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| | mrcA | Fused penicillin-binding protein 1a: murein transglycosylase; Function experimentally demonstrated in the studied species; enzyme. (850 aa) |
| | gntY | Putative gluconate transport associated protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (191 aa) |
| | yhhF | Putative methyltransferase; Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle; Belongs to the methyltransferase superfamily. RsmD family. (198 aa) |
| | yhiQ | Putative SAM-dependent methyltransferase; Specifically methylates the guanosine in position 1516 of 16S rRNA. (250 aa) |
| | yhiR | Putative DNA (exogenous) processing protein; Specifically methylates the adenine in position 2030 of 23S rRNA. (280 aa) |
| | lpfC | Outer membrane usher protein lpfC precursor; Function of homologous gene experimentally demonstrated in an other organism; membrane component. (843 aa) |
| | bax | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (274 aa) |
| | yiaT | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (246 aa) |
| | secB | Protein export chaperone; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (155 aa) |
| | envC | Protease with a role in cell division; Function experimentally demonstrated in the studied species; cell process. (419 aa) |
| | rph | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (246 aa) |
| | yicC | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (287 aa) |
| | yieF | Chromate reductase, Class I, flavoprotein; Function experimentally demonstrated in the studied species; enzyme. (188 aa) |
| | lpfC-2 | Putative fimbrial usher; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (840 aa) |
| | glmU | Fused N-acetyl glucosamine-1-phosphate uridyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (456 aa) |
| | gidB | Methyltransferase, SAM-dependent methyltransferase, glucose-inhibited cell-division protein; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. (207 aa) |
| | rfe | UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (367 aa) |
| | cyaY | Frataxin, iron-binding and oxidizing protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. (106 aa) |
| | yihA | GTP-binding protein; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. (198 aa) |
| | yihI | Conserved hypothetical protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. (169 aa) |
| | bipA | GTP-binding protein; Function experimentally demonstrated in the studied species; factor. (607 aa) |
| | fpr | ferredoxin-NADP reductase; Function experimentally demonstrated in the studied species; enzyme. (248 aa) |
| | yiiU | Conserved hypothetical protein; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. (81 aa) |
| | ftsN | Essential cell division protein; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. (319 aa) |
| | murI | Glutamate racemase; Function experimentally demonstrated in the studied species; enzyme. (285 aa) |
| | murB | UDP-N-acetylenolpyruvoylglucosamine reductase, FAD-binding; Cell wall formation. (342 aa) |
| | yjbC | 23S rRNA pseudouridine synthase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the pseudouridine synthase RsuA family. (290 aa) |
| | alr | Alanine racemase 1, PLP-binding, biosynthetic; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (359 aa) |
| | nrfE | Heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfE; Function experimentally demonstrated in the studied species; factor. (552 aa) |
| | nrfF | Heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfF; Possible subunit of a heme lyase. (127 aa) |
| | htrE_2 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (103 aa) |
| | CAQ96912.1 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (83 aa) |
| | ksgA | S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (273 aa) |
| | surA | Peptidyl-prolyl cis-trans isomerase (PPIase); Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (428 aa) |
| | imp | Exported protein required for envelope biosynthesis and integrity; Function experimentally demonstrated in the studied species; factor. (784 aa) |
| | rluA | Pseudouridine synthase for 23S rRNA (position 746) and tRNAphe(position 32); Function experimentally demonstrated in the studied species; enzyme. (219 aa) |
| | mraW | S-adenosyl-dependent methyltransferase activity on membrane-located substrates; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (313 aa) |
| | ftsI | Transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3); Function experimentally demonstrated in the studied species; enzyme. (588 aa) |
| | murE | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso- diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (495 aa) |
| | murF | UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (452 aa) |
| | mraY | phospho-N-acetylmuramoyl-pentapeptide transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (360 aa) |
| | murD | UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase; Function experimentally demonstrated in the studied species; enzyme. (438 aa) |
