STRINGSTRING
mdlB mdlB dnaX dnaX ybbL ybbL ybbA ybbA fepC fepC gltL gltL modF modF modC modC ybhF ybhF glnQ glnQ ybiT ybiT yliA yliA potG potG artP artP macB macB clpA clpA cydC cydC cydD cydD ycaJ ycaJ msbA msbA ssuB ssuB uup uup lolD lolD potA potA dhaR dhaR oppD oppD oppF oppF sapF sapF sapD sapD pspF pspF ycjV ycjV tyrR tyrR hrpA hrpA ydcT ydcT ddpF ddpF ddpD ddpD yddA yddA ego ego lhr lhr sufC sufC btuD btuD ynjD ynjD CAQ98791.1 CAQ98791.1 znuC znuC ruvB ruvB araG araG yecC yecC fliI fliI wzt wzt yehL yehL yehX yehX mglA mglA yejF yejF ccmA ccmA yojI yojI hisP hisP cysA cysA hyfR hyfR yphE yphE yfhA yfhA clpB clpB proV proV recA recA norR norR fhlA fhlA recD recD ygeV ygeV ecfA1_2 ecfA1_2 ecfA1_1 ecfA1_1 CAQ99883.1 CAQ99883.1 yggR yggR epsE epsE ftsH ftsH yrbF yrbF lptB lptB aapP aapP yheS yheS rtcR rtcR ugpC ugpC livF livF livG livG ftsE ftsE nikD nikD nikE nikE rbbA rbbA dppF dppF dppD dppD xylG xylG dnaA dnaA pstB pstB atpD atpD ravA ravA rbsA rbsA yifB yifB rho rho glnG glnG hslU hslU zraR zraR malK malK dnaB dnaB phnL phnL phnK phnK phnC phnC ytfR ytfR dnaC dnaC radA radA yjjK yjjK thiQ thiQ yadG yadG fhuC fhuC metN metN clpV1_4 clpV1_4 rbsA_1 rbsA_1 prpR prpR tauB tauB lon lon mdlA mdlA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mdlBPutative fused ATPase and permease component of metabolite ABC transporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (593 aa)
dnaXDNA polymerase III/DNA elongation factor III, tau and gamma subunits; Function experimentally demonstrated in the studied species; enzyme. (643 aa)
ybbLPutative transporter subunit: ATP-binding component of ABC superfamily; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (225 aa)
ybbAPutative transporter subunit: ATP-binding component of ABC superfamily; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (228 aa)
fepCIron-enterobactin transporter subunit; Function experimentally demonstrated in the studied species; transporter. (271 aa)
gltLGlutamate and aspartate transporter subunit; Function experimentally demonstrated in the studied species; transporter. (241 aa)
modFFused molybdate transporter subunits of ABC superfamily: ATP-binding components; Function experimentally demonstrated in the studied species; transporter. (490 aa)
modCMolybdate transporter subunit; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. (352 aa)
ybhFPutative transporter fused subunits of ABC superfamily: ATP-binding components; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (578 aa)
glnQGlutamine transporter subunit; Function experimentally demonstrated in the studied species; transporter. (240 aa)
ybiTPutative transporter fused subunits of ABC superfamily: ATP-binding components; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (530 aa)
yliAPutative peptide transport fused subunits of ABC superfamily: ATP-binding components; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the ABC transporter superfamily. (612 aa)
potGPutrescine transporter subunit: ATP-binding component of ABC superfamily; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system. (377 aa)
artPArginine transporter subunit; Function experimentally demonstrated in the studied species; transporter. (242 aa)
macBFused macrolide transporter subunits of ABC superfamily: ATP-binding component; Function experimentally demonstrated in the studied species; transporter. (648 aa)
clpAATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity; Function experimentally demonstrated in the studied species; enzyme; Belongs to the ClpA/ClpB family. (758 aa)
cydCFused cysteine transporter subunits of ABC superfamily: membrane component; Function experimentally demonstrated in the studied species; transporter. (573 aa)
cydDFused cysteine transporter subunits of ABC superfamily: membrane component; Function experimentally demonstrated in the studied species; transporter. (588 aa)
ycaJRecombination protein; Function experimentally demonstrated in the studied species; cell process. (447 aa)
msbAFused lipid transporter subunits of ABC superfamily: membrane component; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (582 aa)
ssuBAlkanesulfonate transporter subunit; Function experimentally demonstrated in the studied species; transporter. (255 aa)
uupFused ATP-binding subunits of ABC superfamily protein involved in precise excision of transposons; Function experimentally demonstrated in the studied species; enzyme. (635 aa)
lolDOuter membrane-specific lipoprotein transporter subunit; Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. (233 aa)
potAPolyamine transporter subunit; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. (378 aa)
dhaRDNA-binding transcriptional regulator, dihydroxyacetone metabolism; Function experimentally demonstrated in the studied species; regulator. (639 aa)
oppDOligopeptide transporter subunit; Function experimentally demonstrated in the studied species; transporter. (337 aa)
oppFOligopeptide transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the ABC transporter superfamily. (334 aa)
sapFAntimicrobial peptide transporter subunit; Function of homologous gene experimentally demonstrated in an other organism; transporter. (268 aa)
sapDAntimicrobial peptide transporter subunit; Function of homologous gene experimentally demonstrated in an other organism; transporter; Belongs to the ABC transporter superfamily. (330 aa)
pspFDNA-binding transcriptional activator; Function experimentally demonstrated in the studied species; regulator. (325 aa)
ycjVPutative sugar transporter subunit: ATP-binding component of ABC superfamily transporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (360 aa)
