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| | thrA | Fused aspartokinase I; Function experimentally demonstrated in the studied species; enzyme; Belongs to the aspartokinase family. (820 aa) |
| | thrB | Homoserine kinase; Function experimentally demonstrated in the studied species; enzyme. (310 aa) |
| | thrC | Threonine synthase; Function experimentally demonstrated in the studied species; enzyme. (428 aa) |
| | talB | Transaldolase B; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 1 subfamily. (317 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa) |
| | leuD | 3-isopropylmalate isomerase subunit; Function experimentally demonstrated in the studied species; enzyme. (201 aa) |
| | leuC | 3-isopropylmalate isomerase subunit, dehydratase component; Function experimentally demonstrated in the studied species; enzyme. (466 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Function experimentally demonstrated in the studied species; enzyme. (363 aa) |
| | leuA | 2-isopropylmalate synthase; Function experimentally demonstrated in the studied species; enzyme. (523 aa) |
| | ilvI | Acetolactate synthase III, large subunit; Function experimentally demonstrated in the studied species; enzyme. (574 aa) |
| | ilvH | Acetolactate synthase III, thiamin-dependent, small subunit; Function experimentally demonstrated in the studied species; enzyme. (163 aa) |
| | acnB | Bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase; Function experimentally demonstrated in the studied species; enzyme. (865 aa) |
| | pfs | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulatio [...] (232 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the transferase hexapeptide repeat family. (274 aa) |
| | proB | Gamma-glutamate kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (367 aa) |
| | proA | Gamma-glutamylphosphate reductase; Function experimentally demonstrated in the studied species; enzyme. (417 aa) |
| | proC | Pyrroline-5-carboxylate reductase, NAD(P)-binding; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (269 aa) |
| | aroL | Shikimate kinase II; Function experimentally demonstrated in the studied species; enzyme. (174 aa) |
| | asnB | Asparagine synthetase B; Function experimentally demonstrated in the studied species; enzyme. (554 aa) |
| | gltA | Citrate synthase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the citrate synthase family. (427 aa) |
| | aroG | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine repressible; Function experimentally demonstrated in the studied species; enzyme. (350 aa) |
| | gpmA | Function experimentally demonstrated in the studied species; enzyme. (250 aa) |
| | ybhJ | Putative enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (753 aa) |
| | ltaE | L-allo-threonine aldolase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme. (333 aa) |
| | serC | 3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa) |
| | aroA | 5-enolpyruvylshikimate-3-phosphate synthetase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (427 aa) |
| | aspC | Aspartate aminotransferase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme. (396 aa) |
| | icd | Isocitrate dehydrogenase, specific for NADP+; Function experimentally demonstrated in the studied species; extrachromosomal origin. (416 aa) |
| | prsA | Phosphoribosylpyrophosphate synthase; Function experimentally demonstrated in the studied species; enzyme. (315 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa) |
| | trpC | Fused indole-3-glycerolphosphate synthetase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the TrpF family. (452 aa) |
| | trpD | Fused glutamine amidotransferase (component II) of anthranilate synthase; Function experimentally demonstrated in the studied species; enzyme. (531 aa) |
| | trpE | Component I of anthranilate synthase; Function experimentally demonstrated in the studied species; enzyme. (520 aa) |
| | acnA | Aconitate hydratase 1; Function experimentally demonstrated in the studied species; enzyme. (891 aa) |
| | gapC | Glyceraldehyde-3-phosphate dehydrogenase C; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (333 aa) |
| | malY | Bifunctional beta-cystathionase, PLP-dependent and regulator of maltose regulon; Function experimentally demonstrated in the studied species; enzyme. (390 aa) |
| | pykF | Pyruvate kinase I; Function experimentally demonstrated in the studied species; enzyme; Belongs to the pyruvate kinase family. (470 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (252 aa) |
| | aroH | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repressible; Function experimentally demonstrated in the studied species; enzyme. (348 aa) |
| | pfkB | 6-phosphofructokinase II; Function experimentally demonstrated in the studied species; enzyme; Belongs to the carbohydrate kinase PfkB family. (309 aa) |
| | gapA | Glyceraldehyde-3-phosphate dehydrogenase A; Function experimentally demonstrated in the studied species; enzyme. (331 aa) |
| | sdaA | L-serine deaminase I; Function experimentally demonstrated in the studied species; enzyme. (454 aa) |
| | pykA | Pyruvate kinase II; Function experimentally demonstrated in the studied species; enzyme; Belongs to the pyruvate kinase family. (480 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (299 aa) |
| | hisD | Bifunctional histidinal dehydrogenase and histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Function experimentally demonstrated in the studied species; enzyme. (356 aa) |
| | hisB | Fused histidinol-phosphatase; Function experimentally demonstrated in the studied species; enzyme. (355 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit with HisF; Function experimentally demonstrated in the studied species; enzyme. (196 aa) |
| | hisA | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the HisA/HisF family. (245 aa) |
| | hisF | Imidazole glycerol phosphate synthase, catalytic subunit with HisH; Function experimentally demonstrated in the studied species; enzyme; Belongs to the HisA/HisF family. (258 aa) |
| | hisI | Fused phosphoribosyl-AMP cyclohydrolase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the PRA-PH family. (202 aa) |
| | fbaB | Fructose-bisphosphate aldolase class I; Function experimentally demonstrated in the studied species; enzyme. (350 aa) |
| | yfbQ | Putative aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (405 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa) |
| | cysK | Cysteine synthase A, O-acetylserine sulfhydrolase A subunit; Function experimentally demonstrated in the studied species; enzyme; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa) |