| | ftsW | Integral membrane protein involved in stabilizing FstZ ring during cell division; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (414 aa) |
| | murG | N-acetylglucosaminyl transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (355 aa) |
| | murC | UDP-N-acetylmuramate:L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (491 aa) |
| | ddlB | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (306 aa) |
| | ftsQ | Membrane anchored protein involved in growth of wall at septum; Function experimentally demonstrated in the studied species; cell process. (276 aa) |
| | ftsZ | GTP-binding tubulin-like cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (383 aa) |
| | yacF | Conserved hypothetical protein; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity. (247 aa) |
| | ppdD | Putative major pilin subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative structure. (146 aa) |
| | htrE | Outer membrane usher protein; Function of strongly homologous gene; factor. (866 aa) |
| | hrpB | ATP-dependent (RNA) helicase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (809 aa) |
| | mrcB | Fused glycosyl transferase; Function experimentally demonstrated in the studied species; enzyme. (844 aa) |
| | yadR | Putative chaperone involved in Fe-S cluster assembly and activation; Required for insertion of 4Fe-4S clusters for at least IspG. (114 aa) |
| | ispU | Undecaprenyl pyrophosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (253 aa) |
| | yaeT | Outer membrane protein assembly factor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. (810 aa) |
| | hlpA | Periplasmic chaperone; Function experimentally demonstrated in the studied species; factor; Belongs to the skp family. (161 aa) |
| | yafK | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (246 aa) |
| | yagX | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (841 aa) |
| | ddlA | D-alanine-D-alanine ligase A; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (364 aa) |
| | yajL | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; 99173753, 99311269. (196 aa) |
| | bolA | Regulator of penicillin binding proteins and beta lactamase transcription (morphogene); Function experimentally demonstrated in the studied species; regulator; Belongs to the BolA/IbaG family. (105 aa) |
| | sfmD | Putative outer membrane export usher protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (869 aa) |
| | cusC | Copper/silver efflux system, outer membrane component; Function experimentally demonstrated in the studied species; transporter. (460 aa) |
| | dacA | D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5); Function experimentally demonstrated in the studied species; enzyme; Belongs to the peptidase S11 family. (403 aa) |
| | mrdB | Cell wall shape-determining protein; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (370 aa) |
| | mrdA | Transpeptidase involved in peptidoglycan synthesis (penicillin-binding protein 2); Function experimentally demonstrated in the studied species; enzyme. (633 aa) |
| | ybeA | Conserved hypothetical protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (155 aa) |
| | ybeB | Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (105 aa) |
| | rlpB | Minor lipoprotein; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. (193 aa) |
| | ybeY | Putative metal-dependent hydrolase; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (155 aa) |
| | nagA | N-acetylglucosamine-6-phosphate deacetylase; Function experimentally demonstrated in the studied species; enzyme. (382 aa) |
| | ybgQ | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (833 aa) |
| | ybgF | Putative RNA binding protein; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family. (263 aa) |
| | rhlE | RNA helicase; Function experimentally demonstrated in the studied species; enzyme. (454 aa) |
| | ybiN | Putative AdoMet-dependent methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the methyltransferase superfamily. (308 aa) |
| | ybiS | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; 9298646. (306 aa) |
| | dacC | D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 6a); Function experimentally demonstrated in the studied species; enzyme. (400 aa) |
| | ybjG | Undecaprenyl pyrophosphate phosphatase; Function experimentally demonstrated in the studied species; enzyme. (198 aa) |
| | ybjN | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (158 aa) |
| | rumB | 23S rRNA m(5)U747 methyltransferase; Function experimentally demonstrated in the studied species; enzyme. (375 aa) |
| | ycbB | Putative exported enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (615 aa) |
| | ycbS | Putative outer membrane export usher protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (866 aa) |
| | ycbW | Conserved hypothetical protein; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ. (180 aa) |
| | ycbY | Putative conserved AdoMet-dependent methyltransferase with RNA interaction domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the methyltransferase superfamily. (702 aa) |
