STRINGSTRING
ftsI ftsI ftsL ftsL ftsW ftsW ftsQ ftsQ ftsA ftsA ftsZ ftsZ yacF yacF tolQ tolQ tolR tolR tolB tolB pal pal ycbW ycbW mviN mviN ymgF ymgF blr blr yedR yedR dedD dedD zipA zipA dapE dapE yfiN yfiN nlpD nlpD ygcF ygcF ygeR ygeR zapA zapA sufI sufI ecfH ecfH yhcM yhcM damX damX ftsE ftsE envC envC ftsN ftsN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ftsITranspeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3); Function experimentally demonstrated in the studied species; enzyme. (588 aa)
ftsLMembrane bound cell division protein at septum containing leucine zipper motif; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (121 aa)
ftsWIntegral membrane protein involved in stabilizing FstZ ring during cell division; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (414 aa)
ftsQMembrane anchored protein involved in growth of wall at septum; Function experimentally demonstrated in the studied species; cell process. (276 aa)
ftsAATP-binding cell division protein involved in recruitment of FtsK to Z ring; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (420 aa)
ftsZGTP-binding tubulin-like cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (383 aa)
yacFConserved hypothetical protein; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity. (247 aa)
tolQMembrane spanning protein in TolA-TolQ-TolR complex; Function experimentally demonstrated in the studied species; membrane component. (230 aa)
tolRMembrane spanning protein in TolA-TolQ-TolR complex; Function experimentally demonstrated in the studied species; membrane component. (142 aa)
tolBPeriplasmic protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane. (430 aa)
palPeptidoglycan-associated outer membrane lipoprotein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (173 aa)
ycbWConserved hypothetical protein; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ. (180 aa)
mviNConserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (511 aa)
ymgFConserved hypothetical protein; Homologs of previously reported genes of unknown function. (72 aa)
blrBeta-lactam resistance membrane protein; Function experimentally demonstrated in the studied species; membrane component. (66 aa)
yedRConserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (121 aa)
dedDConserved hypothetical protein; Homologs of previously reported genes of unknown function. (220 aa)
zipACell division protein involved in Z ring assembly; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. (328 aa)
dapEN-succinyl-diaminopimelate deacylase; Function experimentally demonstrated in the studied species; enzyme. (375 aa)
yfiNPutative diguanylate cyclase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (408 aa)
nlpDFragment of RNA polymerase, sigma S (sigma 38) factor (part 1); Gene remnant; factor. (379 aa)
ygcFConserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (223 aa)
ygeRTetratricopeptide repeat transcriptional regulator; Function experimentally demonstrated in the studied species; regulator. (251 aa)
zapAProtein that localizes to the cytokinetic ring; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. (109 aa)
sufIRepressor protein for FtsI; Function experimentally demonstrated in the studied species; regulator. (470 aa)
ecfHConserved hypothetical protein; Homologs of previously reported genes of unknown function. (191 aa)
yhcMConserved hypothetical protein; Homologs of previously reported genes of unknown function. (375 aa)
damXConserved hypothetical protein; Homologs of previously reported genes of unknown function. (428 aa)
ftsETransporter subunit: ATP-binding component of ABC superfamily; Part of the ABC transporter FtsEX involved in cellular division. (222 aa)
envCProtease with a role in cell division; Function experimentally demonstrated in the studied species; cell process. (419 aa)
ftsNEssential cell division protein; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. (319 aa)
Your Current Organism:
Escherichia coli IAI1
NCBI taxonomy Id: 585034
Other names: E. coli IAI1, Escherichia coli str. IAI1, Escherichia coli strain IAI1
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