylates OPET (5-oxo-pent-3-ene-1,2,5-tricarboxylic acid) into HHDD (2-hydroxy-hept-2,4-diene-1,7-dioate) and isomerizes it to OHED (2-oxo-hept-3-ene-1,7-dioate). (431 aa)
hpaE5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Transforms 5-carboxymethyl-2-hydroxy-muconic semialdehyde (CHMS) into 5-carboxymethyl-2-hydroxy-muconic acid (CHM); Belongs to the aldehyde dehydrogenase family. (488 aa)
hpaI2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2- ketoheptane-1,7-dioate (HKHD) to pyruvate and succinate semialdehyde. Is also able to catalyze the aldol cleavage of 4-hydroxy-2- ketopentanoate and 4-hydroxy-2-ketohexanoate. Is not stereospecific since it can cleave both substrate enantiomers. Also exhibits significant oxaloacetate decarboxylase activity in vitro. In the reverse direction, is able to condense a range of aldehyde acceptors (from two to five carbons in length) with pyruvate or 2-oxobutanoate. Unlike with BphI [...] (309 aa)
hpaB4-hydroxyphenylacetate 3-monooxygenase large component; Utilizes FADH(2) supplied by HpaC or by another flavin reductase, to catalyze the hydroxylation of 4-hydroxyphenylacetic acid, leading to the production of 3,4-DHPA. Can also oxidize phenol to catechol, and hydroxylate other phenol derivatives. Belongs to the FADH(2)-utilizing monooxygenase family. (520 aa)
uxuAMannonate hydrolase; Catalyzes the dehydration of D-mannonate. (394 aa)
gntPFructuronate transporter; Function experimentally demonstrated in the studied species; transporter. (447 aa)
yjgBPutative alcohol dehydrogenase, Zn-dependent and NAD(P)-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (339 aa)
yjeKPutative lysine aminomutase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (342 aa)
fdhFFormate dehydrogenase-H, selenopolypeptide subunit; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (715 aa)
nrfCFormate-dependent nitrite reductase, 4Fe4S subunit; Function experimentally demonstrated in the studied species; carrier. (223 aa)
acsacetyl-CoA synthetase; Function experimentally demonstrated in the studied species; enzyme. (652 aa)
ubiCChorismate pyruvate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (165 aa)
pgiGlucosephosphate isomerase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the GPI family. (549 aa)
aceKIsocitrate dehydrogenase kinase/phosphatase; Function experimentally demonstrated in the studied species; enzyme. (578 aa)
aceAIsocitrate lyase; Function experimentally demonstrated in the studied species; enzyme. (434 aa)
aceBMalate synthase A; Function experimentally demonstrated in the studied species; enzyme; Belongs to the malate synthase family. (533 aa)
fabRDNA-binding transcriptional repressor; Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. (234 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa)
pfkA6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa)
fdoHFormate dehydrogenase-O, Fe-S subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (300 aa)
yiiDPutative acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (329 aa)
fadBFatty acid oxidation complex subunit alpha; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (729 aa)
fadA3-ketoacyl-CoA thiolase (thiolase I); Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (387 aa)
dgoK2-oxo-3-deoxygalactonate kinase; Function experimentally demonstrated in the studied species; enzyme. (292 aa)
dgoA2-oxo-3-deoxygalactonate 6-phosphate aldolase; Function experimentally demonstrated in the studied species; enzyme. (205 aa)
dgoDGalactonate dehydratase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (382 aa)
yidRConserved hypothetical protein; Homologs of previously reported genes of unknown function. (404 aa)
dfpFused 4'-phosphopantothenoylcysteine decarboxylase; Function experimentally demonstrated in the studied species; enzyme. (406 aa)
gpmIPhosphoglycero mutase III, cofactor-independent; Function experimentally demonstrated in the studied species; enzyme. (514 aa)
lldDL-lactate dehydrogenase, FMN-linked; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. (396 aa)
tiaE2-oxo-carboxylic acid reductase (glyoxalate reductase) (2-ketoaldonate reductase); Function experimentally demonstrated in the studied species; enzyme. (324 aa)
yhhKConserved hypothetical protein; Homologs of previously reported genes of unknown function. (127 aa)
gntUGluconate transporter, low affinity GNT 1 system; Function experimentally demonstrated in the studied species; transporter. (446 aa)
bioHCarboxylesterase of pimeloyl-CoA synthesis; Function experimentally demonstrated in the studied species; enzyme. (256 aa)
gphPhosphoglycolate phosphatase; Function experimentally demonstrated in the studied species; enzyme. (252 aa)
yheTPutative hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (340 aa)
slyXConserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the SlyX family. (72 aa)
aroEDehydroshikimate reductase, NAD(P)-binding; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa)