| | sulA | SOS cell division inhibitor; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. (169 aa) |
| | yccW | Putative AdoMet-dependent methyltransferase, UPF0064 family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the methyltransferase superfamily. (367 aa) |
| | torD | Chaperone involved in maturation of TorA subunit of trimethylamine N-oxide reductase system I; Function experimentally demonstrated in the studied species; factor. (199 aa) |
| | csgG | Putative outer membrane lipoprotein involved in curli production assembly/transport; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; lipoprotein. (277 aa) |
| | csgF | Putative transport/assembly protein for curli synthesis; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative membrane component. (138 aa) |
| | csgE | Putative transport/assembly protein for curli synthesis; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (129 aa) |
| | rimJ | ribosomal-protein-S5-alanine N-acetyltransferase; Function experimentally demonstrated in the studied species; enzyme. (194 aa) |
| | mviN | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (511 aa) |
| | flgN | Export chaperone for FlgK and FlgL; Function experimentally demonstrated in the studied species; factor. (138 aa) |
| | flgA | Assembly protein for flagellar basal-body periplasmic P ring; Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P- ring assembly; Belongs to the FlgA family. (219 aa) |
| | flgJ | Muramidase; Function experimentally demonstrated in the studied species; enzyme. (313 aa) |
| | flgK | Flagellar hook-filament junction protein 1; Function experimentally demonstrated in the studied species; structure. (547 aa) |
| | rne | Fused ribonucleaseE: endoribonuclease; Function experimentally demonstrated in the studied species; enzyme. (1061 aa) |
| | rluC | 23S rRNA pseudouridylate synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (319 aa) |
| | yceD | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; 1447160. (173 aa) |
| | yceG | Putative conserved membrane associated protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative membrane component. (340 aa) |
| | ycfM | Putative outer membrane lipoprotein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative membrane component. (213 aa) |
| | nagZ | Beta N-acetyl-glucosaminidase; Function experimentally demonstrated in the studied species; enzyme. (341 aa) |
| | ycfS | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (320 aa) |
| | ymfC | 23S rRNA pseudouridine synthase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the pseudouridine synthase RsuA family. (217 aa) |
| | minD | Membrane ATPase of the MinC-MinD-MinE system; Function experimentally demonstrated in the studied species; factor. (270 aa) |
| | minC | Cell division inhibitor; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization. (231 aa) |
| | ldcA | Function experimentally demonstrated in the studied species; enzyme. (304 aa) |
| | narJ | Molybdenum-cofactor-assembly chaperone subunit (delta subunit) of nitrate reductase 1; Function experimentally demonstrated in the studied species; factor. (236 aa) |
| | yciV | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (293 aa) |
| | rluB | 23S rRNA pseudouridylate synthase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the pseudouridine synthase RsuA family. (299 aa) |
| | dbpA | ATP-dependent RNA helicase, specific for 23S rRNA; Function experimentally demonstrated in the studied species; enzyme; Belongs to the DEAD box helicase family. (457 aa) |
| | hrpA | ATP-dependent helicase; Function experimentally demonstrated in the studied species; enzyme. (1281 aa) |
| | ydcF | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (266 aa) |
| | narW | Nitrate reductase 2 (NRZ), delta subunit (assembly subunit); Function experimentally demonstrated in the studied species; factor. (231 aa) |
| | fimD_3 | Putative fimbrial outer membrane usher protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative membrane component. (883 aa) |
| | ydhD | Monothiol glutaredoxin; Function experimentally demonstrated in the studied species; enzyme; Belongs to the glutaredoxin family. Monothiol subfamily. (115 aa) |
| | ynhG | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (334 aa) |
| | sufE | Sulfur acceptor protein; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process; Belongs to the SufE family. (138 aa) |
| | sufD | Component of SufBCD complex; Function experimentally demonstrated in the studied species; factor. (423 aa) |
| | sufC | Component of SufBCD complex, ATP-binding component of ABC superfamily; Function experimentally demonstrated in the studied species; transporter. (248 aa) |
| | sufB | Component of SufBCD complex; Function of strongly homologous gene; putative transporter. (495 aa) |
| | sufA | Fe-S cluster assembly protein; Function experimentally demonstrated in the studied species; factor; Belongs to the HesB/IscA family. (122 aa) |
| | rplT | 50S ribosomal subunit protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (118 aa) |