tyrRDNA-binding transcriptional dual regulator, tyrosine-binding; Function experimentally demonstrated in the studied species; regulator. (513 aa)
hrpAATP-dependent helicase; Function experimentally demonstrated in the studied species; enzyme. (1281 aa)
ydcTPutative spermidine/putrescine transporter subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the ABC transporter superfamily. (337 aa)
ddpFD-ala-D-ala transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the ABC transporter superfamily. (308 aa)
ddpDD-ala-D-ala transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the ABC transporter superfamily. (328 aa)
yddAPutative multidrug transporter fused subunits of ABC superfamily transporter: permease component; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (561 aa)
egoFused AI2 transporter subunits of ABC superfamily: ATP-binding components; Function experimentally demonstrated in the studied species; transporter. (511 aa)
lhrPutative ATP-dependent helicase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (1538 aa)
sufCComponent of SufBCD complex, ATP-binding component of ABC superfamily; Function experimentally demonstrated in the studied species; transporter. (248 aa)
btuDVitamin B12 transporter subunit : ATP-binding component of ABC superfamily; Function experimentally demonstrated in the studied species; transporter. (249 aa)
ynjDATP-binding cassette domain-containing protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (217 aa)
CAQ98791.1Sugar-binding transport (ABC transporter) ATP-binding protein (CymD protein); Function of strongly homologous gene; transporter. (375 aa)
znuCZinc transporter subunit: ATP-binding component of ABC superfamily; Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family. (251 aa)
ruvBATP-dependent DNA helicase, component of RuvABC resolvasome; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (336 aa)
araGFused L-arabinose transporter subunits of ABC superfamily: ATP-binding components; Function experimentally demonstrated in the studied species; transporter. (504 aa)
yecCPutative transporter subunit: ATP-binding component of ABC superfamily transporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (250 aa)
fliIFlagellum-specific ATP synthase; Function experimentally demonstrated in the studied species; enzyme. (457 aa)
wztATP binding component of ABC-transporter; Function of strongly homologous gene; transporter. (404 aa)
yehLPutative ABC superfamily protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (362 aa)
yehXPutative transporter subunit: ATP-binding component of ABC superfamily transporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (308 aa)
mglAFused methyl-galactoside transporter subunits of ABC superfamily: ATP-binding components; Function experimentally demonstrated in the studied species; transporter. (506 aa)
yejFPutative fused oligopeptide transporter subunits of ABC superfamily: ATP-binding components; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the ABC transporter superfamily. (529 aa)
ccmAHeme exporter subunit; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. (207 aa)
yojIMultidrug transporter membrane component/ATP-binding component; Function experimentally demonstrated in the studied species; transporter. (547 aa)
hisPHistidine/lysine/arginine/ornithine transporter subunit; Function experimentally demonstrated in the studied species; transporter. (257 aa)
cysASulfate/thiosulfate transporter subunit; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (365 aa)
hyfRDNA-binding transcriptional activator, formate sensing; Function experimentally demonstrated in the studied species; regulator. (670 aa)
yphEFused putative sugar transporter subunits of ABC superfamily: ATP-binding components; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (503 aa)
yfhAPutative DNA-binding response regulator in two-component system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (444 aa)
clpBProtein disaggregation chaperone; Function experimentally demonstrated in the studied species; factor. (857 aa)
proVGlycine betaine transporter subunit; Function experimentally demonstrated in the studied species; transporter. (400 aa)
recADNA strand exchange and recombination protein with protease and nuclease activity; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (353 aa)
norRDNA-binding transcriptional activator; Function experimentally demonstrated in the studied species; regulator. (504 aa)
fhlADNA-binding transcriptional activator; Function experimentally demonstrated in the studied species; regulator. (692 aa)
recDExonuclease V (RecBCD complex), alpha chain; Function experimentally demonstrated in the studied species; enzyme. (608 aa)
ygeVPutative DNA-binding transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (592 aa)
ecfA1_2Putative ATP-binding protein of ABC transport system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (227 aa)
ecfA1_1Putative ATP-binding protein of ABC transport system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (236 aa)
CAQ99883.1Putative NtrC family transcriptional regulators, ATPase domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (946 aa)
yggRTransporter; Function of homologous gene experimentally demonstrated in an other organism; transporter. (326 aa)
epsEGeneral secretion pathway protein E; Function of strongly homologous gene; transporter. (497 aa)
ftsHProtease, ATP-dependent zinc-metallo; Function experimentally demonstrated in the studied species; enzyme. (644 aa)
yrbFToluene transporter subunit: ATP-binding component of ABC superfamily; Function of strongly homologous gene; transporter. (269 aa)