accCacetyl-CoA carboxylase, biotin carboxylase subunit; Function experimentally demonstrated in the studied species; enzyme. (449 aa)
accBAcetyl CoA carboxylase, BCCP subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (156 aa)
yhbOPutative intracellular protease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (172 aa)
garRTartronate semialdehyde reductase; Function experimentally demonstrated in the studied species; enzyme. (296 aa)
tdcADNA-binding transcriptional activator; Function experimentally demonstrated in the studied species; regulator; Belongs to the LysR transcriptional regulatory family. (312 aa)
tdcBCatabolic threonine dehydratase, PLP-dependent; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (329 aa)
tdcDPropionate kinase/acetate kinase C, anaerobic; Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. (406 aa)
tdcFL-PSP (mRNA) endoribonuclease; Function of strongly homologous gene; enzyme. (129 aa)
yhaMConserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0597 family. (436 aa)
uxaCUronate isomerase; Function experimentally demonstrated in the studied species; enzyme. (470 aa)
uxaAAltronate hydrolase; Function experimentally demonstrated in the studied species; enzyme. (495 aa)
fadH2,4-dienoyl-CoA reductase, NADH and FMN-linked; Function experimentally demonstrated in the studied species; enzyme. (672 aa)
hybBFunction of strongly homologous gene; carrier. (392 aa)
CAQ99941.1Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (82 aa)
glcDGlycolate oxidase subunit, FAD-linked; Function experimentally demonstrated in the studied species; enzyme. (499 aa)
glcEGlycolate oxidase FAD binding subunit; Function experimentally demonstrated in the studied species; enzyme. (350 aa)
glcFGlycolate oxidase iron-sulfur subunit; Function experimentally demonstrated in the studied species; carrier. (407 aa)
glcBMalate synthase G; Function experimentally demonstrated in the studied species; enzyme. (723 aa)
pgkPhosphoglycerate kinase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the phosphoglycerate kinase family. (387 aa)
fbaAFructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa)
ygfHpropionyl-CoA:succinate-CoA transferase; Function experimentally demonstrated in the studied species; enzyme. (492 aa)
ygfGmethylmalonyl-CoA decarboxylase, biotin-independent; Function experimentally demonstrated in the studied species; enzyme. (261 aa)
yliKmethylmalonyl-CoA mutase; Function experimentally demonstrated in the studied species; enzyme. (714 aa)
kduD2-deoxy-D-gluconate 3-dehydrogenase; Function experimentally demonstrated in the studied species; enzyme. (253 aa)
aasFused 2-acylglycerophospho-ethanolamine acyl transferase; Function experimentally demonstrated in the studied species; enzyme. (719 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (432 aa)
ygcUPutative FAD containing dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (484 aa)
ispD4-diphosphocytidyl-2C-methyl-D-erythritol synthase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (236 aa)
ispF2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (159 aa)
ygbMConserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the hyi family. (258 aa)
hycBHydrogenase 3, Fe-S subunit; Function experimentally demonstrated in the studied species; carrier. (203 aa)
hycDHydrogenase 3, membrane subunit; Function experimentally demonstrated in the studied species; membrane component. (307 aa)
hycFFormate hydrogenlyase complex iron-sulfur protein; Function experimentally demonstrated in the studied species; carrier. (180 aa)
gabT4-aminobutyrate aminotransferase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa)
gabDSuccinate-semialdehyde dehydrogenase I, NADP-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the aldehyde dehydrogenase family. (482 aa)
acpSHolo-[acyl-carrier-protein] synthase 1; Function experimentally demonstrated in the studied species; enzyme. (126 aa)
hcaB2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Converts 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol) into 3-(2,3- dihydroxylphenyl)propanoic acid (DHPP) and 2,3-dihydroxicinnamic acid (DHCI), respectively; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (270 aa)
hcaC3-phenylpropionate dioxygenase, putative ferredoxin subunit; Function experimentally demonstrated in the studied species; putative carrier. (106 aa)
hcaF3-phenylpropionate dioxygenase, small (beta) subunit; Function experimentally demonstrated in the studied species; enzyme. (172 aa)
hcaE3-phenylpropionate dioxygenase, large (alpha) subunit; Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3- phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid- dihydrodiol (CI-dihydrodiol), respectively; Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family. (453 aa)
Your Current Organism:
Escherichia coli IAI1
NCBI taxonomy Id: 585034
Other names: E. coli IAI1, Escherichia coli str. IAI1, Escherichia coli strain IAI1
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