| | osmE | DNA-binding transcriptional activator; Function experimentally demonstrated in the studied species; regulator. (112 aa) |
| | mipA | Scaffolding protein for murein synthesizing machinery; Function experimentally demonstrated in the studied species; factor. (248 aa) |
| | yebU | Putative RNA AdoMet-dependent methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (479 aa) |
| | cutC | Copper homeostasis protein; Participates in the control of copper homeostasis. (248 aa) |
| | flhA | Putative flagellar export pore protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (692 aa) |
| | flhB | Flagellar export pore protein; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family. (382 aa) |
| | flhD | DNA-binding transcriptional dual regulator with FlhC; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family. (119 aa) |
| | fliS | Flagellar protein potentiates polymerization; Function experimentally demonstrated in the studied species; factor. (136 aa) |
| | fliI | Flagellum-specific ATP synthase; Function experimentally demonstrated in the studied species; enzyme. (457 aa) |
| | fliK | Flagellar hook-length control protein; Function experimentally demonstrated in the studied species; structure. (375 aa) |
| | fliQ | Flagellar biosynthesis protein; Role in flagellar biosynthesis. Belongs to the FliQ/MopD/SpaQ family. (89 aa) |
| | fliR | Flagellar export pore protein; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family. (261 aa) |
| | erfK | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (310 aa) |
| | dacD | D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 6b); Function experimentally demonstrated in the studied species; enzyme; Belongs to the peptidase S11 family. (388 aa) |
| | yehB | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (826 aa) |
| | mrp | Antiporter inner membrane protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (369 aa) |
| | pbpG | D-alanyl-D-alanine endopeptidase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the peptidase S11 family. (310 aa) |
| | yeiU | Undecaprenyl pyrophosphate phosphatase; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family. (237 aa) |
| | rsuA | 16S rRNA pseudouridylate 516 synthase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the pseudouridine synthase RsuA family. (231 aa) |
| | ccmH | Heme lyase, CcmH subunit; Possible subunit of a heme lyase. (350 aa) |
| | ccmG | Periplasmic thioredoxin of cytochrome c-type biogenesis; Function experimentally demonstrated in the studied species; enzyme. (185 aa) |
| | ccmF | Heme lyase, CcmF subunit; Function experimentally demonstrated in the studied species; enzyme. (647 aa) |
| | ccmE | Periplasmic heme chaperone; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. (159 aa) |
| | ccmD | Cytochrome c biogenesis protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family. (69 aa) |
| | ccmC | Heme exporter subunit; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. (245 aa) |
| | ccmB | Heme exporter subunit; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family. (220 aa) |
| | ccmA | Heme exporter subunit; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. (207 aa) |
| | papC | Putative outer membrane usher protein yfcU precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (880 aa) |
| | zipA | Cell division protein involved in Z ring assembly; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. (328 aa) |
| | nlpB | Lipoprotein; Function experimentally demonstrated in the studied species; lipoprotein. (344 aa) |
| | hyfJ | Putative processing element hydrogenase 4; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (137 aa) |
| | der | GTPase involved in ribosome synthesis and maintenance; Function experimentally demonstrated in the studied species; enzyme. (490 aa) |
| | yfgL | Protein assembly complex, lipoprotein component; Function of strongly homologous gene; lipoprotein. (392 aa) |
| | yfgB | Putative Fe-S containing enzyme; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (384 aa) |
| | pbpC | Fused transglycosylase; Function experimentally demonstrated in the studied species; enzyme. (770 aa) |
| | yfhJ | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; putative factor. (66 aa) |
| | hscA | DnaK-like molecular chaperone specific for IscU; Function experimentally demonstrated in the studied species; factor. (616 aa) |
| | hscB | DnaJ-like molecular chaperone specific for IscU; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (171 aa) |
| | iscA | FeS cluster assembly protein; Function experimentally demonstrated in the studied species; factor; Belongs to the HesB/IscA family. (107 aa) |
| | iscU | Scaffold protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (128 aa) |
| | iscS | Cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate. (404 aa) |
| | suhB | Inositol monophosphatase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the inositol monophosphatase superfamily. (267 aa) |
| | era | Membrane-associated, 16S rRNA-binding GTPase; Function experimentally demonstrated in the studied species; enzyme. (301 aa) |
