STRINGSTRING
secA secA yajC yajC ribD ribD kdpE kdpE aroG aroG oppA oppA oppB oppB oppC oppC oppD oppD oppF oppF trpE trpE ribA ribA gmr gmr mppA mppA ydcS ydcS ydcT ydcT ydcU ydcU ydcV ydcV ydcZ ydcZ ddpF ddpF ddpD ddpD ddpC ddpC ddpB ddpB ddpA ddpA gadC gadC gadB gadB lsrK lsrK lsrR lsrR ego ego lsrC lsrC lsrD lsrD lsrB lsrB lsrF lsrF lsrG lsrG aroH aroH fadD fadD flhC flhC flhD flhD sdiA sdiA rcsA rcsA yfhA yfhA yfhK yfhK aroF aroF ffh ffh luxS luxS qseB qseB qseC qseC secG secG secY secY crp crp livF livF livG livG livM livM livH livH livK livK livJ livJ ftsY ftsY gadA gadA secB secB yidC yidC secE secE zur zur hfq hfq
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
secAPreprotein translocase subunit, ATPase; Function experimentally demonstrated in the studied species; transporter. (901 aa)
yajCSecYEG protein translocase auxillary subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (110 aa)
ribDFused diaminohydroxyphosphoribosylaminopyrimidine deaminase; Function experimentally demonstrated in the studied species; enzyme. (367 aa)
kdpEDNA-binding response regulator in two-component regulatory system with KdpD; Function experimentally demonstrated in the studied species; regulator. (225 aa)
aroG3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine repressible; Function experimentally demonstrated in the studied species; enzyme. (350 aa)
oppAOligopeptide transporter subunit; Function experimentally demonstrated in the studied species; transporter. (543 aa)
oppBOligopeptide transporter subunit; Function experimentally demonstrated in the studied species; transporter. (306 aa)
oppCOligopeptide transporter subunit; Function experimentally demonstrated in the studied species; transporter. (302 aa)
oppDOligopeptide transporter subunit; Function experimentally demonstrated in the studied species; transporter. (337 aa)
oppFOligopeptide transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the ABC transporter superfamily. (334 aa)
trpEComponent I of anthranilate synthase; Function experimentally demonstrated in the studied species; enzyme. (520 aa)
ribAGTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. (196 aa)
gmrModulator of Rnase II stability; Function experimentally demonstrated in the studied species; putative factor. (661 aa)
mppAMurein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit; Function experimentally demonstrated in the studied species; transporter. (537 aa)
ydcSPutative spermidine/putrescine transporter subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (381 aa)
ydcTPutative spermidine/putrescine transporter subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the ABC transporter superfamily. (337 aa)
ydcUPutative spermidine/putrescine transporter subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (313 aa)
ydcVPutative spermidine/putrescine transporter subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (264 aa)
ydcZConserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (149 aa)
ddpFD-ala-D-ala transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the ABC transporter superfamily. (308 aa)
ddpDD-ala-D-ala transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the ABC transporter superfamily. (328 aa)
ddpCD-ala-D-ala transporter subunit; Function experimentally demonstrated in the studied species; transporter. (298 aa)
ddpBD-ala-D-ala transporter subunit; Function experimentally demonstrated in the studied species; transporter. (340 aa)
ddpAD-ala-D-a la transporter subunit; Function experimentally demonstrated in the studied species; transporter. (516 aa)
gadCGlutamate:gamma-aminobutyric acid antiporter; Function experimentally demonstrated in the studied species; transporter. (511 aa)
gadBGlutamate decarboxylase B, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the group II decarboxylase family. (466 aa)
lsrKAutoinducer AI-2 kinase; Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position. (530 aa)
lsrRDNA-binding transcriptional regulator; Function experimentally demonstrated in the studied species; regulator. (317 aa)
egoFused AI2 transporter subunits of ABC superfamily: ATP-binding components; Function experimentally demonstrated in the studied species; transporter. (511 aa)
lsrCAI2 transporter; Function experimentally demonstrated in the studied species; transporter; Belongs to the binding-protein-dependent transport system permease family. (342 aa)
lsrDAI2 transporter; Function experimentally demonstrated in the studied species; transporter; Belongs to the binding-protein-dependent transport system permease family. (330 aa)
