STRINGSTRING
acrB acrB acrA acrA ybhT ybhT macA macA macB macB acrD acrD tolC tolC acrE acrE acrF acrF mdtE mdtE mdtF mdtF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
acrBMultidrug efflux system protein; Function experimentally demonstrated in the studied species; transporter. (1049 aa)
acrAMultidrug efflux system; Function experimentally demonstrated in the studied species; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (397 aa)
ybhTConserved hypothetical protein; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. (49 aa)
macAMacrolide transporter subunit, membrane fusion protein (MFP) component; Function experimentally demonstrated in the studied species; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (371 aa)
macBFused macrolide transporter subunits of ABC superfamily: ATP-binding component; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (648 aa)
acrDAminoglycoside/multidrug efflux system; Function experimentally demonstrated in the studied species; transporter. (1037 aa)
tolCTransport channel; Function experimentally demonstrated in the studied species; transporter. (493 aa)
acrECytoplasmic membrane lipoprotein; Function experimentally demonstrated in the studied species; lipoprotein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (385 aa)
acrFMultidrug efflux system protein; Function experimentally demonstrated in the studied species; transporter. (1034 aa)
mdtEMultidrug resistance efflux transporter; Function experimentally demonstrated in the studied species; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (385 aa)
mdtFMultidrug transporter, RpoS-dependent; Function experimentally demonstrated in the studied species; transporter. (1037 aa)
Your Current Organism:
Escherichia coli UMN026
NCBI taxonomy Id: 585056
Other names: E. coli UMN026
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