| | rnc | RNase III; Function experimentally demonstrated in the studied species; enzyme. (226 aa) |
| | srmB | ATP-dependent RNA helicase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the DEAD box helicase family. (444 aa) |
| | rluD | 23S rRNA pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (326 aa) |
| | yfiO | Putative lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery. (245 aa) |
| | rimM | 16S rRNA processing protein; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (182 aa) |
| | ypjD | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (288 aa) |
| | smpA | Small membrane lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (113 aa) |
| | hycH | Protein required for maturation of hydrogenase 3; Function experimentally demonstrated in the studied species; factor. (136 aa) |
| | rumA | 23S rRNA (uracil-5)-methyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (433 aa) |
| | ygdE | Putative methyltransferase; Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily. (366 aa) |
| | csdA | Cysteine sulfinate desulfinase; Function experimentally demonstrated in the studied species; enzyme. (401 aa) |
| | ygfY | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (88 aa) |
| | zapA | Protein that localizes to the cytokinetic ring; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. (109 aa) |
| | yggJ | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (243 aa) |
| | yqgF | Holliday junction resolvase; Function of strongly homologous gene; cell process. (138 aa) |
| | yggL | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (108 aa) |
| | yqiG | Outer membrane usher protein; Function of strongly homologous gene; factor. (837 aa) |
| | bacA | Undecaprenyl pyrophosphate phosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (273 aa) |
| | ygjO | Putative methyltransferase small domain; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. (378 aa) |
| | eafC | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (900 aa) |
| | yraJ | Putative outer membrane protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative membrane component. (838 aa) |
| | yraL | Putative methyltransferase; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (286 aa) |
| | yraM | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (678 aa) |
| | deaD | ATP-dependent RNA helicase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the DEAD box helicase family. (629 aa) |
| | rbfA | 30s ribosome binding factor; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (133 aa) |
| | yhbC | Conserved hypothetical protein; Required for maturation of 30S ribosomal subunits. Belongs to the RimP family. (150 aa) |
| | rrmJ | 23S rRNA methyltransferase; Function experimentally demonstrated in the studied species; enzyme. (209 aa) |
| | yhbY | Putative RNA-binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (97 aa) |
| | obgE | GTPase involved in cell partioning and DNA repair; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (390 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa) |
| | yrbA | Putative DNA-binding transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator; Belongs to the BolA/IbaG family. (84 aa) |
| | yrbK | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (191 aa) |
| | lptA | Putative lipopolysaccharide transport protein A: periplasmic-binding component of ABC superfamily; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (185 aa) |
| | mtgA | Biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors. Belongs to the glycosyltransferase 51 family. (242 aa) |
| | argR | DNA-binding transcriptional dual regulator, L-arginine-binding; Regulates arginine biosynthesis genes. (156 aa) |
| | rng | Ribonuclease G; Function experimentally demonstrated in the studied species; enzyme. (489 aa) |
| | rsmB | 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (429 aa) |
| | yrfC | Putative fimbrial assembly protein (pilN-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative structure. (179 aa) |
| | nrfG | Heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfG; Function experimentally demonstrated in the studied species; factor. (198 aa) |
| | dipZ | Fused thiol:disulfide interchange protein: activator of DsbC; Function experimentally demonstrated in the studied species; enzyme. (565 aa) |
| | frdC | Fumarate reductase (anaerobic), membrane anchor subunit; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (131 aa) |
| | rsgA | Ribosome small subunit-dependent GTPase A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (350 aa) |
| | rlmB | 23S rRNA (Gm2251)-methyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (243 aa) |
| | mpl | UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (457 aa) |
| | fimD | Outer membrane usher protein, type 1 fimbrial synthesis; Function experimentally demonstrated in the studied species; factor. (878 aa) |
| | rsmC | 16S RNA m2G1207 methylase; Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle; Belongs to the methyltransferase superfamily. RsmC family. (343 aa) |