lsrBAI2 transporter; Function experimentally demonstrated in the studied species; transporter. (340 aa)
lsrFPutative aldolase; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5- phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA; Belongs to the DeoC/FbaB aldolase family. (291 aa)
lsrGConserved hypothetical protein; Homologs of previously reported genes of unknown function. (96 aa)
aroH3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repressible; Function experimentally demonstrated in the studied species; enzyme. (348 aa)
fadDacyl-CoA synthetase (long-chain-fatty-acid--CoA ligase); Function experimentally demonstrated in the studied species; enzyme. (561 aa)
flhCDNA-binding transcriptional dual regulator with FlhD; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family. (192 aa)
flhDDNA-binding transcriptional dual regulator with FlhC; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family. (119 aa)
sdiADNA-binding transcriptional activator; Function experimentally demonstrated in the studied species; regulator. (240 aa)
rcsADNA-binding transcriptional activator, co-regulator with RcsB; Component of the Rcs signaling system, which controls transcription of numerous genes. Binds, with RcsB, to the RcsAB box to regulate expression of genes (By similarity). Involved in regulation of K30 capsular polysaccharide synthesis. (207 aa)
yfhAPutative DNA-binding response regulator in two-component system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (444 aa)
yfhKPutative sensory kinase in two-component system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (475 aa)
aroF3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tyrosine-repressible; Function experimentally demonstrated in the studied species; enzyme. (356 aa)
ffhSignal Recognition Particle (SRP) component with 4.5S RNA (ffs); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex [...] (453 aa)
luxSS-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa)
qseBDNA-binding response regulator in two-component regulatory system with QseC; Function experimentally demonstrated in the studied species; regulator. (219 aa)
qseCSensory histidine kinase in two-component regulatory system with QseB; Function experimentally demonstrated in the studied species; regulator. (449 aa)
secGPreprotein translocase membrane subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (110 aa)
secYPreprotein translocase membrane subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (443 aa)
crpDNA-binding transcriptional dual regulator; Function experimentally demonstrated in the studied species; regulator. (210 aa)
livFLeucine/isoleucine/valine transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the ABC transporter superfamily. (237 aa)
livGLeucine/isoleucine/valine transporter subunit; Function experimentally demonstrated in the studied species; transporter. (255 aa)
livMLeucine/isoleucine/valine transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the binding-protein-dependent transport system permease family. (425 aa)
livHLeucine/isoleucine/valine transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the binding-protein-dependent transport system permease family. (308 aa)
livKLeucine transporter subunit; Function experimentally demonstrated in the studied species; transporter. (369 aa)
livJLeucine/isoleucine/valine transporter subunit; Function experimentally demonstrated in the studied species; transporter. (367 aa)
ftsYFused Signal Recognition Particle (SRP) receptor: membrane binding protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (497 aa)
gadAGlutamate decarboxylase A, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme. (466 aa)
secBProtein export chaperone; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (155 aa)
yidCCytoplasmic insertase into membrane protein, Sec system; Function experimentally demonstrated in the studied species; enzyme. (548 aa)
secEPreprotein translocase membrane subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. (127 aa)
zurDNA-binding transcriptional repressor, Zn(II)-binding; Function experimentally demonstrated in the studied species; regulator; Belongs to the Fur family. (171 aa)
hfqHF-I, host factor for RNA phage Q beta replication; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. (102 aa)
Your Current Organism:
Escherichia coli IAI1
NCBI taxonomy Id: 585034
Other names: E. coli IAI1, Escherichia coli str. IAI1, Escherichia coli strain IAI1
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