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fepC fepC rbsA rbsA yifB yifB rho rho glnG glnG hslU hslU zraR zraR malK malK phnL phnL phnK phnK phnC phnC livG livG yjjK yjjK ftsY ftsY nikD nikD nikE nikE rbbA rbbA dppF dppF dppD dppD xylG xylG pstB pstB atpD atpD ravA ravA livF livF ugpC ugpC rtcR rtcR yheS yheS aapP aapP lptB lptB yrbF yrbF yggR yggR ecfA1_1 ecfA1_1 ecfA1_2 ecfA1_2 ygeV ygeV recA recA proV proV ffh ffh yphE yphE hyfR hyfR cysA cysA hisP hisP yojI yojI ccmA ccmA yejF yejF mglA mglA yehX yehX araG araG ruvB ruvB znuC znuC ftsE ftsE ynjD ynjD btuD btuD sufC sufC ego ego yddA yddA ddpD ddpD ddpF ddpF ydcT ydcT hrpA hrpA ycjV ycjV pspF pspF sapD sapD sapF sapF oppF oppF potA potA lolD lolD uup uup ssuB ssuB msbA msbA cydC cydC clpA clpA artP artP potG potG yliA yliA ybiT ybiT glnQ glnQ ybhF ybhF modC modC modF modF gltL gltL ybbA ybbA ybbL ybbL mdlB mdlB tauB tauB prpR prpR rbsA_1 rbsA_1 clpV1_4 clpV1_4 metN metN fhuC fhuC yadG yadG thiQ thiQ
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fepCIron-enterobactin transporter subunit; Function experimentally demonstrated in the studied species; transporter. (271 aa)
rbsAFused D-ribose transporter subunits of ABC superfamily: ATP-binding components; Function experimentally demonstrated in the studied species; transporter. (501 aa)
yifBPutative bifunctional enzyme and transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (516 aa)
rhoTranscription termination factor; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (419 aa)
glnGDNA-binding transcriptional regulator NtrC; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (469 aa)
hslUMolecular chaperone and ATPase component of HslUV protease; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (443 aa)
zraRTwo-component system response regulator; Function experimentally demonstrated in the studied species; regulator. (441 aa)
malKFused maltose transport subunit, ATP-binding component of ABC superfamily; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family. (371 aa)
phnLCarbon-phosphorus lyase complex subunit; Function experimentally demonstrated in the studied species; enzyme. (226 aa)
phnKCarbon-phosphorus lyase complex subunit; Function experimentally demonstrated in the studied species; enzyme. (252 aa)
phnCPhosphonate/organophosphate ester transporter subunit; Function experimentally demonstrated in the studied species; transporter. (262 aa)
livGLeucine/isoleucine/valine transporter subunit; Function experimentally demonstrated in the studied species; transporter. (255 aa)
yjjKFused putative transporter subunits of ABC superfamily: ATP-binding components; Function of strongly homologous gene; putative transporter. (555 aa)
ftsYFused Signal Recognition Particle (SRP) receptor: membrane binding protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (497 aa)
nikDNickel transporter subunit; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (254 aa)
nikENickel transporter subunit; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (268 aa)
rbbAFused ribosome-associated ATPase: ATP-binding protein; Function experimentally demonstrated in the studied species; enzyme. (911 aa)
dppFDipeptide transporter; Function experimentally demonstrated in the studied species; transporter. (334 aa)
dppDDipeptide transporter; Function experimentally demonstrated in the studied species; transporter; Belongs to the ABC transporter superfamily. (327 aa)
xylGFused D-xylose transporter subunits of ABC superfamily: ATP-binding components; Function experimentally demonstrated in the studied species; transporter. (513 aa)
pstBPhosphate transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the ABC transporter superfamily. (257 aa)
atpDF1 sector of membrane-bound ATP synthase, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (460 aa)
ravAFused regulatory ATPase variant A; Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone; Belongs to the RavA family. (498 aa)
livFLeucine/isoleucine/valine transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the ABC transporter superfamily. (237 aa)
ugpCGlycerol-3-phosphate transporter subunit; Function experimentally demonstrated in the studied species; transporter. (356 aa)
rtcRSigma 54-dependent transcriptional regulator of rtcBA expression; Function experimentally demonstrated in the studied species; regulator. (532 aa)
yheSFused putative transporter subunits of ABC superfamily: ATP-binding components; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (637 aa)
aapPAmino-acid transporter subunit; Function of strongly homologous gene; transporter. (252 aa)
lptBPutative lipopolysaccharide transport protein B: ATP-binding component of ABC superfamily; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (241 aa)
yrbFToluene transporter subunit: ATP-binding component of ABC superfamily; Function of strongly homologous gene; transporter. (269 aa)
yggRTransporter; Function of homologous gene experimentally demonstrated in an other organism; transporter. (326 aa)
ecfA1_1Putative ATP-binding protein of ABC transport system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (236 aa)
ecfA1_2Putative ATP-binding protein of ABC transport system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (227 aa)
ygeVPutative DNA-binding transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (592 aa)
recADNA strand exchange and recombination protein with protease and nuclease activity; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (353 aa)
proVGlycine betaine transporter subunit; Function experimentally demonstrated in the studied species; transporter. (400 aa)
ffhSignal Recognition Particle (SRP) component with 4.5S RNA (ffs); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex [...] (453 aa)
yphEFused putative sugar transporter subunits of ABC superfamily: ATP-binding components; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (503 aa)
hyfRDNA-binding transcriptional activator, formate sensing; Function experimentally demonstrated in the studied species; regulator. (670 aa)
cysASulfate/thiosulfate transporter subunit; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (365 aa)
hisPHistidine/lysine/arginine/ornithine transporter subunit; Function experimentally demonstrated in the studied species; transporter. (257 aa)
yojIMultidrug transporter membrane component/ATP-binding component; Function experimentally demonstrated in the studied species; transporter. (547 aa)
ccmAHeme exporter subunit; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. (207 aa)
yejFPutative fused oligopeptide transporter subunits of ABC superfamily: ATP-binding components; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the ABC transporter superfamily. (529 aa)