lptBPutative lipopolysaccharide transport protein B: ATP-binding component of ABC superfamily; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (241 aa)
aapPAmino-acid transporter subunit; Function of strongly homologous gene; transporter. (252 aa)
yheSFused putative transporter subunits of ABC superfamily: ATP-binding components; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (637 aa)
rtcRSigma 54-dependent transcriptional regulator of rtcBA expression; Function experimentally demonstrated in the studied species; regulator. (532 aa)
ugpCGlycerol-3-phosphate transporter subunit; Function experimentally demonstrated in the studied species; transporter. (356 aa)
livFLeucine/isoleucine/valine transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the ABC transporter superfamily. (237 aa)
livGLeucine/isoleucine/valine transporter subunit; Function experimentally demonstrated in the studied species; transporter. (255 aa)
ftsETransporter subunit: ATP-binding component of ABC superfamily; Part of the ABC transporter FtsEX involved in cellular division. (222 aa)
nikDNickel transporter subunit; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (254 aa)
nikENickel transporter subunit; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (268 aa)
rbbAFused ribosome-associated ATPase: ATP-binding protein; Function experimentally demonstrated in the studied species; enzyme. (911 aa)
dppFDipeptide transporter; Function experimentally demonstrated in the studied species; transporter. (334 aa)
dppDDipeptide transporter; Function experimentally demonstrated in the studied species; transporter; Belongs to the ABC transporter superfamily. (327 aa)
xylGFused D-xylose transporter subunits of ABC superfamily: ATP-binding components; Function experimentally demonstrated in the studied species; transporter. (513 aa)
dnaAChromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator; Function experimentally demonstrated in the studied species; factor. (467 aa)
pstBPhosphate transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the ABC transporter superfamily. (257 aa)
atpDF1 sector of membrane-bound ATP synthase, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (460 aa)
ravAFused regulatory ATPase variant A; Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone; Belongs to the RavA family. (498 aa)
rbsAFused D-ribose transporter subunits of ABC superfamily: ATP-binding components; Function experimentally demonstrated in the studied species; transporter. (501 aa)
yifBPutative bifunctional enzyme and transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (516 aa)
rhoTranscription termination factor; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (419 aa)
glnGDNA-binding transcriptional regulator NtrC; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (469 aa)
hslUMolecular chaperone and ATPase component of HslUV protease; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (443 aa)
zraRTwo-component system response regulator; Function experimentally demonstrated in the studied species; regulator. (441 aa)
malKFused maltose transport subunit, ATP-binding component of ABC superfamily; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family. (371 aa)
dnaBReplicative DNA helicase; Function experimentally demonstrated in the studied species; enzyme. (471 aa)
phnLCarbon-phosphorus lyase complex subunit; Function experimentally demonstrated in the studied species; enzyme. (226 aa)
phnKCarbon-phosphorus lyase complex subunit; Function experimentally demonstrated in the studied species; enzyme. (252 aa)
phnCPhosphonate/organophosphate ester transporter subunit; Function experimentally demonstrated in the studied species; transporter. (262 aa)
ytfRPutative sugar transporter subunit: ATP-binding component of ABC superfamily; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (500 aa)
dnaCDNA biosynthesis protein; Function experimentally demonstrated in the studied species; cell process. (245 aa)
radARepair protein radA homolog; Function of strongly homologous gene; cell process. (460 aa)
yjjKFused putative transporter subunits of ABC superfamily: ATP-binding components; Function of strongly homologous gene; putative transporter. (555 aa)
thiQThiamin transporter subunit; Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family. (232 aa)
yadGPutative transporter subunit: ATP-binding component of ABC superfamily; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (308 aa)
fhuCIron-hydroxamate transporter subunit; Function experimentally demonstrated in the studied species; transporter. (265 aa)
metNDL-methionine transporter subunit; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (343 aa)
clpV1_4Putative ATP-dependent Clp proteinase Aec27 ATP-binding chain, with chaperone activity; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor; Belongs to the ClpA/ClpB family. (979 aa)
rbsA_1Putative ATP-binding component of ABC sugar transport system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (499 aa)
prpRDNA-binding transcriptional activator; Function experimentally demonstrated in the studied species; regulator. (528 aa)
tauBTaurine transporter subunit; Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Taurine importer (TC 3.A.1.17.1) family. (255 aa)
lonDNA-binding ATP-dependent protease La; Function experimentally demonstrated in the studied species; enzyme. (784 aa)
mdlAPutative fused ATPase and permease component of metabolite transporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (590 aa)
Your Current Organism:
Escherichia coli IAI1
NCBI taxonomy Id: 585034
Other names: E. coli IAI1, Escherichia coli str. IAI1, Escherichia coli strain IAI1
Server load: low (34%) [HD]