| | cysM | Cysteine synthase B (O-acetylserine sulfhydrolase B); Function experimentally demonstrated in the studied species; enzyme. (303 aa) |
| | talA | Transaldolase A; Function experimentally demonstrated in the studied species; enzyme. (316 aa) |
| | tktB | Transketolase 2, thiamin-binding; Function experimentally demonstrated in the studied species; enzyme; Belongs to the transketolase family. (667 aa) |
| | dapE | N-succinyl-diaminopimelate deacylase; Function experimentally demonstrated in the studied species; enzyme. (375 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | pheA | Fused chorismate mutase P; Function experimentally demonstrated in the studied species; enzyme. (386 aa) |
| | tyrA | Fused chorismate mutase T; Function experimentally demonstrated in the studied species; enzyme. (373 aa) |
| | aroF | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tyrosine-repressible; Function experimentally demonstrated in the studied species; enzyme. (356 aa) |
| | luxS | S-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (432 aa) |
| | sdaB | L-serine deaminase II; Function experimentally demonstrated in the studied species; enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa) |
| | argA | Fused acetylglutamate kinase homolog (inactive); Function experimentally demonstrated in the studied species; enzyme; Belongs to the acetyltransferase family. ArgA subfamily. (443 aa) |
| | lysA | Diaminopimelate decarboxylase, PLP-binding; Function experimentally demonstrated in the studied species; enzyme. (420 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa) |
| | rpiA | Ribose 5-phosphate isomerase, constitutive; Function experimentally demonstrated in the studied species; enzyme. (219 aa) |
| | fbaA | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa) |
| | pgk | Phosphoglycerate kinase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the phosphoglycerate kinase family. (387 aa) |
| | tktA | Transketolase 1, thiamin-binding; Function experimentally demonstrated in the studied species; enzyme. (663 aa) |
| | metK | Methionine adenosyltransferase 1; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (384 aa) |
| | metC | Cystathionine beta-lyase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme. (395 aa) |
| | tdcG | L-serine dehydratase 3; Function experimentally demonstrated in the studied species; enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa) |
| | tdcB | Catabolic threonine dehydratase, PLP-dependent; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (329 aa) |
| | argG | Argininosuccinate synthetase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (447 aa) |
| | gltB | Glutamate synthase, large subunit; Function experimentally demonstrated in the studied species; enzyme. (1517 aa) |
| | gltD | Glutamate synthase, 4Fe-4S protein, small subunit; Function experimentally demonstrated in the studied species; carrier. (472 aa) |
| | aroE | Dehydroshikimate reductase, NAD(P)-binding; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa) |
| | argD | Bifunctional acetylornithine aminotransferase and succinyldiaminopimelate aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (406 aa) |
| | rpe | D-ribulose-5-phosphate 3-epimerase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (362 aa) |
| | aroK | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase, NAD(P)-binding; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (367 aa) |
| | cysE | Serine acetyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the transferase hexapeptide repeat family. (273 aa) |
| | gpmI | Phosphoglycero mutase III, cofactor-independent; Function experimentally demonstrated in the studied species; enzyme. (514 aa) |
| | ilvN | Acetolactate synthase I, small subunit; Function experimentally demonstrated in the studied species; enzyme. (96 aa) |
| | ilvB | Acetolactate synthase I, large subunit; Function experimentally demonstrated in the studied species; enzyme. (562 aa) |
| | asnA | Asparagine synthetase A; Function experimentally demonstrated in the studied species; enzyme. (330 aa) |
| | ilvG | Acetolactate synthase isozyme II large subunit; Function of strongly homologous gene; enzyme. (548 aa) |
| | ilvM | Acetolactate synthase II, small subunit; Function experimentally demonstrated in the studied species; enzyme. (87 aa) |
| | ilvE | Branched-chain amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (309 aa) |
| | ilvD | Dihydroxyacid dehydratase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the IlvD/Edd family. (616 aa) |
| | ilvA | Threonine deaminase; Function experimentally demonstrated in the studied species; enzyme. (514 aa) |
| | ilvC | Ketol-acid reductoisomerase, NAD(P)-binding; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (491 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (753 aa) |
| | glnA | Glutamine synthetase; Function experimentally demonstrated in the studied species; enzyme. (469 aa) |
| | pfkA | 6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | metB | Cystathionine gamma-synthase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme. (386 aa) |
| | metL | Fused aspartokinase II; Function experimentally demonstrated in the studied species; enzyme. (810 aa) |
| | argE | Acetylornithine deacetylase; Function experimentally demonstrated in the studied species; enzyme. (383 aa) |
| | argC | N-acetyl-gamma-glutamylphosphate reductase, NAD(P)-binding; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (334 aa) |
| | argB | Acetylglutamate kinase; Function experimentally demonstrated in the studied species; enzyme. (257 aa) |
| | argH | Argininosuccinate lyase; Function experimentally demonstrated in the studied species; enzyme. (457 aa) |
| | metA | Homoserine transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (309 aa) |
| | metH | homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; Function experimentally demonstrated in the studied species; enzyme. (1227 aa) |
| | lysC | Aspartokinase III; Function experimentally demonstrated in the studied species; enzyme; Belongs to the aspartokinase family. (449 aa) |
| | tyrB | Tyrosine aminotransferase, tyrosine-repressible, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme. (397 aa) |
| | CAR01066.1 | Putative ribose-5-phosphate isomerase B (rpiB-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (105 aa) |
| | argI | Fragment of conserved hypothetical protein (part 3); Gene remnant. (334 aa) |
| | serB | 3-phosphoserine phosphatase; Function experimentally demonstrated in the studied species; enzyme. (322 aa) |
| | ytjC | Phosphoglyceromutase 2, co-factor independent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (215 aa) |