mglAFused methyl-galactoside transporter subunits of ABC superfamily: ATP-binding components; Function experimentally demonstrated in the studied species; transporter. (506 aa)
yehXPutative transporter subunit: ATP-binding component of ABC superfamily transporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (308 aa)
araGFused L-arabinose transporter subunits of ABC superfamily: ATP-binding components; Function experimentally demonstrated in the studied species; transporter. (504 aa)
ruvBATP-dependent DNA helicase, component of RuvABC resolvasome; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (336 aa)
znuCZinc transporter subunit: ATP-binding component of ABC superfamily; Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family. (251 aa)
ftsETransporter subunit: ATP-binding component of ABC superfamily; Part of the ABC transporter FtsEX involved in cellular division. (222 aa)
ynjDATP-binding cassette domain-containing protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (217 aa)
btuDVitamin B12 transporter subunit : ATP-binding component of ABC superfamily; Function experimentally demonstrated in the studied species; transporter. (249 aa)
sufCComponent of SufBCD complex, ATP-binding component of ABC superfamily; Function experimentally demonstrated in the studied species; transporter. (248 aa)
egoFused AI2 transporter subunits of ABC superfamily: ATP-binding components; Function experimentally demonstrated in the studied species; transporter. (511 aa)
yddAPutative multidrug transporter fused subunits of ABC superfamily transporter: permease component; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (561 aa)
ddpDD-ala-D-ala transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the ABC transporter superfamily. (328 aa)
ddpFD-ala-D-ala transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the ABC transporter superfamily. (308 aa)
ydcTPutative spermidine/putrescine transporter subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the ABC transporter superfamily. (337 aa)
hrpAATP-dependent helicase; Function experimentally demonstrated in the studied species; enzyme. (1281 aa)
ycjVPutative sugar transporter subunit: ATP-binding component of ABC superfamily transporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (360 aa)
pspFDNA-binding transcriptional activator; Function experimentally demonstrated in the studied species; regulator. (325 aa)
sapDAntimicrobial peptide transporter subunit; Function of homologous gene experimentally demonstrated in an other organism; transporter; Belongs to the ABC transporter superfamily. (330 aa)
sapFAntimicrobial peptide transporter subunit; Function of homologous gene experimentally demonstrated in an other organism; transporter. (268 aa)
oppFOligopeptide transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the ABC transporter superfamily. (334 aa)
potAPolyamine transporter subunit; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. (378 aa)
lolDOuter membrane-specific lipoprotein transporter subunit; Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. (233 aa)
uupFused ATP-binding subunits of ABC superfamily protein involved in precise excision of transposons; Function experimentally demonstrated in the studied species; enzyme. (635 aa)
ssuBAlkanesulfonate transporter subunit; Function experimentally demonstrated in the studied species; transporter. (255 aa)
msbAFused lipid transporter subunits of ABC superfamily: membrane component; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (582 aa)
cydCFused cysteine transporter subunits of ABC superfamily: membrane component; Function experimentally demonstrated in the studied species; transporter. (573 aa)
clpAATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity; Function experimentally demonstrated in the studied species; enzyme; Belongs to the ClpA/ClpB family. (758 aa)
artPArginine transporter subunit; Function experimentally demonstrated in the studied species; transporter. (242 aa)
potGPutrescine transporter subunit: ATP-binding component of ABC superfamily; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system. (377 aa)
yliAPutative peptide transport fused subunits of ABC superfamily: ATP-binding components; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the ABC transporter superfamily. (612 aa)
ybiTPutative transporter fused subunits of ABC superfamily: ATP-binding components; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (530 aa)
glnQGlutamine transporter subunit; Function experimentally demonstrated in the studied species; transporter. (240 aa)
ybhFPutative transporter fused subunits of ABC superfamily: ATP-binding components; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (578 aa)
modCMolybdate transporter subunit; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. (352 aa)
modFFused molybdate transporter subunits of ABC superfamily: ATP-binding components; Function experimentally demonstrated in the studied species; transporter. (490 aa)
gltLGlutamate and aspartate transporter subunit; Function experimentally demonstrated in the studied species; transporter. (241 aa)
ybbAPutative transporter subunit: ATP-binding component of ABC superfamily; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (228 aa)
ybbLPutative transporter subunit: ATP-binding component of ABC superfamily; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (225 aa)
mdlBPutative fused ATPase and permease component of metabolite ABC transporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (593 aa)
tauBTaurine transporter subunit; Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Taurine importer (TC 3.A.1.17.1) family. (255 aa)
prpRDNA-binding transcriptional activator; Function experimentally demonstrated in the studied species; regulator. (528 aa)
rbsA_1Putative ATP-binding component of ABC sugar transport system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (499 aa)
clpV1_4Putative ATP-dependent Clp proteinase Aec27 ATP-binding chain, with chaperone activity; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor; Belongs to the ClpA/ClpB family. (979 aa)
metNDL-methionine transporter subunit; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (343 aa)
fhuCIron-hydroxamate transporter subunit; Function experimentally demonstrated in the studied species; transporter. (265 aa)
yadGPutative transporter subunit: ATP-binding component of ABC superfamily; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (308 aa)
thiQThiamin transporter subunit; Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family. (232 aa)
Your Current Organism:
Escherichia coli IAI1
NCBI taxonomy Id: 585034
Other names: E. coli IAI1, Escherichia coli str. IAI1, Escherichia coli strain IAI1
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