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mraZ mraZ mraW mraW ftsL ftsL ftsI ftsI murE murE murF murF mraY mraY murD murD ftsW ftsW murG murG murC murC ddlB ddlB ftsQ ftsQ ftsA ftsA ftsZ ftsZ mrcB mrcB mltD mltD ampH ampH ddlA ddlA dacA dacA mrdB mrdB mrdA mrdA dacC dacC ftsK ftsK CAR12482.1 CAR12482.1 yceG yceG ycfH ycfH ycfM ycfM dadA dadA dadX dadX emtA emtA ydhO ydhO yebA yebA dacD dacD pbpG pbpG spr spr zipA zipA murQ murQ amiA amiA yfgA yfgA pbpC pbpC yfhM yfhM yfhD yfhD mltB mltB ftsB ftsB mltA mltA amiC amiC ygeR ygeR mltC mltC yraM yraM dacB dacB murA murA mtgA mtgA elbB elbB mreD mreD mreC mreC mreB mreB mrcA mrcA ftsX ftsX ftsE ftsE envC envC yibQ yibQ ftsN ftsN murB murB alr alr amiB amiB slt slt
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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mraZConserved hypothetical protein; Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster. (152 aa)
mraWS-adenosyl-dependent methyltransferase activity on membrane-located substrates; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (313 aa)
ftsLMembrane bound cell division protein at septum containing leucine zipper motif; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (121 aa)
ftsITranspeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (588 aa)
murEUDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso- diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (495 aa)
murFUDP-N-acetylmuramoyl-tripeptide:D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (452 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (360 aa)
murDUDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (438 aa)
ftsWIntegral membrane protein involved in stabilizing FstZ ring during cell division; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (414 aa)
murGN-acetylglucosaminyl transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (355 aa)
murCUDP-N-acetylmuramate:L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (491 aa)
ddlBD-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (306 aa)
ftsQMembrane anchored protein involved in growth of wall at septum; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. (276 aa)
ftsAATP-binding cell division protein involved in recruitment of FtsK to Z ring; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (420 aa)
ftsZGTP-binding tubulin-like cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (383 aa)
mrcBFused glycosyl transferase; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (844 aa)
mltDMembrane-bound lytic murein transglycosylase D; Function experimentally demonstrated in the studied species; enzyme. (452 aa)
ampHbeta-lactamase/D-alanine carboxypeptidase; Function experimentally demonstrated in the studied species; enzyme. (385 aa)
ddlAD-alanine-D-alanine ligase A; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (364 aa)
dacAD-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5); Function experimentally demonstrated in the studied species; enzyme; Belongs to the peptidase S11 family. (403 aa)
mrdBCell wall shape-determining protein; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (370 aa)
mrdATranspeptidase involved in peptidoglycan synthesis (penicillin-binding protein 2); Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (633 aa)
dacCD-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 6a); Function experimentally demonstrated in the studied species; enzyme; Belongs to the peptidase S11 family. (400 aa)
ftsKDNA-binding membrane protein required for chromosome resolution and partitioning; Function experimentally demonstrated in the studied species; cell process. (1368 aa)
CAR12482.1Transposase IS605 family, IS200 group; Function of strongly homologous gene; enzyme. (169 aa)
yceGPutative conserved membrane associated protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (340 aa)
ycfHPutative metallodependent hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (265 aa)
ycfMPutative outer membrane lipoprotein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). Belongs to the LpoB family. (213 aa)
dadAD-amino acid dehydrogenase; Oxidative deamination of D-amino acids; Belongs to the DadA oxidoreductase family. (432 aa)
dadXAlanine racemase 2, PLP-binding; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (356 aa)
emtALytic murein endotransglycosylase E; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain. (203 aa)
ydhOPutative exported hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (275 aa)
yebAPutative metallopeptidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (440 aa)
dacDD-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 6b); Function experimentally demonstrated in the studied species; enzyme; Belongs to the peptidase S11 family. (388 aa)
pbpGD-alanyl-D-alanine endopeptidase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the peptidase S11 family. (310 aa)
sprPutative peptidase, outer membrane lipoprotein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (188 aa)
zipACell division protein involved in Z ring assembly; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. (328 aa)
murQD-lactyl ether N-acetylmuramic-6-phosphate acid etherase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the peptidase S12 family. YfeW subfamily. (462 aa)
amiAN-acetylmuramoyl-l-alanine amidase I; Function experimentally demonstrated in the studied species; enzyme. (289 aa)
yfgAConserved hypothetical protein; Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis. (337 aa)
pbpCFused transglycosylase; Function experimentally demonstrated in the studied species; enzyme. (770 aa)
yfhMConserved hypothetical protein; Protects the bacterial cell from host peptidases. (1653 aa)
yfhDPutative transglycosylase; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. (472 aa)
mltBMembrane-bound lytic murein transglycosylase B; Function experimentally demonstrated in the studied species; enzyme. (361 aa)
ftsBCell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (103 aa)
mltAMembrane-bound lytic murein transglycosylase A; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. (365 aa)
amiCN-acetylmuramoyl-L-alanine amidase; Function experimentally demonstrated in the studied species; enzyme. (417 aa)
ygeRTetratricopeptide repeat transcriptional regulator; Function experimentally demonstrated in the studied species; regulator. (258 aa)
mltCMembrane-bound lytic murein transglycosylase C; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. (359 aa)
yraMConserved hypothetical protein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Belongs to the LpoA family. (678 aa)
dacBD-alanyl-D-alanine carboxypeptidase; Function experimentally demonstrated in the studied species; enzyme. (477 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa)
mtgABiosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family. (242 aa)
elbBIsoprenoid biosynthesis protein with amidotransferase-like domain; Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate; Belongs to the peptidase C56 family. (217 aa)
mreDCell wall structural complex MreBCD transmembrane component MreD; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family. (162 aa)
mreCCell wall structural complex MreBCD transmembrane component MreC; Involved in formation and maintenance of cell shape. (338 aa)
mreBCell wall structural complex MreBCD, actin-like component MreB; Function experimentally demonstrated in the studied species; structure. (347 aa)
mrcAFused penicillin-binding protein 1a: murein transglycosylase; Function experimentally demonstrated in the studied species; enzyme. (850 aa)
ftsXTransporter subunit: membrane component of ABC superfamily; Part of the ABC transporter FtsEX involved in cellular division; Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. (352 aa)
ftsETransporter subunit: ATP-binding component of ABC superfamily; Part of the ABC transporter FtsEX involved in cellular division. (222 aa)
envCProtease with a role in cell division; Function experimentally demonstrated in the studied species; cell process. (419 aa)
yibQPutative polysaccharide deacetylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (319 aa)
ftsNEssential cell division protein; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. (319 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD-binding; Cell wall formation. (342 aa)
alrAlanine racemase 1, PLP-binding, biosynthetic; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (359 aa)
amiBN-acetylmuramoyl-l-alanine amidase II; Function experimentally demonstrated in the studied species; enzyme. (445 aa)
sltLytic murein transglycosylase, soluble; Function experimentally demonstrated in the studied species; enzyme. (645 aa)
Your Current Organism:
Escherichia coli UMN026
NCBI taxonomy Id: 585056
Other names: E. coli UMN026
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