(18 nodes) Histidine metabolism, and Tryptophan biosynthetic process network (Escherichia coli UMN026)

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	ybiB	Putative transferase/phosphorylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (320 aa)
	pabC	4-amino-4-deoxychorismate lyase component of para-aminobenzoate synthase multienzyme complex; Function experimentally demonstrated in the studied species; enzyme. (269 aa)
	trpA	Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa)
	trpB	Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa)
	trpC	Fused indole-3-glycerolphosphate synthetase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the TrpC family. (452 aa)
	trpD	Fused glutamine amidotransferase (component II) of anthranilate synthase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (531 aa)
	trpE	Component I of anthranilate synthase; Function experimentally demonstrated in the studied species; enzyme. (520 aa)
	pabB	Aminodeoxychorismate synthase, subunit I; Function experimentally demonstrated in the studied species; enzyme. (453 aa)
	irp	Salicylate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (434 aa)
	hisG	ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (299 aa)
	hisD	Bifunctional histidinal dehydrogenase and histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa)
	hisC	Histidinol-phosphate aminotransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (356 aa)
	hisB	Fused histidinol-phosphatase; Function experimentally demonstrated in the studied species; enzyme; In the N-terminal section; belongs to the histidinol- phosphatase family. (355 aa)
	hisH	Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit with HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa)
	hisA	N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function experimentally demonstrated in the studied species; enzyme. (245 aa)
	hisF	Imidazole glycerol phosphate synthase, catalytic subunit with HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa)
	hisI	Fused phosphoribosyl-AMP cyclohydrolase; Function experimentally demonstrated in the studied species; enzyme; In the N-terminal section; belongs to the PRA-CH family. (203 aa)
	pabA	Aminodeoxychorismate synthase, subunit II; Function experimentally demonstrated in the studied species; enzyme. (187 aa)

Your Current Organism:

Escherichia coli UMN026

NCBI taxonomy Id: 585056
Other names: E. coli UMN026

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
hisA	hisB	ECUMN_2366	ECUMN_2364	N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function experimentally demonstrated in the studied species; enzyme.	Fused histidinol-phosphatase; Function experimentally demonstrated in the studied species; enzyme; In the N-terminal section; belongs to the histidinol- phosphatase family.	0.999
hisA	hisC	ECUMN_2366	ECUMN_2363	N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function experimentally demonstrated in the studied species; enzyme.	Histidinol-phosphate aminotransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	0.997
hisA	hisD	ECUMN_2366	ECUMN_2362	N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function experimentally demonstrated in the studied species; enzyme.	Bifunctional histidinal dehydrogenase and histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.	0.996
hisA	hisF	ECUMN_2366	ECUMN_2367	N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function experimentally demonstrated in the studied species; enzyme.	Imidazole glycerol phosphate synthase, catalytic subunit with HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.	0.999
hisA	hisG	ECUMN_2366	ECUMN_2361	N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function experimentally demonstrated in the studied species; enzyme.	ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.	0.997
hisA	hisH	ECUMN_2366	ECUMN_2365	N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function experimentally demonstrated in the studied species; enzyme.	Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit with HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.999
hisA	hisI	ECUMN_2366	ECUMN_2368	N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function experimentally demonstrated in the studied species; enzyme.	Fused phosphoribosyl-AMP cyclohydrolase; Function experimentally demonstrated in the studied species; enzyme; In the N-terminal section; belongs to the PRA-CH family.	0.999
hisA	trpA	ECUMN_2366	ECUMN_1559	N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function experimentally demonstrated in the studied species; enzyme.	Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.517
hisA	trpB	ECUMN_2366	ECUMN_1560	N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function experimentally demonstrated in the studied species; enzyme.	Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.561
hisA	trpC	ECUMN_2366	ECUMN_1561	N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function experimentally demonstrated in the studied species; enzyme.	Fused indole-3-glycerolphosphate synthetase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the TrpC family.	0.823
hisA	trpD	ECUMN_2366	ECUMN_1562	N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function experimentally demonstrated in the studied species; enzyme.	Fused glutamine amidotransferase (component II) of anthranilate synthase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).	0.655
hisB	hisA	ECUMN_2364	ECUMN_2366	Fused histidinol-phosphatase; Function experimentally demonstrated in the studied species; enzyme; In the N-terminal section; belongs to the histidinol- phosphatase family.	N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function experimentally demonstrated in the studied species; enzyme.	0.999
hisB	hisC	ECUMN_2364	ECUMN_2363	Fused histidinol-phosphatase; Function experimentally demonstrated in the studied species; enzyme; In the N-terminal section; belongs to the histidinol- phosphatase family.	Histidinol-phosphate aminotransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	0.999
hisB	hisD	ECUMN_2364	ECUMN_2362	Fused histidinol-phosphatase; Function experimentally demonstrated in the studied species; enzyme; In the N-terminal section; belongs to the histidinol- phosphatase family.	Bifunctional histidinal dehydrogenase and histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.	0.999
hisB	hisF	ECUMN_2364	ECUMN_2367	Fused histidinol-phosphatase; Function experimentally demonstrated in the studied species; enzyme; In the N-terminal section; belongs to the histidinol- phosphatase family.	Imidazole glycerol phosphate synthase, catalytic subunit with HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.	0.999
hisB	hisG	ECUMN_2364	ECUMN_2361	Fused histidinol-phosphatase; Function experimentally demonstrated in the studied species; enzyme; In the N-terminal section; belongs to the histidinol- phosphatase family.	ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.	0.998
hisB	hisH	ECUMN_2364	ECUMN_2365	Fused histidinol-phosphatase; Function experimentally demonstrated in the studied species; enzyme; In the N-terminal section; belongs to the histidinol- phosphatase family.	Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit with HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.999
hisB	hisI	ECUMN_2364	ECUMN_2368	Fused histidinol-phosphatase; Function experimentally demonstrated in the studied species; enzyme; In the N-terminal section; belongs to the histidinol- phosphatase family.	Fused phosphoribosyl-AMP cyclohydrolase; Function experimentally demonstrated in the studied species; enzyme; In the N-terminal section; belongs to the PRA-CH family.	0.999
hisB	trpA	ECUMN_2364	ECUMN_1559	Fused histidinol-phosphatase; Function experimentally demonstrated in the studied species; enzyme; In the N-terminal section; belongs to the histidinol- phosphatase family.	Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.748
hisB	trpB	ECUMN_2364	ECUMN_1560	Fused histidinol-phosphatase; Function experimentally demonstrated in the studied species; enzyme; In the N-terminal section; belongs to the histidinol- phosphatase family.	Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.688